KLHDC3

Summary

KLHDC3 (kelch domain containing 3, HGNC:20704) is a protein-coding gene on chromosome 6p21.1, encoding Kelch domain-containing protein 3 (Q9BQ90). Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation.

The protein encoded by this gene contains six repeated kelch motifs that are structurally similar to recombination activating gene 2, a protein involved in the activation of the V(D)J recombination. In mouse, this gene is found to be expressed specifically in testis. Its expression in pachytene spermatocytes is localized to cytoplasma and meiotic chromatin, suggesting that this gene may be involved in meiotic recombination.

Source: NCBI Gene 116138 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 43 total
• MANE Select transcript: NM_057161

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:20704
Approved symbol	KLHDC3
Name	kelch domain containing 3
Location	6p21.1
Locus type	gene with protein product
Status	Approved
Aliases	PEAS, hPeas, dJ20C7.3
Ensembl gene	ENSG00000124702
Ensembl biotype	protein_coding
OMIM	611248
Entrez	116138

Gene structure

Transcript identifiers

Ensembl transcripts: 25 — 25 protein_coding

ENST00000244670, ENST00000326974, ENST00000892793, ENST00000892794, ENST00000892795, ENST00000892796, ENST00000892797, ENST00000892798, ENST00000892799, ENST00000892800, ENST00000892801, ENST00000892802, ENST00000892803, ENST00000892804, ENST00000892805, ENST00000931056, ENST00000931057, ENST00000931058, ENST00000931059, ENST00000931060, ENST00000931061, ENST00000931062, ENST00000931063, ENST00000931064, ENST00000965771

RefSeq mRNA: 1 — MANE Select: NM_057161 NM_057161

CCDS: CCDS4880

Canonical transcript exons

ENST00000326974 — 11 exons

Exon	Start	End
ENSE00000751521	43018343	43018556
ENSE00000751522	43018633	43018719
ENSE00000751523	43018863	43018971
ENSE00000751524	43019092	43019165
ENSE00000751525	43019288	43019366
ENSE00000850038	43017853	43017968
ENSE00000850039	43018145	43018216
ENSE00001549974	43014249	43014348
ENSE00003555190	43017519	43017695
ENSE00003650346	43017134	43017346
ENSE00003847291	43020667	43021294

Expression profiles

Bgee: expression breadth ubiquitous, 294 present calls, max score 98.96.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 71.7364 / max 433.3324, expressed in 1827 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
67847	71.5433	1827
67848	0.1024	23
67850	0.0778	25
67849	0.0129	8

Top tissues by expression

302 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right testis	UBERON:0004534	98.96	gold quality
left testis	UBERON:0004533	98.94	gold quality
right frontal lobe	UBERON:0002810	98.82	gold quality
prefrontal cortex	UBERON:0000451	98.51	gold quality
cerebellar hemisphere	UBERON:0002245	98.13	gold quality
right hemisphere of cerebellum	UBERON:0014890	98.13	gold quality
cerebellar cortex	UBERON:0002129	98.11	gold quality
hindlimb stylopod muscle	UBERON:0004252	98.09	gold quality
Brodmann (1909) area 9	UBERON:0013540	97.95	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	97.86	gold quality
triceps brachii	UBERON:0001509	97.83	gold quality
nucleus accumbens	UBERON:0001882	97.80	gold quality
amygdala	UBERON:0001876	97.66	gold quality
cingulate cortex	UBERON:0003027	97.58	gold quality
cerebellum	UBERON:0002037	97.50	gold quality
anterior cingulate cortex	UBERON:0009835	97.48	gold quality
caudate nucleus	UBERON:0001873	97.45	gold quality
putamen	UBERON:0001874	97.43	gold quality
frontal cortex	UBERON:0001870	97.18	gold quality
ganglionic eminence	UBERON:0004023	97.18	gold quality
frontal lobe	UBERON:0016525	97.18	gold quality
cortical plate	UBERON:0005343	97.15	gold quality
apex of heart	UBERON:0002098	97.10	gold quality
testis	UBERON:0000473	97.02	gold quality
neocortex	UBERON:0001950	96.97	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	96.94	gold quality
ventricular zone	UBERON:0003053	96.91	gold quality
muscle of leg	UBERON:0001383	96.82	gold quality
frontal pole	UBERON:0002795	96.82	gold quality
gastrocnemius	UBERON:0001388	96.79	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

