KIF19

Summary

KIF19 (kinesin family member 19, HGNC:26735) is a protein-coding gene on chromosome 17q25.1, encoding Kinesin-like protein KIF19 (Q2TAC6). Plus end-directed microtubule-dependent motor protein that regulates the length of motile cilia by mediating depolymerization of microtubules at ciliary tips.

Predicted to enable ATP hydrolysis activity; microtubule binding activity; and plus-end-directed microtubule motor activity. Predicted to be involved in axonemal microtubule depolymerization; microtubule-based movement; and plus-end specific microtubule depolymerization. Predicted to be located in cilium. Predicted to be part of kinesin complex. Predicted to be active in cytoplasm and microtubule.

Source: NCBI Gene 124602 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 228 total — 1 pathogenic
• MANE Select transcript: NM_153209

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26735
Approved symbol	KIF19
Name	kinesin family member 19
Location	17q25.1
Locus type	gene with protein product
Status	Approved
Aliases	FLJ37300, KIF19A
Ensembl gene	ENSG00000196169
Ensembl biotype	protein_coding
OMIM	619610
Entrez	124602

Gene structure

Transcript identifiers

Ensembl transcripts: 32 — 28 protein_coding, 4 retained_intron

ENST00000359939, ENST00000389916, ENST00000547389, ENST00000549637, ENST00000551017, ENST00000551294, ENST00000894664, ENST00000894665, ENST00000894666, ENST00000894667, ENST00000894668, ENST00000894669, ENST00000894670, ENST00000894671, ENST00000894672, ENST00000894673, ENST00000894674, ENST00000894675, ENST00000894676, ENST00000894677, ENST00000894678, ENST00000894679, ENST00000894680, ENST00000894681, ENST00000894682, ENST00000894683, ENST00000894684, ENST00000894685, ENST00000894686, ENST00000894687, ENST00000894688, ENST00000962457

RefSeq mRNA: 1 — MANE Select: NM_153209 NM_153209

CCDS: CCDS32718

Canonical transcript exons

ENST00000389916 — 20 exons

Exon	Start	End
ENSE00001351619	74326226	74326388
ENSE00001555466	74355182	74355820
ENSE00001631628	74352821	74352954
ENSE00001636641	74354782	74354941
ENSE00001652317	74353196	74353301
ENSE00001658929	74353494	74353581
ENSE00001718033	74351867	74352137
ENSE00001735188	74352219	74352340
ENSE00001755601	74350707	74350905
ENSE00001758070	74354162	74354559
ENSE00003466051	74349184	74349349
ENSE00003510417	74347777	74347899
ENSE00003513976	74344223	74344348
ENSE00003517562	74346378	74346524
ENSE00003554979	74350401	74350575
ENSE00003571680	74344761	74344955
ENSE00003617528	74342630	74342717
ENSE00003621276	74343024	74343160
ENSE00003630890	74328425	74328505
ENSE00003656029	74341876	74341986

Expression profiles

Bgee: expression breadth ubiquitous, 159 present calls, max score 94.86.

FANTOM5 (CAGE): breadth broad, TPM avg 1.7770 / max 139.6221, expressed in 367 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
162597	1.6972	356
162596	0.0798	26

Top tissues by expression

240 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right uterine tube	UBERON:0001302	94.86	gold quality
sural nerve	UBERON:0015488	94.44	gold quality
tibial nerve	UBERON:0001323	93.20	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	86.73	gold quality
spleen	UBERON:0002106	81.43	gold quality
granulocyte	CL:0000094	79.67	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	75.28	gold quality
hypothalamus	UBERON:0001898	75.26	gold quality
amygdala	UBERON:0001876	74.12	gold quality
caudate nucleus	UBERON:0001873	73.97	gold quality
putamen	UBERON:0001874	73.96	gold quality
spinal cord	UBERON:0002240	72.13	gold quality
bronchial epithelial cell	CL:0002328	72.00	gold quality
Brodmann (1909) area 9	UBERON:0013540	71.74	gold quality
buccal mucosa cell	CL:0002336	71.68	silver quality
substantia nigra	UBERON:0002038	70.87	gold quality
bronchus	UBERON:0002185	70.57	gold quality
bone marrow cell	CL:0002092	70.50	gold quality
Ammon’s horn	UBERON:0001954	69.44	gold quality
nucleus accumbens	UBERON:0001882	69.15	gold quality
endocervix	UBERON:0000458	68.98	gold quality
right frontal lobe	UBERON:0002810	68.60	gold quality
midbrain	UBERON:0001891	67.32	gold quality
small intestine Peyer’s patch	UBERON:0003454	66.49	gold quality
mucosa of transverse colon	UBERON:0004991	66.15	gold quality
anterior cingulate cortex	UBERON:0009835	65.75	gold quality
transverse colon	UBERON:0001157	65.37	gold quality
left uterine tube	UBERON:0001303	65.32	gold quality
colonic epithelium	UBERON:0000397	65.15	silver quality
small intestine	UBERON:0002108	64.91	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.29
E-GEOD-98556	no	8.59

