KCTD21-AS1

Summary

KCTD21-AS1 (KCTD21 antisense RNA 1, HGNC:48674) is a long non-coding RNA gene on chromosome 11q14.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48674
Approved symbol	KCTD21-AS1
Name	KCTD21 antisense RNA 1
Location	11q14.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000246174
Ensembl biotype	lncRNA
Entrez	100289388
RNAcentral	URS0000759DB2 — lncRNA, 1083 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 33 — 33 lncRNA

ENST00000500113, ENST00000523626, ENST00000527321, ENST00000528468, ENST00000530261, ENST00000532831, ENST00000600795, ENST00000662186, ENST00000663331, ENST00000667996, ENST00000701360, ENST00000720967, ENST00000720968, ENST00000720969, ENST00000720970, ENST00000720971, ENST00000720972, ENST00000720973, ENST00000720974, ENST00000720975, ENST00000720976, ENST00000720977, ENST00000720978, ENST00000720979, ENST00000720980, ENST00000720981, ENST00000720982, ENST00000720983, ENST00000720984, ENST00000720985, ENST00000720986, ENST00000720987, ENST00000720988

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000500113 — 2 exons

Exon	Start	End
ENSE00001978444	78141396	78143088
ENSE00001982203	78139803	78139898

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 81.62.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 2.8696 / max 97.5973, expressed in 1262 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
116013	1.8355	983
116012	1.0341	589

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.62	gold quality
colonic epithelium	UBERON:0000397	79.59	gold quality
sural nerve	UBERON:0015488	77.50	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	76.72	gold quality
stromal cell of endometrium	CL:0002255	76.02	gold quality
right lobe of liver	UBERON:0001114	74.67	gold quality
right adrenal gland cortex	UBERON:0035827	74.39	gold quality
liver	UBERON:0002107	74.36	gold quality
right adrenal gland	UBERON:0001233	73.40	gold quality
left adrenal gland	UBERON:0001234	72.94	gold quality
corpus callosum	UBERON:0002336	72.87	gold quality
ganglionic eminence	UBERON:0004023	72.73	gold quality
ventricular zone	UBERON:0003053	72.64	gold quality
adrenal gland	UBERON:0002369	72.37	gold quality
left adrenal gland cortex	UBERON:0035825	71.96	gold quality
endometrium	UBERON:0001295	70.99	gold quality
cortical plate	UBERON:0005343	70.67	gold quality
left ovary	UBERON:0002119	70.66	gold quality
ovary	UBERON:0000992	70.59	gold quality
adrenal tissue	UBERON:0018303	70.24	gold quality
skeletal muscle tissue	UBERON:0001134	69.64	gold quality
islet of Langerhans	UBERON:0000006	69.51	gold quality
apex of heart	UBERON:0002098	69.31	gold quality
calcaneal tendon	UBERON:0003701	69.27	gold quality
left lobe of thyroid gland	UBERON:0001120	69.07	gold quality
right lobe of thyroid gland	UBERON:0001119	68.90	gold quality
thyroid gland	UBERON:0002046	68.70	gold quality
right ovary	UBERON:0002118	68.69	gold quality
muscle tissue	UBERON:0002385	68.61	gold quality
descending thoracic aorta	UBERON:0002345	68.25	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.93

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• m6A-methylated KCTD21-AS1 regulates macrophage phagocytosis through CD47 and cell autophagy through TIPR. (PMID:38383737)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.