KHDRBS2

Summary

KHDRBS2 (KH RNA binding domain containing, signal transduction associated 2, HGNC:18114) is a protein-coding gene on chromosome 6q11.1, encoding KH domain-containing, RNA-binding, signal transduction-associated protein 2 (Q5VWX1). RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion.

Predicted to enable mRNA binding activity and poly(A) binding activity. Predicted to be involved in regulation of alternative mRNA splicing, via spliceosome. Predicted to be located in nucleoplasm. Predicted to be active in nucleus.

Source: NCBI Gene 202559 — RefSeq curated summary.

At a glance

• GWAS associations: 9
• Clinical variants (ClinVar): 86 total
• MANE Select transcript: NM_152688

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:18114
Approved symbol	KHDRBS2
Name	KH RNA binding domain containing, signal transduction associated 2
Location	6q11.1
Locus type	gene with protein product
Status	Approved
Aliases	SLM1, SLM-1, MGC26664
Ensembl gene	ENSG00000112232
Ensembl biotype	protein_coding
OMIM	610487
Entrez	202559

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 3 protein_coding, 2 nonsense_mediated_decay

ENST00000281156, ENST00000675091, ENST00000718012, ENST00000931671, ENST00000968831

RefSeq mRNA: 2 — MANE Select: NM_152688 NM_001350622, NM_152688

CCDS: CCDS4963

Canonical transcript exons

ENST00000281156 — 9 exons

Exon	Start	End
ENSE00000798513	61978066	61978212
ENSE00000798514	62047878	62047994
ENSE00000974311	61901244	61901371
ENSE00000974312	61894635	61894833
ENSE00001131050	62177185	62177312
ENSE00001202716	61697195	61697253
ENSE00001202727	61732682	61732764
ENSE00001267739	62285858	62286225
ENSE00004033889	61679961	61681060

Expression profiles

Bgee: expression breadth ubiquitous, 102 present calls, max score 85.25.

FANTOM5 (CAGE): breadth broad, TPM avg 3.9392 / max 200.9506, expressed in 455 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
74197	3.6351	454
74192	0.2359	55
74194	0.1207	54
74196	0.0831	52
74193	0.0719	38
74195	0.0284	15

Top tissues by expression

140 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cortical plate	UBERON:0005343	85.25	gold quality
corpus callosum	UBERON:0002336	82.46	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.28	gold quality
ganglionic eminence	UBERON:0004023	78.87	gold quality
prefrontal cortex	UBERON:0000451	77.75	gold quality
superior frontal gyrus	UBERON:0002661	77.33	gold quality
nucleus accumbens	UBERON:0001882	76.24	gold quality
frontal cortex	UBERON:0001870	74.89	gold quality
primary visual cortex	UBERON:0002436	74.30	gold quality
cerebral cortex	UBERON:0000956	72.70	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	72.69	gold quality
Brodmann (1909) area 9	UBERON:0013540	72.50	gold quality
vastus lateralis	UBERON:0001379	72.40	gold quality
cerebellar vermis	UBERON:0004720	71.59	gold quality
hypothalamus	UBERON:0001898	71.58	gold quality
anterior cingulate cortex	UBERON:0009835	71.46	gold quality
thyroid gland	UBERON:0002046	70.30	gold quality
left lobe of thyroid gland	UBERON:0001120	69.97	gold quality
caudate nucleus	UBERON:0001873	69.97	gold quality
putamen	UBERON:0001874	69.63	gold quality
right frontal lobe	UBERON:0002810	69.07	gold quality
ventricular zone	UBERON:0003053	68.63	gold quality
right lobe of thyroid gland	UBERON:0001119	68.41	gold quality
epithelium of bronchus	UBERON:0002031	67.67	gold quality
brain	UBERON:0000955	67.13	gold quality
central nervous system	UBERON:0001017	66.88	gold quality
lung	UBERON:0002048	66.79	gold quality
temporal lobe	UBERON:0001871	66.63	gold quality
Ammon’s horn	UBERON:0001954	66.48	gold quality
amygdala	UBERON:0001876	66.42	gold quality

Single-cell (SCXA)

Detected in 5 experiment(s), a significant marker in 4.

