KIFC3

Summary

KIFC3 (kinesin family member C3, HGNC:6326) is a protein-coding gene on chromosome 16q21, encoding Kinesin-like protein KIFC3 (Q9BVG8). Minus-end microtubule-dependent motor protein.

This gene encodes a member of the kinesin-14 family of microtubule motors. Members of this family play a role in the formation, maintenance and remodeling of the bipolar mitotic spindle. The protein encoded by this gene has cytoplasmic functions in the interphase cells. It may also be involved in the final stages of cytokinesis. Alternative splicing results in multiple transcript variants encoding different isoforms.

Source: NCBI Gene 3801 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 144 total
• Druggable target: yes
• MANE Select transcript: NM_001130100

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:6326
Approved symbol	KIFC3
Name	kinesin family member C3
Location	16q21
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000140859
Ensembl biotype	protein_coding
OMIM	604535
Entrez	3801

Gene structure

Transcript identifiers

Ensembl transcripts: 51 — 39 protein_coding, 6 protein_coding_CDS_not_defined, 3 retained_intron, 2 nonsense_mediated_decay, 1 TEC

ENST00000379655, ENST00000421376, ENST00000445690, ENST00000465878, ENST00000540079, ENST00000541240, ENST00000543930, ENST00000561524, ENST00000562311, ENST00000562503, ENST00000562903, ENST00000562984, ENST00000563028, ENST00000563266, ENST00000563295, ENST00000564136, ENST00000564204, ENST00000564891, ENST00000565270, ENST00000565351, ENST00000565397, ENST00000565481, ENST00000565684, ENST00000565753, ENST00000565871, ENST00000566648, ENST00000566914, ENST00000566975, ENST00000567059, ENST00000567204, ENST00000567479, ENST00000569112, ENST00000569222, ENST00000569619, ENST00000623271, ENST00000874177, ENST00000874178, ENST00000874179, ENST00000874180, ENST00000874181, ENST00000874182, ENST00000874183, ENST00000874184, ENST00000950445, ENST00000950446, ENST00000950447, ENST00000950448, ENST00000950449, ENST00000950450, ENST00000950451, ENST00000950452

RefSeq mRNA: 9 — MANE Select: NM_001130100 NM_001130099, NM_001130100, NM_001318710, NM_001318711, NM_001318712, NM_001318713, NM_001318714, NM_001318715, NM_005550

CCDS: CCDS10789, CCDS45493, CCDS45494, CCDS81987, CCDS81988, CCDS81989

Canonical transcript exons

ENST00000445690 — 20 exons

Exon	Start	End
ENSE00000945365	57771198	57771437
ENSE00000945366	57770527	57770700
ENSE00000945367	57769808	57769955
ENSE00000945368	57769595	57769725
ENSE00000945369	57766874	57766985
ENSE00000945370	57765459	57765640
ENSE00000945372	57762140	57762270
ENSE00000945373	57761413	57761536
ENSE00001749334	57759125	57759153
ENSE00001928684	57802370	57802491
ENSE00002610080	57771543	57771686
ENSE00003460312	57761042	57761171
ENSE00003472269	57759728	57759836
ENSE00003483212	57758217	57758909
ENSE00003490193	57760282	57760416
ENSE00003577408	57760726	57760955
ENSE00003586488	57798072	57798282
ENSE00003613234	57772223	57772288
ENSE00003643657	57764143	57764247
ENSE00003785773	57794999	57795141

Expression profiles

Bgee: expression breadth ubiquitous, 212 present calls, max score 99.12.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 10.4856 / max 103.4244, expressed in 1651 samples.

FANTOM5 promoters (21 alternative TSS)

Promoter ID	TPM avg	Samples expressed
157559	8.5699	1499
157548	0.6171	337
157560	0.2871	109
157556	0.2117	121
157557	0.1516	76
157571	0.0905	30
157558	0.0706	27
157565	0.0694	28
157552	0.0631	30
157555	0.0583	41

