KDELR3

Summary

KDELR3 (KDEL endoplasmic reticulum protein retention receptor 3, HGNC:6306) is a protein-coding gene on chromosome 22q13.1, encoding ER lumen protein-retaining receptor 3 (O43731). Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum.

This gene encodes a member of the KDEL endoplasmic reticulum protein retention receptor family. Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR3 was the third member of the family to be identified. Alternate splicing results in multiple transcript variants.

Source: NCBI Gene 11015 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 42 total
• MANE Select transcript: NM_006855

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:6306
Approved symbol	KDELR3
Name	KDEL endoplasmic reticulum protein retention receptor 3
Location	22q13.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000100196
Ensembl biotype	protein_coding
OMIM	619900
Entrez	11015

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 5 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000216014, ENST00000409006, ENST00000471268, ENST00000862991, ENST00000943543, ENST00000943544

RefSeq mRNA: 2 — MANE Select: NM_006855 NM_006855, NM_016657

CCDS: CCDS13972, CCDS46705

Canonical transcript exons

ENST00000216014 — 5 exons

Exon	Start	End
ENSE00001122832	38482496	38483447
ENSE00001838269	38468096	38468324
ENSE00003626900	38481212	38481464
ENSE00003633444	38479593	38479751
ENSE00003633752	38474523	38474623

Expression profiles

Bgee: expression breadth ubiquitous, 249 present calls, max score 98.98.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 29.8657 / max 358.8421, expressed in 1467 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
192258	29.4276	1464
192257	0.4381	288

Top tissues by expression

290 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
tibia	UBERON:0000979	98.98	gold quality
parotid gland	UBERON:0001831	97.70	gold quality
periodontal ligament	UBERON:0008266	97.32	gold quality
stromal cell of endometrium	CL:0002255	96.89	gold quality
pancreatic ductal cell	CL:0002079	94.44	gold quality
jejunal mucosa	UBERON:0000399	93.72	gold quality
skin of hip	UBERON:0001554	92.85	gold quality
mucosa of sigmoid colon	UBERON:0004993	92.60	gold quality
parietal pleura	UBERON:0002400	92.50	gold quality
germinal epithelium of ovary	UBERON:0001304	90.77	gold quality
pleura	UBERON:0000977	90.68	gold quality
cartilage tissue	UBERON:0002418	90.23	gold quality
rectum	UBERON:0001052	89.79	gold quality
gall bladder	UBERON:0002110	89.64	gold quality
colonic mucosa	UBERON:0000317	89.63	gold quality
decidua	UBERON:0002450	89.49	gold quality
calcaneal tendon	UBERON:0003701	89.26	gold quality
smooth muscle tissue	UBERON:0001135	88.62	gold quality
ileal mucosa	UBERON:0000331	88.61	gold quality
epithelial cell of pancreas	CL:0000083	87.68	gold quality
duodenum	UBERON:0002114	87.62	gold quality
choroid plexus epithelium	UBERON:0003911	87.62	gold quality
visceral pleura	UBERON:0002401	87.61	gold quality
mucosa of paranasal sinus	UBERON:0005030	87.36	gold quality
renal glomerulus	UBERON:0000074	87.30	gold quality
saliva-secreting gland	UBERON:0001044	86.90	gold quality
nasal cavity mucosa	UBERON:0001826	86.53	gold quality
ascending aorta	UBERON:0001496	86.49	gold quality
corpus epididymis	UBERON:0004359	86.43	gold quality
thoracic aorta	UBERON:0001515	86.37	gold quality

Single-cell (SCXA)

Detected in 5 experiment(s), a significant marker in 3.

Experiment	Marker?	Max mean expression
E-HCAD-13	yes	27.30
E-CURD-112	yes	16.80
E-ANND-3	yes	8.99
E-CURD-10	no	800.96
E-MTAB-7052	no	641.63