54 targeting KLHDC3, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-29A-3P	100.00	73.11	1835
HSA-MIR-29B-3P	100.00	73.18	1833
HSA-MIR-29C-3P	100.00	73.15	1833
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-12118	100.00	65.88	1270
HSA-MIR-6851-5P	100.00	65.63	1294
HSA-MIR-3689D	100.00	66.14	1181
HSA-MIR-513A-5P	100.00	69.77	2465
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-4476	100.00	68.18	2030
HSA-MIR-6876-5P	100.00	67.68	2126
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-27A-3P	99.98	72.13	2955
HSA-MIR-27B-3P	99.98	72.13	2955
HSA-MIR-9985	99.98	72.11	2939
HSA-MIR-3173-3P	99.98	66.49	1217
HSA-MIR-6891-5P	99.98	66.53	1372
HSA-MIR-6825-5P	99.96	69.81	3431
HSA-MIR-4487	99.96	64.58	1252
HSA-MIR-4728-5P	99.85	69.39	4718
HSA-MIR-629-3P	99.85	67.99	1875
HSA-MIR-3663-3P	99.84	70.39	798
HSA-MIR-6756-5P	99.82	67.97	2466
HSA-MIR-6785-5P	99.82	68.68	4428
HSA-MIR-4713-5P	99.78	67.80	1794
HSA-MIR-149-3P	99.72	68.22	3963
HSA-MIR-6883-5P	99.69	68.05	3785
HSA-MIR-6766-5P	99.68	67.70	2325
HSA-MIR-3202	99.66	67.70	2737
HSA-MIR-4690-5P	99.65	66.24	813

Literature-anchored findings (GeneRIF, showing 2)

• cloned human and mouse Peas cDNAs (hPEAS/mPeas) and analyzed their tissue and stage-specific expressions; may be involved in meiotic recombination process (PMID:12606021)
• CRL2(KLHDC3) mediates p14ARF N-terminal ubiquitylation degradation to promote non-small cell lung carcinoma progression. (PMID:35468939)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	klhdc3	ENSDARG00000102772
mus_musculus	Klhdc3	ENSMUSG00000063576
rattus_norvegicus	Klhdc3	ENSRNOG00000017495

Paralogs (10): FBXO42 (ENSG00000037637), LZTR1 (ENSG00000099949), KLHDC4 (ENSG00000104731), HCFC2 (ENSG00000111727), KLHDC10 (ENSG00000128607), RABEPK (ENSG00000136933), KLHDC9 (ENSG00000162755), KLHDC2 (ENSG00000165516), HCFC1 (ENSG00000172534), KLHDC1 (ENSG00000197776)

Protein

Protein identifiers

Kelch domain-containing protein 3 — Q9BQ90 (reviewed: Q9BQ90)

Alternative names: Testis intracellular mediator protein

All UniProt accessions (2): Q9BQ90, F8W6A4

UniProt curated annotations — full annotation on UniProt →

Function. Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(KLHDC3) complex specifically recognizes proteins with a glycine (Gly) at the C-terminus, leading to their ubiquitination and degradation: recognizes the C-terminal -Arg-(Xaa)n-Arg-Gly, -Arg-(Xaa)n-Lys-Gly, and -Arg-(Xaa)n-Gln-Gly degrons. The CRL2(KLHDC3) complex mediates ubiquitination and degradation of truncated SELENOV and SEPHS2 selenoproteins produced by failed UGA/Sec decoding, which end with a glycine. May be involved in meiotic recombination process.

Subunit / interactions. Component of a CRL2(KLHDC3) complex, also named ECS(KLHDC3) complex, composed of CUL2, Elongin BC (ELOB and ELOC), RBX1 and substrate-specific adapter KLHDC3. May form oligomers as a KLHDC3-ELOB-ELOC complex; this interaction is likely autoinhibitory for the E3 ligase complex.

Subcellular location. Cytoplasm.

Pathway. Protein modification; protein ubiquitination.

RefSeq proteins (1): NP_476502* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR006652	Kelch_1	Repeat
IPR015915	Kelch-typ_b-propeller	Homologous_superfamily
IPR052637	KLHDC3-like	Family

Pfam: PF01344, PF24681

UniProt features (46 total): strand 31, turn 7, repeat 5, helix 2, chain 1

Structure

Experimental structures (PDB)

3 structures.

