KLF17

Summary

KLF17 (KLF transcription factor 17, HGNC:18830) is a protein-coding gene on chromosome 1p34.1, encoding Krueppel-like factor 17 (Q5JT82). Transcription repressor that binds to the promoter of target genes and prevents their expression.

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within gamete generation. Predicted to be located in chromatin.

Source: NCBI Gene 128209 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 76 total
• MANE Select transcript: NM_173484

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:18830
Approved symbol	KLF17
Name	KLF transcription factor 17
Location	1p34.1
Locus type	gene with protein product
Status	Approved
Aliases	Zfp393, FLJ40160
Ensembl gene	ENSG00000171872
Ensembl biotype	protein_coding
OMIM	609602
Entrez	128209

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 1 protein_coding, 1 nonsense_mediated_decay

ENST00000372299, ENST00000476802

RefSeq mRNA: 1 — MANE Select: NM_173484 NM_173484

CCDS: CCDS508

Canonical transcript exons

ENST00000372299 — 4 exons

Exon	Start	End
ENSE00001145521	44130512	44130756
ENSE00001236004	44129353	44130196
ENSE00001457463	44133238	44135140
ENSE00001457470	44118821	44118988

Expression profiles

Bgee: expression breadth broad, 83 present calls, max score 76.33.

FANTOM5 (CAGE): breadth broad, TPM avg 0.9560 / max 136.8984, expressed in 284 samples.

FANTOM5 promoters (7 alternative TSS)

Promoter ID	TPM avg	Samples expressed
2588	0.6180	239
2589	0.1342	44
2591	0.1298	8
2593	0.0305	6
2595	0.0289	5
2592	0.0081	6
2594	0.0065	5

Top tissues by expression

226 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left testis	UBERON:0004533	76.33	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	75.83	gold quality
right testis	UBERON:0004534	75.49	gold quality
testis	UBERON:0000473	73.89	gold quality
smooth muscle tissue	UBERON:0001135	60.69	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	60.25	gold quality
sperm	CL:0000019	57.32	silver quality
stromal cell of endometrium	CL:0002255	57.29	gold quality
lower esophagus muscularis layer	UBERON:0035833	56.56	gold quality
lower esophagus	UBERON:0013473	56.52	gold quality
upper leg skin	UBERON:0004262	54.88	silver quality
right lung	UBERON:0002167	54.36	gold quality
left adrenal gland	UBERON:0001234	53.92	gold quality
right adrenal gland	UBERON:0001233	53.59	gold quality
adult organism	UBERON:0007023	53.58	gold quality
left adrenal gland cortex	UBERON:0035825	53.21	gold quality
urinary bladder	UBERON:0001255	52.56	gold quality
right adrenal gland cortex	UBERON:0035827	52.36	gold quality
adrenal gland	UBERON:0002369	52.22	gold quality
adrenal cortex	UBERON:0001235	52.13	gold quality
lower esophagus mucosa	UBERON:0035834	51.87	gold quality
body of uterus	UBERON:0009853	50.64	gold quality
myometrium	UBERON:0001296	50.37	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	50.00	gold quality
gall bladder	UBERON:0002110	49.16	gold quality
vermiform appendix	UBERON:0001154	49.08	gold quality
left uterine tube	UBERON:0001303	48.61	gold quality
upper lobe of left lung	UBERON:0008952	48.41	gold quality
upper lobe of lung	UBERON:0008948	48.22	gold quality
muscle layer of sigmoid colon	UBERON:0035805	47.70	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.11
E-MTAB-8060	no	65.11

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

5 targets.

Target	Regulation
CCND1	Repression
CD44	Repression
PARK7
SERPINE1	Repression
TWIST1	Repression

JASPAR motifs

Motif	Name	Family
MA1514.1	KLF17	Three-zinc finger Kruppel-related
MA1514.2	KLF17	Three-zinc finger Kruppel-related

JASPAR matrix evidence (PMIDs): PMID:11443140

Upstream regulators (CollecTRI, top): TP53, TWIST1

miRNA regulators (miRDB)

