KCNQ2-AS1

Summary

KCNQ2-AS1 (KCNQ2 antisense RNA 1, HGNC:40321) is a long non-coding RNA gene on chromosome 20q13.33.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40321
Approved symbol	KCNQ2-AS1
Name	KCNQ2 antisense RNA 1
Location	20q13.33
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000226390
Ensembl biotype	lncRNA
Entrez	105372720
RNAcentral	URS0000237DC2 — lncRNA, 789 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000436263

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000436263 — 2 exons

Exon	Start	End
ENSE00001679390	63449061	63449329
ENSE00001744458	63448051	63448570

Expression profiles

Bgee: expression breadth broad, 53 present calls, max score 69.10.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0319 / max 5.6992, expressed in 15 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
185811	0.0319	15

Top tissues by expression

53 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left testis	UBERON:0004533	69.10	gold quality
testis	UBERON:0000473	67.88	gold quality
right testis	UBERON:0004534	66.21	gold quality
ganglionic eminence	UBERON:0004023	64.84	gold quality
cortex of kidney	UBERON:0001225	56.78	gold quality
cerebellum	UBERON:0002037	52.91	gold quality
cerebellar cortex	UBERON:0002129	52.71	gold quality
cerebellar hemisphere	UBERON:0002245	52.55	gold quality
stomach	UBERON:0000945	52.53	silver quality
prefrontal cortex	UBERON:0000451	52.30	gold quality
multicellular organism	UBERON:0000468	51.53	gold quality
superior frontal gyrus	UBERON:0002661	50.91	gold quality
right hemisphere of cerebellum	UBERON:0014890	50.55	gold quality
primary visual cortex	UBERON:0002436	50.28	gold quality
gastrocnemius	UBERON:0001388	49.25	gold quality
Brodmann (1909) area 9	UBERON:0013540	48.89	gold quality
blood	UBERON:0000178	48.85	gold quality
anterior cingulate cortex	UBERON:0009835	48.76	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	48.50	gold quality
cerebral cortex	UBERON:0000956	48.43	gold quality
frontal cortex	UBERON:0001870	48.36	gold quality
brain	UBERON:0000955	48.19	gold quality
nucleus accumbens	UBERON:0001882	48.13	gold quality
putamen	UBERON:0001874	47.99	gold quality
Ammon’s horn	UBERON:0001954	47.99	gold quality
islet of Langerhans	UBERON:0000006	47.59	gold quality
adrenal gland	UBERON:0002369	46.84	gold quality
amygdala	UBERON:0001876	46.52	gold quality
left adrenal gland	UBERON:0001234	46.06	gold quality
caudate nucleus	UBERON:0001873	45.95	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.