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

66 targeting KDELR3, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-4531	99.99	69.70	3181
HSA-MIR-302C-5P	99.97	72.56	3642
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-4525	99.94	64.38	675
HSA-MIR-5010-5P	99.94	64.11	705
HSA-MIR-651-3P	99.94	73.48	5177
HSA-MIR-381-3P	99.93	71.87	2854
HSA-MIR-3143	99.93	71.96	3104
HSA-MIR-300	99.92	71.76	2856
HSA-MIR-4302	99.89	67.94	1187
HSA-MIR-137-3P	99.87	74.74	2401
HSA-MIR-5582-3P	99.86	72.48	4221
HSA-MIR-548AR-3P	99.85	71.26	3889
HSA-MIR-6715A-3P	99.83	68.05	1473
HSA-MIR-548AZ-3P	99.82	70.56	3549
HSA-MIR-548BC	99.82	70.61	3524
HSA-MIR-548E-3P	99.82	70.59	3514
HSA-MIR-548F-3P	99.82	70.59	3540
HSA-MIR-6756-5P	99.82	67.97	2466
HSA-MIR-4307	99.82	70.45	3374
HSA-MIR-205-5P	99.81	70.05	1557
HSA-MIR-636	99.80	69.58	1500
HSA-MIR-374C-5P	99.80	72.06	2910
HSA-MIR-655-3P	99.80	72.19	2909
HSA-MIR-548A-3P	99.76	70.58	3524

Literature-anchored findings (GeneRIF, showing 1)

• Cell-type-specific differences in KDEL receptor clustering in mammalian cells. (PMID:32645101)

Cross-species orthologs

7 orthologs

Organism	Symbol	Gene ID
danio_rerio	kdelr3	ENSDARG00000040912
danio_rerio	KDELR3	ENSDARG00000104519
mus_musculus	Kdelr3	ENSMUSG00000010830
rattus_norvegicus	Kdelr3	ENSRNOG00000013577
drosophila_melanogaster	KdelR	FBGN0267330
caenorhabditis_elegans		WBGENE00001331
caenorhabditis_elegans		WBGENE00016195

Paralogs (2): KDELR1 (ENSG00000105438), KDELR2 (ENSG00000136240)

Protein

Protein identifiers

ER lumen protein-retaining receptor 3 — O43731 (reviewed: O43731)

Alternative names: KDEL endoplasmic reticulum protein retention receptor 3

All UniProt accessions (1): O43731

UniProt curated annotations — full annotation on UniProt →

Function. Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum.

Subcellular location. Endoplasmic reticulum membrane. Golgi apparatus membrane. Cytoplasmic vesicle. COPI-coated vesicle membrane.

Domain organisation. Binds the C-terminal sequence motif K-D-E-L in a hydrophilic cavity between the transmembrane domains. This triggers a conformation change that exposes a Lys-rich patch on the cytosolic surface of the protein. This patch mediates recycling from the Golgi to the endoplasmic reticulum, probably via COPI vesicles.

Similarity. Belongs to the ERD2 family.

Isoforms (2)

UniProt ID	Names	Canonical?
O43731-1	1	yes
O43731-2	2

RefSeq proteins (2): NP_006846, NP_057839 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000133	ER_ret_rcpt	Family

Pfam: PF00810

UniProt features (25 total): topological domain 8, transmembrane region 7, region of interest 3, site 3, chain 1, splice variant 1, sequence variant 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O43731-F1	91.42	0.78

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (3): 5 (interaction with the k-d-e-l motif on target proteins); 117 (interaction with the k-d-e-l motif on target proteins); 193 (important for recycling of cargo proteins with the sequence motif k-d-e-l from the golgi to the endoplasmic reticulum)

Function

Pathways and Gene Ontology

Reactome pathways

3 pathways

ID	Pathway
R-HSA-381038	XBP1(S) activates chaperone genes
R-HSA-6807878	COPI-mediated anterograde transport
R-HSA-6811434	COPI-dependent Golgi-to-ER retrograde traffic

MSigDB gene sets: 209 (showing top): REACTOME_UNFOLDED_PROTEIN_RESPONSE_UPR, GOZGIT_ESR1_TARGETS_DN, GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_DN, GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_DN, GOBP_VESICLE_MEDIATED_TRANSPORT, REACTOME_MEMBRANE_TRAFFICKING, PATIL_LIVER_CANCER, GOBP_PROTEIN_LOCALIZATION_TO_ENDOPLASMIC_RETICULUM, MAHAJAN_RESPONSE_TO_IL1A_DN, ONKEN_UVEAL_MELANOMA_UP, RICKMAN_TUMOR_DIFFERENTIATED_WELL_VS_POORLY_DN, GOBP_MAINTENANCE_OF_LOCATION, GOCC_COATED_VESICLE, GOBP_MAINTENANCE_OF_PROTEIN_LOCALIZATION_IN_ORGANELLE, E4F1_Q6

