KIF2B

Summary

KIF2B (kinesin family member 2B, HGNC:29443) is a protein-coding gene on chromosome 17q22, encoding Kinesin-like protein KIF2B (Q8N4N8). Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement.

Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Involved in metaphase chromosome alignment; microtubule depolymerization; and regulation of chromosome segregation. Predicted to be located in cytosol. Predicted to be part of kinesin complex. Predicted to be active in cytoplasm and microtubule cytoskeleton.

Source: NCBI Gene 84643 — RefSeq curated summary.

At a glance

• GWAS associations: 10
• Clinical variants (ClinVar): 112 total
• MANE Select transcript: NM_032559

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:29443
Approved symbol	KIF2B
Name	kinesin family member 2B
Location	17q22
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000141200
Ensembl biotype	protein_coding
OMIM	615142
Entrez	84643

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000268919

RefSeq mRNA: 1 — MANE Select: NM_032559 NM_032559

CCDS: CCDS32685

Canonical transcript exons

ENST00000268919 — 1 exons

Exon	Start	End
ENSE00000946998	53822927	53825193

Expression profiles

Bgee: expression breadth broad, 21 present calls, max score 97.86.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.4073 / max 447.9274, expressed in 8 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
161756	0.3947	6
161758	0.0084	3
161757	0.0042	3

Top tissues by expression

228 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sperm	CL:0000019	97.86	gold quality
left testis	UBERON:0004533	94.06	gold quality
right testis	UBERON:0004534	93.74	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	93.33	gold quality
testis	UBERON:0000473	91.54	gold quality
adult organism	UBERON:0007023	84.08	gold quality
tibialis anterior	UBERON:0001385	60.55	silver quality
pancreatic ductal cell	CL:0002079	59.43	silver quality
deltoid	UBERON:0001476	57.46	gold quality
epithelial cell of pancreas	CL:0000083	54.58	gold quality
cardiac muscle of right atrium	UBERON:0003379	54.34	gold quality
left ventricle myocardium	UBERON:0006566	54.23	gold quality
kidney epithelium	UBERON:0004819	53.93	gold quality
upper arm skin	UBERON:0004263	53.52	gold quality
ileal mucosa	UBERON:0000331	51.23	silver quality
myocardium	UBERON:0002349	50.25	gold quality
cerebellar vermis	UBERON:0004720	49.72	gold quality
quadriceps femoris	UBERON:0001377	48.21	silver quality
nasal cavity epithelium	UBERON:0005384	47.03	gold quality
vastus lateralis	UBERON:0001379	45.66	gold quality
layer of synovial tissue	UBERON:0007616	43.55	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	43.37	gold quality
secondary oocyte	CL:0000655	42.57	gold quality
middle temporal gyrus	UBERON:0002771	42.55	gold quality
skeletal muscle tissue	UBERON:0001134	42.39	gold quality
muscle tissue	UBERON:0002385	42.26	gold quality
thymus	UBERON:0002370	41.42	gold quality
superficial temporal artery	UBERON:0001614	41.33	gold quality
colonic epithelium	UBERON:0000397	41.32	gold quality
upper leg skin	UBERON:0004262	41.21	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.48

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

16 targeting KIF2B, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-103A-3P	99.98	69.14	1595
HSA-MIR-107	99.98	69.14	1595
HSA-MIR-3658	99.96	73.87	4379
HSA-MIR-7856-5P	99.75	69.99	2901
HSA-MIR-1827	99.63	68.57	3265
HSA-MIR-298	99.63	67.56	1916
HSA-MIR-7152-5P	99.60	69.33	2094
HSA-MIR-486-5P	99.51	70.39	707
HSA-MIR-1276	99.36	68.18	1642
HSA-MIR-223-5P	99.24	68.82	1206
HSA-MIR-4520-2-3P	99.14	69.28	1009
HSA-MIR-3074-5P	98.82	66.56	1414
HSA-MIR-4520-3P	98.75	66.55	963
HSA-MIR-6511A-5P	98.13	67.47	1770
HSA-MIR-3664-3P	97.85	67.62	1452
HSA-MIR-4418	97.04	67.16	1372

Literature-anchored findings (GeneRIF, showing 9)