42 targeting KLF17, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-126-5P	100.00	72.71	3180
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-34A-5P	99.99	71.21	1784
HSA-MIR-449A	99.99	71.05	1776
HSA-MIR-3667-3P	99.99	67.17	1636
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-34C-5P	99.97	70.45	1577
HSA-MIR-449B-5P	99.97	70.26	1580
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-9983-3P	99.94	71.48	3631
HSA-MIR-4778-3P	99.93	70.40	1818
HSA-MIR-129-5P	99.88	70.26	3273
HSA-MIR-3180-5P	99.82	69.12	2422
HSA-MIR-2052	99.79	69.37	2031
HSA-MIR-370-5P	99.78	66.81	706
HSA-MIR-3202	99.66	67.70	2737
HSA-MIR-4489	99.50	65.56	785
HSA-MIR-504-3P	99.30	67.18	1745
HSA-MIR-877-3P	99.09	68.10	1637
HSA-MIR-1294	98.91	69.26	1030
HSA-MIR-9986	98.91	69.28	1024
HSA-MIR-3194-3P	98.83	66.22	1167
HSA-MIR-4755-3P	98.77	65.59	1915
HSA-MIR-2467-3P	98.65	67.18	1969
HSA-MIR-210-5P	98.57	64.37	832
HSA-MIR-4726-3P	98.49	63.89	1385

Literature-anchored findings (GeneRIF, showing 26)

• KLF17 is a new member of the Sp/KLF family of transcription factors. (PMID:16460907)
• demonstrate that KLF17 expression is significantly downregulated in primary human breast cancer samples and that the combined expression pattern of KLF17 and Id1 can serve as a potential biomarker for lymph node metastasis in breast cancer (PMID:19801974)
• KLF17 has a role in transcriptional regulation of metastasis by Id1 [review] (PMID:19951400)
• it is possible that KLF17 inhibits tumor growth in lung adenocarcinoma. (PMID:22240024)
• Overall, these findings suggest a repressing role of KLF17 in tumor invasion (PMID:23325444)
• KLF17 may have an oncogenic role during EEC progression via initiating EMT through the regulation of TWIST1 (PMID:24220291)
• KLF17 might be one of the downstream signalling molecules of DJ-1. (PMID:24504364)
• The reduced expression of KLF17 protein in gastric cancer was correlated with tumor size, pN stage and lymphovascular invasion and was an independent predictor for poor survival in patients undergoing surgery for gastric cancer. (PMID:24947617)
• The reduced expression of KLF17 promoted the motility and proliferation ability of TPC1 cells by altering the expression of tight junction protein 1 and Snai1, and activating the AKT pathway by upregulating inhibitor of DNA binding 1. (PMID:25109837)
• mutant p53 enhances cancer progression by inhibiting KLF17 expression in invasive breast carcinoma cells (PMID:25111898)
• In this review, we focus on the functions, roles, and regulatory networks of these five KLFs in HCC, summarize key pathways, and propose areas for further investigation (PMID:25652467)
• A small subset of Myoepithelial tumors harbor FUS rearrangements, two thirds of them being associated with KLF17 fusion. (PMID:25706482)
• KLF17 empowers TGF-beta/Smad signaling by targeting Smad3-dependent pathway to suppress tumor growth and metastasis during cancer progression. (PMID:25766320)
• Tumor-suppressive p53 signaling is critical for KLF17 to inhibit cancer metastasis in Non-small Cell Lung Cancer. (PMID:25911104)
• Suggest that KLF17 inhibits esophageal carcinoma development and may serve as a potential therapeutic target. (PMID:26617836)
• Enhanced KLF17 expression sensitizes ERalpha-positive breast cancer cells to endocrine therapy.KLF17-ERalpha interaction plays a potential role in inhibition of ERalpha-dependent breast cancer progression. (PMID:27107895)
• Low Expressions of KLF17 is associated with lung adenocarcinoma. (PMID:28454121)
• The above data show that normal levels of melatonin may help in preventing breast cancer metastasis through inhibiting DJ-1/KLF17/ID-1 signaling pathway. The combination of melatonin and taxol is a potent candidate against breast cancer metastasis, better than using melatonin or taxol as a single drug (PMID:30260001)
• Results revealed that KLF17 expression was abnormally decreased in colorectal cancer (CRC) and associated with lymph node metastasis and unfavorable overall survival. Moreover, ectopic KLF17 expression suppressed CRC cell growth and invasion in vitro and in vivo. In addition, the downregulation of KLF17 was associated with the hypermethylation of the CpG nucleotides on the KLF17 promoter. (PMID:31545467)
• Overexpression of KLF17 Predicts a Favorable Prognosis in Patients with Oral Squamous Cell Carcinoma: A Retrospective Study. (PMID:32019121)
• Kruppel-like factor 17 upregulates uterine corin expression and promotes spiral artery remodeling in pregnancy. (PMID:32719113)
• Precision hyperthermia-induced miRNA-409-3p upregulation inhibits migration, invasion, and EMT of gastric cancer cells by targeting KLF17. (PMID:33667708)
• Up-regulation of KLF17 expression increases the sensitivity of gastric cancer to 5-fluorouracil. (PMID:33960231)
• KLF17 promotes human naive pluripotency but is not required for its establishment. (PMID:34661235)
• Effect of KLF17 overexpression on epithelial-mesenchymal transition of gastric cancer cells. (PMID:34738482)
• KLF17 promotes human naive pluripotency through repressing MAPK3 and ZIC2. (PMID:35391627)

