KCNS1

Summary

KCNS1 (potassium voltage-gated channel modifier subfamily S member 1, HGNC:6300) is a protein-coding gene on chromosome 20q13.12, encoding Delayed-rectifier potassium channel regulatory subunit KCNS1 (Q96KK3). Potassium channel regulatory subunit that modulate the delayed rectifier voltage-gated potassium channel activity of KCNB1 and KCNB2 by altering their kinetics, expression levels, and shifting the half-inactivation potential to more polarized values.

Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2 types: those that are functional by themselves and those that are electrically silent but capable of modulating the activity of specific functional alpha subunits. The protein encoded by this gene is not functional by itself but can form heteromultimers with member 1 and with member 2 (and possibly other members) of the Shab-related subfamily of potassium voltage-gated channel proteins. This gene belongs to the S subfamily of the potassium channel family.

Source: NCBI Gene 3787 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 86 total
• Druggable target: yes
• MANE Select transcript: NM_001322799

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:6300
Approved symbol	KCNS1
Name	potassium voltage-gated channel modifier subfamily S member 1
Location	20q13.12
Locus type	gene with protein product
Status	Approved
Aliases	Kv9.1
Ensembl gene	ENSG00000124134
Ensembl biotype	protein_coding
OMIM	602905
Entrez	3787

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000306117, ENST00000537075

RefSeq mRNA: 2 — MANE Select: NM_001322799 NM_001322799, NM_002251

CCDS: CCDS13342

Canonical transcript exons

ENST00000537075 — 4 exons

Exon	Start	End
ENSE00002227656	45100921	45101127
ENSE00002268458	45091214	45095340
ENSE00003893521	45099161	45099239
ENSE00003894528	45097662	45098695

Expression profiles

Bgee: expression breadth ubiquitous, 125 present calls, max score 97.32.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.5024 / max 53.0562, expressed in 102 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
187379	0.3871	84
187378	0.1018	28
187380	0.0135	4

Top tissues by expression

248 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
type B pancreatic cell	CL:0000169	97.32	gold quality
olfactory bulb	UBERON:0002264	96.36	gold quality
middle temporal gyrus	UBERON:0002771	96.33	gold quality
Brodmann (1909) area 23	UBERON:0013554	93.63	gold quality
primary visual cortex	UBERON:0002436	92.03	gold quality
triceps brachii	UBERON:0001509	91.90	gold quality
tongue squamous epithelium	UBERON:0006919	91.67	gold quality
cardia of stomach	UBERON:0001162	91.51	silver quality
gluteal muscle	UBERON:0002000	91.07	gold quality
occipital lobe	UBERON:0002021	90.93	gold quality
vena cava	UBERON:0004087	89.98	silver quality
Brodmann (1909) area 46	UBERON:0006483	89.74	gold quality
superior frontal gyrus	UBERON:0002661	89.44	gold quality
postcentral gyrus	UBERON:0002581	89.23	gold quality
parietal lobe	UBERON:0001872	88.92	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	88.40	gold quality
body of tongue	UBERON:0011876	87.17	gold quality
tongue	UBERON:0001723	86.96	gold quality
orbitofrontal cortex	UBERON:0004167	86.75	gold quality
dorsal root ganglion	UBERON:0000044	86.51	silver quality
pancreatic ductal cell	CL:0002079	86.40	silver quality
ventral tegmental area	UBERON:0002691	86.40	silver quality
superior surface of tongue	UBERON:0007371	86.34	gold quality
diaphragm	UBERON:0001103	86.26	gold quality
right frontal lobe	UBERON:0002810	86.04	gold quality
epithelial cell of pancreas	CL:0000083	85.76	gold quality
frontal cortex	UBERON:0001870	85.75	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	85.61	gold quality
superior vestibular nucleus	UBERON:0007227	85.59	silver quality
trigeminal ganglion	UBERON:0001675	85.40	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.71

