KIF18B

Summary

KIF18B (kinesin family member 18B, HGNC:27102) is a protein-coding gene on chromosome 17q21.31, encoding Kinesin-like protein KIF18B (Q86Y91). In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. It is a selective cancer dependency (DepMap: 36.3% of cell lines).

Enables cytoskeletal motor activity and kinesin binding activity. Involved in microtubule depolymerization; mitotic cell cycle; and regulation of cell division. Located in cytosol; microtubule; and nuclear lumen.

Source: NCBI Gene 146909 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 17 total
• Druggable target: yes — 1 molecules with ChEMBL bioactivity
• Cancer dependency (DepMap): dependent in 36.3% of screened cell lines
• MANE Select transcript: NM_001265577

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27102
Approved symbol	KIF18B
Name	kinesin family member 18B
Location	17q21.31
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000186185
Ensembl biotype	protein_coding
OMIM	614570
Entrez	146909

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 7 protein_coding, 1 retained_intron

ENST00000585687, ENST00000587309, ENST00000590129, ENST00000593135, ENST00000914031, ENST00000914032, ENST00000914033, ENST00000914034

RefSeq mRNA: 2 — MANE Select: NM_001265577 NM_001264573, NM_001265577

CCDS: CCDS45709, CCDS58555

Canonical transcript exons

ENST00000593135 — 16 exons

Exon	Start	End
ENSE00001333432	44926989	44927078
ENSE00001333435	44928026	44928578
ENSE00001333438	44928819	44929024
ENSE00001333442	44931602	44931729
ENSE00001346132	44926414	44926499
ENSE00001373135	44934831	44934935
ENSE00001373929	44934233	44934430
ENSE00001375404	44936032	44936358
ENSE00001379110	44935259	44935416
ENSE00001380539	44934507	44934617
ENSE00001387309	44933923	44934099
ENSE00001558686	44932673	44932773
ENSE00002828821	44924711	44926186
ENSE00002905319	44932056	44932206
ENSE00002936573	44947628	44947773
ENSE00003499773	44932912	44932986

Expression profiles

Bgee: expression breadth ubiquitous, 186 present calls, max score 89.46.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 7.4970 / max 69.1848, expressed in 1218 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
166480	6.9538	1154
166479	0.3427	185
166478	0.2004	69

Top tissues by expression

272 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
trabecular bone tissue	UBERON:0002483	89.46	gold quality
ventricular zone	UBERON:0003053	89.44	gold quality
cervix squamous epithelium	UBERON:0006922	87.94	silver quality
esophagus squamous epithelium	UBERON:0006920	85.01	gold quality
secondary oocyte	CL:0000655	84.80	gold quality
embryo	UBERON:0000922	84.76	gold quality
squamous epithelium	UBERON:0006914	84.51	gold quality
oocyte	CL:0000023	83.39	gold quality
epithelium of esophagus	UBERON:0001976	82.86	gold quality
thymus	UBERON:0002370	82.76	gold quality
ganglionic eminence	UBERON:0004023	82.48	gold quality
gingival epithelium	UBERON:0001949	81.98	silver quality
lower esophagus mucosa	UBERON:0035834	80.26	gold quality
bone marrow	UBERON:0002371	80.07	gold quality
mucosa of transverse colon	UBERON:0004991	80.00	gold quality
gingiva	UBERON:0001828	78.47	silver quality
hair follicle	UBERON:0002073	77.57	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	77.29	gold quality
stromal cell of endometrium	CL:0002255	77.07	gold quality
bone marrow cell	CL:0002092	76.69	silver quality
tibia	UBERON:0000979	75.96	gold quality
esophagus mucosa	UBERON:0002469	75.51	gold quality
oral cavity	UBERON:0000167	74.79	gold quality
vermiform appendix	UBERON:0001154	74.57	gold quality
epithelium of nasopharynx	UBERON:0001951	74.55	silver quality
tongue squamous epithelium	UBERON:0006919	74.52	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	74.40	gold quality
amniotic fluid	UBERON:0000173	73.05	silver quality
cartilage tissue	UBERON:0002418	72.81	silver quality
caecum	UBERON:0001153	70.65	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-6678	yes	9.90
E-ANND-3	yes	3.99

