KCTD5

Summary

KCTD5 (potassium channel tetramerization domain containing 5, HGNC:21423) is a protein-coding gene on chromosome 16p13.3, encoding BTB/POZ domain-containing protein KCTD5 (Q9NXV2). Its interaction with CUL3 suggests that it may act as a substrate adapter in some E3 ligase complex.

Enables identical protein binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Located in cytosol.

Source: NCBI Gene 54442 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 41 total — 1 pathogenic
• MANE Select transcript: NM_018992

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:21423
Approved symbol	KCTD5
Name	potassium channel tetramerization domain containing 5
Location	16p13.3
Locus type	gene with protein product
Status	Approved
Aliases	FLJ20040
Ensembl gene	ENSG00000167977
Ensembl biotype	protein_coding
OMIM	611285
Entrez	54442

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 4 protein_coding, 3 protein_coding_CDS_not_defined

ENST00000301738, ENST00000564195, ENST00000564246, ENST00000569689, ENST00000570005, ENST00000855086, ENST00000956038

RefSeq mRNA: 1 — MANE Select: NM_018992 NM_018992

CCDS: CCDS10475

Canonical transcript exons

ENST00000301738 — 6 exons

Exon	Start	End
ENSE00001118879	2707298	2709030
ENSE00001118883	2682523	2682800
ENSE00003482289	2702353	2702478
ENSE00003521016	2695935	2696043
ENSE00003587810	2697906	2697997
ENSE00003608322	2699821	2699916

Expression profiles

Bgee: expression breadth ubiquitous, 272 present calls, max score 99.04.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 33.4220 / max 445.3931, expressed in 1820 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
152263	33.4220	1820

Top tissues by expression

288 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
secondary oocyte	CL:0000655	99.04	gold quality
oocyte	CL:0000023	97.89	gold quality
mucosa of transverse colon	UBERON:0004991	91.90	gold quality
lower esophagus mucosa	UBERON:0035834	91.62	gold quality
esophagus mucosa	UBERON:0002469	90.02	gold quality
colonic mucosa	UBERON:0000317	89.48	gold quality
mucosa of sigmoid colon	UBERON:0004993	89.35	gold quality
esophagus squamous epithelium	UBERON:0006920	88.56	gold quality
granulocyte	CL:0000094	88.45	gold quality
epithelium of esophagus	UBERON:0001976	88.38	gold quality
ganglionic eminence	UBERON:0004023	88.21	gold quality
ventricular zone	UBERON:0003053	88.00	gold quality
transverse colon	UBERON:0001157	87.84	gold quality
leukocyte	CL:0000738	87.51	gold quality
monocyte	CL:0000576	87.48	gold quality
mononuclear cell	CL:0000842	87.42	gold quality
pharyngeal mucosa	UBERON:0000355	87.27	gold quality
tongue squamous epithelium	UBERON:0006919	87.14	silver quality
stromal cell of endometrium	CL:0002255	87.08	gold quality
palpebral conjunctiva	UBERON:0001812	86.66	gold quality
gingival epithelium	UBERON:0001949	86.14	gold quality
esophagus	UBERON:0001043	86.11	gold quality
gingiva	UBERON:0001828	85.80	gold quality
colon	UBERON:0001155	85.73	gold quality
large intestine	UBERON:0000059	85.64	gold quality
skin of leg	UBERON:0001511	85.54	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	85.53	gold quality
small intestine Peyer’s patch	UBERON:0003454	85.18	gold quality
intestine	UBERON:0000160	85.16	gold quality
cortical plate	UBERON:0005343	85.16	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 3.

Experiment	Marker?	Max mean expression
E-CURD-112	yes	15.31
E-MTAB-9067	yes	12.21
E-ANND-3	yes	3.55

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

93 targeting KCTD5, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-29A-3P	100.00	73.11	1835
HSA-MIR-29B-3P	100.00	73.18	1833
HSA-MIR-29C-3P	100.00	73.15	1833
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-6758-5P	100.00	66.21	1470
HSA-MIR-6856-5P	100.00	65.47	1298
HSA-MIR-196A-1-3P	99.99	72.15	2772
HSA-MIR-4531	99.99	69.70	3181
HSA-MIR-548N	99.98	71.94	4170
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-551B-5P	99.96	71.28	3493
HSA-MIR-6753-3P	99.93	66.57	637
HSA-MIR-7107-3P	99.93	66.73	627
HSA-MIR-6508-5P	99.92	70.67	2465
HSA-MIR-3119	99.92	71.34	2390
HSA-MIR-5682	99.89	72.56	1005
HSA-MIR-9902	99.89	69.15	2250

