KDM4A-AS1

Summary

KDM4A-AS1 (KDM4A antisense RNA 1, HGNC:40528) is a long non-coding RNA gene on chromosome 1p34.2-p34.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40528
Approved symbol	KDM4A-AS1
Name	KDM4A antisense RNA 1
Location	1p34.2-p34.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000236200
Ensembl biotype	lncRNA
Entrez	100132774
RNAcentral	URS000075DBBD — lncRNA, 1574 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 9 lncRNA

ENST00000398804, ENST00000418149, ENST00000434346, ENST00000439057, ENST00000453015, ENST00000659644, ENST00000663424, ENST00000816755, ENST00000816756

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000398804 — 5 exons

Exon	Start	End
ENSE00001593617	43708108	43708138
ENSE00001603015	43704353	43704457
ENSE00001714796	43699765	43700063
ENSE00001723378	43702656	43702728
ENSE00001765209	43703564	43703647

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 87.07.

FANTOM5 (CAGE): breadth broad, TPM avg 1.3669 / max 54.1666, expressed in 668 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
12053	0.8709	463
12052	0.4960	261

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	87.07	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	85.49	gold quality
mucosa of transverse colon	UBERON:0004991	83.40	gold quality
right adrenal gland cortex	UBERON:0035827	79.24	gold quality
right adrenal gland	UBERON:0001233	78.03	gold quality
apex of heart	UBERON:0002098	77.22	gold quality
adrenal tissue	UBERON:0018303	76.95	gold quality
lower esophagus mucosa	UBERON:0035834	76.95	gold quality
right lobe of liver	UBERON:0001114	76.42	gold quality
skin of leg	UBERON:0001511	75.93	gold quality
left adrenal gland	UBERON:0001234	75.83	gold quality
left adrenal gland cortex	UBERON:0035825	75.78	gold quality
adrenal gland	UBERON:0002369	75.65	gold quality
zone of skin	UBERON:0000014	75.20	gold quality
adenohypophysis	UBERON:0002196	74.84	gold quality
granulocyte	CL:0000094	74.58	gold quality
pituitary gland	UBERON:0000007	74.27	gold quality
skin of abdomen	UBERON:0001416	74.27	gold quality
spleen	UBERON:0002106	74.13	gold quality
endometrium	UBERON:0001295	74.05	gold quality
liver	UBERON:0002107	73.75	gold quality
hindlimb stylopod muscle	UBERON:0004252	73.69	gold quality
right lobe of thyroid gland	UBERON:0001119	73.57	gold quality
ventricular zone	UBERON:0003053	73.40	gold quality
sural nerve	UBERON:0015488	73.02	gold quality
metanephros cortex	UBERON:0010533	72.62	gold quality
prostate gland	UBERON:0002367	72.60	gold quality
minor salivary gland	UBERON:0001830	72.36	gold quality
cortical plate	UBERON:0005343	72.18	gold quality
gastrocnemius	UBERON:0001388	71.82	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.19

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• HIF-1alpha-activated long non-coding RNA KDM4A-AS1 promotes hepatocellular carcinoma progression via the miR-411-5p/KPNA2/AKT pathway. (PMID:34903711)
• Long noncoding RNAs with peptide-encoding potential identified in esophageal squamous cell carcinoma: KDM4A-AS1-encoded peptide weakens cancer cell viability and migratory capacity. (PMID:36965032)
• E2F1-mediated KDM4A-AS1 up-regulation promotes EMT of hepatocellular carcinoma cells by recruiting ILF3 to stabilize AURKA mRNA. (PMID:36973424)
• KDM4A-AS1 Promotes Cell Proliferation, Migration, and Invasion via the miR-4306/STX6 Axis in Hepatocellular Carcinoma. (PMID:38505873)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.