Regulation

Is transcription factor: no

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 36.3% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 23)

• the expression of KIF18B is regulated in a cell cycle-dependent manner and therefore may play an important role(s) in cell division. (PMID:20600703)
• Kif18B is a new microtubule dynamics regulatory protein that interacts with EB1 to control astral microtubule length (PMID:21737685)
• Results uncover a novel role for Aurora A/B kinases in regulating spindle MT dynamics through Kif18b-MCAK and suggest that the Kif18b-MCAK complex constitutes the major MT plus-end depolymerizing activity in mitotic cells. (PMID:21820309)
• High KIF18B expression is associated with neoplasms. (PMID:25236463)
• Kif18B is only modestly processive and that the motor switches frequently between directed and diffusive modes of motility. (PMID:26150501)
• we demonstrate that Kif18b shortens microtubules by increasing the catastrophe rate of dynamic microtubules. Overall, our work reveals that Kif18b uses its motile properties to reach microtubule ends, where it regulates astral microtubule length to ensure spindle centering. (PMID:29661912)
• Bioinformatics Analysis Suggests the Combined Expression of AURKB and KIF18B Being an Important Event in the Development of Clear Cell Renal Cell Carcinoma. (PMID:31489573)
• KIF18B is highly expressed in cutaneous melanoma and this overexpression is correlated with a worse prognosis. (PMID:31617652)
• KIF18B might promote lung adenocarcinoma cell proliferation, migration, and invasion by activating Rac1 and mediating the AKT/mTOR signaling pathway. (PMID:31759406)
• KIF18B promotes the proliferation of pancreatic ductal adenocarcinoma via activating the expression of CDCA8. (PMID:31875977)
• KIF18B promotes hepatocellular carcinoma progression through activating Wnt/beta-catenin-signaling pathway. (PMID:32052444)
• Role of kif2c, A Gene Related to ALL Relapse, in Embryonic Hematopoiesis in Zebrafish. (PMID:32354205)
• KIF18B promotes tumor progression in osteosarcoma by activating beta-catenin. (PMID:32587775)
• Silencing KIF18B enhances radiosensitivity: identification of a promising therapeutic target in sarcoma. (PMID:33038765)
• Kinesin family member 18B regulates the proliferation and invasion of human prostate cancer cells. (PMID:33753726)
• Silencing of KIF18B restricts proliferation and invasion and enhances the chemosensitivity of breast cancer via modulating Akt/GSK-3beta/beta-catenin pathway. (PMID:34058791)
• The nuclear kinesin KIF18B promotes 53BP1-mediated DNA double-strand break repair. (PMID:34192545)
• KIF18B as a regulator in tumor microenvironment accelerates tumor progression and triggers poor outcome in hepatocellular carcinoma. (PMID:34217812)
• KIF18b-dependent hypomethylation of PARPBP gene promoter enhances oxaliplatin resistance in colorectal cancer. (PMID:34508743)
• miR-139-3p/Kinesin family member 18B axis suppresses malignant progression of gastric cancer. (PMID:35137670)
• Upregulation of KIF18B facilitates malignant phenotype of esophageal squamous cell carcinoma by activating CDCA8/mTORC1 pathway. (PMID:36085568)
• Kinesin Family Member B18 Is Related to Gastric Mucin Phenotype and Contributes to Gastric Cancer Progression by Regulating Epithelial-Mesenchymal Transition. (PMID:37812924)
• Differential Expression of KIF18B in Gastric Cancer and Its Role in Chemotherapy Sensitivity. (PMID:38305287)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Kif18b	ENSMUSG00000051378
rattus_norvegicus	Kif18b	ENSRNOG00000021713