Literature-anchored findings (GeneRIF, showing 10)

• we have identified a novel cellular AAV-2 Rep78/Rep68 interaction partner, KCTD5, located predominantly in the cytoplasm. (PMID:17239418)
• Analysis of the interaction with cullin3 showed that, in addition to the BTB domain, some amino acids in the N-terminus of KCTD5 are required for binding to cullin3. Findings suggest that KCTD5 is a substrate-specific adaptor for cullin3-based E3 ligases (PMID:18573101)
• structure reveals assemblies of five subunits while tetramers were anticipated; pentameric stoichiometry is observed also in solution by scanning transmission electron microscopy mass analysis and analytical ultracentrifugation (PMID:19361449)
• Identification of MCM7, ZNF711 and FAM193 as KCTD5 interaction partners.KCTD5 is not involved in polyubiquitylation of MCM7 replication factor.The KCTD5/cullin3 complex stabilizes ZNF711 transcription factor. (PMID:26188516)
• genetic modifier screen exposes suppressors of the KCTD5 phenotype and mechanistically demonstrates that KCTD5 acts as an off-switch for GPCR signalling by triggering proteolysis of Gbetagamma heterodimers dissociated from the Galpha subunit (PMID:28562590)
• Cullin3/KCTD5 downregulates the DNA-binding affinity of DeltaNp63alpha, impairing either its transactivity or its transinhibitory activity. Functionally, Cullin3/KCTD5 abates the proproliferation activity of DeltaNp63alpha. These findings suggest that KCTD5-based CRL3 may mediate monoubiquitination and is a novel regulator of DeltaNp63alpha. (PMID:29782646)
• KCTD5, a novel TRPM4-regulatory protein required for cell migration as a new predictor for breast cancer prognosis. (PMID:32301552)
• K(+) Channel Tetramerization Domain 5 (KCTD5) Protein Regulates Cell Migration, Focal Adhesion Dynamics and Spreading through Modulation of Ca(2+) Signaling and Rac1 Activity. (PMID:33053687)
• Members of the KCTD family are major regulators of cAMP signaling. (PMID:34934014)
• KCTD Proteins Have Redundant Functions in Controlling Cellular Growth. (PMID:38732215)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	KCTD5	ENSDARG00000098817
mus_musculus	Kctd5	ENSMUSG00000016946
rattus_norvegicus	Kctd5	ENSRNOG00000057186
drosophila_melanogaster	inc	FBGN0025394
caenorhabditis_elegans		WBGENE00016871

Paralogs (3): KCTD17 (ENSG00000100379), KCTD9 (ENSG00000104756), KCTD2 (ENSG00000180901)

Protein

Protein identifiers

BTB/POZ domain-containing protein KCTD5 — Q9NXV2 (reviewed: Q9NXV2)

All UniProt accessions (2): Q9NXV2, H3BSS5

UniProt curated annotations — full annotation on UniProt →

Function. Its interaction with CUL3 suggests that it may act as a substrate adapter in some E3 ligase complex. Does not affect the function of Kv channel Kv2.1/KCNB1, Kv1.2/KCNA2, Kv4.2/KCND2 and Kv3.4/KCNC4.

Subunit / interactions. Homopentamer. Interacts (via C-terminus) with GRASP55/GORASP2. Interacts with CUL3 and with ubiquitinated proteins. Interacts with CRY1. (Microbial infection) Interacts with adeno-associated virus 2 (AAV-2) REP proteins.

Subcellular location. Cytoplasm. Cytosol. Nucleus.

Domain organisation. The BTB (POZ) domain is atypical and mediates the formation of a homopentamer instead of a homotetramer. Homopentamerization is due to the presence of 4 residues in the BTB (POZ) domain: Leu-56, Gly-100, Val-112 and Ala-118.

Induction. Up-regulated in peripheral blood lymphocytes stimulated through the T-cell receptor.