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

129 targeting KCNS1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6873-3P	100.00	71.42	2626
HSA-MIR-4747-5P	100.00	67.90	2681
HSA-MIR-5196-5P	100.00	67.98	2761
HSA-MIR-6867-5P	100.00	82.21	3464
HSA-MIR-7110-3P	100.00	73.18	2486
HSA-MIR-4533	100.00	69.48	2758
HSA-MIR-6748-5P	100.00	65.81	1057
HSA-MIR-432-3P	100.00	67.86	705
HSA-MIR-4534	99.99	66.58	1907
HSA-MIR-8068	99.98	73.85	2376
HSA-MIR-4487	99.96	64.58	1252
HSA-MIR-8082	99.95	67.27	1170
HSA-MIR-9983-3P	99.94	71.48	3631
HSA-MIR-1236-3P	99.94	68.04	1695
HSA-MIR-9718	99.94	68.91	918
HSA-MIR-450B-5P	99.92	71.48	3175
HSA-MIR-329-3P	99.91	66.56	1234
HSA-MIR-362-3P	99.91	66.38	1267
HSA-MIR-6783-3P	99.89	67.92	2059
HSA-MIR-1343-3P	99.89	66.78	1815
HSA-MIR-129-5P	99.88	70.26	3273
HSA-MIR-4492	99.87	68.25	3611
HSA-MIR-4728-5P	99.85	69.39	4718
HSA-MIR-6785-5P	99.82	68.68	4428
HSA-MIR-4420	99.82	70.08	1624
HSA-MIR-944	99.82	70.85	3042
HSA-MIR-181B-2-3P	99.81	70.06	1646
HSA-MIR-181B-3P	99.81	70.06	1646
HSA-MIR-6817-3P	99.79	68.35	2126
HSA-MIR-3934-3P	99.76	65.51	1351

Literature-anchored findings (GeneRIF, showing 4)

• Thia study presented the KCNS1 allele rs734784 as one of the first prognostic indicators of chronic pain risk. (PMID:20724292)
• Several haplotypes of population-specific tagSNPs correlated with pain intensity in black southern African population with HIV-associated sensory neuropathy. (PMID:23314412)
• There was moderate statistical evidence for interactions shoulder pain phenotypes between KCNS1 and depressive symptoms, pain catastrophizing, or kinesiophobia (PMID:24373571)
• For KCNS1 rs4499491, individuals homozygous for the rare A allele (CC+ CA versus AA) had a 3.0-fold increase in the odds of reporting preoperative breast pain. (PMID:24392765)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	si:dkey-43k4.5	ENSDARG00000026084
mus_musculus	Kcns1	ENSMUSG00000040164
rattus_norvegicus	Kcns1	ENSRNOG00000013681

Paralogs (31): KCNG1 (ENSG00000026559), KCNQ1 (ENSG00000053918), KCNQ2 (ENSG00000075043), KCND1 (ENSG00000102057), KCNA7 (ENSG00000104848), KCNA1 (ENSG00000111262), KCNC4 (ENSG00000116396), KCNQ4 (ENSG00000117013), KCNC1 (ENSG00000129159), KCNA5 (ENSG00000130037), KCNC3 (ENSG00000131398), KCNA10 (ENSG00000143105), KCNA6 (ENSG00000151079), KCNS2 (ENSG00000156486), KCNB1 (ENSG00000158445), KCNF1 (ENSG00000162975), KCNV1 (ENSG00000164794), KCNC2 (ENSG00000166006), KCNV2 (ENSG00000168263), KCNG4 (ENSG00000168418), KCNS3 (ENSG00000170745), KCNG3 (ENSG00000171126), KCND3 (ENSG00000171385), KCNA3 (ENSG00000177272), KCNA2 (ENSG00000177301), KCNG2 (ENSG00000178342), KCNA4 (ENSG00000182255), KCNB2 (ENSG00000182674), KCNQ3 (ENSG00000184156), KCND2 (ENSG00000184408), KCNQ5 (ENSG00000185760)