• when microtubules are absent, the neck linker exists in equilibrium between two structural states; microtubule binding may activate the nucleotide-sensing mechanism of kinesin (PMID:12368902)
• kinesin-I-dependent neuronal AbetaPP transport, which controls AbetaPP processing, may be regulated by JIP1 (PMID:12893827)
• These data demonstrate that Kif2b function is required for spindle assembly and chromosome movement and that the microtubule depolymerase activities of Kif2a, Kif2b, and MCAK fulfill distinct functions during mitosis in human cells. (PMID:17538014)
• Here we show that two microtubule-depolymerizing kinesins, Kif2b and MCAK, stimulate kinetochore-microtubule dynamics during distinct phases of mitosis to correct mal-orientations. (PMID:19060894)
• Data show that CLASP1-astrin-Kif2b complex acts as a central switch at kinetochores that defines mitotic progression and promotes fidelity by temporally regulating kinetochore-microtuble attachments. (PMID:20852589)
• Data show that Polo-like kinase 1 (Plk1) regulates both the localization and activity of kinesin-13 protein Kif2b during mitosis to promote the correction of k-MT attachment errors to ensure mitotic fidelity. (PMID:22535524)
• Data indicate that Cep170 association with the C-terminus of Kif2b enhances localization of Kif2b to the spindle. (PMID:23087211)
• GSK3beta-SKAP-Kif2b signaling axis constitutes a dynamic link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division. (PMID:27982129)
• Chromosomal instability suppresses the growth of K-Ras-induced lung adenomas. (PMID:31179849)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Kif2b	ENSMUSG00000046755
rattus_norvegicus	Kif2b	ENSRNOG00000086201

Paralogs (41): KIF1B (ENSG00000054523), KIF26A (ENSG00000066735), KIF2A (ENSG00000068796), KIF22 (ENSG00000079616), KIF3C (ENSG00000084731), KIF9 (ENSG00000088727), KIF16B (ENSG00000089177), KIF4A (ENSG00000090889), KIF3B (ENSG00000101350), KIF20A (ENSG00000112984), KIF21B (ENSG00000116852), KIF17 (ENSG00000117245), KIF14 (ENSG00000118193), KIF18A (ENSG00000121621), KIF25 (ENSG00000125337), KIF1C (ENSG00000129250), KIF1A (ENSG00000130294), KIF3A (ENSG00000131437), KIF12 (ENSG00000136883), KIF13A (ENSG00000137177), KIF23 (ENSG00000137807), KIF11 (ENSG00000138160), CENPE (ENSG00000138778), KIF21A (ENSG00000139116), KIFC3 (ENSG00000140859), KIF2C (ENSG00000142945), KIF5A (ENSG00000155980), KIF26B (ENSG00000162849), KIF15 (ENSG00000163808), KIF6 (ENSG00000164627), KIF27 (ENSG00000165115), KIF7 (ENSG00000166813), KIFC2 (ENSG00000167702), KIF5C (ENSG00000168280), KIF5B (ENSG00000170759), KIF18B (ENSG00000186185), KIF24 (ENSG00000186638), KIF19 (ENSG00000196169), KIF13B (ENSG00000197892), KIF4B (ENSG00000226650)

Protein

Protein identifiers

Kinesin-like protein KIF2B — Q8N4N8 (reviewed: Q8N4N8)

All UniProt accessions (2): A0A140VKG5, Q8N4N8

UniProt curated annotations — full annotation on UniProt →

Function. Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement. Has microtubule depolymerization activity. Plays a role in chromosome congression.

Subcellular location. Cytoplasm. Cytoskeleton. Microtubule organizing center. Centrosome. Spindle. Chromosome. Centromere. Kinetochore.

Tissue specificity. Highest level in lung. High level in ovary, moderate levels in heart, kidney, placenta, skeletal muscle and spleen (at protein level). Pancreas and spleen express a shorter isoform (at protein level).

Post-translational modifications. Phosphorylation at Thr-125 by PLK1 is required for activity in the correction of kinetochore-microtubules attachment errors, while phosphorylation at Ser-204 also by PLK1 is required for the kinetochore localization and activity in prometaphase.

Miscellaneous. Osteosarcoma cells (U2OS) lacking KIF2B show disorganised often monopolar mitotic spindles, severely reduced velocity of chromosome movement and blocked cytokinesis. Bipolar mitotic spindles can be restored by simultaneous depletion of KIF2B, KIFC1 and NUMA1.

Similarity. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. MCAK/KIF2 subfamily.

