KIAA1217

Summary

KIAA1217 (HGNC:25428) is a protein-coding gene on chromosome 10p12.2-p12.1, encoding Sickle tail protein homolog (Q5T5P2). Required for normal development of intervertebral disks.

Predicted to be involved in embryonic skeletal system development. Located in centrosome.

Source: NCBI Gene 56243 — RefSeq curated summary.

At a glance

• Gene–disease (curated): skeletal system disorder (Moderate, GenCC)
• GWAS associations: 15
• Clinical variants (ClinVar): 338 total
• MANE Select transcript: NM_019590

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25428
Approved symbol	KIAA1217
Name	KIAA1217
Location	10p12.2-p12.1
Locus type	gene with protein product
Status	Approved
Aliases	DKFZP761L0424, SKT, ETL4
Ensembl gene	ENSG00000120549
Ensembl biotype	protein_coding
OMIM	617367
Entrez	56243

Gene structure

Transcript identifiers

Ensembl transcripts: 25 — 22 protein_coding, 2 protein_coding_CDS_not_defined, 1 retained_intron

ENST00000307544, ENST00000376451, ENST00000376452, ENST00000376454, ENST00000376456, ENST00000376462, ENST00000396445, ENST00000396446, ENST00000430453, ENST00000438429, ENST00000458595, ENST00000460373, ENST00000481700, ENST00000492009, ENST00000635163, ENST00000635504, ENST00000636305, ENST00000696626, ENST00000881132, ENST00000881133, ENST00000881134, ENST00000881135, ENST00000881136, ENST00000914453, ENST00000914454

RefSeq mRNA: 7 — MANE Select: NM_019590 NM_001098500, NM_001282767, NM_001282768, NM_001282769, NM_001282770, NM_001321681, NM_019590

CCDS: CCDS31165, CCDS41496, CCDS60501, CCDS60502, CCDS60504, CCDS60505

Canonical transcript exons

ENST00000376454 — 21 exons

Exon	Start	End
ENSE00000504067	24494500	24494604
ENSE00000694242	24513259	24513434
ENSE00000694247	24521782	24521929
ENSE00000985424	24524323	24524764
ENSE00000985426	24531830	24531993
ENSE00000985427	24533070	24533237
ENSE00001137271	24542693	24542770
ENSE00001137278	24536774	24536893
ENSE00001244543	24520123	24520253
ENSE00001244561	24495147	24495196
ENSE00001470585	24542883	24544481
ENSE00001470610	24545827	24547843
ENSE00001737093	24432995	24433193
ENSE00001799508	24438386	24438479
ENSE00001904791	24209138	24209263
ENSE00002700858	24544981	24545103
ENSE00003459586	24380869	24381067
ENSE00003511563	24501379	24501545
ENSE00003577228	24219626	24219909
ENSE00003726774	24527936	24528119
ENSE00003758710	24473228	24474060

Expression profiles

Bgee: expression breadth ubiquitous, 256 present calls, max score 98.00.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 22.7746 / max 487.4990, expressed in 1467 samples.

FANTOM5 promoters (39 alternative TSS)

Promoter ID	TPM avg	Samples expressed
104342	7.8022	1075
104311	3.5741	762
104318	2.4787	445
104308	1.5155	603
104336	1.0274	384
104319	0.8937	310
104343	0.6491	323
104309	0.6061	304
104329	0.5733	240
104328	0.5567	285

