KCNS2

Summary

KCNS2 (potassium voltage-gated channel modifier subfamily S member 2, HGNC:6301) is a protein-coding gene on chromosome 8q22.2, encoding Delayed-rectifier potassium channel regulatory subunit KCNS2 (Q9ULS6). Potassium channel regulatory subunit that modulate the delayed rectifier voltage-gated potassium channel activity of KCNB1 and KCNB2 by altering their kinetics, expression levels, and shifting the half-inactivation potential to more polarized values.

Predicted to enable potassium channel regulator activity. Predicted to be involved in action potential; potassium ion transmembrane transport; and regulation of potassium ion transmembrane transport. Predicted to be located in perinuclear region of cytoplasm and plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in membrane.

Source: NCBI Gene 3788 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 49 total — 1 pathogenic
• Druggable target: yes
• MANE Select transcript: NM_020697

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:6301
Approved symbol	KCNS2
Name	potassium voltage-gated channel modifier subfamily S member 2
Location	8q22.2
Locus type	gene with protein product
Status	Approved
Aliases	Kv9.2
Ensembl gene	ENSG00000156486
Ensembl biotype	protein_coding
OMIM	602906
Entrez	3788

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000287042, ENST00000521839

RefSeq mRNA: 1 — MANE Select: NM_020697 NM_020697

CCDS: CCDS6279

Canonical transcript exons

ENST00000287042 — 2 exons

Exon	Start	End
ENSE00001026786	98427938	98432853
ENSE00001478412	98426958	98427329

Expression profiles

Bgee: expression breadth ubiquitous, 128 present calls, max score 93.39.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.6047 / max 30.8201, expressed in 175 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
89938	0.2979	87
89937	0.1334	78
205270	0.0732	45
89935	0.0556	35
89936	0.0447	32

Top tissues by expression

234 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
endothelial cell	CL:0000115	93.39	gold quality
middle temporal gyrus	UBERON:0002771	78.74	gold quality
Brodmann (1909) area 23	UBERON:0013554	77.95	gold quality
primary visual cortex	UBERON:0002436	75.36	gold quality
prefrontal cortex	UBERON:0000451	75.25	gold quality
occipital lobe	UBERON:0002021	72.93	gold quality
buccal mucosa cell	CL:0002336	72.19	silver quality
frontal cortex	UBERON:0001870	70.93	gold quality
Brodmann (1909) area 9	UBERON:0013540	69.32	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	69.31	gold quality
superior frontal gyrus	UBERON:0002661	68.86	gold quality
neocortex	UBERON:0001950	68.68	gold quality
right frontal lobe	UBERON:0002810	66.27	gold quality
cerebral cortex	UBERON:0000956	66.07	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	66.06	gold quality
saphenous vein	UBERON:0007318	65.79	gold quality
nipple	UBERON:0002030	65.61	gold quality
trabecular bone tissue	UBERON:0002483	65.46	gold quality
cardia of stomach	UBERON:0001162	65.29	gold quality
pericardium	UBERON:0002407	65.26	gold quality
subthalamic nucleus	UBERON:0001906	65.19	gold quality
dorsal plus ventral thalamus	UBERON:0001897	65.15	gold quality
inferior vagus X ganglion	UBERON:0005363	65.08	gold quality
parietal lobe	UBERON:0001872	65.07	silver quality
vena cava	UBERON:0004087	65.05	gold quality
postcentral gyrus	UBERON:0002581	64.99	silver quality
superior surface of tongue	UBERON:0007371	64.92	gold quality
pharyngeal mucosa	UBERON:0000355	64.91	gold quality
body of tongue	UBERON:0011876	64.84	gold quality
medulla oblongata	UBERON:0001896	64.79	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.45