GO Biological Process (4): protein retention in ER lumen (GO:0006621), retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum (GO:0006890), protein transport (GO:0015031), vesicle-mediated transport (GO:0016192)

GO Molecular Function (3): KDEL sequence binding (GO:0005046), ER lumen protein retrieval receptor activity (GO:0046923), protein binding (GO:0005515)

GO Cellular Component (9): Golgi membrane (GO:0000139), endoplasmic reticulum (GO:0005783), endoplasmic reticulum membrane (GO:0005789), cis-Golgi network (GO:0005801), transport vesicle (GO:0030133), COPI-coated vesicle membrane (GO:0030663), Golgi apparatus (GO:0005794), membrane (GO:0016020), cytoplasmic vesicle (GO:0031410)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
IRE1alpha activates chaperones	1
ER to Golgi Anterograde Transport	1
Golgi-to-ER retrograde transport	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cytoplasm	3
endomembrane system	3
intracellular membrane-bounded organelle	3
transport	2
Golgi apparatus	2
maintenance of protein localization in endoplasmic reticulum	1
Golgi vesicle transport	1
intracellular protein localization	1
establishment of protein localization	1
cellular process	1
ER lumen protein retrieval receptor activity	1
signal sequence receptor activity	1
binding	1
bounding membrane of organelle	1
organelle membrane	1
nuclear outer membrane-endoplasmic reticulum membrane network	1
endoplasmic reticulum subcompartment	1
cytoplasmic vesicle	1
COPI-coated vesicle	1
Golgi-associated vesicle membrane	1
coated vesicle membrane	1
cellular anatomical structure	1
intracellular vesicle	1

Protein interactions and networks

STRING

842 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
KDELR3	CUL7	Q14999	446
KDELR3	TMEM229B	Q8NBD8	443
KDELR3	TMEM131L	A2VDJ0	436
KDELR3	MANF	P55145	395
KDELR3	YIF1A	O95070	394
KDELR3	SEC31A	O94979	377
KDELR3	PPFIA1	Q13136	366
KDELR3	CREB3L1	Q96BA8	362
KDELR3	SEC24D	O94855	360
KDELR3	ARF4	P18085	357
KDELR3	AGAP5	A6NIR3	355
KDELR3	IL2RG	P31785	353
KDELR3	PREB	Q9HCU5	351
KDELR3	COPB2	P35606	340
KDELR3	CREB3L2	Q70SY1	339

IntAct

31 interactions, top by confidence:

A	B	Type	Score
CFTR	ESYT2	psi-mi:“MI:0914”(association)	0.710
TMEM63A	AP3D1	psi-mi:“MI:0914”(association)	0.530
GPR17	IPO8	psi-mi:“MI:0914”(association)	0.530
	ESYT2	psi-mi:“MI:0914”(association)	0.350
CRELD1	TMEM223	psi-mi:“MI:0914”(association)	0.350
SLC22A4	RTL8C	psi-mi:“MI:0914”(association)	0.350
KDELR3	SLC4A2	psi-mi:“MI:0914”(association)	0.350
FFAR1	SLC12A8	psi-mi:“MI:0914”(association)	0.350
GPR182	SLC12A8	psi-mi:“MI:0914”(association)	0.350
REEP5	ESYT2	psi-mi:“MI:0914”(association)	0.350
DUOXA2	TMEM131L	psi-mi:“MI:0914”(association)	0.350
GPR45	VWA8	psi-mi:“MI:0914”(association)	0.350
KDELR3	POTEF	psi-mi:“MI:0914”(association)	0.350
OPALIN	FAM171A2	psi-mi:“MI:0914”(association)	0.350
SLC1A1	UBXN8	psi-mi:“MI:0914”(association)	0.350
ATP2A3	UBXN8	psi-mi:“MI:0914”(association)	0.350
SPPL2B	HAS3	psi-mi:“MI:0914”(association)	0.350
VIPR1	SLC33A1	psi-mi:“MI:0914”(association)	0.350
SLC2A1	SLC33A1	psi-mi:“MI:0914”(association)	0.350
LPAR2	EI24	psi-mi:“MI:0914”(association)	0.350
VIPR2	EI24	psi-mi:“MI:0914”(association)	0.350
TSPAN2	TPP1	psi-mi:“MI:0914”(association)	0.350
FPR2	SCAMP3	psi-mi:“MI:0914”(association)	0.350
GP5	MGST3	psi-mi:“MI:0914”(association)	0.350
TMEM72	MGST3	psi-mi:“MI:0914”(association)	0.350
P2RY8	BTAF1	psi-mi:“MI:0914”(association)	0.350
S1PR4	NPC1	psi-mi:“MI:0914”(association)	0.350
BSCL2	QSOX1	psi-mi:“MI:0914”(association)	0.350
CXCR4	ESYT2	psi-mi:“MI:0914”(association)	0.350
SLC10A4	ILVBL	psi-mi:“MI:0914”(association)	0.350