RefSeq proteins (1): NP_061865* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000210	BTB/POZ_dom	Domain
IPR003131	T1-type_BTB	Domain
IPR011333	SKP1/BTB/POZ_sf	Homologous_superfamily

Pfam: PF02214

UniProt features (24 total): helix 7, strand 7, turn 2, modified residue 2, initiator methionine 1, chain 1, domain 1, region of interest 1, compositionally biased region 1, sequence conflict 1

Structure

Experimental structures (PDB)

9 structures.

PDB	Method	Resolution (Å)
3DRZ	X-RAY DIFFRACTION	1.9
8U7Z	ELECTRON MICROSCOPY	2.97
3DRX	X-RAY DIFFRACTION	3.11
3DRY	X-RAY DIFFRACTION	3.3
8U80	ELECTRON MICROSCOPY	3.6
8U81	ELECTRON MICROSCOPY	3.82
8U82	ELECTRON MICROSCOPY	3.84
8U84	ELECTRON MICROSCOPY	3.88
8U83	ELECTRON MICROSCOPY	3.98

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9NXV2-F1	78.97	0.55

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 2, 10

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 184 (showing top): TGGTGCT_MIR29A_MIR29B_MIR29C, FXR_IR1_Q6, RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP, RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP, GOBP_MACROMOLECULE_CATABOLIC_PROCESS, ACEVEDO_NORMAL_TISSUE_ADJACENT_TO_LIVER_TUMOR_DN, CTATGCA_MIR153, GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_BLUE_UP, GTGCCTT_MIR506, RICKMAN_TUMOR_DIFFERENTIATED_WELL_VS_POORLY_DN, OCT1_06, TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P, GOBP_PROTEIN_HOMOOLIGOMERIZATION, GOBP_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS, P53_DECAMER_Q2

GO Biological Process (2): proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161), protein homooligomerization (GO:0051260)

GO Molecular Function (4): identical protein binding (GO:0042802), protein-containing complex binding (GO:0044877), cullin family protein binding (GO:0097602), protein binding (GO:0005515)

GO Cellular Component (4): nucleus (GO:0005634), cytoplasm (GO:0005737), cytosol (GO:0005829), Cul3-RING ubiquitin ligase complex (GO:0031463)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
protein binding	2
binding	2
cellular anatomical structure	2
ubiquitin-dependent protein catabolic process	1
proteasomal protein catabolic process	1
protein complex oligomerization	1
intracellular membrane-bounded organelle	1
intracellular anatomical structure	1
cytoplasm	1
cullin-RING ubiquitin ligase complex	1

Protein interactions and networks

STRING

768 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
KCTD5	CUL3	Q13618	977
KCTD5	KCTD11	Q693B1	762
KCTD5	KCTD1	Q719H9	671
KCTD5	KCTD15	Q96SI1	576
KCTD5	KCTD20	Q7Z5Y7	572
KCTD5	BTBD10	Q9BSF8	557
KCTD5	KCNC4	Q03721	556
KCTD5	KCTD19	Q17RG1	515
KCTD5	KCNA2	P16389	479
KCTD5	KCNB1	Q14721	477
KCTD5	SKP1	P34991	473
KCTD5	KCND2	Q9NZV8	471
KCTD5	RBX1	P62877	431
KCTD5	KCTD13	Q8WZ19	425
KCTD5	RND2	P52198	422

IntAct

80 interactions, top by confidence:

A	B	Type	Score
NHERF2	PODXL	psi-mi:“MI:0914”(association)	0.770
ARRDC1	NEDD4	psi-mi:“MI:0914”(association)	0.640
REPIN1	IPO8	psi-mi:“MI:0914”(association)	0.640
GNG8	GNB5	psi-mi:“MI:0914”(association)	0.640
NPM1	MPHOSPH10	psi-mi:“MI:0914”(association)	0.610
KSR2	POLR3A	psi-mi:“MI:0914”(association)	0.530
KCND2	BAG3	psi-mi:“MI:0914”(association)	0.530
KCTD17	CBX4	psi-mi:“MI:0914”(association)	0.530
GNG2	GNB5	psi-mi:“MI:0914”(association)	0.530
KCTD5	KCTD5	psi-mi:“MI:0407”(direct interaction)	0.520
PRDX2	PRDX3	psi-mi:“MI:0914”(association)	0.510
NHERF2	ACTN4	psi-mi:“MI:0914”(association)	0.510
Rep68	KCTD5	psi-mi:“MI:0915”(physical association)	0.510
KCTD5	Rep68	psi-mi:“MI:0915”(physical association)	0.510
NXF1	KCTD5	psi-mi:“MI:0915”(physical association)	0.490
Rep78	KCTD5	psi-mi:“MI:0915”(physical association)	0.490
KCTD5	Rep78	psi-mi:“MI:0915”(physical association)	0.490
Kctd5	CKAP5	psi-mi:“MI:0915”(physical association)	0.400
TMEM45A	KCTD5	psi-mi:“MI:0915”(physical association)	0.400
KCTD5	lcrD	psi-mi:“MI:0915”(physical association)	0.370