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

87 targeting KCNS2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-548P	99.98	72.25	3784
HSA-MIR-548AN	99.97	70.91	2817
HSA-MIR-548AJ-3P	99.96	73.38	5345
HSA-MIR-548X-3P	99.96	73.38	5345
HSA-MIR-545-3P	99.95	70.74	2783
HSA-MIR-9718	99.94	68.91	918
HSA-MIR-548J-3P	99.94	72.61	4881
HSA-MIR-6845-3P	99.94	66.88	1439
HSA-MIR-548AE-3P	99.93	72.66	4867
HSA-MIR-548AH-3P	99.93	72.54	4872
HSA-MIR-548AM-3P	99.93	72.54	4872
HSA-MIR-548AQ-3P	99.93	72.66	4867
HSA-MIR-3143	99.93	71.96	3104
HSA-MIR-498-3P	99.91	71.27	1114
HSA-MIR-10527-5P	99.91	72.28	3754
HSA-MIR-4753-3P	99.90	71.03	3786
HSA-MIR-4496	99.88	68.89	2236
HSA-MIR-4447	99.85	67.81	2900
HSA-MIR-548AR-3P	99.85	71.26	3889
HSA-MIR-130B-5P	99.83	68.50	1888
HSA-MIR-4420	99.82	70.08	1624
HSA-MIR-548AZ-3P	99.82	70.56	3549
HSA-MIR-548BC	99.82	70.61	3524
HSA-MIR-548E-3P	99.82	70.59	3514
HSA-MIR-548F-3P	99.82	70.59	3540
HSA-MIR-181B-2-3P	99.81	70.06	1646
HSA-MIR-181B-3P	99.81	70.06	1646
HSA-MIR-4668-5P	99.79	70.58	3782
HSA-MIR-548A-3P	99.76	70.58	3524
HSA-MIR-1179	99.71	68.70	1040

Literature-anchored findings (GeneRIF, showing 1)

• KCNS2 mutation is associated with Essential Tremor. (PMID:29769701)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Kcns2	ENSMUSG00000050963
rattus_norvegicus	Kcns2	ENSRNOG00000066111

Paralogs (31): KCNG1 (ENSG00000026559), KCNQ1 (ENSG00000053918), KCNQ2 (ENSG00000075043), KCND1 (ENSG00000102057), KCNA7 (ENSG00000104848), KCNA1 (ENSG00000111262), KCNC4 (ENSG00000116396), KCNQ4 (ENSG00000117013), KCNS1 (ENSG00000124134), KCNC1 (ENSG00000129159), KCNA5 (ENSG00000130037), KCNC3 (ENSG00000131398), KCNA10 (ENSG00000143105), KCNA6 (ENSG00000151079), KCNB1 (ENSG00000158445), KCNF1 (ENSG00000162975), KCNV1 (ENSG00000164794), KCNC2 (ENSG00000166006), KCNV2 (ENSG00000168263), KCNG4 (ENSG00000168418), KCNS3 (ENSG00000170745), KCNG3 (ENSG00000171126), KCND3 (ENSG00000171385), KCNA3 (ENSG00000177272), KCNA2 (ENSG00000177301), KCNG2 (ENSG00000178342), KCNA4 (ENSG00000182255), KCNB2 (ENSG00000182674), KCNQ3 (ENSG00000184156), KCND2 (ENSG00000184408), KCNQ5 (ENSG00000185760)

Protein

Protein identifiers

Delayed-rectifier potassium channel regulatory subunit KCNS2 — Q9ULS6 (reviewed: Q9ULS6)

Alternative names: Delayed-rectifier K(+) channel alpha subunit 2, Delayed-rectifier potassium channel subunit Kv9.2, Potassium voltage-gated channel subfamily S member 2

All UniProt accessions (1): Q9ULS6

UniProt curated annotations — full annotation on UniProt →

Function. Potassium channel regulatory subunit that modulate the delayed rectifier voltage-gated potassium channel activity of KCNB1 and KCNB2 by altering their kinetics, expression levels, and shifting the half-inactivation potential to more polarized values. While it does not form functional channels on its own, it can form functional heterotetrameric channels with KCNB1 and KCNB2. Each regulatory subunit has unique regulatory properties that can lead to extensive inhibition, significant changes in kinetics, and/or substantial shifts in the voltage dependencies of the inactivation process.

Subunit / interactions. Heterotetramer with KCNB1 and KCNB2. Does not form homomultimers.