RefSeq proteins (1): NP_115948* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001752	Kinesin_motor_dom	Domain
IPR019821	Kinesin_motor_CS	Conserved_site
IPR027417	P-loop_NTPase	Homologous_superfamily
IPR027640	Kinesin-like_fam	Family
IPR036961	Kinesin_motor_dom_sf	Homologous_superfamily
IPR054473	KIF2A-like_N	Domain

Pfam: PF00225, PF22923

UniProt features (19 total): sequence conflict 7, sequence variant 5, coiled-coil region 2, modified residue 2, chain 1, domain 1, binding site 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8N4N8-F1	72.93	0.34

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (1): 303–310

Post-translational modifications (2): 125, 204

Function

Pathways and Gene Ontology

Reactome pathways

29 pathways

ID	Pathway
R-HSA-141444	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-2132295	MHC class II antigen presentation
R-HSA-2467813	Separation of Sister Chromatids
R-HSA-2500257	Resolution of Sister Chromatid Cohesion
R-HSA-5663220	RHO GTPases Activate Formins
R-HSA-6811434	COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-68877	Mitotic Prometaphase
R-HSA-9648025	EML4 and NUDC in mitotic spindle formation
R-HSA-983189	Kinesins
R-HSA-109582	Hemostasis
R-HSA-1280218	Adaptive Immune System
R-HSA-141424	Amplification of signal from the kinetochores
R-HSA-162582	Signal Transduction
R-HSA-1640170	Cell Cycle
R-HSA-168256	Immune System
R-HSA-194315	Signaling by Rho GTPases
R-HSA-195258	RHO GTPase Effectors
R-HSA-199991	Membrane Trafficking
R-HSA-2555396	Mitotic Metaphase and Anaphase
R-HSA-5653656	Vesicle-mediated transport
R-HSA-6811442	Intra-Golgi and retrograde Golgi-to-ER traffic
R-HSA-68882	Mitotic Anaphase
R-HSA-68886	M Phase
R-HSA-69278	Cell Cycle, Mitotic
R-HSA-69618	Mitotic Spindle Checkpoint
R-HSA-69620	Cell Cycle Checkpoints
R-HSA-8856688	Golgi-to-ER retrograde transport
R-HSA-9716542	Signaling by Rho GTPases, Miro GTPases and RHOBTB3
R-HSA-983231	Factors involved in megakaryocyte development and platelet production

MSigDB gene sets: 105 (showing top): REACTOME_ADAPTIVE_IMMUNE_SYSTEM, GOBP_CHROMOSOME_LOCALIZATION, GOCC_KINESIN_COMPLEX, REACTOME_MEMBRANE_TRAFFICKING, HATADA_METHYLATED_IN_LUNG_CANCER_DN, GOCC_MICROTUBULE_ORGANIZING_CENTER, GOBP_MICROTUBULE_DEPOLYMERIZATION, GOBP_REGULATION_OF_CHROMOSOME_SEGREGATION, OCT1_03, GOBP_REGULATION_OF_CELL_CYCLE, GOMF_CYTOSKELETAL_MOTOR_ACTIVITY, GOCC_CENTROSOME, AFP1_Q6, GOBP_PROTEIN_DEPOLYMERIZATION, GOBP_REGULATION_OF_CELL_CYCLE_PROCESS

GO Biological Process (5): microtubule-based movement (GO:0007018), microtubule depolymerization (GO:0007019), cell division (GO:0051301), metaphase chromosome alignment (GO:0051310), regulation of chromosome segregation (GO:0051983)

GO Molecular Function (6): microtubule motor activity (GO:0003777), ATP binding (GO:0005524), microtubule binding (GO:0008017), ATP hydrolysis activity (GO:0016887), nucleotide binding (GO:0000166), cytoskeletal motor activity (GO:0003774)

GO Cellular Component (10): kinetochore (GO:0000776), cytoplasm (GO:0005737), centrosome (GO:0005813), spindle (GO:0005819), cytosol (GO:0005829), kinesin complex (GO:0005871), microtubule (GO:0005874), chromosome, centromeric region (GO:0000775), chromosome (GO:0005694), cytoskeleton (GO:0005856)

Reactome top-level categories

Rollup of top-13 pathways:

Category	Pathways
Mitotic Prometaphase	2
M Phase	2
Amplification of signal from the kinetochores	1
Adaptive Immune System	1
Mitotic Anaphase	1
RHO GTPase Effectors	1
Golgi-to-ER retrograde transport	1
Factors involved in megakaryocyte development and platelet production	1
Immune System	1
Mitotic Spindle Checkpoint	1
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	1
Signaling by Rho GTPases	1
Vesicle-mediated transport	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
intracellular membraneless organelle	4
ATP-dependent activity	2
cellular anatomical structure	2
microtubule cytoskeleton	2
microtubule-based process	1
microtubule polymerization or depolymerization	1
protein depolymerization	1
supramolecular fiber organization	1
cellular process	1
chromosome localization	1
nuclear chromosome segregation	1
chromosome segregation	1
regulation of cell cycle process	1
cytoskeletal motor activity	1
polypeptide conformation or assembly isomerase activity	1
adenyl ribonucleotide binding	1
purine ribonucleoside triphosphate binding	1
tubulin binding	1
ribonucleoside triphosphate phosphatase activity	1
nucleoside phosphate binding	1
heterocyclic compound binding	1
molecular_function	1
condensed chromosome, centromeric region	1
supramolecular complex	1
intracellular anatomical structure	1
centriole	1
microtubule organizing center	1
cytoplasm	1
microtubule associated complex	1
polymeric cytoskeletal fiber	1
chromosomal region	1