Top tissues by expression

259 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
epithelial cell of pancreas	CL:0000083	98.00	gold quality
oviduct epithelium	UBERON:0004804	97.67	gold quality
tibialis anterior	UBERON:0001385	96.61	gold quality
pancreatic ductal cell	CL:0002079	96.59	gold quality
gastrocnemius	UBERON:0001388	96.40	gold quality
sural nerve	UBERON:0015488	95.77	gold quality
muscle of leg	UBERON:0001383	95.65	gold quality
minor salivary gland	UBERON:0001830	94.78	gold quality
skeletal muscle organ	UBERON:0014892	94.74	gold quality
saliva-secreting gland	UBERON:0001044	93.98	gold quality
deltoid	UBERON:0001476	93.98	gold quality
right uterine tube	UBERON:0001302	93.97	gold quality
mouth mucosa	UBERON:0003729	93.96	gold quality
mucosa of paranasal sinus	UBERON:0005030	93.54	gold quality
hindlimb stylopod muscle	UBERON:0004252	93.38	gold quality
endothelial cell	CL:0000115	93.08	gold quality
gingival epithelium	UBERON:0001949	92.79	gold quality
thyroid gland	UBERON:0002046	92.34	gold quality
skeletal muscle tissue	UBERON:0001134	92.31	gold quality
left lobe of thyroid gland	UBERON:0001120	92.24	gold quality
esophagus mucosa	UBERON:0002469	92.11	gold quality
mammary gland	UBERON:0001911	91.73	gold quality
thoracic mammary gland	UBERON:0005200	91.66	gold quality
epithelium of mammary gland	UBERON:0003244	91.43	gold quality
right lobe of thyroid gland	UBERON:0001119	91.40	gold quality
mammary duct	UBERON:0001765	91.40	gold quality
gingiva	UBERON:0001828	91.35	gold quality
parotid gland	UBERON:0001831	91.12	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	91.07	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	91.03	gold quality

Single-cell (SCXA)

Detected in 11 experiment(s), a significant marker in 10.

Experiment	Marker?	Max mean expression
E-GEOD-180759	yes	2565.73
E-HCAD-30	yes	2560.06
E-HCAD-35	yes	2454.39
E-HCAD-25	yes	2053.47
E-GEOD-75367	yes	206.70
E-GEOD-83139	yes	10.66
E-CURD-119	yes	9.99
E-MTAB-6678	yes	8.30
E-MTAB-9388	yes	5.86
E-ANND-2	no	2835.00
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): AR

miRNA regulators (miRDB)

138 targeting KIAA1217, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-98-3P	100.00	74.08	3907
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-4476	100.00	68.18	2030
HSA-MIR-6876-5P	100.00	67.68	2126
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-4533	100.00	69.48	2758
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-9-5P	100.00	72.28	2361
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-1252-5P	100.00	69.80	2774
HSA-MIR-656-3P	100.00	72.15	2788
HSA-MIR-34A-5P	99.99	71.21	1784
HSA-MIR-449A	99.99	71.05	1776
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-4789-5P	99.98	70.76	2721
HSA-LET-7F-2-3P	99.98	70.98	2588
HSA-MIR-1185-1-3P	99.98	71.04	2593
HSA-MIR-1185-2-3P	99.98	71.04	2593
HSA-MIR-19A-3P	99.98	75.33	2762
HSA-MIR-19B-3P	99.98	75.44	2754
HSA-MIR-4775	99.98	75.00	6394

Literature-anchored findings (GeneRIF, showing 6)

• Using tag SNPs, we examined the association in two independent Japanese case-control populations and found a significant association of lumbar herniation with SKT rs16924573 in the allele frequency model (PMID:19338451)
• SKT is involved in the etiology of intervertebral disc degeneration among young adults. (PMID:22107760)
• Data suggest that the KIAA1217-RET-fusion gene is a promising target for lung cancer treatment. (PMID:27150058)
• KIAA1217: A novel candidate gene associated with isolated and syndromic vertebral malformations. (PMID:32369272)
• KIAA1217 Promotes Epithelial-Mesenchymal Transition and Hepatocellular Carcinoma Metastasis by Interacting with and Activating STAT3. (PMID:35008530)
• Genetic polymorphism of KIAA1217 is functionally associated with lumbar disc herniation in the Chinese population. (PMID:38311218)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	si:ch211-207d6.2	ENSDARG00000031658
mus_musculus	Etl4	ENSMUSG00000036617
rattus_norvegicus	Etl4	ENSRNOG00000008666
drosophila_melanogaster	CG32809	FBGN0023531
caenorhabditis_elegans		WBGENE00022180