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

33 targeting KIF19, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-96-5P	99.95	72.80	2140
HSA-MIR-12133	99.92	71.82	2006
HSA-MIR-1271-5P	99.91	71.99	1972
HSA-MIR-6783-3P	99.89	67.92	2059
HSA-MIR-6780A-5P	99.88	66.69	2776
HSA-MIR-182-5P	99.87	74.03	2589
HSA-MIR-4728-5P	99.85	69.39	4718
HSA-MIR-6785-5P	99.82	68.68	4428
HSA-MIR-1273H-5P	99.77	66.32	2471
HSA-MIR-149-3P	99.72	68.22	3963
HSA-MIR-30B-3P	99.70	65.76	2325
HSA-MIR-3689A-3P	99.70	65.73	2306
HSA-MIR-3689B-3P	99.70	65.71	2311
HSA-MIR-3689C	99.70	65.71	2311
HSA-MIR-6779-5P	99.70	65.76	2363
HSA-MIR-6883-5P	99.69	68.05	3785
HSA-MIR-3202	99.66	67.70	2737
HSA-MIR-802	99.61	67.70	1254
HSA-MIR-1290	99.59	69.90	2079
HSA-MIR-2053	99.57	69.15	1635
HSA-MIR-4480	99.42	66.02	735
HSA-MIR-5693	99.24	66.67	1106
HSA-MIR-2054	99.20	68.89	1699
HSA-MIR-196A-3P	99.19	67.34	1204
HSA-MIR-6799-5P	99.14	65.72	2093
HSA-MIR-4758-3P	99.12	63.96	869
HSA-MIR-5701	98.97	69.54	1502
HSA-MIR-5089-5P	98.45	66.06	1388
HSA-MIR-6793-3P	97.66	65.78	1084
HSA-MIR-3173-5P	97.35	65.82	1282

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	kif19	ENSDARG00000053026
mus_musculus	Kif19a	ENSMUSG00000010021
rattus_norvegicus	Kif19	ENSRNOG00000003105

Paralogs (41): KIF1B (ENSG00000054523), KIF26A (ENSG00000066735), KIF2A (ENSG00000068796), KIF22 (ENSG00000079616), KIF3C (ENSG00000084731), KIF9 (ENSG00000088727), KIF16B (ENSG00000089177), KIF4A (ENSG00000090889), KIF3B (ENSG00000101350), KIF20A (ENSG00000112984), KIF21B (ENSG00000116852), KIF17 (ENSG00000117245), KIF14 (ENSG00000118193), KIF18A (ENSG00000121621), KIF25 (ENSG00000125337), KIF1C (ENSG00000129250), KIF1A (ENSG00000130294), KIF3A (ENSG00000131437), KIF12 (ENSG00000136883), KIF13A (ENSG00000137177), KIF23 (ENSG00000137807), KIF11 (ENSG00000138160), CENPE (ENSG00000138778), KIF21A (ENSG00000139116), KIFC3 (ENSG00000140859), KIF2B (ENSG00000141200), KIF2C (ENSG00000142945), KIF5A (ENSG00000155980), KIF26B (ENSG00000162849), KIF15 (ENSG00000163808), KIF6 (ENSG00000164627), KIF27 (ENSG00000165115), KIF7 (ENSG00000166813), KIFC2 (ENSG00000167702), KIF5C (ENSG00000168280), KIF5B (ENSG00000170759), KIF18B (ENSG00000186185), KIF24 (ENSG00000186638), KIF13B (ENSG00000197892), KIF4B (ENSG00000226650)

Protein

Protein identifiers

Kinesin-like protein KIF19 — Q2TAC6 (reviewed: Q2TAC6)

All UniProt accessions (2): Q2TAC6, F8VW50

UniProt curated annotations — full annotation on UniProt →

Function. Plus end-directed microtubule-dependent motor protein that regulates the length of motile cilia by mediating depolymerization of microtubules at ciliary tips.