Protein interactions and networks

STRING

1230 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
KIF2B	CLASP1	Q7Z460	901
KIF2B	CEP170	Q5SW79	788
KIF2B	AURKB	Q96GD4	599
KIF2B	NDC80	O14777	544
KIF2B	BUB1	O43683	527
KIF2B	PLK1	P53350	520
KIF2B	CAMKMT	Q7Z624	509
KIF2B	SPAG5	Q96R06	506
KIF2B	DYNLL2	Q96FJ2	498
KIF2B	BUB1B	O60566	469
KIF2B	CKAP5	Q14008	461
KIF2B	CLASP2	O75122	453
KIF2B	CLASRP	Q8N2M8	447
KIF2B	KNSTRN	Q9Y448	447
KIF2B	FAM227B	Q96M60	444

IntAct

12 interactions, top by confidence:

A	B	Type	Score
KIF2B	rep	psi-mi:“MI:0915”(physical association)	0.550
KIF2B	BACH1	psi-mi:“MI:0914”(association)	0.530
KIF2B	H1-5	psi-mi:“MI:0915”(physical association)	0.400
KIF2B	BICD2	psi-mi:“MI:0915”(physical association)	0.400
KIF2B	STAU1	psi-mi:“MI:0915”(physical association)	0.400
Prdm16	ESYT2	psi-mi:“MI:0914”(association)	0.350
Mecom	ESYT2	psi-mi:“MI:0914”(association)	0.350
rep	URB1	psi-mi:“MI:0914”(association)	0.350
KIF2B	HERC2	psi-mi:“MI:0914”(association)	0.350

BioGRID (90): SIKE1 (Affinity Capture-MS), DAPK3 (Affinity Capture-MS), CEP170B (Affinity Capture-MS), SAV1 (Affinity Capture-MS), BACH1 (Affinity Capture-MS), SPC25 (Affinity Capture-MS), TXLNG (Affinity Capture-MS), KLC4 (Affinity Capture-MS), CEP170 (Affinity Capture-MS), STK3 (Affinity Capture-MS), HOMER1 (Affinity Capture-MS), MIS12 (Affinity Capture-MS), CCDC22 (Affinity Capture-MS), VPS8 (Affinity Capture-MS), KLC1 (Affinity Capture-MS)

ESM2 similar proteins: A0A1L8GXY4, A0A1L8I2C5, A1A5R7, A6PWY4, A9X1C6, B1ANS9, B2KIQ4, D3Z3I0, E9Q7R9, F1QHZ6, O13286, O74845, O94411, P26309, P43254, P51956, P93471, Q09786, Q4V837, Q5R6T6, Q5TKR9, Q5XHI9, Q5ZKI7, Q6DTM3, Q6GM71, Q6GPU3, Q6VZ17, Q7Z2W4, Q80Z32, Q86VD1, Q86Y33, Q8BZ21, Q8CDP0, Q8K3E5, Q8L4H0, Q8N157, Q8N4N8, Q8NA75, Q8NDM7, Q8NEM8

Diamond homologs: A0A068FIK2, A1ZAJ2, A6H750, A8BKD1, B7EJ91, B7ZNG0, B9EY52, B9F2Y7, B9F7C8, B9FMJ3, E2RTQ2, F1M4A4, F4ICA0, F4IIS5, F4K0J3, L0N7N1, O00139, O14343, O15066, O23826, O35071, O35787, O43896, O45935, O59751, O60282, O95239, P21613, P23678, P28740, P28741, P33173, P33174, P33176, P46863, P46867, P46874, P53086, P70096, P82266

SIGNOR signaling

5 interactions.