BioGRID (195): KCTD5 (Affinity Capture-MS), KCTD5 (Affinity Capture-MS), KCTD5 (Affinity Capture-MS), KCTD5 (Affinity Capture-MS), KCTD5 (Affinity Capture-MS), KCTD5 (Affinity Capture-MS), KCTD5 (Reconstituted Complex), KCTD5 (Affinity Capture-MS), ZNF711 (Two-hybrid), MCM7 (Two-hybrid), FAM193B (Two-hybrid), ZNF711 (Affinity Capture-Western), MCM7 (Affinity Capture-Western), FAM193B (Affinity Capture-Western), KCTD5 (Affinity Capture-Western)

ESM2 similar proteins: A3KMV1, A4IFB4, A5PKG7, A9ULR9, B1WC97, B5DEL1, O70479, O73916, P0C5J9, Q01820, Q0VD00, Q0VFV7, Q12259, Q13829, Q28DC9, Q2HJ48, Q2T9W0, Q2TUM3, Q3URF8, Q4G0X4, Q5EAX2, Q5F3E8, Q5M956, Q5RBH4, Q5XJ34, Q5ZJP7, Q6DC02, Q6DCX3, Q6DG99, Q6P3P4, Q6P7W2, Q719H9, Q7TNY1, Q7TPL3, Q7Z3E5, Q863D4, Q8BGV7, Q8BJK1, Q8BNL5, Q8K0E1

Diamond homologs: A3KMV1, A4IFB4, A5PKG7, A6H6X4, B1WC97, B5DEL1, D5SHR0, G5EFC3, O65555, P0C5J9, P15388, P17971, P17972, P25122, P48547, P59994, P59995, Q01956, Q03607, Q03719, Q0VD00, Q0VFV7, Q14003, Q14681, Q29RJ0, Q2HJ48, Q2TUM3, Q3URF8, Q4G0X4, Q50H33, Q52PG9, Q54KH0, Q5DTY9, Q5M956, Q5XJ34, Q5ZJP7, Q62897, Q63881, Q63959, Q68DU8

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

41 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	28
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
4279197	GRCh37/hg19 16p13.3(chr16:2747326-2817288)x1	Pathogenic

SpliceAI

1731 predictions. Top by Δscore:

Variant	Effect	Δscore
16:2682797:CAAGG:C	donor_loss	1.0000
16:2682798:AAGG:A	donor_loss	1.0000
16:2682799:AGG:A	donor_loss	1.0000
16:2682800:GGTG:G	donor_loss	1.0000
16:2695930:TTTA:T	acceptor_loss	1.0000
16:2695933:A:AG	acceptor_gain	1.0000
16:2695934:G:GG	acceptor_gain	1.0000
16:2696039:GGAAG:G	donor_gain	1.0000
16:2696040:GAAGG:G	donor_gain	1.0000
16:2696041:A:T	donor_gain	1.0000
16:2696041:AAGGT:A	donor_loss	1.0000
16:2696044:G:GA	donor_loss	1.0000
16:2696045:T:G	donor_loss	1.0000
16:2697905:GGA:G	acceptor_gain	1.0000
16:2699818:CA:C	acceptor_loss	1.0000
16:2699819:A:AG	acceptor_gain	1.0000
16:2699819:AG:A	acceptor_gain	1.0000
16:2699819:AGGT:A	acceptor_gain	1.0000
16:2699820:G:GC	acceptor_gain	1.0000
16:2699820:GG:G	acceptor_gain	1.0000
16:2699820:GGT:G	acceptor_gain	1.0000
16:2699820:GGTG:G	acceptor_gain	1.0000
16:2699820:GGTGC:G	acceptor_gain	1.0000
16:2699904:G:GT	donor_gain	1.0000
16:2699913:GCAG:G	donor_gain	1.0000
16:2699914:CAGG:C	donor_loss	1.0000
16:2699915:AGGT:A	donor_loss	1.0000
16:2699917:G:GA	donor_loss	1.0000
16:2699918:T:A	donor_loss	1.0000
16:2702348:TGCA:T	acceptor_loss	1.0000