Top tissues by expression

270 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
metanephros cortex	UBERON:0010533	99.12	gold quality
right lobe of thyroid gland	UBERON:0001119	97.95	gold quality
left lobe of thyroid gland	UBERON:0001120	97.41	gold quality
sural nerve	UBERON:0015488	97.16	gold quality
body of pancreas	UBERON:0001150	97.13	gold quality
right testis	UBERON:0004534	96.60	gold quality
left testis	UBERON:0004533	96.45	gold quality
skin of leg	UBERON:0001511	96.09	gold quality
thyroid gland	UBERON:0002046	96.09	gold quality
apex of heart	UBERON:0002098	96.00	gold quality
right lobe of liver	UBERON:0001114	95.55	gold quality
upper lobe of left lung	UBERON:0008952	95.25	gold quality
skin of abdomen	UBERON:0001416	95.17	gold quality
lower esophagus mucosa	UBERON:0035834	94.80	gold quality
tibial nerve	UBERON:0001323	94.26	gold quality
upper lobe of lung	UBERON:0008948	93.89	gold quality
right lung	UBERON:0002167	93.52	gold quality
renal medulla	UBERON:0000362	93.40	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	93.12	gold quality
pancreas	UBERON:0001264	93.04	gold quality
heart left ventricle	UBERON:0002084	92.91	gold quality
testis	UBERON:0000473	92.88	gold quality
cardiac ventricle	UBERON:0002082	92.48	gold quality
adenohypophysis	UBERON:0002196	92.46	gold quality
ascending aorta	UBERON:0001496	92.36	gold quality
stromal cell of endometrium	CL:0002255	92.29	gold quality
thoracic aorta	UBERON:0001515	92.14	gold quality
right atrium auricular region	UBERON:0006631	92.05	gold quality
small intestine Peyer’s patch	UBERON:0003454	91.95	gold quality
cortical plate	UBERON:0005343	91.58	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	8.80

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

16 targeting KIFC3, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3121-3P	99.82	71.96	3630
HSA-MIR-2116-5P	99.32	69.34	1273
HSA-MIR-148A-5P	99.30	68.27	1141
HSA-MIR-4667-3P	99.26	65.45	1608
HSA-MIR-5584-3P	99.23	68.79	1351
HSA-MIR-6815-3P	99.13	68.98	1530
HSA-MIR-4755-3P	98.77	65.59	1915
HSA-MIR-2115-5P	98.66	68.07	1191
HSA-MIR-6868-3P	98.63	69.64	2259
HSA-MIR-1237-3P	98.55	67.65	1423
HSA-MIR-876-5P	97.99	68.49	1345
HSA-MIR-3085-5P	97.72	65.43	544
HSA-MIR-7703	97.64	67.00	965
HSA-MIR-3167	96.81	67.09	1236
HSA-MIR-3194-5P	96.80	64.90	1027
HSA-MIR-6734-5P	95.70	65.56	950

Literature-anchored findings (GeneRIF, showing 8)

• High expression of KIFC3 is associated with docetaxel resistance in breast cancer. (PMID:19789344)
• KifC3 may play a regulatory role in minus-end directed peroxisomal transport for example by blocking the motor function of dynein at peroxisomes. (PMID:23954441)
• KIFC3 may guide free microtubules to their destination at the bridge and/or may slide and crosslink central bridge microtubules in order to stage the cells for abscission. (PMID:24275865)
• Data indicate that E-cadherin ubiquitination consistently increases after depletion of kinesin-like protein KIFC3 or ubiquitin-specific protease USP47. (PMID:25253721)
• Study found that in peripheral blood mononuclear cells the median expression of KIFC3, KIF1B, and KIF5C was much lower than the expression of dynactin subunits DCTN1 and DCTN3, in both sporadic amyotrophic lateral sclerosis and healthy cases (PMID:26954557)
• KIFC3 activity becomes the main driving force of centrosome cohesion to prevent premature spindle formation after linker dissolution as it counteracts the increasing EG5-driven pushing forces (PMID:31481795)
• Microtubule Minus-End Binding Protein CAMSAP2 and Kinesin-14 Motor KIFC3 Control Dendritic Microtubule Organization. (PMID:32084403)
• KIFC3 Regulates the progression and metastasis of gastric cancer via Notch1 pathway. (PMID:36890049)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	kifc3	ENSDARG00000054978
mus_musculus	Kifc3	ENSMUSG00000031788
rattus_norvegicus	Kifc3	ENSRNOG00000014087
caenorhabditis_elegans		WBGENE00002216