Subcellular location. Cytoplasm. Cytoskeleton. Cell projection. Cilium.

Miscellaneous. Due to intron retention. Due to intron retention.

Similarity. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q2TAC6-1	1	yes
Q2TAC6-2	2
Q2TAC6-3	3

RefSeq proteins (1): NP_694941* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001752	Kinesin_motor_dom	Domain
IPR019821	Kinesin_motor_CS	Conserved_site
IPR027417	P-loop_NTPase	Homologous_superfamily
IPR027640	Kinesin-like_fam	Family
IPR036961	Kinesin_motor_dom_sf	Homologous_superfamily

Pfam: PF00225

UniProt features (24 total): compositionally biased region 6, region of interest 5, sequence variant 4, splice variant 3, coiled-coil region 3, chain 1, domain 1, binding site 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q2TAC6-F1	65.40	0.20

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (1): 104–111

Function

Pathways and Gene Ontology

Reactome pathways

8 pathways

ID	Pathway
R-HSA-6811434	COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-983189	Kinesins
R-HSA-109582	Hemostasis
R-HSA-199991	Membrane Trafficking
R-HSA-5653656	Vesicle-mediated transport
R-HSA-6811442	Intra-Golgi and retrograde Golgi-to-ER traffic
R-HSA-8856688	Golgi-to-ER retrograde transport
R-HSA-983231	Factors involved in megakaryocyte development and platelet production

MSigDB gene sets: 87 (showing top): GOBP_CYTOPLASMIC_MICROTUBULE_ORGANIZATION, GOCC_KINESIN_COMPLEX, REACTOME_MEMBRANE_TRAFFICKING, GOBP_MICROTUBULE_DEPOLYMERIZATION, GOBP_CILIUM_ORGANIZATION, GOMF_CYTOSKELETAL_MOTOR_ACTIVITY, GOBP_PROTEIN_DEPOLYMERIZATION, GOBP_CELL_PROJECTION_ORGANIZATION, CCCNNGGGAR_OLF1_01, NIKOLSKY_BREAST_CANCER_17Q21_Q25_AMPLICON, GOBP_ORGANELLE_DISASSEMBLY, GOCC_CYTOPLASMIC_REGION, GOCC_CILIUM, GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES, GOMF_CYTOSKELETAL_PROTEIN_BINDING

GO Biological Process (3): microtubule-based movement (GO:0007018), axonemal microtubule depolymerization (GO:0060404), plus-end specific microtubule depolymerization (GO:0070462)

GO Molecular Function (7): microtubule motor activity (GO:0003777), ATP binding (GO:0005524), microtubule binding (GO:0008017), plus-end-directed microtubule motor activity (GO:0008574), ATP hydrolysis activity (GO:0016887), nucleotide binding (GO:0000166), cytoskeletal motor activity (GO:0003774)

GO Cellular Component (7): cytoplasm (GO:0005737), kinesin complex (GO:0005871), microtubule (GO:0005874), cilium (GO:0005929), axoneme (GO:0005930), cytoskeleton (GO:0005856), cell projection (GO:0042995)

Reactome top-level categories

Rollup of top-6 pathways:

Category	Pathways
Golgi-to-ER retrograde transport	1
Factors involved in megakaryocyte development and platelet production	1
Vesicle-mediated transport	1
Membrane Trafficking	1
Intra-Golgi and retrograde Golgi-to-ER traffic	1
Hemostasis	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
ATP-dependent activity	2
microtubule-based process	1
axoneme	1
cytoplasmic microtubule depolymerization	1
cilium disassembly	1
microtubule depolymerization	1
cytoskeletal motor activity	1
polypeptide conformation or assembly isomerase activity	1
adenyl ribonucleotide binding	1
purine ribonucleoside triphosphate binding	1
tubulin binding	1
microtubule motor activity	1
ribonucleoside triphosphate phosphatase activity	1
nucleoside phosphate binding	1
heterocyclic compound binding	1
molecular_function	1
intracellular anatomical structure	1
microtubule associated complex	1
microtubule cytoskeleton	1
polymeric cytoskeletal fiber	1
intraciliary transport particle	1
membrane-bounded organelle	1
plasma membrane bounded cell projection	1
cytoskeleton	1
microtubule	1
ciliary plasm	1
intracellular membraneless organelle	1