Paralogs (1): SRCIN1 (ENSG00000277363)

Protein

Protein identifiers

Sickle tail protein homolog — Q5T5P2 (reviewed: Q5T5P2)

All UniProt accessions (7): A0A0U1RQK8, A0A0U1RRK8, A0A1B0GU17, A0A8Q3WMI8, Q5T5P2, Q5T5P0, Q5T5P1

UniProt curated annotations — full annotation on UniProt →

Function. Required for normal development of intervertebral disks.

Subunit / interactions. Interacts with CPNE4 (via VWFA domain).

Subcellular location. Cytoplasm. Cytoskeleton. Microtubule organizing center. Centrosome.

Isoforms (9)

UniProt ID	Names	Canonical?
Q5T5P2-1	1	yes
Q5T5P2-2	2
Q5T5P2-3	3
Q5T5P2-4	4
Q5T5P2-7	5
Q5T5P2-6	6
Q5T5P2-8	7
Q5T5P2-9	9
Q5T5P2-10	10

RefSeq proteins (7): NP_001091970, NP_001269696, NP_001269697, NP_001269698, NP_001269699, NP_001308610, NP_062536* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR022782	AIP3-like_C	Domain
IPR051825	SRCIN1	Family

Pfam: PF03915

UniProt features (80 total): compositionally biased region 21, modified residue 19, region of interest 11, splice variant 9, sequence conflict 9, coiled-coil region 5, sequence variant 4, chain 1, glycosylation site 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q5T5P2-F1	46.88	0.09

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (19): 169, 244, 361, 365, 393, 470, 474, 526, 809, 1027, 1030, 1033, 1044, 1461, 1739, 1841, 1896, 1899, 1902

Glycosylation sites (1): 357

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 190 (showing top): GSE18804_SPLEEN_MACROPHAGE_VS_COLON_TUMORAL_MACROPHAGE_DN, GOBP_EMBRYO_DEVELOPMENT_ENDING_IN_BIRTH_OR_EGG_HATCHING, GOBP_SKELETAL_SYSTEM_DEVELOPMENT, GOBP_EMBRYONIC_SKELETAL_SYSTEM_DEVELOPMENT, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, ACEVEDO_LIVER_CANCER_WITH_H3K27ME3_UP, GOCC_MICROTUBULE_ORGANIZING_CENTER, KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_DN, GOCC_CENTROSOME, SENESE_HDAC1_TARGETS_UP, GOBP_EMBRYO_DEVELOPMENT, GTATGAT_MIR154_MIR487, GRYDER_PAX3FOXO1_ENHANCERS_IN_TADS, RIGGI_EWING_SARCOMA_PROGENITOR_UP, TTTGCAC_MIR19A_MIR19B

GO Biological Process (1): embryonic skeletal system development (GO:0048706)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (3): cytoplasm (GO:0005737), centrosome (GO:0005813), cytoskeleton (GO:0005856)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
skeletal system development	1
chordate embryonic development	1
binding	1
intracellular anatomical structure	1
cellular anatomical structure	1
centriole	1
microtubule organizing center	1
intracellular membraneless organelle	1

Protein interactions and networks

STRING

930 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
KIAA1217	IDH3A	P50213	824
KIAA1217	ACAN	P16112	701
KIAA1217	IDH2	P48735	649
KIAA1217	FBLN1	P23142	494
KIAA1217	GFM1	Q96RP9	491
KIAA1217	TMEM270	Q6UE05	477
KIAA1217	RET	P07949	467
KIAA1217	LRPAP1	P30533	445
KIAA1217	RELCH	Q9P260	430
KIAA1217	FBLN2	P98095	429
KIAA1217	ADAMTS3	O15072	423
KIAA1217	TTLL4	Q14679	422
KIAA1217	FBXO38	Q6PIJ6	420
KIAA1217	PLXDC2	Q6UX71	409
KIAA1217	RET	P07949	400

