KIF9

Summary

KIF9 (kinesin family member 9, HGNC:16666) is a protein-coding gene on chromosome 3p21.31, encoding Kinesin-like protein KIF9 (Q9HAQ2). Essential for normal male fertility and for progressive motility of spermatozoa.

Enables identical protein binding activity. Involved in extracellular matrix disassembly; organelle disassembly; and regulation of podosome assembly. Located in microtubule; podosome; and vesicle.

Source: NCBI Gene 64147 — RefSeq curated summary.

At a glance

• GWAS associations: 10
• Clinical variants (ClinVar): 148 total
• Druggable target: yes
• MANE Select transcript: NM_182902

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:16666
Approved symbol	KIF9
Name	kinesin family member 9
Location	3p21.31
Locus type	gene with protein product
Status	Approved
Aliases	MGC104186
Ensembl gene	ENSG00000088727
Ensembl biotype	protein_coding
OMIM	607910
Entrez	64147

Gene structure

Transcript identifiers

Ensembl transcripts: 20 — 15 protein_coding, 2 protein_coding_CDS_not_defined, 2 retained_intron, 1 nonsense_mediated_decay

ENST00000265529, ENST00000425452, ENST00000425853, ENST00000432493, ENST00000443784, ENST00000444589, ENST00000452770, ENST00000456548, ENST00000484629, ENST00000487440, ENST00000489391, ENST00000498584, ENST00000684063, ENST00000888734, ENST00000888735, ENST00000888736, ENST00000888737, ENST00000964529, ENST00000964530, ENST00000964531

RefSeq mRNA: 9 — MANE Select: NM_182902 NM_001134878, NM_001377474, NM_001377475, NM_001377476, NM_001377477, NM_001413975, NM_001413976, NM_022342, NM_182902

CCDS: CCDS2751, CCDS2752, CCDS93262

Canonical transcript exons

ENST00000684063 — 21 exons

Exon	Start	End
ENSE00001080808	47236443	47236619
ENSE00001804907	47235513	47235617
ENSE00003460241	47265730	47265877
ENSE00003465650	47240801	47241015
ENSE00003530673	47277282	47277379
ENSE00003534487	47264286	47264350
ENSE00003547071	47273552	47273658
ENSE00003564866	47243051	47243245
ENSE00003573508	47257483	47257560
ENSE00003575096	47266976	47267068
ENSE00003587340	47275325	47275490
ENSE00003594742	47246197	47246252
ENSE00003646750	47236034	47236149
ENSE00003651396	47248018	47248086
ENSE00003656057	47247373	47247477
ENSE00003657334	47271237	47271461
ENSE00003672991	47244791	47244924
ENSE00003678018	47245421	47245511
ENSE00003689403	47267180	47267263
ENSE00003916407	47282495	47282799
ENSE00003920900	47227998	47228702

Expression profiles

Bgee: expression breadth ubiquitous, 255 present calls, max score 98.24.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 7.8740 / max 111.8691, expressed in 1744 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
42038	4.2428	1663
42037	1.7390	933
42036	0.8972	499
42035	0.5002	254
42034	0.4948	176

Top tissues by expression

260 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bronchial epithelial cell	CL:0002328	98.24	gold quality
bronchus	UBERON:0002185	97.56	gold quality
sperm	CL:0000019	95.95	gold quality
caput epididymis	UBERON:0004358	95.18	gold quality
left testis	UBERON:0004533	95.18	gold quality
mucosa of paranasal sinus	UBERON:0005030	94.95	gold quality
kidney epithelium	UBERON:0004819	94.87	gold quality
right testis	UBERON:0004534	94.75	gold quality
adult organism	UBERON:0007023	94.73	gold quality
testis	UBERON:0000473	93.95	gold quality
right uterine tube	UBERON:0001302	93.42	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	92.86	gold quality
tendon of biceps brachii	UBERON:0008188	92.61	gold quality
corpus epididymis	UBERON:0004359	92.46	gold quality
pancreatic ductal cell	CL:0002079	92.45	silver quality
epithelial cell of pancreas	CL:0000083	91.39	gold quality
oviduct epithelium	UBERON:0004804	91.14	gold quality
left ventricle myocardium	UBERON:0006566	90.73	silver quality
epithelium of nasopharynx	UBERON:0001951	89.99	gold quality
nasopharynx	UBERON:0001728	89.97	gold quality
amniotic fluid	UBERON:0000173	89.46	gold quality
myocardium	UBERON:0002349	89.14	silver quality
parotid gland	UBERON:0001831	89.01	gold quality
cardiac muscle of right atrium	UBERON:0003379	88.63	silver quality
nasal cavity epithelium	UBERON:0005384	88.54	silver quality
ileal mucosa	UBERON:0000331	88.34	gold quality
left lobe of thyroid gland	UBERON:0001120	88.24	gold quality
thyroid gland	UBERON:0002046	87.92	gold quality
fallopian tube	UBERON:0003889	87.90	gold quality
hypothalamus	UBERON:0001898	87.21	gold quality