Paralogs (41): KIF1B (ENSG00000054523), KIF26A (ENSG00000066735), KIF2A (ENSG00000068796), KIF22 (ENSG00000079616), KIF3C (ENSG00000084731), KIF9 (ENSG00000088727), KIF16B (ENSG00000089177), KIF4A (ENSG00000090889), KIF3B (ENSG00000101350), KIF20A (ENSG00000112984), KIF21B (ENSG00000116852), KIF17 (ENSG00000117245), KIF14 (ENSG00000118193), KIF18A (ENSG00000121621), KIF25 (ENSG00000125337), KIF1C (ENSG00000129250), KIF1A (ENSG00000130294), KIF3A (ENSG00000131437), KIF12 (ENSG00000136883), KIF13A (ENSG00000137177), KIF23 (ENSG00000137807), KIF11 (ENSG00000138160), CENPE (ENSG00000138778), KIF21A (ENSG00000139116), KIF2B (ENSG00000141200), KIF2C (ENSG00000142945), KIF5A (ENSG00000155980), KIF26B (ENSG00000162849), KIF15 (ENSG00000163808), KIF6 (ENSG00000164627), KIF27 (ENSG00000165115), KIF7 (ENSG00000166813), KIFC2 (ENSG00000167702), KIF5C (ENSG00000168280), KIF5B (ENSG00000170759), KIF18B (ENSG00000186185), KIF24 (ENSG00000186638), KIF19 (ENSG00000196169), KIF13B (ENSG00000197892), KIF4B (ENSG00000226650)

Protein

Protein identifiers

Kinesin-like protein KIFC3 — Q9BVG8 (reviewed: Q9BVG8)

All UniProt accessions (18): Q9BVG8, A0A0C4DGM9, B7Z896, F5H3M2, H3BMJ1, H3BMQ3, H3BMR0, H3BMZ5, H3BNZ0, H3BPE2, H3BRQ1, H3BSN2, H3BTE9, H3BTL6, H3BTN1, H3BTU1, H3BUC0, H3BV47

UniProt curated annotations — full annotation on UniProt →

Function. Minus-end microtubule-dependent motor protein. Involved in apically targeted transport. Required for zonula adherens maintenance.

Subcellular location. Cell junction. Adherens junction. Cytoplasm. Cytoskeleton. Microtubule organizing center. Centrosome. Cytoplasmic vesicle membrane.

Miscellaneous. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Similarity. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

Isoforms (5)

UniProt ID	Names	Canonical?
Q9BVG8-3	1	yes
Q9BVG8-2	2
Q9BVG8-4	3
Q9BVG8-5	4
Q9BVG8-6	5

RefSeq proteins (9): NP_001123571, NP_001123572, NP_001305639, NP_001305640, NP_001305641, NP_001305642, NP_001305643, NP_001305644, NP_005541 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001752	Kinesin_motor_dom	Domain
IPR019821	Kinesin_motor_CS	Conserved_site
IPR027417	P-loop_NTPase	Homologous_superfamily
IPR027640	Kinesin-like_fam	Family
IPR036961	Kinesin_motor_dom_sf	Homologous_superfamily

Pfam: PF00225

UniProt features (49 total): helix 14, strand 12, splice variant 5, sequence conflict 4, modified residue 2, region of interest 2, turn 2, coiled-coil region 2, compositionally biased region 2, chain 1, domain 1, sequence variant 1, binding site 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
5WDE	X-RAY DIFFRACTION	1.85

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9BVG8-F1	74.78	0.31

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (1): 528–535

Post-translational modifications (2): 817, 813

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-390471	Association of TriC/CCT with target proteins during biosynthesis

MSigDB gene sets: 186 (showing top): MORF_RAGE, GOCC_KINESIN_COMPLEX, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, GOBP_CELLULAR_COMPONENT_MAINTENANCE, CAGCTG_AP4_Q5, GOCC_MICROTUBULE_ORGANIZING_CENTER, GOBP_CELL_CELL_ADHESION, GOBP_EPITHELIAL_CELL_CELL_ADHESION, GOBP_CELL_JUNCTION_ORGANIZATION, LI_WILMS_TUMOR_VS_FETAL_KIDNEY_1_UP, MORF_FANCG, GOBP_SENSORY_PERCEPTION_OF_LIGHT_STIMULUS, GOMF_CYTOSKELETAL_MOTOR_ACTIVITY, GOCC_CENTROSOME, GOBP_ENDOMEMBRANE_SYSTEM_ORGANIZATION

GO Biological Process (6): microtubule-based process (GO:0007017), microtubule-based movement (GO:0007018), Golgi organization (GO:0007030), visual perception (GO:0007601), zonula adherens maintenance (GO:0045218), epithelial cell-cell adhesion (GO:0090136)

