KCNQ1DN

Summary

KCNQ1DN (KCNQ1 downstream neighbor, HGNC:13335) is a long non-coding RNA gene on chromosome 11p15.4.

Imprinting is a phenomenon in which epigenetic modifications lead to expression or suppression of alleles of some genes based on their parental origin. Wilms tumor-2 (WT2; MIM 194071) is defined by maternal-specific loss of heterozygosity of a critical region on chromosome 11p15.5 that includes several imprinted genes. KCNQ1DN is an imprinted gene located within the WT2 critical region that is expressed from the maternal allele (Xin et al., 2000 [PubMed 11056398]).

Source: NCBI Gene 55539 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:13335
Approved symbol	KCNQ1DN
Name	KCNQ1 downstream neighbor
Location	11p15.4
Locus type	RNA, long non-coding
Status	Approved
Aliases	BWRT, HSA404617
Ensembl gene	ENSG00000237941
Ensembl biotype	lncRNA
OMIM	610980
Entrez	55539
RNAcentral	URS000075B205 — lncRNA, 1109 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000441418

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000441418 — 2 exons

Exon	Start	End
ENSE00001635900	2871845	2872105
ENSE00001691872	2870033	2870864

Expression profiles

Bgee: expression breadth broad, 78 present calls, max score 92.36.

Top tissues by expression

78 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	92.36	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	80.80	gold quality
substantia nigra	UBERON:0002038	62.98	gold quality
left testis	UBERON:0004533	61.19	gold quality
testis	UBERON:0000473	60.25	gold quality
ganglionic eminence	UBERON:0004023	58.77	silver quality
right testis	UBERON:0004534	58.63	gold quality
Ammon’s horn	UBERON:0001954	58.17	gold quality
prefrontal cortex	UBERON:0000451	56.73	gold quality
lymph node	UBERON:0000029	56.61	gold quality
putamen	UBERON:0001874	54.22	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	53.81	gold quality
hypothalamus	UBERON:0001898	53.34	gold quality
skeletal muscle tissue	UBERON:0001134	53.23	silver quality
frontal cortex	UBERON:0001870	53.14	gold quality
multicellular organism	UBERON:0000468	51.88	gold quality
muscle of leg	UBERON:0001383	51.70	gold quality
cortex of kidney	UBERON:0001225	51.66	gold quality
cerebral cortex	UBERON:0000956	51.53	gold quality
temporal lobe	UBERON:0001871	51.42	gold quality
amygdala	UBERON:0001876	51.26	gold quality
brain	UBERON:0000955	50.91	gold quality
Brodmann (1909) area 9	UBERON:0013540	50.54	gold quality
superior frontal gyrus	UBERON:0002661	50.16	gold quality
primary visual cortex	UBERON:0002436	49.86	silver quality
blood	UBERON:0000178	49.16	silver quality
monocyte	CL:0000576	48.95	silver quality
right lobe of liver	UBERON:0001114	48.91	silver quality
caudate nucleus	UBERON:0001873	48.55	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	48.06	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.