Experiment	Marker?	Max mean expression
E-ANND-2	yes	3574.72
E-GEOD-180759	yes	1983.21
E-HCAD-35	yes	1923.50
E-HCAD-25	yes	91.64
E-ANND-3	no	3.89

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

113 targeting KHDRBS2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-196A-1-3P	99.99	72.15	2772
HSA-MIR-3185	99.99	68.12	1959
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-4789-3P	99.99	70.75	2484
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-8068	99.98	73.85	2376
HSA-MIR-3617-3P	99.98	67.86	918
HSA-MIR-302C-5P	99.97	72.56	3642
HSA-MIR-5688	99.96	73.23	4504
HSA-MIR-495-3P	99.96	72.81	4197
HSA-MIR-9-3P	99.96	70.88	2068
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-101-3P	99.94	75.03	2230
HSA-MIR-141-3P	99.94	72.79	2421
HSA-MIR-200A-3P	99.94	72.68	2420
HSA-MIR-552-5P	99.93	68.56	1583
HSA-MIR-6508-5P	99.92	70.67	2465
HSA-MIR-7-1-3P	99.91	71.53	4384
HSA-MIR-7-2-3P	99.91	71.40	4394
HSA-MIR-329-3P	99.91	66.56	1234
HSA-MIR-362-3P	99.91	66.38	1267

Literature-anchored findings (GeneRIF, showing 1)

• molecular cloning and characterization (PMID:12549823)

Cross-species orthologs

11 orthologs

Organism	Symbol	Gene ID
danio_rerio	khdrbs2	ENSDARG00000069469
mus_musculus	Khdrbs2	ENSMUSG00000026058
rattus_norvegicus	Khdrbs2	ENSRNOG00000012284
drosophila_melanogaster	qkr58E-3	FBGN0022984
drosophila_melanogaster	qkr58E-2	FBGN0022985
drosophila_melanogaster	qkr58E-1	FBGN0022986
drosophila_melanogaster	qkr54B	FBGN0022987
drosophila_melanogaster	CG4021	FBGN0034659
drosophila_melanogaster	CG10384	FBGN0034731
drosophila_melanogaster	CG3927	FBGN0034739
drosophila_melanogaster	nsr	FBGN0034740

Paralogs (4): QKI (ENSG00000112531), KHDRBS1 (ENSG00000121774), KHDRBS3 (ENSG00000131773), SF1 (ENSG00000168066)

Protein

Protein identifiers

KH domain-containing, RNA-binding, signal transduction-associated protein 2 — Q5VWX1 (reviewed: Q5VWX1)

Alternative names: Sam68-like mammalian protein 1

All UniProt accessions (2): Q5VWX1, A0A6Q8PGH5

UniProt curated annotations — full annotation on UniProt →

Function. RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds both poly(A) and poly(U) homopolymers. Phosphorylation by PTK6 inhibits its RNA-binding ability. Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. Can regulate alternative splicing of NRXN1 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. Regulates cell-type specific alternative splicing of NRXN1 at AS4 and acts synergystically with SAM68 in exon skipping. In contrast acts antagonistically with SAM68 in NRXN3 exon skipping at AS4. Its phosphorylation by FYN inhibits its ability to regulate splice site selection. May function as an adapter protein for Src kinases during mitosis.

Subunit / interactions. Self-associates to form homooligomers. Interacts with KHDRBS1/SAM68; heterooligomer formation of KHDRBS family proteins may modulate RNA substrate specificity. Interacts with RBMX. Interacts with SAFB, SFRS9 and YTHDC1. Interacts with FYN and PLCG1 (via SH3 domain). Interacts (phosphorylated) with FYN, GRB2, PLCG1 and RASA1 (via SH2 domain).

Subcellular location. Nucleus.

Tissue specificity. Highly expressed in brain, lung, kidney and small intestine. Weakly expressed in placenta, liver, spleen, thymus, ovary and colon.

Post-translational modifications. Methylated. Tyrosine phosphorylated by FYN, PTK6 and SRC. Tyrosine phosphorylated by SRC during mitosis.

Similarity. Belongs to the KHDRBS family.