IntAct

26 interactions, top by confidence:

A	B	Type	Score
TBK1	TBKBP1	psi-mi:“MI:0914”(association)	0.860
YWHAH	BLTP3B	psi-mi:“MI:2364”(proximity)	0.570
TRIB2	POTEF	psi-mi:“MI:0914”(association)	0.530
LRRK1	KIAA1217	psi-mi:“MI:0407”(direct interaction)	0.440
KIAA1217	ABI2	psi-mi:“MI:0915”(physical association)	0.370
SORBS3	KIAA1217	psi-mi:“MI:0915”(physical association)	0.370
NCK2	KIAA1217	psi-mi:“MI:0915”(physical association)	0.370
KIAA1217	EXOSC5	psi-mi:“MI:0915”(physical association)	0.370
TEX11	KIAA1217	psi-mi:“MI:0915”(physical association)	0.370
KIAA1217	GCC1	psi-mi:“MI:0915”(physical association)	0.370
KRT15	KIAA1217	psi-mi:“MI:0915”(physical association)	0.370
FXR2	KIAA1217	psi-mi:“MI:0915”(physical association)	0.370
KIAA1217	FHL2	psi-mi:“MI:0915”(physical association)	0.370
SEC16A	NCOR2	psi-mi:“MI:0914”(association)	0.350
Xpo1	IFT56	psi-mi:“MI:0914”(association)	0.350
NEK4	E2F8	psi-mi:“MI:0914”(association)	0.350
SYNGAP1	POM121C	psi-mi:“MI:0914”(association)	0.350
MAPRE1	SCAMP1	psi-mi:“MI:0914”(association)	0.350
ATG16L1	ESYT2	psi-mi:“MI:0914”(association)	0.350
CNTROB	CNOT1	psi-mi:“MI:2364”(proximity)	0.270
NINL	CCDC66	psi-mi:“MI:2364”(proximity)	0.270
CDH1	ESYT2	psi-mi:“MI:2364”(proximity)	0.270
HOOK2	SEC16A	psi-mi:“MI:2364”(proximity)	0.270
CDH5	ESYT2	psi-mi:“MI:2364”(proximity)	0.270
CDH5	MYO1C	psi-mi:“MI:2364”(proximity)	0.270

BioGRID (118): KIAA1217 (Two-hybrid), KIAA1217 (Two-hybrid), KIAA1217 (Two-hybrid), KIAA1217 (Two-hybrid), KIAA1217 (Two-hybrid), KIAA1217 (Two-hybrid), KIAA1217 (Two-hybrid), KIAA1217 (Two-hybrid), KIAA1217 (Affinity Capture-RNA), KIAA1217 (Affinity Capture-MS), KIAA1217 (Two-hybrid), KIAA1217 (Two-hybrid), EXOSC5 (Two-hybrid), KIAA1217 (Two-hybrid), GCC1 (Two-hybrid)

ESM2 similar proteins: A0A0G2JTY4, A0JNC2, A2AQ25, E1BEQ5, O09000, O57539, O70305, O93602, P15336, P16951, P17544, P70365, P97305, Q00969, Q02930, Q12968, Q14157, Q15032, Q15596, Q15788, Q1LY51, Q4PJW2, Q4VCS5, Q5R9C9, Q5SFM8, Q5T5P2, Q5T6F2, Q61026, Q62415, Q6GP15, Q80TM6, Q80X50, Q86YP4, Q8CHY6, Q8IY63, Q8VCB2, Q8VHG2, Q8VHR5, Q8WXI9, Q91VX2

Diamond homologs: A2AQ25, Q5T5P2, Q9C0H9, Q9QWI6, Q9QXY2, Q7PQ25

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 36 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Signaling by Rho GTPases	6	8.2×	7e-03
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	6	8.0×	7e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

