KIF3C

Summary

KIF3C (kinesin family member 3C, HGNC:6321) is a protein-coding gene on chromosome 2p23.3, encoding Kinesin-like protein KIF3C (O14782). Microtubule-based anterograde translocator for membranous organelles.

Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in microtubule-based movement. Predicted to be located in microtubule cytoskeleton; neuronal cell body; and neuronal ribonucleoprotein granule. Predicted to be part of kinesin complex. Predicted to be active in cytoplasm and microtubule.

Source: NCBI Gene 3797 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 114 total
• Druggable target: yes
• MANE Select transcript: NM_002254

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:6321
Approved symbol	KIF3C
Name	kinesin family member 3C
Location	2p23.3
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000084731
Ensembl biotype	protein_coding
OMIM	602845
Entrez	3797

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 3 protein_coding, 2 nonsense_mediated_decay, 2 retained_intron, 1 protein_coding_CDS_not_defined

ENST00000264712, ENST00000405914, ENST00000417737, ENST00000455394, ENST00000475453, ENST00000488341, ENST00000496378, ENST00000852054

RefSeq mRNA: 1 — MANE Select: NM_002254 NM_002254

CCDS: CCDS1719

Canonical transcript exons

ENST00000264712 — 8 exons

Exon	Start	End
ENSE00000962985	25951789	25951905
ENSE00001753692	25980373	25982497
ENSE00003500686	25929305	25929477
ENSE00003513476	25929955	25930063
ENSE00003545553	25956343	25956444
ENSE00003555909	25926598	25929071
ENSE00003623752	25955541	25955663
ENSE00003685467	25954267	25954385

Expression profiles

Bgee: expression breadth ubiquitous, 208 present calls, max score 98.99.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 12.3177 / max 349.0110, expressed in 1647 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
27406	5.9108	1470
27410	5.4671	1426
27405	0.4847	198
27407	0.4551	231

Top tissues by expression

284 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cortical plate	UBERON:0005343	98.99	gold quality
ganglionic eminence	UBERON:0004023	97.44	gold quality
Brodmann (1909) area 46	UBERON:0006483	97.19	gold quality
pons	UBERON:0000988	97.11	gold quality
prefrontal cortex	UBERON:0000451	97.07	gold quality
orbitofrontal cortex	UBERON:0004167	97.01	gold quality
frontal cortex	UBERON:0001870	96.33	gold quality
frontal pole	UBERON:0002795	96.14	gold quality
right frontal lobe	UBERON:0002810	95.85	gold quality
neocortex	UBERON:0001950	95.78	gold quality
superior frontal gyrus	UBERON:0002661	95.75	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	95.57	gold quality
postcentral gyrus	UBERON:0002581	95.55	gold quality
CA1 field of hippocampus	UBERON:0003881	95.52	gold quality
Brodmann (1909) area 9	UBERON:0013540	95.51	gold quality
Brodmann (1909) area 10	UBERON:0013541	95.46	gold quality
parietal lobe	UBERON:0001872	95.23	gold quality
cerebral cortex	UBERON:0000956	95.21	gold quality
cingulate cortex	UBERON:0003027	94.60	gold quality
anterior cingulate cortex	UBERON:0009835	94.52	gold quality
dorsal root ganglion	UBERON:0000044	94.50	gold quality
entorhinal cortex	UBERON:0002728	94.43	gold quality
telencephalon	UBERON:0001893	93.93	gold quality
cerebellar cortex	UBERON:0002129	93.91	gold quality
cerebellar hemisphere	UBERON:0002245	93.88	gold quality
right hemisphere of cerebellum	UBERON:0014890	93.65	gold quality
cerebellum	UBERON:0002037	93.55	gold quality
lateral nuclear group of thalamus	UBERON:0002736	93.46	gold quality
middle temporal gyrus	UBERON:0002771	93.45	gold quality
temporal lobe	UBERON:0001871	93.44	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.87