Paralogs (41): KIF1B (ENSG00000054523), KIF26A (ENSG00000066735), KIF2A (ENSG00000068796), KIF22 (ENSG00000079616), KIF3C (ENSG00000084731), KIF9 (ENSG00000088727), KIF16B (ENSG00000089177), KIF4A (ENSG00000090889), KIF3B (ENSG00000101350), KIF20A (ENSG00000112984), KIF21B (ENSG00000116852), KIF17 (ENSG00000117245), KIF14 (ENSG00000118193), KIF18A (ENSG00000121621), KIF25 (ENSG00000125337), KIF1C (ENSG00000129250), KIF1A (ENSG00000130294), KIF3A (ENSG00000131437), KIF12 (ENSG00000136883), KIF13A (ENSG00000137177), KIF23 (ENSG00000137807), KIF11 (ENSG00000138160), CENPE (ENSG00000138778), KIF21A (ENSG00000139116), KIFC3 (ENSG00000140859), KIF2B (ENSG00000141200), KIF2C (ENSG00000142945), KIF5A (ENSG00000155980), KIF26B (ENSG00000162849), KIF15 (ENSG00000163808), KIF6 (ENSG00000164627), KIF27 (ENSG00000165115), KIF7 (ENSG00000166813), KIFC2 (ENSG00000167702), KIF5C (ENSG00000168280), KIF5B (ENSG00000170759), KIF24 (ENSG00000186638), KIF19 (ENSG00000196169), KIF13B (ENSG00000197892), KIF4B (ENSG00000226650)

Protein

Protein identifiers

Kinesin-like protein KIF18B — Q86Y91 (reviewed: Q86Y91)

All UniProt accessions (2): A0A494BYR6, Q86Y91

UniProt curated annotations — full annotation on UniProt →

Function. In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules.

Subunit / interactions. Interacts with MAPRE1; this interaction is required for efficient accumulation at microtubule plus ends. Interacts with KIF2C at microtubule tips; this interaction increases the affinity of both partners for microtubule plus ends and is required for robust microtubule depolymerization. KIF2C phosphorylation by AURKA or AURKB strongly reduces KIF18B-binding.

Subcellular location. Nucleus. Cytoplasm. Cytoskeleton.

Tissue specificity. Shows a prominent expression in the amygdala.

Similarity. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q86Y91-5	1	yes
Q86Y91-6	2

RefSeq proteins (2): NP_001251503, NP_001252506* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001752	Kinesin_motor_dom	Domain
IPR019821	Kinesin_motor_CS	Conserved_site
IPR027417	P-loop_NTPase	Homologous_superfamily
IPR027640	Kinesin-like_fam	Family
IPR036961	Kinesin_motor_dom_sf	Homologous_superfamily

Pfam: PF00225

UniProt features (31 total): modified residue 10, region of interest 6, short sequence motif 4, compositionally biased region 3, splice variant 3, chain 1, domain 1, binding site 1, sequence variant 1, coiled-coil region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q86Y91-F1	62.96	0.31

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (1): 109–116

Post-translational modifications (10): 404, 417, 452, 480, 558, 633, 639, 662, 674, 822

Function

Pathways and Gene Ontology

Reactome pathways

8 pathways

ID	Pathway
R-HSA-6811434	COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-983189	Kinesins
R-HSA-109582	Hemostasis
R-HSA-199991	Membrane Trafficking
R-HSA-5653656	Vesicle-mediated transport
R-HSA-6811442	Intra-Golgi and retrograde Golgi-to-ER traffic
R-HSA-8856688	Golgi-to-ER retrograde transport
R-HSA-983231	Factors involved in megakaryocyte development and platelet production

MSigDB gene sets: 240 (showing top): GOBP_CHROMOSOME_ORGANIZATION, HORIUCHI_WTAP_TARGETS_DN, BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN, GNF2_CENPF, GOCC_KINESIN_COMPLEX, GNF2_H2AFX, MITSIADES_RESPONSE_TO_APLIDIN_DN, REACTOME_MEMBRANE_TRAFFICKING, GNF2_RRM2, GNF2_RRM1, GNF2_HMMR, GOBP_ORGANELLE_FISSION, GOBP_MICROTUBULE_DEPOLYMERIZATION, GNF2_SMC4L1, FISCHER_G2_M_CELL_CYCLE

