KLF3-AS1

Summary

KLF3-AS1 (KLF3 antisense RNA 1, HGNC:25796) is a long non-coding RNA gene on chromosome 4p14.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25796
Approved symbol	KLF3-AS1
Name	KLF3 antisense RNA 1
Location	4p14
Locus type	RNA, long non-coding
Status	Approved
Aliases	FLJ13197
Ensembl gene	ENSG00000231160
Ensembl biotype	lncRNA
Entrez	79667
RNAcentral	URS00001229EA — lncRNA, 2368 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 111 — 109 lncRNA, 2 retained_intron

ENST00000436901, ENST00000440181, ENST00000504219, ENST00000505240, ENST00000507091, ENST00000610668, ENST00000620339, ENST00000655930, ENST00000661050, ENST00000665526, ENST00000665931, ENST00000666430, ENST00000668230, ENST00000668586, ENST00000669118, ENST00000669212, ENST00000670431, ENST00000685156, ENST00000685630, ENST00000686710, ENST00000689848, ENST00000690832, ENST00000692145, ENST00000693285, ENST00000701803, ENST00000701850, ENST00000767038, ENST00000767039, ENST00000767040, ENST00000767041, ENST00000767042, ENST00000767043, ENST00000767044, ENST00000767045, ENST00000767046, ENST00000767047, ENST00000767048, ENST00000767049, ENST00000767050, ENST00000767051, ENST00000767052, ENST00000767053, ENST00000767054, ENST00000767055, ENST00000767056, ENST00000767057, ENST00000767058, ENST00000767059, ENST00000767060, ENST00000767061, ENST00000767062, ENST00000767063, ENST00000767064, ENST00000767065, ENST00000767066, ENST00000767067, ENST00000767068, ENST00000767069, ENST00000767070, ENST00000767071, ENST00000767072, ENST00000767073, ENST00000767074, ENST00000767075, ENST00000767076, ENST00000767077, ENST00000767078, ENST00000767079, ENST00000767080, ENST00000767081, ENST00000767082, ENST00000767083, ENST00000767084, ENST00000767085, ENST00000767086, ENST00000767087, ENST00000767088, ENST00000767089, ENST00000767090, ENST00000767091, ENST00000767092, ENST00000767093, ENST00000767094, ENST00000767095, ENST00000767096, ENST00000767097, ENST00000767098, ENST00000767099, ENST00000767100, ENST00000767101, ENST00000767102, ENST00000767103, ENST00000767104, ENST00000767105, ENST00000767106, ENST00000767107, ENST00000767108, ENST00000767109, ENST00000767110, ENST00000767111, ENST00000767112, ENST00000767113, ENST00000767114, ENST00000767115, ENST00000767116, ENST00000767117, ENST00000767118, ENST00000767119, ENST00000767120, ENST00000767121, ENST00000767122

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000436901 — 4 exons

Exon	Start	End
ENSE00001747212	38626408	38628102
ENSE00003722200	38635956	38636058
ENSE00003725763	38630500	38630581
ENSE00003872724	38664794	38664914

Expression profiles

Bgee: expression breadth ubiquitous, 237 present calls, max score 92.96.

FANTOM5 (CAGE): breadth broad, TPM avg 2.7285 / max 102.2443, expressed in 899 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
51802	2.7285	899

Top tissues by expression

285 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left ovary	UBERON:0002119	92.96	gold quality
right uterine tube	UBERON:0001302	92.22	gold quality
caput epididymis	UBERON:0004358	90.49	gold quality
right ovary	UBERON:0002118	89.69	gold quality
ovary	UBERON:0000992	87.76	gold quality
corpus epididymis	UBERON:0004359	86.13	gold quality
right hemisphere of cerebellum	UBERON:0014890	86.08	gold quality
pituitary gland	UBERON:0000007	85.80	gold quality
cerebellar hemisphere	UBERON:0002245	85.66	gold quality
endocervix	UBERON:0000458	85.50	gold quality
cerebellar cortex	UBERON:0002129	85.46	gold quality
right lobe of thyroid gland	UBERON:0001119	85.35	gold quality
left lobe of thyroid gland	UBERON:0001120	85.33	gold quality
mucosa of paranasal sinus	UBERON:0005030	85.29	gold quality
thyroid gland	UBERON:0002046	84.86	gold quality
body of pancreas	UBERON:0001150	84.80	gold quality
bronchial epithelial cell	CL:0002328	84.79	gold quality
adenohypophysis	UBERON:0002196	84.66	gold quality
cerebellum	UBERON:0002037	84.19	gold quality
cortical plate	UBERON:0005343	84.01	gold quality
ectocervix	UBERON:0012249	83.56	gold quality
ganglionic eminence	UBERON:0004023	83.49	gold quality
body of uterus	UBERON:0009853	83.18	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.87	gold quality
ventricular zone	UBERON:0003053	82.63	gold quality
left uterine tube	UBERON:0001303	82.06	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.25	gold quality
adrenal tissue	UBERON:0018303	81.22	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	81.20	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	81.09	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-MTAB-9543	yes	1171.48
E-ANND-3	no	4.64

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• Exosomal KLF3-AS1 derived from mesenchymal stem cells is involved in MSC-exosome-mediated chondrocyte proliferation induction and chondrocyte apoptosis inhibition via miR-206/GIT1 axis. (PMID:30324848)
• Overexpression of KLF3-AS1 in exosomes leads to reduced myocardial infarction area, decreased cell apoptosis and pyroptosis, and attenuated myocardial infarction progression. KLF3-AS1 can sponge miR-138-5p to regulate Sirt1 expression. miR-138-5p inhibitor transfection and KLF3-AS1 exosome incubation contribute to attenuated pyroptosis and myocardial infarction both in vivo and in vitro (PMID:31847890)
• Silencing of lncRNA KLF3-AS1 represses cell growth in osteosarcoma via miR-338-3p/MEF2C axis. (PMID:36250223)
• The long non-coding RNA KLF3-AS1/miR-10a-3p/ZBTB20 axis improves the degenerative changes in human nucleus pulposus cells. (PMID:37052702)
• Bone marrow mesenchymal stem cell-derived exosomes promote osteoblast proliferation, migration and inhibit apoptosis by regulating KLF3-AS1/miR-338-3p. (PMID:38336637)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.