PDB	Method	Resolution (Å)
9D1Z	X-RAY DIFFRACTION	1.88
9D1I	X-RAY DIFFRACTION	2
9D1Y	X-RAY DIFFRACTION	2.6

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9BQ90-F1	94.31	0.88

Function

Pathways and Gene Ontology

Reactome pathways

5 pathways

ID	Pathway
R-HSA-381038	XBP1(S) activates chaperone genes
R-HSA-2262752	Cellular responses to stress
R-HSA-381070	IRE1alpha activates chaperones
R-HSA-381119	Unfolded Protein Response (UPR)
R-HSA-8953897	Cellular responses to stimuli

MSigDB gene sets: 194 (showing top): TGGTGCT_MIR29A_MIR29B_MIR29C, MODULE_52, REACTOME_UNFOLDED_PROTEIN_RESPONSE_UPR, TGCGCANK_UNKNOWN, ATACCTC_MIR202, GOBP_MACROMOLECULE_CATABOLIC_PROCESS, DACOSTA_UV_RESPONSE_VIA_ERCC3_UP, GGGTGGRR_PAX4_03, GGAMTNNNNNTCCY_UNKNOWN, MODULE_66, MODULE_120, CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1, GOBP_ORGANELLE_FISSION, GOBP_POST_TRANSLATIONAL_PROTEIN_MODIFICATION, HIF1_Q3

GO Biological Process (5): reciprocal meiotic recombination (GO:0007131), protein ubiquitination (GO:0016567), proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161), ubiquitin-dependent protein catabolic process via the C-end degron rule pathway (GO:0140627), meiotic cell cycle (GO:0051321)

GO Molecular Function (3): chromatin binding (GO:0003682), ubiquitin-like ligase-substrate adaptor activity (GO:1990756), protein binding (GO:0005515)

GO Cellular Component (5): chromatin (GO:0000785), nucleoplasm (GO:0005654), cytoplasm (GO:0005737), cytosol (GO:0005829), Cul2-RING ubiquitin ligase complex (GO:0031462)

Reactome top-level categories

Rollup of top-4 pathways:

Category	Pathways
IRE1alpha activates chaperones	1
Cellular responses to stimuli	1
Unfolded Protein Response (UPR)	1
Cellular responses to stress	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	4
binding	2
meiosis I	1
reciprocal homologous recombination	1
meiotic cell cycle process	1
protein modification by small protein conjugation	1
ubiquitin-dependent protein catabolic process	1
proteasomal protein catabolic process	1
proteasome-mediated ubiquitin-dependent protein catabolic process	1
cell cycle	1
sexual reproduction	1
reproductive process	1
meiotic nuclear division	1
enzyme-substrate adaptor activity	1
chromosome	1
nuclear lumen	1
intracellular anatomical structure	1
cytoplasm	1
cullin-RING ubiquitin ligase complex	1

Protein interactions and networks

STRING

796 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
KLHDC3	MEA1	Q16626	942
KLHDC3	PPP2R5D	Q14738	937
KLHDC3	SELENOS	Q9BQE4	557
KLHDC3	APPBP2	Q92624	516
KLHDC3	SELENOK	Q9Y6D0	510
KLHDC3	SEPHS2	Q99611	499
KLHDC3	SPATA4	Q8NEY3	471
KLHDC3	SELENOV	P59797	470
KLHDC3	PLAAT5	Q96KN8	467
KLHDC3	CUL3	Q13618	463
KLHDC3	RAG2	P55895	460
KLHDC3	PRAMEF6	Q5VXH4	445
KLHDC3	FEM1C	Q96JP0	441
KLHDC3	SFI1	A8K8P3	439
KLHDC3	PHKG2	P11800	431

IntAct

69 interactions, top by confidence:

A	B	Type	Score
CUL2	VHL	psi-mi:“MI:0914”(association)	0.940
EAF1	ELL2	psi-mi:“MI:0914”(association)	0.840
KLHDC3	CUL2	psi-mi:“MI:0914”(association)	0.770
KLHDC3	CUL2	psi-mi:“MI:0915”(physical association)	0.770
CUL2	COPS2	psi-mi:“MI:0914”(association)	0.640
CUL5	SOCS7	psi-mi:“MI:0914”(association)	0.640
CHCHD4	SSNA1	psi-mi:“MI:0914”(association)	0.640
GLMN	FKBP5	psi-mi:“MI:0914”(association)	0.640
USP10	ANKRD28	psi-mi:“MI:0914”(association)	0.610
WDR55	PES1	psi-mi:“MI:0914”(association)	0.530
GLMN	CUL1	psi-mi:“MI:0914”(association)	0.530
SLC31A1	C2orf72	psi-mi:“MI:0914”(association)	0.530
VSIG4	TCAF2	psi-mi:“MI:0914”(association)	0.530
KLHDC3	DPYSL4	psi-mi:“MI:0914”(association)	0.530
IMPDH1	BCAT2	psi-mi:“MI:0914”(association)	0.530
SUV39H1	MAGEC1	psi-mi:“MI:0914”(association)	0.530
MISP	OBSL1	psi-mi:“MI:0914”(association)	0.530
THOC3	CLUH	psi-mi:“MI:0914”(association)	0.530
G3BP2	NUP214	psi-mi:“MI:0914”(association)	0.530
CHCHD4	ENSA	psi-mi:“MI:0914”(association)	0.530
KLHDC3	CLUH	psi-mi:“MI:0914”(association)	0.530
POP7	RPP40	psi-mi:“MI:0914”(association)	0.530
ZSCAN9	SCAND1	psi-mi:“MI:0914”(association)	0.530
CSNK1E	ZSWIM8	psi-mi:“MI:0914”(association)	0.530