BioGRID (68): KDELR3 (Affinity Capture-MS), KDELR3 (Affinity Capture-MS), KDELR3 (Affinity Capture-MS), KDELR3 (Affinity Capture-MS), KDELR3 (Affinity Capture-MS), KDELR3 (Affinity Capture-MS), TMEM56 (Affinity Capture-MS), ALG8 (Affinity Capture-MS), KDELR3 (Affinity Capture-MS), LPCAT3 (Affinity Capture-MS), SLC4A2 (Affinity Capture-MS), KDELR3 (Affinity Capture-MS), KDELR3 (Affinity Capture-MS), KDELR3 (Affinity Capture-MS), KDELR3 (Affinity Capture-MS)

ESM2 similar proteins: A0A097ZPD8, A0A0E3D8M2, A0A0E3D8Q2, A0A140JWT2, A0A1B7YCX1, A0A2I6PJ07, A0A3G9H8P0, A9JPE3, E3UBL6, J7FIJ6, K2RU64, M1VJS5, O42580, O43731, O44017, O76767, O94270, P18413, P18414, P24390, P33946, P33947, P33948, P35402, P48583, P9WEX1, P9WEX7, P9WEY0, Q09473, Q2KJ37, Q4WLD2, Q569A6, Q5U305, Q5XHA2, Q5ZKX9, Q611C8, Q66JF2, Q68ES4, Q6NRS2, Q6P257

Diamond homologs: O42580, O43731, O44017, O76767, O94270, P18413, P18414, P24390, P33946, P33947, P33948, P35402, P48583, Q09473, Q2KJ37, Q569A6, Q5U305, Q5XHA2, Q5ZKX9, Q611C8, Q66JF2, Q68ES4, Q6P257, Q6PAB8, Q6PEH1, Q6PFS5, Q76NM1, Q7ZXS5, Q86JE5, Q8R1L4, Q8VWI1, Q99JH8, Q9CQM2, Q9ZTN2

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 49 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

GO biological processes:

GO term	Partners	Fold	FDR
G protein-coupled receptor signaling pathway	9	7.6×	7e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

42 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	30
Likely benign	1
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

900 predictions. Top by Δscore:

Variant	Effect	Δscore
22:38468296:G:GT	donor_gain	1.0000
22:38468296:G:T	donor_gain	1.0000
22:38468305:G:GT	donor_gain	1.0000
22:38468323:GG:G	donor_gain	1.0000
22:38468324:GG:G	donor_gain	1.0000
22:38474514:T:TA	acceptor_gain	1.0000
22:38474517:CCACA:C	acceptor_loss	1.0000
22:38474518:CACAG:C	acceptor_loss	1.0000
22:38474521:A:AG	acceptor_gain	1.0000
22:38474521:AGGC:A	acceptor_loss	1.0000
22:38474522:G:GC	acceptor_loss	1.0000
22:38474522:G:GG	acceptor_gain	1.0000
22:38474615:G:GG	donor_gain	1.0000
22:38474621:AAGG:A	donor_loss	1.0000
22:38474622:AGG:A	donor_loss	1.0000
22:38474623:GGTGA:G	donor_loss	1.0000
22:38481204:T:TA	acceptor_gain	1.0000
22:38481324:T:TA	acceptor_gain	1.0000
22:38481325:G:A	acceptor_gain	1.0000
22:38482494:A:AG	acceptor_gain	1.0000
22:38482495:G:GG	acceptor_gain	1.0000
22:38468323:GGGT:G	donor_loss	0.9900
22:38468344:G:T	donor_gain	0.9900
22:38474515:G:A	acceptor_gain	0.9900
22:38474522:GGC:G	acceptor_gain	0.9900
22:38479589:TTA:T	acceptor_loss	0.9900
22:38479590:TAG:T	acceptor_loss	0.9900
22:38479591:AGGT:A	acceptor_gain	0.9900
22:38479592:GGTG:G	acceptor_gain	0.9900
22:38479747:TGGAG:T	donor_loss	0.9900