Protein

Protein identifiers

Delayed-rectifier potassium channel regulatory subunit KCNS1 — Q96KK3 (reviewed: Q96KK3)

Alternative names: Delayed-rectifier K(+) channel alpha subunit 1, Delayed-rectifier potassium channel subunit Kv9.1, Potassium voltage-gated channel modifier subfamily S member 1

All UniProt accessions (2): A2RUL8, Q96KK3

UniProt curated annotations — full annotation on UniProt →

Function. Potassium channel regulatory subunit that modulate the delayed rectifier voltage-gated potassium channel activity of KCNB1 and KCNB2 by altering their kinetics, expression levels, and shifting the half-inactivation potential to more polarized values. While it does not form functional channels on its own, it can form functional heterotetrameric channels with KCNB1 and KCNB2. Each regulatory subunit has unique regulatory properties that can lead to extensive inhibition, significant changes in kinetics, and/or substantial shifts in the voltage dependencies of the inactivation process.

Subunit / interactions. Heterotetramer with KCNB1. Heterotetramer with KCNB2. Does not form homomultimers.

Subcellular location. Cell membrane.

Tissue specificity. Detected in all tissues tested with the exception of skeletal muscle. Highly expressed in adult and fetal brain, fetal kidney and lung, and adult prostate and testis.

Domain organisation. The transmembrane segment S4 functions as a voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.

Similarity. Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.1/KCNS1 sub-subfamily.

RefSeq proteins (2): NP_001309728, NP_002242 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000210	BTB/POZ_dom	Domain
IPR003131	T1-type_BTB	Domain
IPR003968	K_chnl_volt-dep_Kv	Family
IPR003971	K_chnl_volt-dep_Kv5/Kv9	Family
IPR005821	Ion_trans_dom	Domain
IPR011333	SKP1/BTB/POZ_sf	Homologous_superfamily
IPR027359	Volt_channel_dom_sf	Homologous_superfamily
IPR028325	VG_K_chnl	Family

Pfam: PF00520, PF02214

UniProt features (22 total): topological domain 8, transmembrane region 6, intramembrane region 2, sequence variant 2, chain 1, region of interest 1, short sequence motif 1, compositionally biased region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96KK3-F1	78.83	0.42

Function

Pathways and Gene Ontology

Reactome pathways

3 pathways

ID	Pathway
R-HSA-1296072	Voltage gated Potassium channels
R-HSA-112316	Neuronal System
R-HSA-1296071	Potassium Channels

MSigDB gene sets: 106 (showing top): GSE37336_LY6C_POS_VS_NEG_NAIVE_CD4_TCELL_DN, GOBP_POTASSIUM_ION_TRANSPORT, YAGI_AML_WITH_INV_16_TRANSLOCATION, REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS, REACTOME_POTASSIUM_CHANNELS, LHX3_01, GOBP_MONOATOMIC_CATION_TRANSPORT, NKX62_Q2, MODULE_99, SLEBOS_HEAD_AND_NECK_CANCER_WITH_HPV_UP, GOBP_PROTEIN_HOMOOLIGOMERIZATION, CDPCR3HD_01, GOBP_REGULATION_OF_TRANSPORT, GOBP_REGULATION_OF_MONOATOMIC_ION_TRANSPORT, GOBP_TRANSMEMBRANE_TRANSPORT

GO Biological Process (8): action potential (GO:0001508), potassium ion transport (GO:0006813), protein homooligomerization (GO:0051260), potassium ion transmembrane transport (GO:0071805), regulation of potassium ion transmembrane transport (GO:1901379), monoatomic ion transport (GO:0006811), monoatomic ion transmembrane transport (GO:0034220), transmembrane transport (GO:0055085)

GO Molecular Function (5): voltage-gated potassium channel activity (GO:0005249), potassium channel regulator activity (GO:0015459), monoatomic ion channel activity (GO:0005216), potassium channel activity (GO:0005267), protein binding (GO:0005515)

