KIF9-AS1

Summary

KIF9-AS1 (KIF9 antisense RNA 1, HGNC:26822) is a long non-coding RNA gene on chromosome 3p21.31.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26822
Approved symbol	KIF9-AS1
Name	KIF9 antisense RNA 1
Location	3p21.31
Locus type	RNA, long non-coding
Status	Approved
Aliases	FLJ39534
Ensembl gene	ENSG00000227398
Ensembl biotype	lncRNA
Entrez	285352
RNAcentral	URS000075A14F — lncRNA, 2540 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 27 — 27 lncRNA

ENST00000429315, ENST00000670818, ENST00000689153, ENST00000701172, ENST00000723160, ENST00000723161, ENST00000723162, ENST00000723163, ENST00000723164, ENST00000723165, ENST00000723166, ENST00000723167, ENST00000723168, ENST00000723169, ENST00000723170, ENST00000723171, ENST00000723172, ENST00000723173, ENST00000723174, ENST00000723175, ENST00000723176, ENST00000723177, ENST00000723178, ENST00000723179, ENST00000723180, ENST00000723181, ENST00000723182

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000429315 — 7 exons

Exon	Start	End
ENSE00001334400	47239615	47240194
ENSE00001639751	47231767	47231863
ENSE00001656400	47169169	47169396
ENSE00001691138	47236057	47236159
ENSE00001713252	47242979	47246601
ENSE00001753637	47238404	47238569
ENSE00002054691	47164497	47164597

Expression profiles

Bgee: expression breadth ubiquitous, 163 present calls, max score 73.98.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 4.4853 / max 82.5033, expressed in 1555 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
36530	3.6776	1495
36531	0.7799	319
36529	0.0278	4

Top tissues by expression

236 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	73.98	silver quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	73.27	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	72.67	gold quality
stromal cell of endometrium	CL:0002255	71.33	gold quality
cortical plate	UBERON:0005343	71.01	gold quality
bone marrow cell	CL:0002092	70.07	silver quality
cerebellar hemisphere	UBERON:0002245	69.95	gold quality
cerebellar cortex	UBERON:0002129	69.90	gold quality
right hemisphere of cerebellum	UBERON:0014890	69.72	gold quality
cerebellum	UBERON:0002037	68.55	gold quality
ventricular zone	UBERON:0003053	68.16	gold quality
right frontal lobe	UBERON:0002810	67.99	gold quality
anterior cingulate cortex	UBERON:0009835	66.72	gold quality
prefrontal cortex	UBERON:0000451	66.70	gold quality
ganglionic eminence	UBERON:0004023	66.44	gold quality
hypothalamus	UBERON:0001898	66.20	gold quality
Brodmann (1909) area 9	UBERON:0013540	66.03	gold quality
islet of Langerhans	UBERON:0000006	65.12	gold quality
nucleus accumbens	UBERON:0001882	65.02	gold quality
hindlimb stylopod muscle	UBERON:0004252	64.92	gold quality
neocortex	UBERON:0001950	64.72	gold quality
pigmented layer of retina	UBERON:0001782	64.69	silver quality
putamen	UBERON:0001874	64.65	gold quality
gastrocnemius	UBERON:0001388	64.49	gold quality
caudate nucleus	UBERON:0001873	64.40	gold quality
muscle of leg	UBERON:0001383	64.31	gold quality
colonic epithelium	UBERON:0000397	64.29	silver quality
frontal cortex	UBERON:0001870	64.21	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	64.06	gold quality
amygdala	UBERON:0001876	64.03	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.54

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• there were significantly positive correlations in KIF9AS1, LINC01272 and DIO3OS expression between IBD tissue and plasma samples. Therefore, the present study indicated that KIF9AS1, LINC01272 and DIO3OS may be potential diagnostic biomarkers for IBD. (PMID:29207070)
• KIF9-AS1 Regulates Transforming Growth Factor-beta and Autophagy Signaling to Enhance Renal Cell Carcinoma Chemoresistance via microRNA-497-5p (PMID:32343913)
• Long noncoding RNA KIF9-AS1 promotes cell apoptosis by targeting the microRNA-148a-3p/suppressor of cytokine signaling axis in inflammatory bowel disease. (PMID:34750325)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.