Single-cell (SCXA)

Detected in 8 experiment(s), a significant marker in 6.

Experiment	Marker?	Max mean expression
E-MTAB-10485	yes	503.82
E-CURD-114	yes	62.93
E-HCAD-1	yes	30.21
E-MTAB-10287	yes	27.40
E-ANND-3	yes	10.38
E-MTAB-9388	yes	7.36
E-GEOD-125970	no	3.89
E-CURD-112	no	2.54

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

28 targeting KIF9, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4778-3P	99.93	70.40	1818
HSA-MIR-3617-5P	99.75	69.41	1968
HSA-MIR-641	99.75	69.35	1975
HSA-MIR-24-3P	99.59	69.97	1934
HSA-MIR-3123	99.47	67.15	2693
HSA-MIR-1324	99.46	66.57	1302
HSA-MIR-3925-5P	99.21	67.90	1466
HSA-MIR-548AS-3P	99.12	69.12	2294
HSA-MIR-10524-5P	99.05	66.08	963
HSA-MIR-7977	98.65	66.18	2590
HSA-MIR-7114-5P	98.51	67.87	1349
HSA-MIR-2117	98.48	67.97	1307
HSA-MIR-3187-5P	98.36	65.74	1776
HSA-MIR-6811-5P	97.98	64.96	848
HSA-MIR-6511B-5P	97.98	65.64	823
HSA-MIR-4660	97.79	67.44	1328
HSA-MIR-1285-3P	97.72	67.02	1932
HSA-MIR-5189-5P	97.72	66.96	1814
HSA-MIR-708-3P	97.50	68.67	1082
HSA-MIR-6501-5P	97.41	68.24	712
HSA-MIR-612	97.26	65.95	1597
HSA-MIR-6131	97.22	66.72	960
HSA-MIR-6860	97.21	66.31	1656
HSA-MIR-6748-3P	97.20	65.66	836
HSA-MIR-656-5P	96.82	67.67	372
HSA-MIR-1182	96.41	64.89	336
HSA-MIR-920	95.97	63.95	811
HSA-MIR-4268	94.45	64.09	819

Literature-anchored findings (GeneRIF, showing 3)

• kinesin KIF9 and reggie/flotillin proteins are novel regulators of macrophage podosomes and their interaction is critical for podosomal matrix-degradation (PMID:21119006)
• Data show a mechanism by which GTPase Gem contributes to the mitotic progression by maintaining correct spindle length through the kinesin Kif9. (PMID:22964304)
• Identification of bi-allelic KIF9 loss-of-function variants contributing to asthenospermia and male infertility in two Chinese families. (PMID:36686457)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Kif9	ENSMUSG00000032489
rattus_norvegicus	Kif9	ENSRNOG00000020891