GO Molecular Function (7): microtubule motor activity (GO:0003777), ATP binding (GO:0005524), microtubule binding (GO:0008017), identical protein binding (GO:0042802), nucleotide binding (GO:0000166), cytoskeletal motor activity (GO:0003774), protein binding (GO:0005515)

GO Cellular Component (15): mitochondrion (GO:0005739), Golgi apparatus (GO:0005794), centrosome (GO:0005813), kinesin complex (GO:0005871), microtubule (GO:0005874), zonula adherens (GO:0005915), microtubule cytoskeleton (GO:0015630), cytoplasmic vesicle membrane (GO:0030659), extracellular exosome (GO:0070062), cytoplasm (GO:0005737), cytoskeleton (GO:0005856), adherens junction (GO:0005912), membrane (GO:0016020), cytoplasmic vesicle (GO:0031410), anchoring junction (GO:0070161)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Chaperonin-mediated protein folding	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cytoplasm	3
intracellular membrane-bounded organelle	2
cellular anatomical structure	2
cellular process	1
microtubule-based process	1
organelle organization	1
endomembrane system organization	1
sensory perception of light stimulus	1
adherens junction maintenance	1
cell-cell adhesion	1
cytoskeletal motor activity	1
polypeptide conformation or assembly isomerase activity	1
ATP-dependent activity	1
adenyl ribonucleotide binding	1
purine ribonucleoside triphosphate binding	1
tubulin binding	1
protein binding	1
nucleoside phosphate binding	1
heterocyclic compound binding	1
molecular_function	1
binding	1
endomembrane system	1
centriole	1
microtubule organizing center	1
microtubule associated complex	1
microtubule cytoskeleton	1
polymeric cytoskeletal fiber	1
adherens junction	1
apical junction complex	1
cytoskeleton	1
vesicle membrane	1
cytoplasmic vesicle	1
extracellular vesicle	1
intracellular anatomical structure	1
intracellular membraneless organelle	1
cell-cell junction	1
intracellular vesicle	1
cell junction	1

Protein interactions and networks

STRING

1911 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
KIFC3	CAMSAP3	Q9P1Y5	976
KIFC3	PLEKHA7	Q6IQ23	955
KIFC3	CEP170	Q5SW79	744
KIFC3	CNGB1	Q14028	700
KIFC3	FAM227B	Q96M60	515
KIFC3	CYFIP2	Q96F07	494
KIFC3	CTNNA1	P35221	493
KIFC3	CNGA4	Q8IV77	470
KIFC3	WDR62	O43379	456
KIFC3	MCRS1	Q96EZ8	451
KIFC3	NUFIP1	Q9UHK0	439
KIFC3	DYNC1H1	Q14204	432
KIFC3	CNGA2	Q16280	428
KIFC3	FXR2	P51116	417
KIFC3	NUFIP2	Q7Z417	416

IntAct

302 interactions, top by confidence:

A	B	Type	Score
KIFC3	CEP170P1	psi-mi:“MI:0915”(physical association)	0.750
CEP170P1	KIFC3	psi-mi:“MI:0915”(physical association)	0.750
KANSL1	KIFC3	psi-mi:“MI:0915”(physical association)	0.670
RAD51D	KIFC3	psi-mi:“MI:0915”(physical association)	0.670
PSMB1	KIFC3	psi-mi:“MI:0915”(physical association)	0.670
KIFC3	PRKAA2	psi-mi:“MI:0915”(physical association)	0.670
KIFC3	ZGPAT	psi-mi:“MI:0915”(physical association)	0.670
KIFC3	SMARCE1	psi-mi:“MI:0915”(physical association)	0.670
ABI2	KIFC3	psi-mi:“MI:0915”(physical association)	0.670
KIFC3	AIRIM	psi-mi:“MI:0915”(physical association)	0.670
KIFC3	RAD51D	psi-mi:“MI:0915”(physical association)	0.670
ZGPAT	KIFC3	psi-mi:“MI:0915”(physical association)	0.670
AIRIM	KIFC3	psi-mi:“MI:0915”(physical association)	0.670
PRKAA2	KIFC3	psi-mi:“MI:0915”(physical association)	0.670
KIFC3	ZNF572	psi-mi:“MI:0915”(physical association)	0.560
NEFL	KIFC3	psi-mi:“MI:0915”(physical association)	0.560
DCX	KIFC3	psi-mi:“MI:0915”(physical association)	0.560
HSBP1	KIFC3	psi-mi:“MI:0915”(physical association)	0.560
USP2	KIFC3	psi-mi:“MI:0915”(physical association)	0.560
KIFC3	FCHSD2	psi-mi:“MI:0915”(physical association)	0.560
SCEL	KIFC3	psi-mi:“MI:0915”(physical association)	0.560
MOS	KIFC3	psi-mi:“MI:0915”(physical association)	0.560
KRT6A	KIFC3	psi-mi:“MI:0915”(physical association)	0.560
KRT6B	KIFC3	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (324): USP47 (Affinity Capture-Western), USP47 (Affinity Capture-MS), KIFC3 (Two-hybrid), KIFC3 (Two-hybrid), KIFC3 (Two-hybrid), KIFC3 (Two-hybrid), KIFC3 (Two-hybrid), KIFC3 (Two-hybrid), KIFC3 (Two-hybrid), KIFC3 (Two-hybrid), KIFC3 (Two-hybrid), KIFC3 (Two-hybrid), KIFC3 (Two-hybrid), KRT5 (Two-hybrid), KRT6A (Two-hybrid)