A	Effect	B	Mechanism
PLK1	“up-regulates activity”	KIF2B	phosphorylation
KIF2B	down-regulates	Mitotic_checkpoint
KNSTRN	“down-regulates activity”	KIF2B	relocalization
KIF2B	up-regulates	“Minus-end directed microtubule movement”

Disease & clinical

Clinical variants and AI predictions

ClinVar

112 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	102
Likely benign	8
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

18 predictions. Top by Δscore:

Variant	Effect	Δscore
17:53823727:GACC:G	donor_gain	0.2800
17:53823950:G:T	donor_gain	0.2700
17:53823950:G:GT	donor_gain	0.2600
17:53824967:T:TA	acceptor_gain	0.2600
17:53823690:G:GT	donor_gain	0.2300
17:53823989:G:GT	donor_gain	0.2300
17:53824917:TG:T	donor_gain	0.2300
17:53824918:GG:G	donor_gain	0.2300
17:53824228:G:GT	donor_gain	0.2100
17:53823866:T:A	donor_gain	0.2000
17:53824190:T:TA	donor_loss	0.2000
17:53824208:AAGAG:A	donor_loss	0.2000
17:53824209:AGAGG:A	donor_loss	0.2000
17:53824210:GAGGT:G	donor_loss	0.2000
17:53824211:AGGT:A	donor_loss	0.2000
17:53824212:GGTG:G	donor_loss	0.2000
17:53824213:GTGT:G	donor_loss	0.2000
17:53824214:T:G	donor_loss	0.2000

AlphaMissense

4428 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
17:53823871:T:G	Y280D	0.977
17:53823928:T:C	C299R	0.974
17:53824642:G:C	A537P	0.974
17:53823690:G:C	R219S	0.969
17:53823690:G:T	R219S	0.969
17:53823823:T:C	F264L	0.967
17:53823825:C:A	F264L	0.967
17:53823825:C:G	F264L	0.967
17:53824643:C:A	A537E	0.964
17:53823829:T:C	F266L	0.960
17:53823831:C:A	F266L	0.960
17:53823831:C:G	F266L	0.960
17:53823884:C:A	A284D	0.960
17:53823680:T:A	V216D	0.956
17:53823170:T:A	V46D	0.955
17:53824042:T:C	F337L	0.955
17:53824044:T:A	F337L	0.955
17:53824044:T:G	F337L	0.955
17:53823841:T:C	F270L	0.954
17:53823843:C:A	F270L	0.954
17:53823843:C:G	F270L	0.954
17:53823211:T:A	W60R	0.950
17:53823211:T:C	W60R	0.950
17:53824513:T:C	F494L	0.946
17:53824515:C:A	F494L	0.946
17:53824515:C:G	F494L	0.946
17:53823164:C:A	A44D	0.945
17:53824355:G:A	G441D	0.943
17:53823200:T:A	V56D	0.939
17:53823931:T:C	F300L	0.939

dbSNP variants (sampled 300 via entrez): RS1001128863 (17:53824145 A>C,T), RS1005210451 (17:53822730 T>A,C), RS1005264267 (17:53822516 G>T), RS1006226691 (17:53825277 C>A,T), RS1007481877 (17:53821652 T>C), RS1007884592 (17:53821254 T>C), RS1008113239 (17:53823997 C>A,G,T), RS1009148564 (17:53822694 A>G), RS1009572223 (17:53822893 C>T), RS1009696541 (17:53824369 G>A,C,T), RS1010756273 (17:53825504 A>G), RS1011405161 (17:53821598 A>G,T), RS1012633958 (17:53822465 A>C), RS1012681383 (17:53822188 G>A), RS1014012793 (17:53822014 A>G)

Disease associations

OMIM: gene MIM:615142 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

10 associations (top):

Study	Trait	p-value
GCST003992_21	Photic sneeze reflex	2.000000e-08
GCST009379_210	Type 2 diabetes	2.000000e-08
GCST009391_121	Metabolite levels	8.000000e-06
GCST009391_1213	Metabolite levels	1.000000e-07
GCST009391_1846	Metabolite levels	4.000000e-06
GCST009391_275	Metabolite levels	1.000000e-06
GCST009391_315	Metabolite levels	8.000000e-06
GCST009391_949	Metabolite levels	2.000000e-06
GCST010151_28	Carotid intima media thickness x smoking interaction	4.000000e-06
GCST010988_63	Adult body size	3.000000e-08

EFO canonical traits (8, from GWAS)

EFO ID	Trait name
EFO:0007887	autosomal dominant compelling helio-ophthalmic outburst syndrome
EFO:0010354	diacylglycerol 36:1 measurement
EFO:0010420	triacylglycerol 54:2 measurement
EFO:0010413	triacylglycerol 52:1 measurement
EFO:0010429	triacylglycerol 56:2 measurement
EFO:0010430	triacylglycerol 56:3 measurement
EFO:0010403	triacylglycerol 48:0 measurement
EFO:0006527	smoking status measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

2 total (human), top 2 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	affects methylation, decreases methylation, increases methylation	2
Methotrexate	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.