Cross-species orthologs

16 orthologs

Organism	Symbol	Gene ID
danio_rerio	klf1	ENSDARG00000017400
danio_rerio	klf5l	ENSDARG00000018757
danio_rerio	klf17	ENSDARG00000038792
danio_rerio	klf2b	ENSDARG00000040432
danio_rerio	klf2a	ENSDARG00000042667
danio_rerio	klf13	ENSDARG00000061368
danio_rerio	zgc:153115	ENSDARG00000069342
danio_rerio	si:ch211-117k10.3	ENSDARG00000090914
danio_rerio	sp5l	ENSDARG00000115868
mus_musculus	Klf17	ENSMUSG00000048626
rattus_norvegicus	Klf17	ENSRNOG00000019479
drosophila_melanogaster	Klf15	FBGN0025679
drosophila_melanogaster	luna	FBGN0040765
drosophila_melanogaster	CG42741	FBGN0261705
drosophila_melanogaster	dar1	FBGN0263239
caenorhabditis_elegans		WBGENE00018990

Paralogs (22): KLF6 (ENSG00000067082), KLF8 (ENSG00000102349), KLF5 (ENSG00000102554), KLF1 (ENSG00000105610), KLF3 (ENSG00000109787), KLF7 (ENSG00000118263), KLF12 (ENSG00000118922), KLF9 (ENSG00000119138), KLF2 (ENSG00000127528), KLF16 (ENSG00000129911), KLF4 (ENSG00000136826), KLF10 (ENSG00000155090), KLF15 (ENSG00000163884), SP8 (ENSG00000164651), KLF13 (ENSG00000169926), SP7 (ENSG00000170374), KLF11 (ENSG00000172059), SP6 (ENSG00000189120), SP5 (ENSG00000204335), SP9 (ENSG00000217236), KLF14 (ENSG00000266265), KLF18 (ENSG00000283039)

Protein

Protein identifiers

Krueppel-like factor 17 — Q5JT82 (reviewed: Q5JT82)

Alternative names: Zinc finger protein 393

All UniProt accessions (2): Q5JT82, A0A0U1RR65

UniProt curated annotations — full annotation on UniProt →

Function. Transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5’-CACCC-3’ sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression. May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development.

Subcellular location. Nucleus.

Similarity. Belongs to the Sp1 C2H2-type zinc-finger protein family.

RefSeq proteins (1): NP_775755* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR013087	Znf_C2H2_type	Domain
IPR036236	Znf_C2H2_sf	Homologous_superfamily

Pfam: PF00096

UniProt features (14 total): sequence variant 4, zinc finger region 3, region of interest 3, compositionally biased region 3, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q5JT82-F1	54.30	0.00

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 49 (showing top): GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP, chr1p34, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, FOSTER_KDM1A_TARGETS_UP, ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY, GSE13522_WT_VS_IFNG_KO_SKIN_UP, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, MIR4795_3P, GOLDRATH_EFF_VS_MEMORY_CD8_TCELL_DN, MIR9983_3P, MIR129_5P, MIR2052, MIR7156_3P, MIR6872_3P

GO Biological Process (1): regulation of transcription by RNA polymerase II (GO:0006357)

