KCNMB2-AS1

Summary

KCNMB2-AS1 (KCNMB2 antisense RNA 1, HGNC:51409) is a long non-coding RNA gene on chromosome 3q26.32.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51409
Approved symbol	KCNMB2-AS1
Name	KCNMB2 antisense RNA 1
Location	3q26.32
Locus type	RNA, long non-coding
Status	Approved
Aliases	RP11-385J1.2
Ensembl gene	ENSG00000237978
Ensembl biotype	lncRNA
Entrez	104797538
RNAcentral	URS00007E41B7 — lncRNA, 2055 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 14 lncRNA

ENST00000421498, ENST00000425330, ENST00000432385, ENST00000437488, ENST00000451742, ENST00000668466, ENST00000730825, ENST00000730826, ENST00000730827, ENST00000730828, ENST00000730829, ENST00000730830, ENST00000730831, ENST00000730832

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000421498 — 2 exons

Exon	Start	End
ENSE00001686671	178748988	178749236
ENSE00001737090	178801793	178801936

Expression profiles

Bgee: expression breadth ubiquitous, 149 present calls, max score 90.92.

Top tissues by expression

238 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	90.92	silver quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.40	gold quality
bone marrow cell	CL:0002092	73.96	silver quality
olfactory segment of nasal mucosa	UBERON:0005386	73.01	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	71.84	gold quality
colonic epithelium	UBERON:0000397	71.48	gold quality
gall bladder	UBERON:0002110	65.50	gold quality
corpus callosum	UBERON:0002336	62.67	gold quality
endothelial cell	CL:0000115	61.85	gold quality
ganglionic eminence	UBERON:0004023	61.68	gold quality
sural nerve	UBERON:0015488	61.23	silver quality
lower esophagus mucosa	UBERON:0035834	60.89	gold quality
adrenal tissue	UBERON:0018303	58.44	gold quality
nasal cavity mucosa	UBERON:0001826	58.41	gold quality
islet of Langerhans	UBERON:0000006	57.56	gold quality
monocyte	CL:0000576	57.15	gold quality
amygdala	UBERON:0001876	56.98	gold quality
ascending aorta	UBERON:0001496	56.64	gold quality
anterior cingulate cortex	UBERON:0009835	56.52	gold quality
prefrontal cortex	UBERON:0000451	56.41	gold quality
thoracic aorta	UBERON:0001515	56.11	gold quality
nasal cavity epithelium	UBERON:0005384	56.09	gold quality
superficial temporal artery	UBERON:0001614	56.06	gold quality
right coronary artery	UBERON:0001625	55.55	gold quality
Brodmann (1909) area 9	UBERON:0013540	54.95	gold quality
nucleus accumbens	UBERON:0001882	54.73	gold quality
left coronary artery	UBERON:0001626	54.34	gold quality
cerebellar cortex	UBERON:0002129	54.25	gold quality
right uterine tube	UBERON:0001302	54.11	gold quality
aorta	UBERON:0000947	54.10	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-HCAD-25	yes	2249.92
E-ANND-3	no	3.64

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Long noncoding RNA KCNMB2-AS1 promotes the development of esophageal cancer by modulating the miR-3194-3p/PYGL axis. (PMID:34516362)
• Long noncoding RNA KCNMB2-AS1 acts as an oncogene in ovarian cancer. (PMID:37710992)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.