ESM2 similar proteins: A0A8I3NFE2, A2AP18, A6QP29, A6QPL4, A8WFU8, B1AVH7, B5DFA1, D2H0G5, D7PF45, O15357, O43304, O75038, O75808, Q0GNC1, Q0QWG9, Q14807, Q27J81, Q3V300, Q4R918, Q5I0E8, Q5REP4, Q5VV41, Q5XI63, Q60443, Q60806, Q61152, Q61846, Q69ZT1, Q6DT37, Q6L512, Q6P3R1, Q6P549, Q6ZMV9, Q7ZYL5, Q80UW5, Q8BL80, Q8C7W7, Q99952, Q9BVG8, Q9BW19

Diamond homologs: A2ZRG4, A3BFT0, A8BB91, A8BKD1, B2GU58, B3H6Z8, B7EJ91, B9EUM5, B9F7C8, B9FAF3, B9FL70, B9FTR1, B9G2X9, B9G8P1, F1QN54, F4HZF0, F4I1T9, F4IAR2, F4IBQ9, F4IIS5, F4IJK6, F4IL57, F4J2M6, F4JGP4, F4JX00, F4K4C5, O08672, O15066, O23826, O35231, O43093, O81635, O95239, P17119, P20480, P23678, P28025, P28739, P28741, P33174

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 81 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Formation of the cornified envelope	8	13.8×	4e-05
Keratinization	8	8.7×	6e-04

GO biological processes:

GO term	Partners	Fold	FDR
intermediate filament organization	9	30.1×	8e-09
morphogenesis of an epithelium	6	28.7×	2e-05

Disease & clinical

Clinical variants and AI predictions

ClinVar

144 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	115
Likely benign	1
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

4396 predictions. Top by Δscore:

Variant	Effect	Δscore
16:57755837:A:AG	acceptor_gain	1.0000
16:57755838:C:G	acceptor_gain	1.0000
16:57755838:CA:C	acceptor_loss	1.0000
16:57755839:A:AG	acceptor_gain	1.0000
16:57755839:AGAC:A	acceptor_gain	1.0000
16:57755840:G:GC	acceptor_gain	1.0000
16:57755840:GAC:G	acceptor_gain	1.0000
16:57755840:GACG:G	acceptor_gain	1.0000
16:57755840:GACGT:G	acceptor_gain	1.0000
16:57755913:AAAGC:A	donor_gain	1.0000
16:57755914:AAGC:A	donor_gain	1.0000
16:57755915:AGC:A	donor_gain	1.0000
16:57755916:GC:G	donor_gain	1.0000
16:57755916:GCG:G	donor_gain	1.0000
16:57755917:CG:C	donor_loss	1.0000
16:57755918:G:GG	donor_gain	1.0000
16:57755990:A:AG	acceptor_gain	1.0000
16:57755991:G:GG	acceptor_gain	1.0000
16:57756307:T:A	acceptor_gain	1.0000
16:57756313:T:TA	acceptor_gain	1.0000
16:57756320:T:TA	acceptor_gain	1.0000
16:57756353:A:G	acceptor_gain	1.0000
16:57756354:A:AG	acceptor_gain	1.0000
16:57756355:G:GA	acceptor_gain	1.0000
16:57756355:GCTAC:G	acceptor_gain	1.0000
16:57756464:G:GT	donor_gain	1.0000
16:57756469:AGAG:A	donor_loss	1.0000
16:57756472:GG:G	donor_loss	1.0000
16:57756473:GTGA:G	donor_loss	1.0000
16:57756474:T:A	donor_loss	1.0000