GO Biological Process (6): mitotic sister chromatid segregation (GO:0000070), mitotic cell cycle (GO:0000278), microtubule-based movement (GO:0007018), microtubule depolymerization (GO:0007019), cell division (GO:0051301), regulation of cell division (GO:0051302)

GO Molecular Function (9): cytoskeletal motor activity (GO:0003774), ATP binding (GO:0005524), microtubule binding (GO:0008017), plus-end-directed microtubule motor activity (GO:0008574), ATP hydrolysis activity (GO:0016887), kinesin binding (GO:0019894), nucleotide binding (GO:0000166), microtubule motor activity (GO:0003777), protein binding (GO:0005515)

GO Cellular Component (15): astral microtubule (GO:0000235), nucleus (GO:0005634), nucleoplasm (GO:0005654), nucleolus (GO:0005730), cytoplasm (GO:0005737), cytosol (GO:0005829), kinesin complex (GO:0005871), nuclear body (GO:0016604), microtubule plus-end (GO:0035371), mitotic spindle astral microtubule (GO:0061673), mitotic spindle midzone (GO:1990023), microtubule end (GO:1990752), cytoskeleton (GO:0005856), microtubule (GO:0005874), spindle microtubule (GO:0005876)

Reactome top-level categories

Rollup of top-6 pathways:

Category	Pathways
Golgi-to-ER retrograde transport	1
Factors involved in megakaryocyte development and platelet production	1
Vesicle-mediated transport	1
Membrane Trafficking	1
Intra-Golgi and retrograde Golgi-to-ER traffic	1
Hemostasis	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	4
intracellular membraneless organelle	3
mitotic nuclear division	2
ATP-dependent activity	2
nuclear lumen	2
mitotic spindle	2
microtubule	2
sister chromatid segregation	1
mitotic cell cycle process	1
cell cycle	1
microtubule-based process	1
microtubule polymerization or depolymerization	1
protein depolymerization	1
supramolecular fiber organization	1
cellular process	1
regulation of cellular process	1
cell division	1
molecular_function	1
adenyl ribonucleotide binding	1
purine ribonucleoside triphosphate binding	1
tubulin binding	1
microtubule motor activity	1
ribonucleoside triphosphate phosphatase activity	1
cytoskeletal protein binding	1
nucleoside phosphate binding	1
heterocyclic compound binding	1
cytoskeletal motor activity	1
polypeptide conformation or assembly isomerase activity	1
binding	1
aster	1
spindle microtubule	1
cytoplasmic microtubule	1
intracellular membrane-bounded organelle	1
intracellular anatomical structure	1
cytoplasm	1
microtubule associated complex	1
nucleoplasm	1
microtubule end	1
astral microtubule	1
spindle midzone	1

Protein interactions and networks

STRING

1153 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
KIF18B	KIF2C	Q99661	845
KIF18B	CIB3	Q96Q77	653
KIF18B	HJURP	Q8NCD3	607
KIF18B	UBE2C	O00762	589
KIF18B	CEP55	Q53EZ4	586
KIF18B	NUF2	Q9BZD4	568
KIF18B	DLGAP5	Q15398	556
KIF18B	MAPRE1	Q15691	533
KIF18B	BIRC5	O15392	523
KIF18B	CDCA8	Q53HL2	512
KIF18B	KIF4A	O95239	506
KIF18B	KIF23	Q02241	504
KIF18B	MELK	Q14680	503
KIF18B	BUB1B	O60566	478
KIF18B	TPX2	Q9ULW0	477

IntAct

59 interactions, top by confidence:

A	B	Type	Score
MAPRE1	CLASP2	psi-mi:“MI:0914”(association)	0.850
NUP50	KPNA4	psi-mi:“MI:0914”(association)	0.830
IMP3	MPHOSPH10	psi-mi:“MI:0914”(association)	0.670
KIFBP	KIF3C	psi-mi:“MI:0914”(association)	0.530
KIF2B	BACH1	psi-mi:“MI:0914”(association)	0.530
TXLNB	LAMC1	psi-mi:“MI:0914”(association)	0.530
KPNB1	POM121C	psi-mi:“MI:0914”(association)	0.530
NUP62	RGPD8	psi-mi:“MI:0914”(association)	0.530
PNMA2	CCDC85C	psi-mi:“MI:0914”(association)	0.530
S100A4	OIP5	psi-mi:“MI:0914”(association)	0.530
H3C1	SMCHD1	psi-mi:“MI:2364”(proximity)	0.410
KIF18B	FLOT2	psi-mi:“MI:0915”(physical association)	0.400
Ppp1cb	MYO1C	psi-mi:“MI:0914”(association)	0.350
Cdc23	ANAPC15	psi-mi:“MI:0914”(association)	0.350
MAPRE1	CTNNB1	psi-mi:“MI:0914”(association)	0.350
Mapre1	TPM1	psi-mi:“MI:0914”(association)	0.350
LTN1	KIF2A	psi-mi:“MI:0914”(association)	0.350
PPP1CB	PLEKHG3	psi-mi:“MI:0914”(association)	0.350
MKI67	ARHGAP10	psi-mi:“MI:0914”(association)	0.350
Prdm16	ESYT2	psi-mi:“MI:0914”(association)	0.350
P4HA2	CCDC85C	psi-mi:“MI:0914”(association)	0.350
PLOD1	COL25A1	psi-mi:“MI:0914”(association)	0.350
MAPRE1	CLASP2	psi-mi:“MI:0914”(association)	0.350
NELL2	MATN2	psi-mi:“MI:0914”(association)	0.350

BioGRID (96): KIF18B (Affinity Capture-RNA), KIF18B (Affinity Capture-RNA), KIF18B (Affinity Capture-MS), KIF18B (Affinity Capture-MS), KIF18B (Proximity Label-MS), KIF18B (Proximity Label-MS), KIF18B (Affinity Capture-MS), KIF18B (Affinity Capture-MS), KIF18B (Affinity Capture-MS), KIF18B (Affinity Capture-MS), KIF18B (Affinity Capture-MS), KIF18B (Affinity Capture-MS), KIF18B (Affinity Capture-MS), KIF18B (Affinity Capture-MS), KIF18B (Affinity Capture-MS)

ESM2 similar proteins: A0JNH6, A0JNT9, A1A5D9, B7ZNG0, O35071, O35231, O35787, O43896, O95996, P58660, Q2M1P5, Q2TAC6, Q3TMW1, Q3UMT1, Q3UP38, Q3V0F0, Q4KLL9, Q58G59, Q5XI63, Q5XIS1, Q5ZLK6, Q63312, Q6NSJ2, Q6PFD6, Q7M6Z4, Q7M6Z5, Q80TF6, Q80U38, Q80VM7, Q86Y91, Q8C2K5, Q8CHW5, Q8CI12, Q8K330, Q8N283, Q8TDY4, Q8TE77, Q8TF21, Q90640, Q96FN5

Diamond homologs: A0A068FIK2, A0JN40, A1ZAJ2, A8BB91, A8BKD1, B1AVY7, B7ZC32, B9FUF9, B9GE13, D3YXS5, F1M4A4, F1QN54, F4J1U4, F4K0J3, F8WLE0, L0N7N1, O14782, O15066, O35066, O35071, O35787, O43093, O43896, O55165, O60282, O60333, O88658, O95239, P17210, P23678, P28738, P28741, P33173, P33174, P33175, P33176, P34540, P46863, P46865, P46867

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
KIF18B	up-regulates	“Plus-end directed sliding movement”