RefSeq proteins (2): NP_001337551, NP_689901* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR004087	KH_dom	Domain
IPR032335	Sam68-YY	Domain
IPR032571	Qua1_dom	Domain
IPR036612	KH_dom_type_1_sf	Homologous_superfamily
IPR045071	BBP-like	Family
IPR055256	KH_1_KHDC4/BBP-like	Domain

Pfam: PF16274, PF16568, PF22675

UniProt features (11 total): sequence conflict 3, region of interest 2, modified residue 2, chain 1, domain 1, compositionally biased region 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q5VWX1-F1	70.39	0.36

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 230, 240

Function

Pathways and Gene Ontology

Reactome pathways

4 pathways

ID	Pathway
R-HSA-8849468	PTK6 Regulates Proteins Involved in RNA Processing
R-HSA-162582	Signal Transduction
R-HSA-8848021	Signaling by PTK6
R-HSA-9006927	Signaling by Non-Receptor Tyrosine Kinases

MSigDB gene sets: 134 (showing top): GSE18804_BRAIN_VS_COLON_TUMORAL_MACROPHAGE_DN, RORA1_01, GOBP_ALTERNATIVE_MRNA_SPLICING_VIA_SPLICEOSOME, AREB6_03, ATGTTAA_MIR302C, PUJANA_CHEK2_PCC_NETWORK, GOMF_SH2_DOMAIN_BINDING, AAAGACA_MIR511, GOBP_RNA_SPLICING, GOBP_REGULATION_OF_MRNA_SPLICING_VIA_SPLICEOSOME, GOBP_REGULATION_OF_RNA_SPLICING, TGGAAA_NFAT_Q4_01, ATGTAGC_MIR221_MIR222, GOMF_POLY_A_BINDING, GOMF_POLY_PYRIMIDINE_TRACT_BINDING

GO Biological Process (3): regulation of alternative mRNA splicing, via spliceosome (GO:0000381), mRNA processing (GO:0006397), regulation of mRNA splicing, via spliceosome (GO:0048024)

GO Molecular Function (8): mRNA binding (GO:0003729), poly(A) binding (GO:0008143), poly(U) RNA binding (GO:0008266), SH3 domain binding (GO:0017124), SH2 domain binding (GO:0042169), nucleic acid binding (GO:0003676), RNA binding (GO:0003723), protein binding (GO:0005515)

GO Cellular Component (2): nucleus (GO:0005634), nucleoplasm (GO:0005654)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Signaling by PTK6	1
Signaling by Non-Receptor Tyrosine Kinases	1
Signal Transduction	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
protein domain specific binding	2
binding	2
alternative mRNA splicing, via spliceosome	1
regulation of mRNA splicing, via spliceosome	1
RNA processing	1
mRNA metabolic process	1
mRNA splicing, via spliceosome	1
regulation of RNA splicing	1
regulation of mRNA processing	1
RNA binding	1
poly-purine tract binding	1
poly-pyrimidine tract binding	1
nucleic acid binding	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
cellular anatomical structure	1

Protein interactions and networks

STRING

1256 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
KHDRBS2	CRYL1	Q9Y2S2	817
KHDRBS2	PRMT1	Q99873	732
KHDRBS2	PTK6	Q13882	591
KHDRBS2	LGSN	Q5TDP6	557
KHDRBS2	ESRP1	Q6NXG1	516
KHDRBS2	ESRP2	Q9H6T0	504
KHDRBS2	TFEB	P19484	492
KHDRBS2	ARHGAP9	Q9BRR9	483
KHDRBS2	KHSRP	Q92945	476
KHDRBS2	RBMX	P38159	474
KHDRBS2	MITF	O75030	473
KHDRBS2	SERPINA4	P29622	467
KHDRBS2	C4orf33	Q8N1A6	460
KHDRBS2	ZNF540	Q8NDQ6	447
KHDRBS2	HNRNPM	P52272	431
KHDRBS2	HNRNPA0	Q13151	431

IntAct

216 interactions, top by confidence:

A	B	Type	Score
RBMX	KHDRBS2	psi-mi:“MI:0915”(physical association)	0.850
KHDRBS2	RBMX	psi-mi:“MI:0915”(physical association)	0.850
KHDRBS2	RBM3	psi-mi:“MI:0915”(physical association)	0.830
RBM3	KHDRBS2	psi-mi:“MI:0915”(physical association)	0.830
KHDRBS3	KHDRBS2	psi-mi:“MI:0915”(physical association)	0.800
PRPF31	KHDRBS2	psi-mi:“MI:0915”(physical association)	0.790
KHDRBS2	PRPF31	psi-mi:“MI:0915”(physical association)	0.790
KHDRBS2	TYK2	psi-mi:“MI:0915”(physical association)	0.780
TYK2	KHDRBS2	psi-mi:“MI:0915”(physical association)	0.780
KHDRBS2	SDCBP	psi-mi:“MI:0915”(physical association)	0.720
KHDRBS2	PRR3	psi-mi:“MI:0915”(physical association)	0.720
KHDRBS2	CATSPER1	psi-mi:“MI:0915”(physical association)	0.720
DOCK2	KHDRBS2	psi-mi:“MI:0915”(physical association)	0.720
YTHDC1	KHDRBS2	psi-mi:“MI:0915”(physical association)	0.720