Subcellular location. Cell membrane.

Domain organisation. The transmembrane segment S4 functions as a voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.

Similarity. Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.2/KCNS2 sub-subfamily.

RefSeq proteins (1): NP_065748* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000210	BTB/POZ_dom	Domain
IPR003131	T1-type_BTB	Domain
IPR003968	K_chnl_volt-dep_Kv	Family
IPR003971	K_chnl_volt-dep_Kv5/Kv9	Family
IPR005821	Ion_trans_dom	Domain
IPR011333	SKP1/BTB/POZ_sf	Homologous_superfamily
IPR027359	Volt_channel_dom_sf	Homologous_superfamily
IPR028325	VG_K_chnl	Family

Pfam: PF00520, PF02214

UniProt features (18 total): topological domain 8, transmembrane region 6, intramembrane region 2, chain 1, short sequence motif 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9ULS6-F1	81.14	0.41

Function

Pathways and Gene Ontology

Reactome pathways

3 pathways

ID	Pathway
R-HSA-1296072	Voltage gated Potassium channels
R-HSA-112316	Neuronal System
R-HSA-1296071	Potassium Channels

MSigDB gene sets: 107 (showing top): GOBP_POTASSIUM_ION_TRANSPORT, BENPORATH_ES_WITH_H3K27ME3, E2F4DP1_01, REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS, REACTOME_POTASSIUM_CHANNELS, CAGCTG_AP4_Q5, GOBP_MONOATOMIC_CATION_TRANSPORT, E2F1DP1_01, E2F1DP2_01, NIKOLSKY_BREAST_CANCER_8Q12_Q22_AMPLICON, chr8q22, AACTTT_UNKNOWN, GOBP_PROTEIN_HOMOOLIGOMERIZATION, EGR1_01, GOBP_REGULATION_OF_TRANSPORT

GO Biological Process (8): action potential (GO:0001508), potassium ion transport (GO:0006813), protein homooligomerization (GO:0051260), potassium ion transmembrane transport (GO:0071805), regulation of potassium ion transmembrane transport (GO:1901379), monoatomic ion transport (GO:0006811), monoatomic ion transmembrane transport (GO:0034220), transmembrane transport (GO:0055085)

GO Molecular Function (5): voltage-gated potassium channel activity (GO:0005249), potassium channel regulator activity (GO:0015459), monoatomic ion channel activity (GO:0005216), potassium channel activity (GO:0005267), protein binding (GO:0005515)

GO Cellular Component (6): plasma membrane (GO:0005886), voltage-gated potassium channel complex (GO:0008076), membrane (GO:0016020), perinuclear region of cytoplasm (GO:0048471), cytoplasm (GO:0005737), monoatomic ion channel complex (GO:0034702)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Potassium Channels	1
Neuronal System	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
transport	2
potassium channel activity	2
regulation of membrane potential	1
metal ion transport	1
protein complex oligomerization	1
potassium ion transport	1
monoatomic cation transmembrane transport	1
regulation of potassium ion transport	1
potassium ion transmembrane transport	1
regulation of monoatomic cation transmembrane transport	1
monoatomic ion transport	1
transmembrane transport	1
cellular process	1
voltage-gated monoatomic cation channel activity	1
ion channel regulator activity	1
monoatomic ion transmembrane transporter activity	1
channel activity	1
monoatomic cation channel activity	1
potassium ion transmembrane transporter activity	1
binding	1
membrane	1
cell periphery	1
potassium channel complex	1
plasma membrane protein complex	1
cytoplasm	1
intracellular anatomical structure	1
transmembrane transporter complex	1

Protein interactions and networks

STRING

1758 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
KCNS2	HAPLN4	Q86UW8	633
KCNS2	CCDC183	Q5T5S1	540
KCNS2	USP46	P62068	507
KCNS2	KCNH4	Q9UQ05	500
KCNS2	KCNH3	Q9ULD8	487
KCNS2	SCN11A	Q9UI33	486
KCNS2	TENM4	Q6N022	484
KCNS2	STK32B	Q9NY57	479
KCNS2	SCN4A	P35499	458
KCNS2	GPR151	Q8TDV0	442
KCNS2	KCNH7	Q9NS40	432
KCNS2	KCNB1	Q14721	429
KCNS2	KCNU1	A8MYU2	390
KCNS2	KCNK15	Q9H427	385
KCNS2	KCNJ15	Q99712	374