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

148 targeting KIF3C, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-4692	100.00	67.32	2066
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-12118	100.00	65.88	1270
HSA-MIR-1252-5P	100.00	69.80	2774
HSA-MIR-6851-5P	100.00	65.63	1294
HSA-MIR-3689D	100.00	66.14	1181
HSA-MIR-4476	100.00	68.18	2030
HSA-MIR-6876-5P	100.00	67.68	2126
HSA-MIR-4514	99.99	67.10	1870
HSA-MIR-4534	99.99	66.58	1907
HSA-MIR-33B-5P	99.99	68.58	1062
HSA-MIR-10401-5P	99.99	65.79	948
HSA-MIR-4789-3P	99.99	70.75	2484
HSA-MIR-3173-3P	99.98	66.49	1217
HSA-MIR-6891-5P	99.98	66.53	1372
HSA-MIR-499A-5P	99.98	70.79	1323
HSA-MIR-3065-5P	99.97	71.56	3281
HSA-MIR-185-3P	99.95	67.01	1743
HSA-MIR-8082	99.95	67.27	1170
HSA-MIR-651-3P	99.94	73.48	5177
HSA-MIR-6721-5P	99.93	68.92	2981
HSA-MIR-218-5P	99.93	72.22	2103
HSA-MIR-1305	99.91	71.43	3443
HSA-MIR-3671	99.90	73.04	3897
HSA-MIR-8087	99.90	69.55	1351
HSA-MIR-548E-5P	99.89	72.73	4486
HSA-MIR-4302	99.89	67.94	1187

Literature-anchored findings (GeneRIF, showing 6)

• FMRP acts also as a molecular adaptor between RNA granules and the neurospecific kinesin KIF3C. (PMID:17881655)
• Results suggest that high expression of KIF3C in breast cancer may be associated with tumor progression and metastasis. (PMID:26272184)
• KIF3C is associated with favorable prognosis in glioma patients and may be regulated by PI3K/AKT/mTOR pathway. (PMID:32020481)
• KIF3C Promotes Proliferation, Migration, and Invasion of Glioma Cells by Activating the PI3K/AKT Pathway and Inducing EMT. (PMID:33150178)
• Kinesin family member 3C (KIF3C) is a novel non-small cell lung cancer (NSCLC) oncogene whose expression is modulated by microRNA-150-5p (miR-150-5p) and microRNA-186-3p (miR-186-3p). (PMID:34193018)
• Double heterozygous pathogenic mutations in KIF3C and ZNF513 cause hereditary gingival fibromatosis. (PMID:37752101)

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
danio_rerio	kif3ca	ENSDARG00000017162
danio_rerio	kif3cb	ENSDARG00000079500
mus_musculus	Kif3c	ENSMUSG00000020668
rattus_norvegicus	Kif3c	ENSRNOG00000011394
drosophila_melanogaster	Klp68D	FBGN0004381
caenorhabditis_elegans		WBGENE00002222

Paralogs (41): KIF1B (ENSG00000054523), KIF26A (ENSG00000066735), KIF2A (ENSG00000068796), KIF22 (ENSG00000079616), KIF9 (ENSG00000088727), KIF16B (ENSG00000089177), KIF4A (ENSG00000090889), KIF3B (ENSG00000101350), KIF20A (ENSG00000112984), KIF21B (ENSG00000116852), KIF17 (ENSG00000117245), KIF14 (ENSG00000118193), KIF18A (ENSG00000121621), KIF25 (ENSG00000125337), KIF1C (ENSG00000129250), KIF1A (ENSG00000130294), KIF3A (ENSG00000131437), KIF12 (ENSG00000136883), KIF13A (ENSG00000137177), KIF23 (ENSG00000137807), KIF11 (ENSG00000138160), CENPE (ENSG00000138778), KIF21A (ENSG00000139116), KIFC3 (ENSG00000140859), KIF2B (ENSG00000141200), KIF2C (ENSG00000142945), KIF5A (ENSG00000155980), KIF26B (ENSG00000162849), KIF15 (ENSG00000163808), KIF6 (ENSG00000164627), KIF27 (ENSG00000165115), KIF7 (ENSG00000166813), KIFC2 (ENSG00000167702), KIF5C (ENSG00000168280), KIF5B (ENSG00000170759), KIF18B (ENSG00000186185), KIF24 (ENSG00000186638), KIF19 (ENSG00000196169), KIF13B (ENSG00000197892), KIF4B (ENSG00000226650)