AlphaMissense

5327 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
16:57760934:A:G	L675S	1.000
16:57764177:C:T	G528D	1.000
16:57760364:G:T	A762D	0.999
16:57760366:A:C	F761L	0.999
16:57760366:A:T	F761L	0.999
16:57760368:A:G	F761L	0.999
16:57760373:A:G	L759P	0.999
16:57760856:A:G	L701P	0.999
16:57760856:A:T	L701Q	0.999
16:57760864:G:C	N698K	0.999
16:57760864:G:T	N698K	0.999
16:57760868:A:T	I697N	0.999
16:57760878:C:G	A694P	0.999
16:57760928:C:T	G677D	0.999
16:57760929:C:A	G677C	0.999
16:57760929:C:G	G677R	0.999
16:57760931:G:T	A676D	0.999
16:57760934:A:C	L675W	0.999
16:57760936:G:C	D674E	0.999
16:57760936:G:T	D674E	0.999
16:57760937:T:A	D674V	0.999
16:57760937:T:C	D674G	0.999
16:57760937:T:G	D674A	0.999
16:57760943:A:G	L672P	0.999
16:57760949:A:G	L670P	0.999
16:57761100:G:C	H648Q	0.999
16:57761100:G:T	H648Q	0.999
16:57761112:G:C	S644R	0.999
16:57761112:G:T	S644R	0.999
16:57761114:T:G	S644R	0.999

dbSNP variants (sampled 300 via entrez): RS1000060520 (16:57815296 C>A,G,T), RS1000083313 (16:57795635 C>G,T), RS1000128749 (16:57861340 T>C), RS1000159371 (16:57787440 C>T), RS1000178218 (16:57842401 A>C,G), RS1000293674 (16:57827504 C>G,T), RS1000302266 (16:57770398 G>A,T), RS1000316425 (16:57787235 C>T), RS1000353874 (16:57833532 G>A), RS1000415462 (16:57861588 C>T), RS1000457339 (16:57792483 C>T), RS1000552165 (16:57845536 A>G), RS1000557846 (16:57839311 G>A), RS1000587071 (16:57827702 C>T), RS1000599581 (16:57798342 G>A,C,T)

Disease associations

OMIM: gene MIM:604535 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL1075119 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

37 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	increases abundance, increases expression, affects cotreatment, decreases expression	3
Arsenic	affects methylation, affects cotreatment, decreases expression, increases abundance	2
Benzo(a)pyrene	affects methylation, increases methylation	2
Estradiol	increases expression, decreases expression, affects cotreatment	2
Phenylmercuric Acetate	affects cotreatment, increases expression	2
Particulate Matter	affects methylation, increases abundance, increases expression	2
GSK-J4	increases expression	1
triphenyl phosphate	affects expression	1
titanium dioxide	decreases methylation	1
ethyl-p-hydroxybenzoate	increases expression	1
methylparaben	increases expression	1
aflatoxin B2	decreases methylation	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	increases reaction, affects binding	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
clothianidin	increases expression	1
abrine	increases expression	1
dorsomorphin	affects cotreatment, increases expression	1
Docetaxel	decreases response to substance	1
Sunitinib	decreases expression	1
Air Pollutants	affects methylation, increases abundance	1
Vehicle Emissions	increases abundance, increases expression	1
Cadmium	decreases expression	1
Caffeine	decreases phosphorylation	1
Cisplatin	decreases expression	1
Thiram	increases expression	1
Tobacco Smoke Pollution	decreases expression	1
Triclosan	increases expression	1
Vanadates	increases expression	1
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	decreases expression	1

ChEMBL screening assays

7 unique, capped per target: 7 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL1101864	Binding	Inhibition of human KIFC3 at 1 uM	The discovery and optimization of hexahydro-2H-pyrano[3,2-c]quinolines (HHPQs) as potent and selective inhibitors of the mitotic kinesin-5. — Bioorg Med Chem Lett

Cellosaurus cell lines

5 cell lines: 5 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_1084	BFTC-909	Cancer cell line	Male
CVCL_2909	G-292 clone A141B1	Cancer cell line	Female
CVCL_B1V9	Abcam HeLa KIFC3 KO	Cancer cell line	Female
CVCL_YB38	BFTC-909 pBabeAR1	Cancer cell line	Male
CVCL_YB39	BFTC-909 pBabeAR2	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.