IntAct

13 interactions, top by confidence:

A	B	Type	Score
KCNS2	FATE1	psi-mi:“MI:0915”(physical association)	0.720
FATE1	KCNS2	psi-mi:“MI:0915”(physical association)	0.720
NOTCH2NLC	KCNS2	psi-mi:“MI:0915”(physical association)	0.560
CYSRT1	KCNS2	psi-mi:“MI:0915”(physical association)	0.560
KCNS2	NOTCH2NLC	psi-mi:“MI:0915”(physical association)	0.000
KCNS2	FATE1	psi-mi:“MI:0915”(physical association)	0.000
KCNS2	CYSRT1	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (10): FATE1 (Two-hybrid), KCNS2 (Affinity Capture-MS), KCNS2 (Two-hybrid), CYSRT1 (Two-hybrid), NOTCH2NL (Two-hybrid), NBPF19 (Two-hybrid), KCNS2 (Negative Genetic), KCNV1 (Negative Genetic), KCNS2 (Two-hybrid), KCNS2 (Two-hybrid)

ESM2 similar proteins: A0A072VMJ3, F4IME1, F4IME2, G7IBJ4, G7JND3, O35174, O48538, O81209, O81210, O81211, O82226, O88759, Q5ZAJ0, Q6J2K5, Q6R8G2, Q6R8G3, Q6R8G6, Q84M97, Q8BQZ8, Q8GWD2, Q8L7Z0, Q8RWS9, Q948U0, Q9BQ31, Q9ER26, Q9FIJ0, Q9FJD6, Q9FXH6, Q9LD37, Q9LD40, Q9LDR2, Q9LEQ3, Q9LH74, Q9LNJ0, Q9LPG3, Q9LYG9, Q9LZU9, Q9M0A4, Q9S9N5, Q9SBI0

Diamond homologs: A2BDX4, A4K2M4, A4K2N8, A4K2P6, A4K2Q6, A4K2R3, A4K2S2, A4K2T1, A4K2V2, A4K2W6, A4K2X4, A4K2Y2, A6H8H5, D4AD53, D4ADX7, G5EFC3, O18868, O35173, O35174, O73606, O88758, O88759, P10499, P15384, P15385, P15387, P15388, P16388, P16390, P17970, P17971, P17972, P22001, P22459, P22739, P25122, P48547, P59053, P59994, P59995

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

49 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	42
Likely benign	2
Benign	2

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
3245482	NC_000008.10:g.(?99346108)(100589843_?)del	Pathogenic

SpliceAI

163 predictions. Top by Δscore:

Variant	Effect	Δscore
8:98427326:CCAG:C	donor_loss	0.9900
8:98427327:CAGG:C	donor_loss	0.9900
8:98427329:GGTAA:G	donor_loss	0.9900
8:98427330:G:GA	donor_loss	0.9900
8:98427331:T:A	donor_loss	0.9900
8:98429291:G:GT	donor_gain	0.9900
8:98427933:TCCA:T	acceptor_loss	0.9700
8:98427934:CCA:C	acceptor_loss	0.9700
8:98427935:CA:C	acceptor_loss	0.9700
8:98427936:A:AC	acceptor_loss	0.9700
8:98429076:G:GA	donor_gain	0.9700
8:98427330:G:GG	donor_gain	0.9600
8:98427937:GGT:G	acceptor_gain	0.9600
8:98429036:G:GT	donor_gain	0.9600
8:98429089:C:A	donor_gain	0.9600
8:98429075:T:TA	donor_gain	0.9400
8:98429315:G:T	donor_gain	0.9400
8:98429314:GGAC:G	donor_gain	0.9300
8:98427287:G:T	donor_gain	0.9200
8:98429090:A:AG	donor_gain	0.9200
8:98429091:G:GG	donor_gain	0.9200
8:98427287:G:GT	donor_gain	0.9100
8:98427937:G:T	acceptor_gain	0.8800
8:98427937:GGTGT:G	acceptor_gain	0.8800
8:98427935:CAGG:C	acceptor_gain	0.8700
8:98427936:A:AG	acceptor_gain	0.8700
8:98427936:AGG:A	acceptor_gain	0.8700
8:98427937:G:GG	acceptor_gain	0.8700
8:98429211:A:AG	donor_gain	0.8700
8:98427934:CCAGG:C	acceptor_gain	0.8600