Protein

Protein identifiers

Kinesin-like protein KIF3C — O14782 (reviewed: O14782)

All UniProt accessions (4): O14782, A2RU78, F8WAR6, F8WER6

UniProt curated annotations — full annotation on UniProt →

Function. Microtubule-based anterograde translocator for membranous organelles.

Subunit / interactions. Heterodimer of KIF3A and KIF3C.

Subcellular location. Cytoplasm. Cytoskeleton.

Similarity. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.

RefSeq proteins (1): NP_002245* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001752	Kinesin_motor_dom	Domain
IPR019821	Kinesin_motor_CS	Conserved_site
IPR027417	P-loop_NTPase	Homologous_superfamily
IPR027640	Kinesin-like_fam	Family
IPR036961	Kinesin_motor_dom_sf	Homologous_superfamily

Pfam: PF00225

UniProt features (46 total): strand 13, helix 12, sequence conflict 5, region of interest 4, turn 3, compositionally biased region 3, sequence variant 2, chain 1, domain 1, binding site 1, coiled-coil region 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
3B6V	X-RAY DIFFRACTION	2.7

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O14782-F1	70.40	0.24

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (1): 97–104

Function

Pathways and Gene Ontology

Reactome pathways

14 pathways

ID	Pathway
R-HSA-2132295	MHC class II antigen presentation
R-HSA-5620924	Intraflagellar transport
R-HSA-6811434	COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-983189	Kinesins
R-HSA-109582	Hemostasis
R-HSA-1280218	Adaptive Immune System
R-HSA-168256	Immune System
R-HSA-1852241	Organelle biogenesis and maintenance
R-HSA-199991	Membrane Trafficking
R-HSA-5617833	Cilium Assembly
R-HSA-5653656	Vesicle-mediated transport
R-HSA-6811442	Intra-Golgi and retrograde Golgi-to-ER traffic
R-HSA-8856688	Golgi-to-ER retrograde transport
R-HSA-983231	Factors involved in megakaryocyte development and platelet production

MSigDB gene sets: 194 (showing top): GSE18804_BRAIN_VS_COLON_TUMORAL_MACROPHAGE_UP, GSE45365_NK_CELL_VS_CD8A_DC_DN, RNGTGGGC_UNKNOWN, GNF2_RTN1, REACTOME_ADAPTIVE_IMMUNE_SYSTEM, GOCC_KINESIN_COMPLEX, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, REACTOME_MEMBRANE_TRAFFICKING, GGGTGGRR_PAX4_03, AGTCTTA_MIR499, CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1, KOYAMA_SEMA3B_TARGETS_UP, CHARAFE_BREAST_CANCER_BASAL_VS_MESENCHYMAL_DN, GOMF_CYTOSKELETAL_MOTOR_ACTIVITY, GNF2_TM4SF2

GO Biological Process (1): microtubule-based movement (GO:0007018)

GO Molecular Function (7): cytoskeletal motor activity (GO:0003774), microtubule motor activity (GO:0003777), ATP binding (GO:0005524), microtubule binding (GO:0008017), ATP hydrolysis activity (GO:0016887), nucleotide binding (GO:0000166), protein binding (GO:0005515)

GO Cellular Component (7): cytoplasm (GO:0005737), cytosol (GO:0005829), kinesin complex (GO:0005871), microtubule (GO:0005874), cilium (GO:0005929), ciliary tip (GO:0097542), cytoskeleton (GO:0005856)

Reactome top-level categories

Rollup of top-10 pathways:

Category	Pathways
Adaptive Immune System	1
Assembly of the 9+0 primary cilium	1
Golgi-to-ER retrograde transport	1
Factors involved in megakaryocyte development and platelet production	1
Immune System	1
Vesicle-mediated transport	1
Organelle biogenesis and maintenance	1
Membrane Trafficking	1
Intra-Golgi and retrograde Golgi-to-ER traffic	1
Hemostasis	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
ATP-dependent activity	2
microtubule-based process	1
molecular_function	1
cytoskeletal motor activity	1
polypeptide conformation or assembly isomerase activity	1
adenyl ribonucleotide binding	1
purine ribonucleoside triphosphate binding	1
tubulin binding	1
ribonucleoside triphosphate phosphatase activity	1
nucleoside phosphate binding	1
heterocyclic compound binding	1
binding	1
intracellular anatomical structure	1
cytoplasm	1
microtubule associated complex	1
microtubule cytoskeleton	1
polymeric cytoskeletal fiber	1
intraciliary transport particle	1
membrane-bounded organelle	1
plasma membrane bounded cell projection	1
cilium	1
intracellular membraneless organelle	1

Protein interactions and networks

STRING

1276 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
KIF3C	KIFAP3	Q92845	980
KIF3C	KIF3A	Q9Y496	907
KIF3C	ASXL2	Q76L83	774
KIF3C	FMR1	Q06787	711
KIF3C	PLEKHA7	Q6IQ23	703
KIF3C	PDK2	Q15119	638
KIF3C	KLC1	Q07866	611
KIF3C	IFT52	Q9Y366	572
KIF3C	MATN3	O15232	569
KIF3C	DTNB	O60941	555
KIF3C	IFT57	Q9NWB7	552
KIF3C	CAMSAP3	Q9P1Y5	552
KIF3C	FXR2	P51116	545
KIF3C	ASXL1	Q8IXJ9	531
KIF3C	FXR1	P51114	522

IntAct

38 interactions, top by confidence:

A	B	Type	Score
KIF3A	KIF3C	psi-mi:“MI:0914”(association)	0.730
KIFAP3	KIF3C	psi-mi:“MI:0914”(association)	0.640
KIF3C	MCC	psi-mi:“MI:0915”(physical association)	0.560
KIF3C	TFIP11	psi-mi:“MI:0915”(physical association)	0.560
KIFBP	KIF3C	psi-mi:“MI:0914”(association)	0.530
PLEC	KIF3C	psi-mi:“MI:0915”(physical association)	0.400
KIF3C	ZC3H3	psi-mi:“MI:0914”(association)	0.350
CAMK2D	DVL2	psi-mi:“MI:0914”(association)	0.350
KIF3A	MAP1LC3B2	psi-mi:“MI:0914”(association)	0.350
BMI1	MEIS3P1	psi-mi:“MI:0914”(association)	0.350
NCKAP5	KIF3C	psi-mi:“MI:0914”(association)	0.350
UL41	KIF3C	psi-mi:“MI:0914”(association)	0.350
	TTC8	psi-mi:“MI:0914”(association)	0.350
	NFIB	psi-mi:“MI:0914”(association)	0.350
	RPS10-NUDT3	psi-mi:“MI:0914”(association)	0.350
CDH5	ESYT2	psi-mi:“MI:2364”(proximity)	0.270
KIF3C	CDC5L	psi-mi:“MI:0915”(physical association)	0.000
KIF3C	DISC1	psi-mi:“MI:0915”(physical association)	0.000
KIF3B	KIF3C	psi-mi:“MI:0915”(physical association)	0.000
AKAP12	KIF3C	psi-mi:“MI:0915”(physical association)	0.000
STK4	KIF3C	psi-mi:“MI:0915”(physical association)	0.000
DYRK2	KIF3C	psi-mi:“MI:0915”(physical association)	0.000
SAV1	KIF3C	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (32): KIF3A (Affinity Capture-MS), KIFAP3 (Affinity Capture-MS), ZC3H3 (Affinity Capture-MS), KIF3C (Affinity Capture-MS), KIF3C (Affinity Capture-MS), KIF3C (Affinity Capture-MS), KIF3C (Affinity Capture-MS), KIF3C (Affinity Capture-MS), KIF3C (Affinity Capture-MS), KIF3C (Affinity Capture-MS), KIF3C (Affinity Capture-MS), KIF3C (Affinity Capture-MS), KIF3C (Affinity Capture-RNA), KIF3C (Synthetic Lethality), KIF3C (Affinity Capture-MS)