BioGRID (203): KHDRBS2 (Two-hybrid), KHDRBS2 (Two-hybrid), KHDRBS2 (Two-hybrid), KHDRBS2 (Two-hybrid), KHDRBS2 (Two-hybrid), KHDRBS2 (Two-hybrid), KHDRBS2 (Two-hybrid), KHDRBS2 (Two-hybrid), KHDRBS2 (Two-hybrid), KHDRBS2 (Two-hybrid), KHDRBS2 (Two-hybrid), KHDRBS2 (Two-hybrid), KHDRBS2 (Two-hybrid), KHDRBS2 (Two-hybrid), KHDRBS2 (Two-hybrid)

ESM2 similar proteins: B2GV05, B5FXN8, G3V9R8, O08583, O75525, O77768, P07910, P19600, P23588, P52756, P55795, P70333, P97379, P97855, Q08DJ0, Q0VFL7, Q13148, Q13283, Q1RMU5, Q28FB9, Q32LC7, Q3SZF3, Q3T0I4, Q58EA2, Q5R5W2, Q5R9L3, Q5RA82, Q5RB87, Q5RD26, Q5SRX1, Q5VWX1, Q5ZLN5, Q60HC3, Q64012, Q6AY09, Q6GLW1, Q86SE5, Q86V81, Q8BGD9, Q8BTF8

Diamond homologs: G5EFF1, O01367, O74555, O75525, P0CO44, P0CO45, P13230, Q07666, Q08BJ2, Q0VFL3, Q0WLR1, Q12186, Q15637, Q17339, Q32NN2, Q4P0H7, Q4WXV6, Q54BM5, Q5AED9, Q5VWX1, Q5W9D5, Q5W9D6, Q5W9D7, Q60749, Q64213, Q6BSP4, Q6C187, Q6FW77, Q6IRN2, Q6P0D0, Q6P104, Q750X2, Q75GR5, Q7JJZ8, Q8GWR3, Q8GYR4, Q8NIW7, Q8UUW7, Q91V33, Q91XU1

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 59 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
mRNA Splicing - Major Pathway	6	9.1×	5e-03

GO biological processes:

GO term	Partners	Fold	FDR
positive regulation of mRNA splicing, via spliceosome	5	55.5×	5e-06
regulation of alternative mRNA splicing, via spliceosome	7	34.9×	4e-07
mRNA splicing, via spliceosome	8	14.9×	6e-06

Disease & clinical

Clinical variants and AI predictions

ClinVar

86 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	68
Likely benign	4
Benign	6

Top pathogenic / likely-pathogenic (0)

SpliceAI

5929 predictions. Top by Δscore:

Variant	Effect	Δscore
6:61697251:ACA:A	acceptor_gain	1.0000
6:61697252:CA:C	acceptor_gain	1.0000
6:61697252:CAC:C	acceptor_gain	1.0000
6:61697254:C:CC	acceptor_gain	1.0000
6:61707328:A:AC	donor_gain	1.0000
6:61707329:C:CC	donor_gain	1.0000
6:61732676:CCTTA:C	donor_loss	1.0000
6:61732677:CTTA:C	donor_loss	1.0000
6:61732678:TTA:T	donor_loss	1.0000
6:61732679:TACCT:T	donor_loss	1.0000
6:61732680:A:AC	donor_gain	1.0000
6:61732680:A:AG	donor_loss	1.0000
6:61732680:AC:A	donor_gain	1.0000
6:61732681:C:A	donor_loss	1.0000
6:61732681:C:CC	donor_gain	1.0000
6:61732681:CC:C	donor_gain	1.0000
6:61732681:CCT:C	donor_gain	1.0000
6:61732760:TAACC:T	acceptor_gain	1.0000
6:61732761:AACC:A	acceptor_gain	1.0000
6:61732762:ACC:A	acceptor_gain	1.0000
6:61732763:CC:C	acceptor_gain	1.0000
6:61732763:CCC:C	acceptor_gain	1.0000
6:61732763:CCCTG:C	acceptor_loss	1.0000
6:61732764:CC:C	acceptor_gain	1.0000
6:61732765:C:CA	acceptor_loss	1.0000
6:61732765:C:CC	acceptor_gain	1.0000
6:61732765:C:T	acceptor_gain	1.0000
6:61732766:T:A	acceptor_loss	1.0000
6:61732771:C:CT	acceptor_gain	1.0000
6:61732772:A:T	acceptor_gain	1.0000