AlphaMissense

3160 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
8:98428191:T:C	F71S	1.000
8:98428197:G:C	R73P	1.000
8:98428301:T:A	W108R	1.000
8:98428301:T:C	W108R	1.000
8:98428303:G:C	W108C	1.000
8:98428303:G:T	W108C	1.000
8:98429078:T:A	W367R	1.000
8:98429078:T:C	W367R	1.000
8:98429090:A:C	S371R	1.000
8:98429092:T:A	S371R	1.000
8:98429092:T:G	S371R	1.000
8:98429105:G:T	G376W	1.000
8:98429106:G:A	G376E	1.000
8:98429161:C:G	C394W	1.000
8:98429171:G:C	G398R	1.000
8:98429172:G:A	G398D	1.000
8:98429193:C:A	P405H	1.000
8:98429193:C:G	P405R	1.000
8:98429216:T:C	F413L	1.000
8:98429218:C:A	F413L	1.000
8:98429218:C:G	F413L	1.000
8:98428116:T:C	L46S	0.999
8:98428156:C:G	C59W	0.999
8:98428190:T:C	F71L	0.999
8:98428192:C:A	F71L	0.999
8:98428192:C:G	F71L	0.999
8:98428196:C:A	R73S	0.999
8:98428197:G:T	R73L	0.999
8:98428268:T:C	C97R	0.999
8:98428269:G:A	C97Y	0.999

dbSNP variants (sampled 300 via entrez): RS1000847535 (8:98426866 G>A), RS1001630997 (8:98426290 C>T), RS1001775282 (8:98433327 G>A), RS1002011492 (8:98430498 G>C), RS1002086011 (8:98431871 T>C), RS1002126209 (8:98430214 C>CT), RS1002575074 (8:98425033 G>A,C,T), RS1003641148 (8:98430114 G>A), RS1003760502 (8:98430415 T>G), RS1004969573 (8:98432005 C>T), RS1004976019 (8:98429993 T>C), RS1005148346 (8:98425811 A>G), RS1005263331 (8:98429747 T>G), RS1005350956 (8:98427305 C>G,T), RS1005484870 (8:98427136 A>T)

Disease associations

OMIM: gene MIM:602906 | disease phenotypes: MIM:216550

GenCC curated gene-disease

Mondo (1): Cohen syndrome (MONDO:0008999)

Orphanet (1): Cohen syndrome (Orphanet:193)

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST003991_12	Childhood ear infection	1.000000e-08
GCST005013_62	Childhood ear infection	1.000000e-08

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0007904	susceptibility to childhood ear infection measurement

MeSH disease descriptors (1)

Descriptor	Name	Tree numbers
C536438	Cohen syndrome (supp.)

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL2362996 (PROTEIN FAMILY)

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: vgic — Voltage-gated potassium channels (K_v)

ChEMBL bioactivities

2 potent at pChembl≥5 of 2 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
9.82	Ki	0.15	nM	CHEMBL5722941
9.74	IC50	0.18	nM	CHEMBL5722941