ESM2 similar proteins: A0JN40, A8BB91, A8BKD1, B1AVY7, B9F2Y7, F1M4A4, F1M5N7, F1QN54, F4K0J3, G5EGS3, O14782, O15066, O35066, O55165, O60333, O75037, O88658, P28741, P33173, P33176, P34540, P35978, P46867, P46871, P46872, P46873, Q10E64, Q12756, Q29DY1, Q2PQA9, Q4R628, Q5JKW1, Q5R4H3, Q5R706, Q60575, Q61768, Q61771, Q6YUL8, Q7Z4S6, Q86Z98

Diamond homologs: A0A068FIK2, A0JN40, A1ZAJ2, A8BB91, A8BKD1, B1AVY7, B7EJ91, B7ZNG0, B9F2Y7, B9GE13, F1M4A4, F1M5N7, F1QN54, F4IIS5, F4J1U4, F4K0J3, G5EGS3, O14343, O14782, O15066, O23826, O35066, O35071, O35787, O43896, O45935, O55165, O60282, O60333, O75037, O88658, O95239, P17210, P21613, P23678, P28738, P28741, P33173, P33174, P33175

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
KIF3C	up-regulates	“Minus-end directed microtubule movement”

Disease & clinical

Clinical variants and AI predictions

ClinVar

114 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	98
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1617 predictions. Top by Δscore:

Variant	Effect	Δscore
2:25930059:TACTG:T	acceptor_gain	1.0000
2:25930061:CTG:C	acceptor_gain	1.0000
2:25930062:TG:T	acceptor_gain	1.0000
2:25930064:C:CA	acceptor_loss	1.0000
2:25930064:C:CC	acceptor_gain	1.0000
2:25951782:GACT:G	donor_loss	1.0000
2:25951784:CTCA:C	donor_loss	1.0000
2:25951787:A:AC	donor_gain	1.0000
2:25951787:A:T	donor_loss	1.0000
2:25951787:ACACG:A	donor_gain	1.0000
2:25951788:C:CA	donor_gain	1.0000
2:25951788:CA:C	donor_gain	1.0000
2:25951788:CACG:C	donor_gain	1.0000
2:25951788:CACGC:C	donor_gain	1.0000
2:25951817:T:TA	donor_gain	1.0000
2:25951902:GTAC:G	acceptor_gain	1.0000
2:25951903:TAC:T	acceptor_gain	1.0000
2:25951903:TACC:T	acceptor_loss	1.0000
2:25951904:AC:A	acceptor_gain	1.0000
2:25951905:CC:C	acceptor_gain	1.0000
2:25951905:CCTGG:C	acceptor_loss	1.0000
2:25951906:C:CC	acceptor_gain	1.0000
2:25951907:T:G	acceptor_loss	1.0000
2:25951913:C:CT	acceptor_gain	1.0000
2:25951914:A:T	acceptor_gain	1.0000
2:25951918:A:C	acceptor_gain	1.0000
2:25954265:A:AC	donor_gain	1.0000
2:25954266:C:CC	donor_gain	1.0000
2:25954386:C:CC	acceptor_gain	1.0000
2:25955537:TCAC:T	donor_loss	1.0000