Paralogs (41): KIF1B (ENSG00000054523), KIF26A (ENSG00000066735), KIF2A (ENSG00000068796), KIF22 (ENSG00000079616), KIF3C (ENSG00000084731), KIF16B (ENSG00000089177), KIF4A (ENSG00000090889), KIF3B (ENSG00000101350), KIF20A (ENSG00000112984), KIF21B (ENSG00000116852), KIF17 (ENSG00000117245), KIF14 (ENSG00000118193), KIF18A (ENSG00000121621), KIF25 (ENSG00000125337), KIF1C (ENSG00000129250), KIF1A (ENSG00000130294), KIF3A (ENSG00000131437), KIF12 (ENSG00000136883), KIF13A (ENSG00000137177), KIF23 (ENSG00000137807), KIF11 (ENSG00000138160), CENPE (ENSG00000138778), KIF21A (ENSG00000139116), KIFC3 (ENSG00000140859), KIF2B (ENSG00000141200), KIF2C (ENSG00000142945), KIF5A (ENSG00000155980), KIF26B (ENSG00000162849), KIF15 (ENSG00000163808), KIF6 (ENSG00000164627), KIF27 (ENSG00000165115), KIF7 (ENSG00000166813), KIFC2 (ENSG00000167702), KIF5C (ENSG00000168280), KIF5B (ENSG00000170759), KIF18B (ENSG00000186185), KIF24 (ENSG00000186638), KIF19 (ENSG00000196169), KIF13B (ENSG00000197892), KIF4B (ENSG00000226650)

Protein

Protein identifiers

Kinesin-like protein KIF9 — Q9HAQ2 (reviewed: Q9HAQ2)

All UniProt accessions (5): Q9HAQ2, B4DZK5, C9JWZ7, E7EUW8, Q6PJI1

UniProt curated annotations — full annotation on UniProt →

Function. Essential for normal male fertility and for progressive motility of spermatozoa.

Subunit / interactions. Interacts with HYDIN.

Subcellular location. Cytoplasm. Cytoskeleton. Cell projection. Cilium. Flagellum. Flagellum axoneme.

Similarity. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9HAQ2-1	1	yes
Q9HAQ2-2	2

RefSeq proteins (9): NP_001128350, NP_001364403, NP_001364404, NP_001364405, NP_001364406, NP_001400904, NP_001400905, NP_071737, NP_878905* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001752	Kinesin_motor_dom	Domain
IPR019821	Kinesin_motor_CS	Conserved_site
IPR027417	P-loop_NTPase	Homologous_superfamily
IPR027640	Kinesin-like_fam	Family
IPR036961	Kinesin_motor_dom_sf	Homologous_superfamily
IPR056524	KIF6/9_C	Domain

Pfam: PF00225, PF23735

UniProt features (47 total): helix 15, strand 14, sequence variant 3, compositionally biased region 3, modified residue 2, turn 2, coiled-coil region 2, binding site 2, chain 1, domain 1, splice variant 1, region of interest 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
3NWN	X-RAY DIFFRACTION	2

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9HAQ2-F1	74.86	0.37

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (2): 12–14; 93–100

Post-translational modifications (2): 530, 546

Function

Pathways and Gene Ontology

Reactome pathways

8 pathways

ID	Pathway
R-HSA-6811434	COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-983189	Kinesins
R-HSA-109582	Hemostasis
R-HSA-199991	Membrane Trafficking
R-HSA-5653656	Vesicle-mediated transport
R-HSA-6811442	Intra-Golgi and retrograde Golgi-to-ER traffic
R-HSA-8856688	Golgi-to-ER retrograde transport
R-HSA-983231	Factors involved in megakaryocyte development and platelet production

MSigDB gene sets: 191 (showing top): GSE18804_BRAIN_VS_COLON_TUMORAL_MACROPHAGE_UP, GOBP_REGULATION_OF_MICROTUBULE_BASED_PROCESS, TGCGCANK_UNKNOWN, GOBP_REGULATION_OF_PODOSOME_ASSEMBLY, SP3_Q3, GOCC_KINESIN_COMPLEX, TAL1ALPHAE47_01, REACTOME_MEMBRANE_TRAFFICKING, GOBP_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS, MYOD_01, GOBP_CILIUM_MOVEMENT, GOMF_CYTOSKELETAL_MOTOR_ACTIVITY, GOBP_REGULATION_OF_MICROTUBULE_BASED_MOVEMENT, GOBP_CILIUM_OR_FLAGELLUM_DEPENDENT_CELL_MOTILITY, GOBP_REGULATION_OF_REPRODUCTIVE_PROCESS