BioGRID (167): KLHDC3 (Affinity Capture-RNA), KLHDC3 (Affinity Capture-RNA), KLHDC3 (Affinity Capture-RNA), KLHDC3 (Affinity Capture-MS), KLHDC3 (Affinity Capture-MS), COPS2 (Affinity Capture-MS), RPP25L (Affinity Capture-MS), CUL2 (Affinity Capture-MS), COPS6 (Affinity Capture-MS), BRAP (Affinity Capture-MS), DPYSL5 (Affinity Capture-MS), NEDD8 (Affinity Capture-MS), USP10 (Affinity Capture-MS), NUDCD3 (Affinity Capture-MS), TSPYL4 (Affinity Capture-MS)

ESM2 similar proteins: A0A2R8Q1W5, A2AAX3, A4IF63, A6QQY2, D3ZA50, D3ZQG6, F7H9X2, G3X9X1, O95199, P28575, P57790, Q14145, Q28DE7, Q2T9Z7, Q2WGJ6, Q56A24, Q58CV6, Q59H18, Q5BK60, Q5GIG6, Q5R774, Q5RCZ7, Q5RDY3, Q5U3Y0, Q5U580, Q5ZJU2, Q5ZLD3, Q684M4, Q6AYI2, Q6P798, Q6TFL4, Q6ZPT1, Q7TQP6, Q80TF4, Q80YG3, Q8BRG6, Q8BSF5, Q8IY47, Q8N7A1, Q8VEM9

Diamond homologs: A8JAM0, D3ZN95, G5EC23, P38853, P51610, P51611, Q10AZ7, Q4V8F4, Q53EP0, Q5RDA9, Q5RKG2, Q61191, Q6AYI2, Q6NWW9, Q6P3S6, Q7M3S9, Q8H4D4, Q8VEM9, Q93XW5, Q9BQ90, Q9D968, Q9V4C8, Q9Y5Z7, Q5EA50, Q86L99, Q94BT6, Q9C8K7, Q58CV6, Q5R4Q7, Q8N653, Q8W4K1, B8A5G9, C6A5A3, D3BT31, E3KWE1, F7A355, G1FNI6, O58523, O58796, P53177

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 88 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Neddylation	9	7.5×	8e-04

GO biological processes:

GO term	Partners	Fold	FDR
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	5	23.4×	1e-03
proteasome-mediated ubiquitin-dependent protein catabolic process	9	5.9×	4e-03
protein ubiquitination	10	5.2×	4e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

43 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	29
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1184 predictions. Top by Δscore:

Variant	Effect	Δscore
6:43017517:A:AG	acceptor_gain	1.0000
6:43017518:G:GG	acceptor_gain	1.0000
6:43017518:GT:G	acceptor_gain	1.0000
6:43017518:GTGT:G	acceptor_gain	1.0000
6:43017518:GTGTC:G	acceptor_gain	1.0000
6:43017691:CGTCA:C	donor_loss	1.0000
6:43017692:GTCA:G	donor_gain	1.0000
6:43017693:TCA:T	donor_gain	1.0000
6:43017694:CAGT:C	donor_loss	1.0000
6:43017695:AGT:A	donor_loss	1.0000
6:43017696:G:GG	donor_gain	1.0000
6:43017697:T:A	donor_loss	1.0000
6:43017698:GAGT:G	donor_loss	1.0000
6:43017699:AGTA:A	donor_loss	1.0000
6:43017700:G:GG	donor_gain	1.0000
6:43017965:GCAG:G	donor_gain	1.0000
6:43018553:GCCT:G	donor_gain	1.0000
6:43018557:G:GG	donor_gain	1.0000
6:43018627:TTCCA:T	acceptor_loss	1.0000
6:43018628:TCCA:T	acceptor_loss	1.0000
6:43018629:CCAGT:C	acceptor_loss	1.0000
6:43018630:CAGTT:C	acceptor_loss	1.0000
6:43018631:A:AC	acceptor_loss	1.0000
6:43018631:A:AG	acceptor_gain	1.0000
6:43018631:AGTT:A	acceptor_gain	1.0000
6:43018631:AGTTG:A	acceptor_gain	1.0000
6:43018632:G:GG	acceptor_gain	1.0000
6:43018632:GT:G	acceptor_gain	1.0000
6:43018632:GTT:G	acceptor_gain	1.0000
6:43018632:GTTG:G	acceptor_gain	1.0000