PubChem BioAssay actives

2 with measured affinity, of 34 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
3-[(1R,2aS,4S,5aS,8aS,10S,11aR,14aS,16S,17aS,19S,20aS,22S,23aS,25S,26aS,28S,29aS,31R,32aS,35aS,36R,38aS,39S,41aS,42S,44aS,45S,48R,50aS,51S,53aS,54S,56aS,57S,59aS,60S,63S,66S,69S,72S,75S,78S,87R,93S,96S,99S)-17a,20a,23a,53a,63-pentakis(4-aminobutyl)-31-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-5-carbamimidamido-2-[[(2S)-5-carbamimidamido-2-[[(2S)-1-[(2S)-5-oxopyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]pentanoyl]amino]pentanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]-16,29a,72,78-tetrakis(2-amino-2-oxoethyl)-14a,26a-bis(3-amino-3-oxopropyl)-2a,38a,66-tribenzyl-28,50a,57-tris[(2S)-butan-2-yl]-4,5a,19,42,45,69-hexakis(3-carbamimidamidopropyl)-51,54-bis(2-carboxyethyl)-56a,99-bis(carboxymethyl)-36-[[(2S,3S)-1-(carboxymethylamino)-3-methyl-1-oxopentan-2-yl]carbamoyl]-39,60-bis[(1R)-1-hydroxyethyl]-75,93-bis(hydroxymethyl)-32a,35a,59a-tris[(4-hydroxyphenyl)methyl]-22-(1H-imidazol-4-ylmethyl)-96-(1H-indol-3-ylmethyl)-41a-methyl-25-(2-methylpropyl)-1a,3,4a,6,7a,9,10a,13a,15,16a,18,19a,21,22a,24,25a,27,28a,30,31a,34a,37a,38,40a,41,43a,44,47,49a,50,52a,53,55a,56,58a,59,61a,62,65,68,71,74,77,80,83,86,89,92,95,98-pentacontaoxo-33,34,63a,64a,67a,68a-hexathia-a,2,3a,5,6a,8,9a,12a,14,15a,17,18a,20,21a,23,24a,26,27a,29,30a,33a,36a,37,39a,40,42a,43,46,48a,49,51a,52,54a,55,57a,58,60a,61,64,67,70,73,76,79,82,85,88,91,94,97-pentacontazapentacyclo[85.74.4.448,111.010,14.0144,148]nonahexacontahectan-8a-yl]propanoic acid	2198828: Binding affinity to KV channel (unknown origin) assessed as inhibition constant	ki	0.0001	uM

CTD chemical–gene interactions

14 total (human), top 14 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	decreases expression	1
2,5,2’,5’-tetrachlorobiphenyl	decreases expression	1
S-(1,2-dichlorovinyl)cysteine	affects response to substance, increases expression	1
nutlin 3	increases expression, affects cotreatment	1
Benzo(a)pyrene	increases methylation	1
Camptothecin	increases expression	1
Cisplatin	increases expression	1
Dactinomycin	affects cotreatment, increases expression	1
Doxorubicin	increases expression	1
Lead	affects expression	1
Lipopolysaccharides	increases expression, affects response to substance	1
Valproic Acid	increases methylation	1
Sodium Selenite	decreases expression	1
Antirheumatic Agents	increases expression	1

ChEMBL screening assays

21 unique, capped per target: 20 binding, 1 toxicity

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL1787442	Binding	Inhibition of human recombinant Kv channel at 10 uM by radioligand binding assay	Structure-activity relationships of pyrrole based S-nitrosoglutathione reductase inhibitors: pyrrole regioisomers and propionic acid replacement. — Bioorg Med Chem Lett
CHEMBL5522525	Toxicity	Inhibition of human K+ channel by automated electrophysiology	Discovery of Clinical Candidate AZD5462, a Selective Oral Allosteric RXFP1 Agonist for Treatment of Heart Failure. — J Med Chem

Cellosaurus cell lines

2 cell lines: 1 spontaneously immortalized cell line, 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D1K3	PrecisION hKv2.1/Kv9.2-CHO	Spontaneously immortalized cell line	Female
CVCL_YA70	IDG-HEK293T-KCNS2-V5-OE	Transformed cell line	Female

Clinical trials (associated diseases)

1 trials via MONDO — disease-level, not drug-specific.

Trial	Phase	Status	Title
NCT01907555	Not specified	COMPLETED	Clinical, Molecular and Physiopathological Study of Cohen Syndrome and Cohen-like Syndromes