GO Molecular Function (9): transcription cis-regulatory region binding (GO:0000976), RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), DNA-binding transcription factor activity (GO:0003700), zinc ion binding (GO:0008270), sequence-specific double-stranded DNA binding (GO:1990837), DNA binding (GO:0003677), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (2): chromatin (GO:0000785), nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of DNA-templated transcription	2
RNA polymerase II transcription regulatory region sequence-specific DNA binding	2
transcription by RNA polymerase II	1
transcription regulatory region nucleic acid binding	1
sequence-specific double-stranded DNA binding	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
regulation of transcription by RNA polymerase II	1
transcription cis-regulatory region binding	1
transcription regulator activity	1
transition metal ion binding	1
double-stranded DNA binding	1
sequence-specific DNA binding	1
nucleic acid binding	1
binding	1
cation binding	1
chromosome	1
cellular anatomical structure	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

764 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
KLF17	ID1	P41134	771
KLF17	ID2	Q02363	702
KLF17	ARFGAP2	Q8N6H7	666
KLF17	TFCP2L1	Q9NZI6	652
KLF17	ARGFX	A6NJG6	591
KLF17	DPPA5	A6NC42	588
KLF17	WNT2	P09544	555
KLF17	DPPA3	Q6W0C5	521
KLF17	SLC5A5	Q92911	495
KLF17	SUSD2	Q9UGT4	480
KLF17	TP53	P04637	477
KLF17	POU5F1	P31359	467
KLF17	FUS	P35637	464
KLF17	FGF4	P08620	457
KLF17	A0A0J9YW77	A0A0J9YW77	457

IntAct

17 interactions, top by confidence:

A	B	Type	Score
KLF17	CIB3	psi-mi:“MI:0915”(physical association)	0.720
CIB3	KLF17	psi-mi:“MI:0915”(physical association)	0.720
KLF17	COL6A1	psi-mi:“MI:0915”(physical association)	0.400
CCL24	KLF17	psi-mi:“MI:0915”(physical association)	0.370
CCL26	KLF17	psi-mi:“MI:0915”(physical association)	0.370
CCL27	KLF17	psi-mi:“MI:0915”(physical association)	0.370
	KLF17	psi-mi:“MI:0915”(physical association)	0.370
IL1RN	KLF17	psi-mi:“MI:0915”(physical association)	0.370
IL23A	KLF17	psi-mi:“MI:0915”(physical association)	0.370
IL31	KLF17	psi-mi:“MI:0915”(physical association)	0.370
TNFSF10	KLF17	psi-mi:“MI:0915”(physical association)	0.370
CIB3	KLF17	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (3): KLF17 (Two-hybrid), KLF17 (Two-hybrid), KLF17 (Proximity Label-MS)

ESM2 similar proteins: A0A0A7EPL0, A2RV66, A4QP16, A6QPF4, C4QM85, F4JYG0, O35892, P11836, P13386, P19437, P20490, P41739, P53762, P56645, P70326, P79778, Q01362, Q148B6, Q29131, Q3C1V0, Q3C2E2, Q3SA47, Q3UNB8, Q3V3Q4, Q3YBM2, Q5I2P1, Q5JT82, Q5R8D6, Q5R8E0, Q60HE7, Q68FU0, Q6A058, Q8BVM2, Q8N1N2, Q8NDZ0, Q8QGQ8, Q8WUU8, Q920C4, Q92540, Q96HJ5

Diamond homologs: A0A0U1RQI7, C7EMF5, Q00453, Q5JT82, Q8CFA7, B5DE03, B7ZSG3, O08876, O14901, O62651, O89091, P19544, P22561, P49952, P49953, P50902, P57682, P79958, Q13118, Q13887, Q19A41, Q60980, Q8K1S5, O35738, O35819, Q60843, Q9ET58, Q9TZ64, Q9VZN4, Q9Y4X4, Q8TD94, Q14V87, Q19A40, Q65ZG6, Q13351, O08584, O15090, O35739, O43474, O62259

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

76 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	64
Likely benign	10
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

471 predictions. Top by Δscore:

Variant	Effect	Δscore
1:44118989:G:GG	donor_gain	1.0000
1:44118989:GT:G	donor_loss	1.0000
1:44130730:G:GT	donor_gain	0.9900
1:44130731:A:T	donor_gain	0.9900
1:44130506:TCCCA:T	acceptor_loss	0.9800
1:44130507:CCCAG:C	acceptor_loss	0.9800
1:44130508:CCAG:C	acceptor_loss	0.9800
1:44130509:CAGG:C	acceptor_loss	0.9800
1:44130510:AGGTG:A	acceptor_loss	0.9800
1:44130511:G:GA	acceptor_loss	0.9800
1:44130567:T:TA	acceptor_gain	0.9800
1:44130500:T:TA	acceptor_loss	0.9700
1:44130749:GTCCT:G	donor_gain	0.9700
1:44130750:TCCTT:T	donor_gain	0.9700
1:44118986:CAG:C	donor_gain	0.9600
1:44118987:AG:A	donor_gain	0.9600
1:44118988:GG:G	donor_gain	0.9600
1:44129432:GCC:G	donor_gain	0.9600
1:44130567:TGATG:T	acceptor_gain	0.9600
1:44130723:A:T	donor_gain	0.9600
1:44118989:G:GA	donor_gain	0.9500
1:44118990:T:A	donor_gain	0.9500
1:44130753:TTAG:T	donor_loss	0.9500
1:44130754:TAGG:T	donor_loss	0.9500
1:44130755:AG:A	donor_loss	0.9500
1:44130756:GGTC:G	donor_loss	0.9500
1:44130757:GT:G	donor_loss	0.9500
1:44130758:T:G	donor_loss	0.9500
1:44118985:CCAGG:C	donor_gain	0.9400
1:44118986:CAGG:C	donor_gain	0.9400

AlphaMissense

2548 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:44130556:T:C	F324L	1.000
1:44130558:C:A	F324L	1.000
1:44130558:C:G	F324L	1.000
1:44130619:T:C	C345R	1.000
1:44130640:T:C	F352L	1.000
1:44130641:T:C	F352S	1.000
1:44130642:C:A	F352L	1.000
1:44130642:C:G	F352L	1.000
1:44130139:T:A	C290S	0.999
1:44130140:G:C	C290S	0.999
1:44130151:T:G	Y294D	0.999
1:44130170:T:C	L300P	0.999
1:44130178:C:G	H303D	0.999
1:44130180:C:A	H303Q	0.999
1:44130180:C:G	H303Q	0.999
1:44130182:A:C	Q304P	0.999
1:44130185:G:C	R305P	0.999
1:44130192:C:A	H307Q	0.999
1:44130192:C:G	H307Q	0.999
1:44130531:C:G	C315W	0.999
1:44130545:G:A	C320Y	0.999
1:44130546:T:G	C320W	0.999
1:44130563:G:C	R326P	0.999
1:44130583:C:G	H333D	0.999
1:44130585:T:A	H333Q	0.999
1:44130585:T:G	H333Q	0.999
1:44130597:C:A	H337Q	0.999
1:44130597:C:G	H337Q	0.999
1:44130619:T:A	C345S	0.999
1:44130620:G:C	C345S	0.999

dbSNP variants (sampled 300 via entrez): RS1000004265 (1:44132209 G>T), RS1000011096 (1:44135182 C>A), RS1000048994 (1:44055072 C>A), RS1000051772 (1:44047096 T>G), RS1000083723 (1:44051260 T>G), RS1000126732 (1:44093639 C>A,T), RS1000236288 (1:44099073 T>A,C), RS1000242487 (1:44109204 A>G), RS1000300871 (1:44081223 A>T), RS1000413804 (1:44093345 G>A), RS1000442500 (1:44071169 C>T), RS1000472778 (1:44044465 C>A), RS1000503725 (1:44085326 G>A), RS1000556425 (1:44126842 T>C), RS1000625215 (1:44079500 A>G)

Disease associations

OMIM: gene MIM:609602 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST004025_7	Systemic juvenile idiopathic arthritis	1.000000e-06
GCST005722_1	Milk allergy (maternal genetic effects)	2.000000e-06
GCST010002_357	Refractive error	3.000000e-13

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0005939	parental genotype effect measurement
EFO:0007019	milk allergy measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

14 total (human), top 14 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
napabucasin	decreases expression	1
bisphenol A	affects cotreatment, decreases methylation	1
terbufos	increases methylation	1
(+)-JQ1 compound	decreases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Fulvestrant	decreases methylation, affects cotreatment	1
Arsenic	affects methylation	1
Benzo(a)pyrene	affects methylation	1
Dichlorodiphenyl Dichloroethylene	decreases expression	1
Diethylhexyl Phthalate	increases expression	1
Fonofos	increases methylation	1
Fenfluramine	increases expression	1
Parathion	increases methylation	1
Plant Extracts	affects cotreatment, decreases expression	1

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_HC80	HEK293 eGFP-KLF17	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.