GO Biological Process (5): microtubule-based movement (GO:0007018), extracellular matrix disassembly (GO:0022617), regulation of podosome assembly (GO:0071801), regulation of flagellated sperm motility (GO:1901317), organelle disassembly (GO:1903008)

GO Molecular Function (8): microtubule motor activity (GO:0003777), ATP binding (GO:0005524), microtubule binding (GO:0008017), ATP hydrolysis activity (GO:0016887), identical protein binding (GO:0042802), nucleotide binding (GO:0000166), cytoskeletal motor activity (GO:0003774), protein binding (GO:0005515)

GO Cellular Component (10): podosome (GO:0002102), cytoplasm (GO:0005737), kinesin complex (GO:0005871), microtubule (GO:0005874), vesicle (GO:0031982), sperm flagellum (GO:0036126), cytoskeleton (GO:0005856), cilium (GO:0005929), motile cilium (GO:0031514), cell projection (GO:0042995)

Reactome top-level categories

Rollup of top-6 pathways:

Category	Pathways
Golgi-to-ER retrograde transport	1
Factors involved in megakaryocyte development and platelet production	1
Vesicle-mediated transport	1
Membrane Trafficking	1
Intra-Golgi and retrograde Golgi-to-ER traffic	1
Hemostasis	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular component disassembly	2
ATP-dependent activity	2
cellular anatomical structure	2
membrane-bounded organelle	2
microtubule-based process	1
extracellular matrix organization	1
regulation of protein-containing complex assembly	1
podosome assembly	1
regulation of plasma membrane bounded cell projection assembly	1
flagellated sperm motility	1
regulation of cilium movement involved in cell motility	1
regulation of reproductive process	1
organelle organization	1
cytoskeletal motor activity	1
polypeptide conformation or assembly isomerase activity	1
adenyl ribonucleotide binding	1
purine ribonucleoside triphosphate binding	1
tubulin binding	1
ribonucleoside triphosphate phosphatase activity	1
protein binding	1
nucleoside phosphate binding	1
heterocyclic compound binding	1
molecular_function	1
binding	1
actin-based cell projection	1
intracellular anatomical structure	1
microtubule associated complex	1
microtubule cytoskeleton	1
polymeric cytoskeletal fiber	1
9+2 motile cilium	1
intracellular membraneless organelle	1
intraciliary transport particle	1
plasma membrane bounded cell projection	1
cilium	1

Protein interactions and networks

STRING

939 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
KIF9	GEM	P55040	911
KIF9	NAT14	Q8WUY8	657
KIF9	KLHL18	O94889	582
KIF9	SUN1	O94901	575
KIF9	NXF2B	Q9GZY0	561
KIF9	CLBA1	Q96F83	557
KIF9	CCDC12	Q8WUD4	544
KIF9	RAC2	P15153	540
KIF9	VWA5B2	Q8N398	474
KIF9	CPLANE2	Q9BU20	473
KIF9	REM2	Q8IYK8	462
KIF9	RSPH6A	Q9H0K4	434
KIF9	LRWD1	Q9UFC0	421
KIF9	RAB40AL	P0C0E4	417
KIF9	TUBD1	Q9UJT1	409

IntAct

159 interactions, top by confidence:

A	B	Type	Score
ACBD4	KIF9	psi-mi:“MI:0915”(physical association)	0.560
KIF9	SLAIN1	psi-mi:“MI:0915”(physical association)	0.560
KIF9	SHISA6	psi-mi:“MI:0915”(physical association)	0.560
PNMA5	KIF9	psi-mi:“MI:0915”(physical association)	0.560
KANK2	KIF9	psi-mi:“MI:0915”(physical association)	0.560
KIF9	IKZF3	psi-mi:“MI:0915”(physical association)	0.560
KIF9	GOLGA6A	psi-mi:“MI:0915”(physical association)	0.560
ALAS1	KIF9	psi-mi:“MI:0915”(physical association)	0.560
IHO1	KIF9	psi-mi:“MI:0915”(physical association)	0.560
HOOK2	KIF9	psi-mi:“MI:0915”(physical association)	0.560
KIF9	AMOTL2	psi-mi:“MI:0915”(physical association)	0.560
HMBOX1	KIF9	psi-mi:“MI:0915”(physical association)	0.560
HSF2BP	KIF9	psi-mi:“MI:0915”(physical association)	0.560
KIF9	LZTS1	psi-mi:“MI:0915”(physical association)	0.560
KRTAP10-6	KIF9	psi-mi:“MI:0915”(physical association)	0.560
TRIM54	KIF9	psi-mi:“MI:0915”(physical association)	0.560
PPP1R13B	KIF9	psi-mi:“MI:0915”(physical association)	0.560
KIF9	MAD1L1	psi-mi:“MI:0915”(physical association)	0.560
KCTD9	KIF9	psi-mi:“MI:0915”(physical association)	0.560
VIM	KIF9	psi-mi:“MI:0915”(physical association)	0.560
KIF9	ZRANB1	psi-mi:“MI:0915”(physical association)	0.560
KIF9	TFIP11	psi-mi:“MI:0915”(physical association)	0.560
PIBF1	KIF9	psi-mi:“MI:0915”(physical association)	0.560
FXR1	KIF9	psi-mi:“MI:0915”(physical association)	0.560
MIPOL1	KIF9	psi-mi:“MI:0915”(physical association)	0.560
EMD	KIF9	psi-mi:“MI:0915”(physical association)	0.560
ZBTB8A	KIF9	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (73): KIF9 (Two-hybrid), KIF9 (Two-hybrid), KIF9 (Two-hybrid), KIF9 (Two-hybrid), KIF9 (Two-hybrid), KIF9 (Two-hybrid), CARD9 (Two-hybrid), EFHC2 (Two-hybrid), LZTS2 (Two-hybrid), SSX2IP (Two-hybrid), KRTAP10-9 (Two-hybrid), KRTAP10-3 (Two-hybrid), ZBTB8A (Two-hybrid), FAM188A (Affinity Capture-MS), KIF9 (Two-hybrid)

ESM2 similar proteins: A0JN40, A1ZAJ2, A8BKD1, F1M4A4, F1QN54, F4J8L3, O00139, O14782, O15066, O35066, O55165, O60333, O88658, P23678, P28740, P28741, P33173, P34540, P46867, P46871, P46873, Q12756, Q15058, Q17BU3, Q28WQ1, Q29DY1, Q2NL05, Q4R628, Q5R4H3, Q5R706, Q5R9Y9, Q5ZKV8, Q60575, Q61771, Q7PHR1, Q8LNZ2, Q8S905, Q8S950, Q91636, Q91637

Diamond homologs: A0A068FIK2, A0JN40, A8BB91, A8BKD1, B2GU58, B7EJ91, B7ZC32, B9EUM5, B9F2Y7, B9F7C8, B9GE13, D3YXS5, F1M4A4, F1M5N7, F1QN54, F4IIS5, F4J1U4, F4K0J3, F8WLE0, O14782, O15066, O23826, O35066, O43093, O45935, O55165, O60333, O75037, O88658, O95239, P17120, P24339, P27895, P28025, P28741, P28742, P33173, P33174, P34540, P46863

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

148 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	116
Likely benign	6
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

4146 predictions. Top by Δscore:

Variant	Effect	Δscore
3:47236028:GCTCA:G	donor_loss	1.0000
3:47236029:CTCA:C	donor_loss	1.0000
3:47236030:TCACC:T	donor_loss	1.0000
3:47236031:CACC:C	donor_loss	1.0000
3:47236032:A:T	donor_loss	1.0000
3:47236045:T:TA	donor_gain	1.0000
3:47236148:TT:T	acceptor_gain	1.0000
3:47236150:C:CC	acceptor_gain	1.0000
3:47236466:TGATC:T	donor_gain	1.0000
3:47236488:A:AC	donor_gain	1.0000
3:47236489:C:CC	donor_gain	1.0000
3:47236498:AGC:A	donor_gain	1.0000
3:47236514:AGGT:A	donor_gain	1.0000
3:47236615:CTTGC:C	acceptor_gain	1.0000
3:47236618:GCCTG:G	acceptor_loss	1.0000
3:47236619:CCTGC:C	acceptor_loss	1.0000
3:47236620:C:CC	acceptor_gain	1.0000
3:47236620:C:T	acceptor_loss	1.0000
3:47240796:TTTA:T	donor_loss	1.0000
3:47240797:TTACC:T	donor_loss	1.0000
3:47240798:TACC:T	donor_loss	1.0000
3:47240800:CCT:C	donor_loss	1.0000
3:47244788:CA:C	donor_loss	1.0000
3:47244789:A:AC	donor_gain	1.0000
3:47244790:C:CC	donor_gain	1.0000
3:47244920:CCCGC:C	acceptor_gain	1.0000
3:47244921:CCGC:C	acceptor_gain	1.0000
3:47244921:CCGCC:C	acceptor_gain	1.0000
3:47244922:CGC:C	acceptor_gain	1.0000
3:47244922:CGCC:C	acceptor_gain	1.0000