Protein interactions and networks

STRING

955 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
KIF19	CIB3	Q96Q77	695
KIF19	BTBD17	A6NE02	596
KIF19	KIF18A	Q8NI77	513
KIF19	IFT46	Q9NQC8	513
KIF19	SMC4	Q9NTJ3	491
KIF19	C19orf81	C9J6K1	447
KIF19	DNAI2	Q9GZS0	435
KIF19	GYG2	O15488	427
KIF19	DCTN5	Q9BTE1	404
KIF19	CEP164	Q9UPV0	392
KIF19	NEK10	Q6ZWH5	372
KIF19	IFT140	Q96RY7	372
KIF19	NCBP2L	A6PVI3	370
KIF19	CD300A	Q9UGN4	363
KIF19	CD300LD	Q6UXZ3	348

IntAct

2 interactions, top by confidence:

A	B	Type	Score
KIF19	HTR2B	psi-mi:“MI:0915”(physical association)	0.370

BioGRID (8): AKAP9 (Two-hybrid), NDEL1 (Two-hybrid), KIF19 (Two-hybrid), MAPRE3 (Two-hybrid), KIF19 (Two-hybrid), KIF19 (Positive Genetic), KIF19 (Affinity Capture-MS), KIF19 (Cross-Linking-MS (XL-MS))

ESM2 similar proteins: A2A5N8, A6NCW0, A6NCW7, A8MUK1, B1AQJ2, B2RQC2, C9J2P7, C9JJH3, C9JLJ4, C9JPN9, C9JVI0, D3ZWK4, D6R901, D6R9N7, D6RA61, D6RBM5, D6RBQ6, D6RCP7, D6RJB6, E9Q9U0, G5E8G2, G5E8I7, O94966, P0C7H9, P0C7I0, P35125, P51784, Q0E2F9, Q0WX57, Q2TAC6, Q3UJD6, Q4KLL9, Q5R7G8, Q5TKR9, Q61068, Q66HE5, Q6J1Y9, Q6PFD6, Q6QN14, Q6R6M4

Diamond homologs: A0A068FIK2, A0JN40, A1ZAJ2, A8BB91, A8BKD1, B1AVY7, B7EJ91, B7ZNG0, B9F2Y7, B9GE13, F1M4A4, F1M5N7, F1QN54, F4IIS5, F4J1U4, F4K0J3, G5EGS3, O14343, O14782, O15066, O23826, O35066, O35071, O35787, O43896, O45935, O55165, O60282, O60333, O75037, O88658, O95239, P17210, P21613, P23678, P28738, P28741, P33173, P33174, P33175

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
KIF19	up-regulates	“Plus-end directed sliding movement”

Disease & clinical

Clinical variants and AI predictions

ClinVar

228 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	205
Likely benign	13
Benign	5

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
1252051	NM_153209.4(KIF19):c.788G>A (p.Arg263His)	Pathogenic

SpliceAI

3089 predictions. Top by Δscore:

Variant	Effect	Δscore
17:74326385:CATGG:C	donor_loss	1.0000
17:74326388:GGTGA:G	donor_loss	1.0000
17:74326389:G:GA	donor_loss	1.0000
17:74326390:T:A	donor_loss	1.0000
17:74341985:AGG:A	donor_loss	1.0000
17:74341986:GGT:G	donor_loss	1.0000
17:74341987:GT:G	donor_loss	1.0000
17:74341988:T:A	donor_loss	1.0000
17:74342628:A:AC	acceptor_loss	1.0000
17:74342628:A:AG	acceptor_gain	1.0000
17:74342628:AG:A	acceptor_gain	1.0000
17:74342629:G:GT	acceptor_gain	1.0000
17:74342629:GG:G	acceptor_gain	1.0000
17:74342629:GGA:G	acceptor_gain	1.0000
17:74342629:GGAGA:G	acceptor_gain	1.0000
17:74342715:CAGGT:C	donor_loss	1.0000
17:74342718:GTAA:G	donor_loss	1.0000
17:74343020:CCAG:C	acceptor_loss	1.0000
17:74343021:CA:C	acceptor_loss	1.0000
17:74343023:GGCT:G	acceptor_gain	1.0000
17:74343130:G:GT	donor_gain	1.0000
17:74343156:TGGAG:T	donor_gain	1.0000
17:74343157:GGAG:G	donor_gain	1.0000
17:74343157:GGAGG:G	donor_gain	1.0000
17:74343158:GAG:G	donor_gain	1.0000
17:74343158:GAGG:G	donor_gain	1.0000
17:74343159:AGGT:A	donor_loss	1.0000
17:74343161:G:GG	donor_gain	1.0000
17:74343161:G:T	donor_loss	1.0000
17:74343162:T:A	donor_loss	1.0000