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 78 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
NS1 Mediated Effects on Host Pathways	6	35.0×	7e-06
ISG15 antiviral mechanism	6	18.4×	2e-04
Mitotic Spindle Checkpoint	5	16.2×	8e-04
HCMV Late Events	6	12.1×	8e-04
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	5	11.9×	2e-03
Mitotic Metaphase and Anaphase	6	11.8×	8e-04
Mitotic Anaphase	6	11.8×	8e-04
HCMV Early Events	6	9.9×	1e-03

GO biological processes:

GO term	Partners	Fold	FDR
protein import into nucleus	6	12.7×	2e-03
cell division	9	6.1×	3e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

17 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	1
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2529 predictions. Top by Δscore:

Variant	Effect	Δscore
17:44928817:A:AC	donor_gain	1.0000
17:44928818:C:CC	donor_gain	1.0000
17:44928818:CTTGA:C	donor_gain	1.0000
17:44928878:AAGG:A	donor_gain	1.0000
17:44928905:T:TA	donor_gain	1.0000
17:44929020:CCAAC:C	acceptor_gain	1.0000
17:44929021:CAAC:C	acceptor_gain	1.0000
17:44929021:CAACC:C	acceptor_gain	1.0000
17:44931597:CCTA:C	donor_gain	1.0000
17:44931600:A:AC	donor_gain	1.0000
17:44931600:ACTG:A	donor_gain	1.0000
17:44931601:C:CA	donor_gain	1.0000
17:44931601:CTG:C	donor_gain	1.0000
17:44931601:CTGC:C	donor_gain	1.0000
17:44931725:GGAAC:G	acceptor_gain	1.0000
17:44931729:CCTAA:C	acceptor_loss	1.0000
17:44931730:C:CC	acceptor_gain	1.0000
17:44931730:CT:C	acceptor_loss	1.0000
17:44932665:GAACT:G	donor_loss	1.0000
17:44932666:AACTC:A	donor_loss	1.0000
17:44932667:ACTCA:A	donor_loss	1.0000
17:44932668:CTC:C	donor_loss	1.0000
17:44932669:TCA:T	donor_loss	1.0000
17:44932670:CACT:C	donor_loss	1.0000
17:44932671:A:AC	donor_gain	1.0000
17:44932672:C:CC	donor_gain	1.0000
17:44932672:CT:C	donor_gain	1.0000
17:44932672:CTG:C	donor_gain	1.0000
17:44932672:CTGTT:C	donor_gain	1.0000
17:44932770:CTAC:C	acceptor_gain	1.0000

AlphaMissense

5486 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
17:44934067:G:C	S306R	0.997
17:44934067:G:T	S306R	0.997
17:44934069:T:G	S306R	0.997
17:44933951:G:T	A345D	0.996
17:44934078:A:C	Y303D	0.996
17:44934925:T:A	E161V	0.996
17:44933960:A:T	L342H	0.995
17:44934068:C:A	S306I	0.995
17:44934267:A:G	L284P	0.995
17:44934050:A:T	L312H	0.994
17:44934074:C:G	R304P	0.994
17:44934363:A:G	L252P	0.994
17:44934050:A:G	L312P	0.993
17:44934053:A:G	L311P	0.993
17:44934282:C:G	R279P	0.993
17:44933960:A:G	L342P	0.992
17:44933942:G:T	A348D	0.991
17:44933952:C:G	A345P	0.991
17:44934046:T:A	K313N	0.991
17:44934046:T:G	K313N	0.991
17:44934276:A:G	L281P	0.991
17:44934357:T:C	D254G	0.991
17:44934047:T:A	K313I	0.990
17:44934267:A:T	L284H	0.990
17:44934518:C:G	A226P	0.990
17:44934910:A:G	L166P	0.990
17:44934056:C:G	R310P	0.989
17:44934074:C:A	R304L	0.989
17:44934250:C:G	A290P	0.989
17:44934354:A:G	L255P	0.989

dbSNP variants (sampled 300 via entrez): RS1000234259 (17:44927946 T>C), RS1000553774 (17:44940836 G>A,C), RS1000589145 (17:44947536 A>C,G), RS1000686049 (17:44941401 C>T), RS1000959686 (17:44947207 G>C,T), RS1000983612 (17:44928463 G>C), RS1001534302 (17:44938266 T>C), RS1001618189 (17:44931936 G>A,C), RS1001862423 (17:44938156 C>T), RS1001940360 (17:44945915 A>G), RS1002328846 (17:44942513 G>A), RS1002463619 (17:44935925 G>A), RS1002592994 (17:44943335 T>C), RS1002659108 (17:44949150 G>T), RS1002856114 (17:44937026 C>T)