AlphaMissense

2245 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
6:61901331:A:G	L175S	1.000
6:61901335:C:T	E174K	1.000
6:61901340:A:G	L172P	1.000
6:61901342:T:A	Q171H	1.000
6:61901342:T:G	Q171H	1.000
6:61901343:T:G	Q171P	1.000
6:61901355:A:C	I167S	1.000
6:61901355:A:G	I167T	1.000
6:61901360:A:C	D165E	1.000
6:61901360:A:T	D165E	1.000
6:61901361:T:A	D165V	1.000
6:61901361:T:C	D165G	1.000
6:61901361:T:G	D165A	1.000
6:61901362:C:A	D165Y	1.000
6:61901362:C:G	D165H	1.000
6:61978067:G:T	P161H	1.000
6:61978073:A:G	L159P	1.000
6:61978073:A:T	L159Q	1.000
6:61978075:G:C	F158L	1.000
6:61978075:G:T	F158L	1.000
6:61978076:A:G	F158S	1.000
6:61978077:A:G	F158L	1.000
6:61978097:G:T	A151E	1.000
6:61978109:C:G	R147P	1.000
6:61978118:G:T	A144D	1.000
6:61978145:A:T	I135N	1.000
6:61978151:A:T	V133E	1.000
6:61978154:T:G	H132P	1.000
6:61978157:A:G	L131P	1.000
6:61978157:A:T	L131H	1.000

dbSNP variants (sampled 300 via entrez): RS1000000425 (6:61660266 G>A,C), RS1000001003 (6:62188974 G>A,T), RS1000002348 (6:61937701 C>A,T), RS1000009440 (6:61681119 A>G,T), RS1000015220 (6:62076848 C>A), RS1000022092 (6:61590615 C>T), RS1000040824 (6:61576588 T>A,C), RS1000044133 (6:61734413 C>T), RS1000046548 (6:62077063 A>G), RS1000049020 (6:61899058 T>C), RS1000050461 (6:62028267 T>A,C), RS1000051669 (6:61590448 T>G), RS1000059590 (6:61893354 A>G), RS1000064486 (6:61739730 A>C), RS1000068538 (6:62241448 A>C)

Disease associations

OMIM: gene MIM:610487 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

9 associations (top):

Study	Trait	p-value
GCST000189_38	Protein quantitative trait loci	3.000000e-07
GCST003563_7	Presence of antiphospholipid antibodies	4.000000e-06
GCST003739_2	Esophageal adenocarcinoma	2.000000e-08
GCST003740_8	Barrett’s esophagus or Esophageal adenocarcinoma	3.000000e-09
GCST004735_23	Epstein-Barr virus copy number in lymphoblastoid cell lines	2.000000e-06
GCST004735_24	Epstein-Barr virus copy number in lymphoblastoid cell lines	9.000000e-06
GCST004735_25	Epstein-Barr virus copy number in lymphoblastoid cell lines	4.000000e-07
GCST007157_4	Corneal astigmatism	4.000000e-06
GCST007576_279	Chronotype	3.000000e-13

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0004736	aspartate aminotransferase measurement
EFO:1002040	Corneal astigmatism
EFO:0008328	chronotype measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

16 total (human), top 16 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	decreases expression, decreases methylation	2
bisphenol A	increases methylation	1
terbufos	increases methylation	1
aflatoxin B2	increases methylation	1
Resveratrol	affects cotreatment, decreases expression	1
Acetaminophen	increases expression	1
Vehicle Emissions	decreases methylation	1
Benzo(a)pyrene	increases methylation	1
Copper	affects cotreatment, decreases expression	1
Diethylhexyl Phthalate	decreases expression	1
Fonofos	increases methylation	1
Estradiol	affects binding, increases reaction	1
Parathion	increases methylation	1
Rotenone	increases expression	1
Aflatoxin B1	decreases methylation	1
Genistein	affects binding, increases reaction	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.