AlphaMissense

2516 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
6:43017202:T:A	W4R	1.000
6:43017202:T:C	W4R	1.000
6:43017227:C:A	P12H	1.000
6:43017233:G:C	R14T	1.000
6:43017233:G:T	R14M	1.000
6:43017234:G:C	R14S	1.000
6:43017234:G:T	R14S	1.000
6:43017238:A:G	N16D	1.000
6:43017240:C:A	N16K	1.000
6:43017240:C:G	N16K	1.000
6:43017241:C:G	H17D	1.000
6:43017242:A:G	H17R	1.000
6:43017247:G:C	A19P	1.000
6:43017248:C:A	A19E	1.000
6:43017280:G:A	G30R	1.000
6:43017280:G:C	G30R	1.000
6:43017280:G:T	G30W	1.000
6:43017281:G:A	G30E	1.000
6:43017281:G:T	G30V	1.000
6:43017283:G:C	G31R	1.000
6:43017283:G:T	G31C	1.000
6:43017284:G:A	G31D	1.000
6:43017284:G:T	G31V	1.000
6:43017530:T:A	W56R	1.000
6:43017530:T:C	W56R	1.000
6:43017531:G:C	W56S	1.000
6:43017532:G:C	W56C	1.000
6:43017532:G:T	W56C	1.000
6:43017585:C:A	P74H	1.000
6:43017593:C:A	R77S	1.000

dbSNP variants (sampled 300 via entrez): RS1000201066 (6:43015228 C>T), RS1001039061 (6:43013797 T>A), RS1001151588 (6:43013978 A>C,G), RS1001268356 (6:43014282 C>T), RS1001475564 (6:43021236 C>T), RS1001819790 (6:43021489 T>C), RS1002256055 (6:43017173 T>C), RS1002910460 (6:43021225 C>T), RS1003230003 (6:43015408 AG>A), RS1003259398 (6:43015942 T>TG), RS1003540136 (6:43021087 C>G,T), RS1003560736 (6:43016394 T>G), RS1003611761 (6:43016047 T>A), RS1003920083 (6:43020006 T>C), RS1004138131 (6:43019755 A>T)

Disease associations

OMIM: gene MIM:611248 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

26 total (human), top 26 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, affects cotreatment, increases abundance	2
Cyclosporine	decreases expression	2
aristolochic acid I	increases expression	1
pirinixic acid	affects binding, decreases expression, increases activity	1
bisphenol A	affects expression	1
manganese chloride	decreases expression, increases abundance, affects cotreatment	1
potassium chromate(VI)	affects cotreatment, decreases expression	1
2,3-bis(3’-hydroxybenzyl)butyrolactone	affects cotreatment, increases expression	1
epigallocatechin gallate	affects cotreatment, decreases expression	1
di-n-butylphosphoric acid	affects expression	1
Resveratrol	affects cotreatment, increases expression	1
Temozolomide	increases expression	1
Acetaminophen	decreases expression	1
Arsenic	affects cotreatment, decreases expression, increases abundance	1
Benzo(a)pyrene	decreases methylation	1
Coumestrol	affects cotreatment, increases expression	1
Doxorubicin	increases expression	1
Manganese	decreases expression, increases abundance, affects cotreatment	1
Plant Extracts	affects cotreatment, increases expression	1
Plant Oils	decreases expression	1
Selenomethionine	affects expression	1
Smoke	decreases expression	1
Thiram	decreases expression	1
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	decreases expression	1
Cadmium Chloride	decreases expression	1
tert-Butylhydroperoxide	decreases expression	1

Cellosaurus cell lines

4 cell lines: 3 cancer cell line, 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B2ZV	Abcam HEK293T KLHDC3 KO	Transformed cell line	Female
CVCL_E2AI	HAP1 KLHDC3 (-) 1	Cancer cell line	Male
CVCL_E2AJ	HAP1 KLHDC3 (-) 2	Cancer cell line	Male
CVCL_E2AK	HAP1 KLHDC3 (-) 3	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.