Disease associations

OMIM: gene MIM:614570 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST004412_12	Craniofacial microsomia	9.000000e-06
GCST008916_39	Asthma	8.000000e-12
GCST010703_91	Brain morphology (MOSTest)	2.000000e-65

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004346	neuroimaging measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6066179 (SINGLE PROTEIN)

Molecules with ChEMBL bioactivity

1 molecules (phase ≥1), by development phase (incl. off-target/promiscuous compounds). Patent mentions across the top 20 by phase: 1,538 (via chembl_molecule»patent_compound — counts attach to the compound, not the gene–compound relationship, so off-target/promiscuous molecules can dominate).

Molecule	Name	Phase	Patents
CHEMBL1232461	MOLIBRESIB	2	1,538

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

1 potent at pChembl≥5 of 1 total, top 1 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
5.17	IC50	6770	nM	MOLIBRESIB

PubChem BioAssay actives

1 with measured affinity, of 6 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
2-[(4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide	2179049: Inhibition of KIF18B (unknown origin) incubated for 1 hr by colloidal coomassie staining based LC-MS/MS analysis	ic50	6.7700	uM

CTD chemical–gene interactions

62 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	affects cotreatment, increases abundance, increases expression, decreases expression	4
Air Pollutants	increases abundance, increases oxidation, decreases expression, affects cotreatment	3
Particulate Matter	decreases expression, increases abundance, increases expression	3
methacrylaldehyde	increases oxidation, increases abundance, affects cotreatment	2
Acetaminophen	decreases expression, increases expression	2
Acrolein	affects cotreatment, increases oxidation, increases abundance	2
Arsenic	increases abundance, increases expression, affects cotreatment, decreases expression	2
Benzo(a)pyrene	increases expression, affects methylation, decreases methylation	2
Ozone	affects cotreatment, increases oxidation, increases abundance	2
Valproic Acid	decreases expression	2
FR900359	decreases phosphorylation	1
dicrotophos	increases expression	1
alpha-pinene	affects cotreatment, increases oxidation, increases abundance	1
propionaldehyde	decreases expression	1
bisphenol A	decreases expression	1
sodium arsenate	increases abundance, increases expression	1
arsenite	affects binding, decreases reaction	1
cobaltous chloride	decreases expression	1
butyraldehyde	decreases expression	1
perfluorooctanoic acid	decreases expression	1
zinc chromate	decreases expression, increases abundance	1
potassium chromate(VI)	increases expression	1
cupric chloride	increases expression	1
coumarin	increases phosphorylation	1
cupric oxide	decreases expression	1
diallyl trisulfide	decreases expression	1
pentanal	decreases expression	1
phenethyl isothiocyanate	decreases expression	1
chromium hexavalent ion	decreases expression, increases abundance	1
perfluoro-n-nonanoic acid	decreases expression	1

ChEMBL screening assays

6 unique, capped per target: 6 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5697779	Binding	Inhibition of KIF18B (unknown origin) assessed as fold change at 10 uM incubated for 1 hr by colloidal coomassie staining based LC-MS/MS analysis	Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia. — Nature

Cellosaurus cell lines

4 cell lines: 4 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_F1M5	HyCyte A-549 KO-hKIF18B	Cancer cell line	Male
CVCL_F1S8	HyCyte NCI-H1975 KO-hKIF18B	Cancer cell line	Female
CVCL_SU72	HAP1 KIF18B (-) 1	Cancer cell line	Male
CVCL_XQ02	HAP1 KIF18B (-) 2	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.