GO Cellular Component (6): nucleoplasm (GO:0005654), plasma membrane (GO:0005886), voltage-gated potassium channel complex (GO:0008076), membrane (GO:0016020), perinuclear region of cytoplasm (GO:0048471), monoatomic ion channel complex (GO:0034702)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Potassium Channels	1
Neuronal System	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
transport	2
potassium channel activity	2
regulation of membrane potential	1
metal ion transport	1
protein complex oligomerization	1
potassium ion transport	1
monoatomic cation transmembrane transport	1
regulation of potassium ion transport	1
potassium ion transmembrane transport	1
regulation of monoatomic cation transmembrane transport	1
monoatomic ion transport	1
transmembrane transport	1
cellular process	1
voltage-gated monoatomic cation channel activity	1
ion channel regulator activity	1
monoatomic ion transmembrane transporter activity	1
channel activity	1
monoatomic cation channel activity	1
potassium ion transmembrane transporter activity	1
binding	1
nuclear lumen	1
membrane	1
cell periphery	1
potassium channel complex	1
plasma membrane protein complex	1
cytoplasm	1
transmembrane transporter complex	1

Protein interactions and networks

STRING

1910 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
KCNS1	KCNK15	Q9H427	862
KCNS1	KCNK9	Q9NPC2	656
KCNS1	KCNK3	O14649	636
KCNS1	KCNB2	Q92953	620
KCNS1	KCNB1	Q14721	615
KCNS1	KCNJ13	O60928	593
KCNS1	SCN9A	Q15858	527
KCNS1	SFT2D2	O95562	506
KCNS1	PRIMA1	Q86XR5	492
KCNS1	CADM2	Q8N3J6	490
KCNS1	CACNG2	Q9Y698	474
KCNS1	SCN3B	Q9NY72	460
KCNS1	C1QL3	Q5VWW1	459
KCNS1	WFDC10A	Q9H1F0	450
KCNS1	MFAP3L	O75121	447

IntAct

0 interactions, top by confidence:

BioGRID (2): KCNS1 (Negative Genetic), KCNS1 (Affinity Capture-MS)

ESM2 similar proteins: A4K2M4, A4K2N8, A4K2P6, A4K2Q6, A4K2R3, A4K2S2, A4K2T1, A4K2V2, A4K2W6, A4K2X4, A4K2Y2, D4ADX7, O35173, O35174, O88758, P15384, P15388, P16390, P17658, P17659, P19024, P22001, P22460, P22462, P25122, P48547, P50638, P59053, P59994, P79197, Q03719, Q03721, Q14B80, Q17ST2, Q61762, Q61923, Q63734, Q7TSH7, Q8CFS6, Q8R1C0

Diamond homologs: A2BDX4, A4K2M4, A4K2N8, A4K2P6, A4K2Q6, A4K2R3, A4K2S2, A4K2T1, A4K2V2, A4K2W6, A4K2X4, A4K2Y2, A6H8H5, D4AD53, D4ADX7, G5EFC3, O18868, O35173, O35174, O73606, O88758, O88759, P10499, P15384, P15385, P15387, P15388, P16388, P16390, P17970, P17971, P17972, P22001, P22459, P22739, P25122, P48547, P59053, P59994, P59995

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
KCNS1	“down-regulates quantity”	potassium(1+)	relocalization

Disease & clinical

Clinical variants and AI predictions

ClinVar

86 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	71
Likely benign	7
Benign	4

Top pathogenic / likely-pathogenic (0)

SpliceAI

509 predictions. Top by Δscore:

Variant	Effect	Δscore
20:45095336:CTGTG:C	acceptor_gain	1.0000
20:45095337:TGTG:T	acceptor_gain	1.0000
20:45095338:GTGC:G	acceptor_loss	1.0000
20:45095340:GC:G	acceptor_loss	1.0000
20:45095341:C:CC	acceptor_gain	1.0000
20:45095342:T:C	acceptor_loss	1.0000
20:45100916:CTTAC:C	donor_loss	1.0000
20:45100917:TTA:T	donor_loss	1.0000
20:45100919:A:AC	donor_gain	1.0000
20:45100919:ACC:A	donor_loss	1.0000
20:45100920:C:CA	donor_loss	1.0000
20:45100920:C:CC	donor_gain	1.0000
20:45095338:GTG:G	acceptor_gain	0.9900
20:45095339:TG:T	acceptor_gain	0.9900
20:45097658:GTA:G	donor_loss	0.9900
20:45097659:TACCT:T	donor_loss	0.9900
20:45097660:A:C	donor_loss	0.9900
20:45097661:C:CT	donor_loss	0.9900
20:45098692:CTCC:C	acceptor_gain	0.9900
20:45098694:CC:C	acceptor_gain	0.9900
20:45098695:CC:C	acceptor_gain	0.9900
20:45098695:CCTGC:C	acceptor_loss	0.9900
20:45098696:CTGC:C	acceptor_loss	0.9900
20:45100919:AC:A	donor_gain	0.9900
20:45100920:CC:C	donor_gain	0.9900
20:45100920:CCT:C	donor_gain	0.9900
20:45100920:CCTGT:C	donor_gain	0.9900
20:45098691:CCTCC:C	acceptor_gain	0.9800
20:45098692:CTCCC:C	acceptor_gain	0.9800
20:45098693:TCCCT:T	acceptor_gain	0.9800

AlphaMissense

3381 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
20:45095071:G:C	F460L	1.000
20:45095071:G:T	F460L	1.000
20:45095073:A:G	F460L	1.000
20:45095197:G:C	S418R	1.000
20:45095197:G:T	S418R	1.000
20:45095199:T:G	S418R	1.000
20:45095209:C:A	W414C	0.999
20:45095209:C:G	W414C	0.999
20:45095211:A:G	W414R	0.999
20:45095211:A:T	W414R	0.999
20:45097708:A:G	L355S	0.999
20:45097920:G:C	S284R	0.999
20:45097920:G:T	S284R	0.999
20:45097922:T:G	S284R	0.999
20:45097923:G:C	F283L	0.999
20:45097923:G:T	F283L	0.999
20:45097925:A:G	F283L	0.999
20:45098461:A:G	F104S	0.999
20:45095072:A:C	F460C	0.998
20:45095072:A:G	F460S	0.998
20:45095080:G:C	F457L	0.998
20:45095080:G:T	F457L	0.998
20:45095082:A:G	F457L	0.998
20:45095096:G:C	P452R	0.998
20:45095096:G:T	P452H	0.998
20:45095117:C:T	G445D	0.998
20:45095118:C:G	G445R	0.998
20:45095165:G:T	P429Q	0.998
20:45095177:C:A	G425V	0.998
20:45095177:C:T	G425E	0.998

dbSNP variants (sampled 300 via entrez): RS1000715383 (20:45094005 C>T), RS1001268351 (20:45099194 G>A), RS1001770522 (20:45099981 C>T), RS1002501007 (20:45092327 T>C), RS1002833051 (20:45092093 A>G), RS1002984834 (20:45098288 T>G), RS1003160194 (20:45095490 T>A,C), RS1003430089 (20:45093404 T>C), RS1003605860 (20:45095944 G>A), RS1004287539 (20:45101347 A>G), RS1004393829 (20:45092619 G>A,C,T), RS1004819900 (20:45090777 A>C,G), RS1005064260 (20:45097221 C>T), RS1005117746 (20:45096646 T>C), RS1005276013 (20:45091370 A>G)

Disease associations

OMIM: gene MIM:602905 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST004599_210	Mean platelet volume	2.000000e-12
GCST008103_18	Bipolar disorder	1.000000e-08
GCST008103_27	Bipolar disorder	3.000000e-08

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL2362996 (PROTEIN FAMILY)

PharmGKB: 1 entry (VIP=true, CPIC=false)

PharmGKB variants

1 variants.