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000016139 (3:47255546 G>A), RS1000098136 (3:47264491 C>A,T), RS1000106868 (3:47260376 C>A,T), RS1000114736 (3:47238650 T>C), RS1000258294 (3:47258211 C>A), RS1000380200 (3:47234473 A>G), RS1000385873 (3:47254066 G>C), RS1000397071 (3:47244504 C>A,T), RS1000441609 (3:47267766 G>T), RS1000527636 (3:47272851 G>A,T), RS1000594018 (3:47246441 G>T), RS1000702185 (3:47279414 T>C), RS1000750863 (3:47253976 T>C), RS1000834144 (3:47271643 C>A,T), RS1000934261 (3:47278249 T>C)

Disease associations

OMIM: gene MIM:607910 | disease phenotypes: MIM:616831

GenCC curated gene-disease

Mondo (1): Luscan-Lumish syndrome (MONDO:0014791)

Orphanet (1): Luscan-Lumish syndrome (Orphanet:597738)

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

10 associations (top):

Study	Trait	p-value
GCST004691_3	Huntington’s disease progression	2.000000e-06
GCST007483_33	Waist-to-hip ratio adjusted for BMI (additive genetic model)	3.000000e-07
GCST007516_4	Type 2 diabetes (adjusted for BMI)	5.000000e-08
GCST009379_247	Type 2 diabetes	2.000000e-08
GCST009379_248	Type 2 diabetes	8.000000e-06
GCST010002_422	Refractive error	4.000000e-14
GCST010050_1	Adiponectin levels	2.000000e-07
GCST90002401_442	Platelet distribution width	1.000000e-12
GCST90002402_306	Platelet count	3.000000e-13
GCST90020029_1169	Waist circumference adjusted for body mass index	6.000000e-12

EFO canonical traits (6, from GWAS)

EFO ID	Trait name
EFO:0008336	disease progression measurement
EFO:0007788	BMI-adjusted waist-hip ratio
EFO:0004502	adiponectin measurement
EFO:0007984	platelet component distribution width
EFO:0004309	platelet count
EFO:0007789	BMI-adjusted waist circumference

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL2321637 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

20 total (human), top 20 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, increases expression	5
Air Pollutants	affects expression, increases abundance, increases expression	2
Smoke	decreases expression, increases abundance, increases expression	2
triphenyl phosphate	affects expression	1
bisphenol A	affects cotreatment, increases methylation, decreases methylation	1
aflatoxin B2	increases methylation	1
NSC 689534	affects binding, decreases expression	1
Bortezomib	decreases expression	1
Sunitinib	increases expression	1
Fulvestrant	affects cotreatment, increases methylation	1
Leflunomide	decreases expression	1
Benzo(a)pyrene	increases methylation	1
Copper	decreases expression, affects binding	1
Demecolcine	increases expression	1
Estradiol	affects cotreatment, decreases expression	1
Ozone	affects expression, increases abundance	1
Phenobarbital	affects expression	1
Tobacco Smoke Pollution	decreases expression	1
Tretinoin	decreases expression	1
Cadmium Chloride	decreases expression	1

ChEMBL screening assays

3 unique, capped per target: 3 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL2330549	Binding	Inhibition of human Kif9 at 200 uM	Optimized S-trityl-L-cysteine-based inhibitors of kinesin spindle protein with potent in vivo antitumor activity in lung cancer xenograft models. — J Med Chem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.