338 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	276
Likely benign	28
Benign	5

Top pathogenic / likely-pathogenic (0)

SpliceAI

5352 predictions. Top by Δscore:

Variant	Effect	Δscore
10:24209259:GCAGG:G	donor_gain	1.0000
10:24209262:GG:G	donor_gain	1.0000
10:24209262:GGGT:G	donor_loss	1.0000
10:24209263:GG:G	donor_gain	1.0000
10:24209264:G:GG	donor_gain	1.0000
10:24209264:GT:G	donor_loss	1.0000
10:24209265:T:G	donor_loss	1.0000
10:24219624:A:AG	acceptor_gain	1.0000
10:24219625:G:GA	acceptor_gain	1.0000
10:24219625:GA:G	acceptor_gain	1.0000
10:24219625:GAA:G	acceptor_gain	1.0000
10:24219625:GAAC:G	acceptor_gain	1.0000
10:24219625:GAACA:G	acceptor_gain	1.0000
10:24219852:G:GT	donor_gain	1.0000
10:24219907:CAGG:C	donor_loss	1.0000
10:24219909:GGTAC:G	donor_loss	1.0000
10:24219910:GTACG:G	donor_loss	1.0000
10:24219911:T:G	donor_loss	1.0000
10:24367628:C:G	donor_gain	1.0000
10:24432991:GCA:G	acceptor_loss	1.0000
10:24432993:A:AG	acceptor_gain	1.0000
10:24432993:A:G	acceptor_loss	1.0000
10:24432993:AG:A	acceptor_gain	1.0000
10:24432993:AGG:A	acceptor_gain	1.0000
10:24432993:AGGG:A	acceptor_gain	1.0000
10:24432994:G:GG	acceptor_gain	1.0000
10:24432994:GG:G	acceptor_gain	1.0000
10:24432994:GGG:G	acceptor_gain	1.0000
10:24432994:GGGG:G	acceptor_gain	1.0000
10:24432994:GGGGT:G	acceptor_gain	1.0000

AlphaMissense

12832 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
10:24219832:T:C	F93L	1.000
10:24219833:T:C	F93S	1.000
10:24219833:T:G	F93C	1.000
10:24219834:C:A	F93L	1.000
10:24219834:C:G	F93L	1.000
10:24219836:T:C	L94P	1.000
10:24219845:T:C	L97P	1.000
10:24219869:C:A	A105D	1.000
10:24219878:T:A	I108N	1.000
10:24219878:T:G	I108S	1.000
10:24381067:G:T	G185W	1.000
10:24433001:T:C	L187P	1.000
10:24433007:T:A	L189H	1.000
10:24433007:T:C	L189P	1.000
10:24433010:A:C	Q190P	1.000
10:24433079:T:C	L213P	1.000
10:24433082:T:C	F214S	1.000
10:24433093:T:C	F218L	1.000
10:24433095:T:A	F218L	1.000
10:24433095:T:G	F218L	1.000
10:24433181:T:C	L247S	1.000
10:24438409:T:A	L259H	1.000
10:24438409:T:C	L259P	1.000
10:24473491:A:C	R370S	1.000
10:24473491:A:T	R370S	1.000
10:24544297:T:C	L1676P	1.000
10:24219825:A:C	R90S	0.999
10:24219825:A:T	R90S	0.999
10:24219842:A:C	H96P	0.999
10:24219845:T:A	L97Q	0.999

dbSNP variants (sampled 300 via entrez): RS1000006650 (10:23941368 T>C), RS1000007763 (10:24361165 A>G), RS1000008575 (10:23903870 A>C), RS1000012527 (10:24540514 G>A,T), RS1000014859 (10:23863321 G>T), RS1000015696 (10:24514941 G>A), RS1000017627 (10:24059040 G>A), RS1000026686 (10:24259876 G>C,T), RS1000032319 (10:23895208 C>A,G,T), RS1000032836 (10:24499639 G>A), RS1000035234 (10:23766547 T>C), RS1000043476 (10:24003382 T>C), RS1000044307 (10:24452647 A>C,G), RS1000045563 (10:24438293 A>G,T), RS1000056801 (10:24135994 T>A,G)

