KDM7A-DT

Summary

KDM7A-DT (KDM7A divergent transcript, HGNC:48959) is a long non-coding RNA gene on chromosome 7q34.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48959
Approved symbol	KDM7A-DT
Name	KDM7A divergent transcript
Location	7q34
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000260231
Ensembl biotype	lncRNA
Entrez	100134229
RNAcentral	URS000075DD76 — lncRNA, 2398 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 lncRNA

ENST00000566699, ENST00000815505, ENST00000815506

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000566699 — 1 exons

Exon	Start	End
ENSE00002627283	140177184	140179640

Expression profiles

Bgee: expression breadth ubiquitous, 224 present calls, max score 87.85.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 2.0644 / max 68.5220, expressed in 916 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
81494	1.3883	697
81496	0.3508	111
81495	0.3252	164

Top tissues by expression

241 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
nasal cavity epithelium	UBERON:0005384	87.85	gold quality
ileal mucosa	UBERON:0000331	85.43	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	84.49	gold quality
mucosa of transverse colon	UBERON:0004991	83.76	gold quality
cartilage tissue	UBERON:0002418	83.58	gold quality
nasal cavity mucosa	UBERON:0001826	83.30	gold quality
tibialis anterior	UBERON:0001385	81.18	silver quality
cardiac atrium	UBERON:0002081	80.16	gold quality
right atrium auricular region	UBERON:0006631	80.14	gold quality
mucosa of paranasal sinus	UBERON:0005030	79.73	gold quality
blood	UBERON:0000178	79.37	gold quality
monocyte	CL:0000576	78.28	gold quality
rectum	UBERON:0001052	78.23	gold quality
skin of leg	UBERON:0001511	78.18	gold quality
leukocyte	CL:0000738	78.08	gold quality
apex of heart	UBERON:0002098	77.86	gold quality
gastrocnemius	UBERON:0001388	77.74	gold quality
muscle of leg	UBERON:0001383	77.16	gold quality
deltoid	UBERON:0001476	76.79	silver quality
esophagus mucosa	UBERON:0002469	76.78	gold quality
esophagus squamous epithelium	UBERON:0006920	76.69	gold quality
upper arm skin	UBERON:0004263	76.36	silver quality
islet of Langerhans	UBERON:0000006	76.30	gold quality
zone of skin	UBERON:0000014	76.09	gold quality
transverse colon	UBERON:0001157	76.02	gold quality
heart left ventricle	UBERON:0002084	76.02	gold quality
heart	UBERON:0000948	75.88	gold quality
cardiac ventricle	UBERON:0002082	75.73	gold quality
skin of abdomen	UBERON:0001416	75.68	gold quality
epithelial cell of pancreas	CL:0000083	75.67	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.37

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• The results revealed a protective role of JHDM1D-AS1 in ROS-induced apoptosis, and validated that JHDM1D-AS1/DNAJC10/phosphorylated-eIF2alpha/Bcl-2 pathway works as an anti-apoptotic signaling axis in periodontal ligament stem cells. (PMID:31276733)
• LncRNA JHDM1D-AS1 Suppresses MPP + -Induced Neuronal Injury in Parkinson’s Disease via miR-134-5p/PIK3R3 Axis. (PMID:34773593)
• The Long Non-Coding Antisense RNA JHDM1D-AS1 Regulates Inflammatory Responses in Human Monocytes. (PMID:35903199)
• LncRNA JHDM1D-AS1 promotes osteogenic differentiation of periodontal ligament cells by targeting miR-532-5p to activate IGF1R signaling. (PMID:37950511)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.