Variant	Genes	Level	Score	#Clin annots	Drugs
rs734784	KCNS1		0.00	0

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: vgic — Voltage-gated potassium channels (K_v)

ChEMBL bioactivities

2 potent at pChembl≥5 of 2 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
9.82	Ki	0.15	nM	CHEMBL5722941
9.74	IC50	0.18	nM	CHEMBL5722941

PubChem BioAssay actives

2 with measured affinity, of 34 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
3-[(1R,2aS,4S,5aS,8aS,10S,11aR,14aS,16S,17aS,19S,20aS,22S,23aS,25S,26aS,28S,29aS,31R,32aS,35aS,36R,38aS,39S,41aS,42S,44aS,45S,48R,50aS,51S,53aS,54S,56aS,57S,59aS,60S,63S,66S,69S,72S,75S,78S,87R,93S,96S,99S)-17a,20a,23a,53a,63-pentakis(4-aminobutyl)-31-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-5-carbamimidamido-2-[[(2S)-5-carbamimidamido-2-[[(2S)-1-[(2S)-5-oxopyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]pentanoyl]amino]pentanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]-16,29a,72,78-tetrakis(2-amino-2-oxoethyl)-14a,26a-bis(3-amino-3-oxopropyl)-2a,38a,66-tribenzyl-28,50a,57-tris[(2S)-butan-2-yl]-4,5a,19,42,45,69-hexakis(3-carbamimidamidopropyl)-51,54-bis(2-carboxyethyl)-56a,99-bis(carboxymethyl)-36-[[(2S,3S)-1-(carboxymethylamino)-3-methyl-1-oxopentan-2-yl]carbamoyl]-39,60-bis[(1R)-1-hydroxyethyl]-75,93-bis(hydroxymethyl)-32a,35a,59a-tris[(4-hydroxyphenyl)methyl]-22-(1H-imidazol-4-ylmethyl)-96-(1H-indol-3-ylmethyl)-41a-methyl-25-(2-methylpropyl)-1a,3,4a,6,7a,9,10a,13a,15,16a,18,19a,21,22a,24,25a,27,28a,30,31a,34a,37a,38,40a,41,43a,44,47,49a,50,52a,53,55a,56,58a,59,61a,62,65,68,71,74,77,80,83,86,89,92,95,98-pentacontaoxo-33,34,63a,64a,67a,68a-hexathia-a,2,3a,5,6a,8,9a,12a,14,15a,17,18a,20,21a,23,24a,26,27a,29,30a,33a,36a,37,39a,40,42a,43,46,48a,49,51a,52,54a,55,57a,58,60a,61,64,67,70,73,76,79,82,85,88,91,94,97-pentacontazapentacyclo[85.74.4.448,111.010,14.0144,148]nonahexacontahectan-8a-yl]propanoic acid	2198828: Binding affinity to KV channel (unknown origin) assessed as inhibition constant	ki	0.0001	uM

CTD chemical–gene interactions

9 total (human), top 9 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
aristolochic acid I	decreases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Benzo(a)pyrene	increases methylation	1
Estradiol	affects cotreatment, increases expression	1
Plant Extracts	affects cotreatment, decreases expression	1
Rotenone	decreases expression	1
Silicon Dioxide	decreases expression	1
Tobacco Smoke Pollution	decreases expression	1
Triclosan	decreases expression	1

ChEMBL screening assays

21 unique, capped per target: 20 binding, 1 toxicity

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL1787442	Binding	Inhibition of human recombinant Kv channel at 10 uM by radioligand binding assay	Structure-activity relationships of pyrrole based S-nitrosoglutathione reductase inhibitors: pyrrole regioisomers and propionic acid replacement. — Bioorg Med Chem Lett
CHEMBL5522525	Toxicity	Inhibition of human K+ channel by automated electrophysiology	Discovery of Clinical Candidate AZD5462, a Selective Oral Allosteric RXFP1 Agonist for Treatment of Heart Failure. — J Med Chem

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_YA69	IDG-HEK293T-KCNS1-V5-OE	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.