AlphaMissense

5225 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:25951849:C:G	R649P	1.000
2:25951884:G:C	F637L	1.000
2:25951884:G:T	F637L	1.000
2:25951886:A:G	F637L	1.000
2:25951900:A:G	L632P	1.000
2:25954276:A:G	L627P	1.000
2:25929995:G:T	A692D	0.999
2:25930003:G:C	S689R	0.999
2:25930003:G:T	S689R	0.999
2:25930005:T:G	S689R	0.999
2:25930012:C:A	R686S	0.999
2:25930012:C:G	R686S	0.999
2:25930013:C:G	R686T	0.999
2:25951820:A:G	W659R	0.999
2:25951820:A:T	W659R	0.999
2:25951882:A:T	I638N	0.999
2:25951885:A:G	F637S	0.999
2:25954270:A:G	L629P	0.999
2:25954282:C:G	R625P	0.999
2:25954318:C:G	R613P	0.999
2:25954372:A:G	L595P	0.999
2:25955548:A:G	L588P	0.999
2:25980749:A:G	L390P	0.999
2:25980842:G:T	A359D	0.999
2:25980960:A:G	S320P	0.999
2:25981028:A:G	L297S	0.999
2:25981034:A:G	L295P	0.999
2:25981040:A:G	I293T	0.999
2:25981178:A:G	L247P	0.999
2:25981193:A:G	L242P	0.999

dbSNP variants (sampled 300 via entrez): RS1000021171 (2:25984036 T>C), RS1000053052 (2:25952998 G>A), RS1000115549 (2:25961019 T>C), RS1000125946 (2:25952793 G>A,C), RS1000169939 (2:25975431 G>T), RS1000226752 (2:25936630 T>G), RS1000239536 (2:25952540 T>C), RS1000264721 (2:25982888 T>G), RS1000324553 (2:25943620 G>A,T), RS1000397914 (2:25943130 C>T), RS1000412979 (2:25965676 G>A), RS1000529616 (2:25960803 G>A,T), RS1000610918 (2:25967172 TCTG>T,TCTGCTG), RS1000618459 (2:25957584 T>C), RS1000683717 (2:25958824 C>T)

Disease associations

OMIM: gene MIM:602845 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST006061_31	Atrial fibrillation	3.000000e-14
GCST006061_69	Atrial fibrillation	6.000000e-12
GCST006414_112	Atrial fibrillation	2.000000e-12

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL1075196 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

39 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, decreases expression, affects expression, increases expression, increases methylation	5
Benzo(a)pyrene	affects methylation, increases expression, increases methylation	4
Smoke	decreases expression, increases abundance	2
Aflatoxin B1	increases expression, increases methylation	2
aristolochic acid I	increases expression	1
triphenyl phosphate	affects expression	1
uranyl acetate	affects expression	1
propionaldehyde	increases expression	1
trichostatin A	affects expression	1
arsenite	affects binding, decreases reaction	1
sodium arsenite	increases expression	1
aflatoxin B2	increases methylation	1
S-(1,2-dichlorovinyl)cysteine	affects response to substance, increases expression	1
beta-methylcholine	affects expression	1
perfluorooctane sulfonic acid	decreases expression	1
10-(fluoroethoxyphosphinyl)-N-(biotinamidopentyl)decanamide	affects binding	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
jinfukang	increases expression	1
Acetaminophen	decreases expression	1
Air Pollutants	decreases expression, increases abundance	1
Calcitriol	increases expression	1
Dichlorodiphenyl Dichloroethylene	decreases expression	1
Doxorubicin	decreases expression	1
Estradiol	affects cotreatment, increases expression	1
Lead	affects expression	1
Lipopolysaccharides	decreases expression, affects response to substance, increases expression	1
Tamoxifen	affects cotreatment, decreases expression	1
Thiram	increases expression	1
Tobacco Smoke Pollution	increases expression	1

ChEMBL screening assays

4 unique, capped per target: 4 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL1101863	Binding	Inhibition of human KIF3C at 1 uM	The discovery and optimization of hexahydro-2H-pyrano[3,2-c]quinolines (HHPQs) as potent and selective inhibitors of the mitotic kinesin-5. — Bioorg Med Chem Lett

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.