Disease associations

OMIM: gene MIM:617367 | disease phenotypes:

GenCC curated gene-disease

Disease	Classification	Inheritance
skeletal system disorder	Moderate	Autosomal dominant

Mondo (1): skeletal system disorder (MONDO:0005172)

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

15 associations (top):

Study	Trait	p-value
GCST000579_58	Cognitive performance	4.000000e-07
GCST001957_8	Obesity (early onset extreme)	1.000000e-07
GCST005192_150	Lobe attachment (rater-scored or self-reported)	9.000000e-68
GCST005193_1	Lobe attachment (rater scored)	2.000000e-08
GCST005196_27	Coronary artery disease	7.000000e-08
GCST006035_11	Breast cancer and/or colorectal cancer	6.000000e-06
GCST006479_61	Diverticular disease	4.000000e-07
GCST007201_39	Schizophrenia	5.000000e-06
GCST008179_7	Moderate-to-late spontaneous preterm birth	7.000000e-06
GCST008508_5	Stress sensitivity (neuroticism score x major depressive disorder status interaction)	4.000000e-06
GCST009615_10	Triglyceride levels x loop diuretics use interaction	1.000000e-08
GCST009615_9	Triglyceride levels x loop diuretics use interaction	7.000000e-07
GCST011981_9	Homeostasis model assessment of insulin resistance	3.000000e-06
GCST012170_11	Cognitive function in longevity	8.000000e-06
GCST90014033_95	Haemorrhoidal disease	3.000000e-11

EFO canonical traits (8, from GWAS)

EFO ID	Trait name
EFO:0003926	neuropsychological test
EFO:0007667	lobe attachment
EFO:0009959	diverticular disease
EFO:0006917	spontaneous preterm birth
EFO:0007660	neuroticism measurement
EFO:0004530	triglyceride measurement
EFO:0004501	HOMA-IR
EFO:0008354	cognitive function measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

50 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	affects methylation, decreases expression	3
Valproic Acid	decreases methylation, affects cotreatment, increases expression	3
Cadmium Chloride	increases abundance, increases palmitoylation, decreases expression, increases expression, decreases reaction	3
bisphenol A	affects methylation, affects cotreatment, increases expression	2
mercuric bromide	increases expression, affects cotreatment	2
Cadmium	decreases reaction, increases abundance, increases palmitoylation, decreases expression	2
Phenylmercuric Acetate	affects cotreatment, increases expression	2
Tobacco Smoke Pollution	increases methylation, decreases expression	2
Aflatoxin B1	increases methylation, affects methylation	2
aristolochic acid I	increases expression	1
FR900359	affects phosphorylation	1
dicrotophos	increases expression	1
pyrogallol 1,3-dimethyl ether	affects localization, increases expression, affects cotreatment	1
trichostatin A	increases expression	1
arsenite	affects binding, decreases reaction, increases reaction	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
2-bromopalmitate	decreases reaction, increases abundance, increases palmitoylation	1
benzo(e)pyrene	increases methylation	1
potassium chromate(VI)	decreases expression	1
aflatoxin B2	affects methylation	1
nickel sulfate	decreases expression	1
coumarin	decreases phosphorylation	1
bicalutamide	decreases expression, decreases reaction	1
2,3,5-(triglutathion-S-yl)hydroquinone	increases ADP-ribosylation	1
entinostat	affects cotreatment, increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
abrine	increases expression	1
dorsomorphin	affects cotreatment, increases expression	1
1,8-dinitro-4,5-dihydroxyanthraquinone	affects response to substance	1
Temozolomide	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.