AlphaMissense

6489 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
17:74344233:A:T	E156V	1.000
17:74346408:G:A	G270R	1.000
17:74346408:G:C	G270R	1.000
17:74346420:A:G	N274D	1.000
17:74346422:C:A	N274K	1.000
17:74346422:C:G	N274K	1.000
17:74346430:T:C	L277P	1.000
17:74346433:T:C	L278P	1.000
17:74346449:C:G	C283W	1.000
17:74346501:A:C	S301R	1.000
17:74346503:C:A	S301R	1.000
17:74346503:C:G	S301R	1.000
17:74342708:G:C	G104R	0.999
17:74342709:G:A	G104D	0.999
17:74343033:A:T	K110I	0.999
17:74344232:G:A	E156K	0.999
17:74344233:A:C	E156A	0.999
17:74344839:C:G	H221D	0.999
17:74344841:C:A	H221Q	0.999
17:74344841:C:G	H221Q	0.999
17:74344930:T:C	L251P	0.999
17:74344944:C:A	R256S	0.999
17:74346408:G:T	G270W	0.999
17:74346409:G:A	G270E	0.999
17:74346411:G:C	A271P	0.999
17:74346412:C:A	A271D	0.999
17:74346418:T:A	I273N	0.999
17:74346418:T:C	I273T	0.999
17:74346418:T:G	I273S	0.999
17:74346421:A:T	N274I	0.999

dbSNP variants (sampled 300 via entrez): RS1000049505 (17:74353058 A>G), RS1000091442 (17:74325858 G>A), RS1000136309 (17:74330393 T>C), RS1000177975 (17:74331445 C>T), RS1000298562 (17:74345267 G>A), RS1000384292 (17:74335963 T>C), RS1000409292 (17:74340751 G>A), RS1000583943 (17:74339743 G>A), RS1000638770 (17:74343926 C>T), RS1000728699 (17:74339567 GC>G), RS1000932591 (17:74324456 C>A), RS1001003365 (17:74354108 G>A,T), RS1001172906 (17:74335089 A>G), RS1001236015 (17:74328182 G>A), RS1001436043 (17:74335277 G>A)

Disease associations

OMIM: gene MIM:619610 | disease phenotypes: MIM:236750

GenCC curated gene-disease

Mondo (1): non-immune hydrops fetalis (MONDO:0009369)

Orphanet (1): Non-immune hydrops fetalis (Orphanet:363999)

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

19 total (human), top 19 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	affects methylation, increases methylation	2
propionaldehyde	decreases expression	1
beta-lapachone	decreases expression	1
butyraldehyde	increases expression	1
benzo(e)pyrene	increases methylation	1
aflatoxin B2	increases methylation	1
pentanal	increases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Air Pollutants	increases abundance, increases expression	1
Methapyrilene	increases methylation	1
Oxygen	decreases expression	1
Phthalic Acids	decreases methylation	1
Plant Extracts	affects cotreatment, decreases expression	1
Silicon Dioxide	decreases expression	1
Smoke	increases abundance, increases expression	1
Tobacco Smoke Pollution	decreases expression	1
Valproic Acid	increases methylation	1
1-Methyl-4-phenylpyridinium	increases expression	1
Aflatoxin B1	decreases methylation	1

Clinical trials (associated diseases)

2 trials via MONDO — disease-level, not drug-specific.

Trial	Phase	Status	Title
NCT04308603	Not specified	COMPLETED	Multicentric Prospective Study to Screen Inborn Errors of Metabolism in Non-immune Hydrops (NIH) Fetalis by Massively Parallel Sequencing
NCT05528796	Not specified	ENROLLING_BY_INVITATION	Uncovering the Etiologies of Non-immune Hydrops Fetalis