AlphaMissense

1509 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
16:2682681:T:A	W45R	1.000
16:2682681:T:C	W45R	1.000
16:2682683:G:C	W45C	1.000
16:2682683:G:T	W45C	1.000
16:2682691:T:A	L48H	1.000
16:2682691:T:C	L48P	1.000
16:2682695:C:A	N49K	1.000
16:2682695:C:G	N49K	1.000
16:2682697:T:A	V50D	1.000
16:2682699:G:C	G51R	1.000
16:2682699:G:T	G51C	1.000
16:2682700:G:A	G51D	1.000
16:2682700:G:T	G51V	1.000
16:2682702:G:C	G52R	1.000
16:2682703:G:A	G52D	1.000
16:2682703:G:T	G52V	1.000
16:2682711:T:C	F55L	1.000
16:2682712:T:C	F55S	1.000
16:2682713:C:A	F55L	1.000
16:2682713:C:G	F55L	1.000
16:2682718:C:T	T57I	1.000
16:2682721:C:T	T58I	1.000
16:2682733:T:A	L62Q	1.000
16:2682733:T:C	L62P	1.000
16:2682750:T:C	S68P	1.000
16:2682753:T:C	F69L	1.000
16:2682754:T:C	F69S	1.000
16:2682755:C:A	F69L	1.000
16:2682755:C:G	F69L	1.000
16:2682757:T:A	L70Q	1.000

dbSNP variants (sampled 300 via entrez): RS1000134103 (16:2704401 C>T), RS1000136576 (16:2690839 C>T), RS1000192137 (16:2696711 C>T), RS1000375491 (16:2700876 C>A,T), RS1000466453 (16:2691051 G>A), RS1000466618 (16:2705054 G>A), RS1000485787 (16:2705113 A>C), RS1000560095 (16:2704877 G>A,C), RS1000668426 (16:2688128 C>A,G,T), RS1000762790 (16:2708118 G>A), RS1000844714 (16:2687422 C>G,T), RS1000957313 (16:2687275 T>C), RS1000963644 (16:2693507 C>A,G,T), RS1000999081 (16:2708880 T>A,C), RS1001000531 (16:2709381 G>A,C)

Disease associations

OMIM: gene MIM:611285 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

45 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
cobaltous chloride	increases expression	2
Tobacco Smoke Pollution	decreases methylation, increases expression	2
Zinc	affects cotreatment, increases expression, decreases expression	2
Cadmium Chloride	increases expression	2
aristolochic acid I	increases expression	1
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	decreases expression	1
FR900359	affects phosphorylation	1
triphenyl phosphate	affects expression	1
alpha-pinene	affects cotreatment, increases oxidation, increases abundance	1
bisphenol A	decreases expression	1
sodium arsenite	increases expression	1
benzo(e)pyrene	decreases methylation	1
4-aminophenylarsenoxide	affects binding, decreases reaction	1
methacrylaldehyde	affects cotreatment, increases oxidation, increases abundance	1
beta-methylcholine	affects expression	1
CGP 52608	affects binding, increases reaction	1
ICG 001	increases expression	1
abrine	increases expression	1
Grape Seed Proanthocyanidins	increases expression, affects cotreatment	1
licochalcone B	increases expression	1
PCI 5002	affects cotreatment, increases expression	1
Resveratrol	affects cotreatment, increases expression	1
Zoledronic Acid	increases expression	1
Arsenic Trioxide	affects binding, decreases reaction	1
Acrolein	increases abundance, affects cotreatment, increases oxidation	1
Air Pollutants	affects cotreatment, increases abundance, increases oxidation	1
Benzo(a)pyrene	increases methylation	1
Catechin	affects cotreatment, increases expression	1
Ivermectin	decreases expression	1
Methapyrilene	decreases methylation	1

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D9HW	Ubigene HEK293 KCTD5 KO	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.