AlphaMissense

1401 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
22:38474571:G:T	R47M	0.993
22:38474537:A:C	S36R	0.991
22:38474539:C:A	S36R	0.991
22:38474539:C:G	S36R	0.991
22:38474561:T:C	F44L	0.990
22:38474563:C:A	F44L	0.990
22:38474563:C:G	F44L	0.990
22:38481258:C:A	P133H	0.990
22:38468255:G:C	G8R	0.987
22:38468256:G:A	G8D	0.987
22:38468264:A:C	S11R	0.987
22:38468266:C:A	S11R	0.987
22:38468266:C:G	S11R	0.987
22:38481237:T:C	L126P	0.987
22:38481240:A:T	E127V	0.987
22:38474571:G:C	R47T	0.985
22:38481248:G:C	A130P	0.985
22:38481258:C:G	P133R	0.985
22:38481228:C:T	S123F	0.984
22:38481249:C:A	A130D	0.984
22:38481440:T:C	F194L	0.983
22:38481442:C:A	F194L	0.983
22:38481442:C:G	F194L	0.983
22:38481336:G:C	R159P	0.982
22:38481257:C:T	P133S	0.980
22:38481356:T:A	W166R	0.980
22:38481356:T:C	W166R	0.980
22:38468267:C:G	H12D	0.979
22:38481241:A:C	E127D	0.979
22:38481241:A:T	E127D	0.979

dbSNP variants (sampled 300 via entrez): RS1000362297 (22:38482655 G>A), RS1000411664 (22:38483710 C>T), RS1000646102 (22:38473100 TAAAAAA>T,TA,TAA,TAAAAA), RS1000708027 (22:38472448 G>C), RS1000912400 (22:38472479 A>T), RS1000947925 (22:38469180 A>G), RS1000965588 (22:38472243 C>T), RS1001161070 (22:38479075 T>C), RS1001350243 (22:38467450 A>G), RS1001364321 (22:38477082 T>A), RS1001572632 (22:38471520 C>T), RS1001637643 (22:38467149 C>T), RS1001833126 (22:38472617 G>C), RS1001984096 (22:38479534 G>C), RS1002062063 (22:38477667 G>T)

Disease associations

OMIM: gene MIM:619900 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST007209_16	Gallstone disease	1.000000e-10
GCST007561_72	Sleep duration	4.000000e-08
GCST007576_168	Chronotype	2.000000e-08
GCST010244_327	Triglyceride levels	2.000000e-14

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0008328	chronotype measurement
EFO:0004530	triglyceride measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

59 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	increases methylation, affects cotreatment, increases expression, decreases expression	5
Tretinoin	decreases expression, increases expression	3
sodium arsenite	affects methylation, increases expression	2
Resveratrol	decreases expression, affects cotreatment, increases expression	2
Cyclosporine	increases expression	2
Particulate Matter	increases expression, decreases expression, increases abundance	2
aristolochic acid I	decreases expression	1
methylmercuric chloride	decreases expression	1
triphenyl phosphate	affects expression	1
deoxynivalenol	decreases expression	1
lead acetate	increases expression	1
salinomycin	decreases expression	1
trichostatin A	increases expression	1
beta-lapachone	decreases expression	1
cobaltous chloride	decreases expression	1
potassium chromate(VI)	affects cotreatment, decreases expression	1
epigallocatechin gallate	affects cotreatment, decreases expression	1
avobenzone	increases expression	1
di-n-butylphosphoric acid	affects expression	1
perfluoro-n-nonanoic acid	decreases expression	1
K 7174	increases expression	1
erucylphospho-N,N,N-trimethylpropylammonium	increases expression	1
ICG 001	increases expression	1
abrine	decreases expression	1
2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine	decreases expression, increases response to substance	1
NSC 689534	increases expression	1
(+)-JQ1 compound	decreases expression	1
Decitabine	affects expression	1
Sunitinib	decreases expression	1
Orlistat	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.