KLHDC7B-DT

Summary

KLHDC7B-DT (KLHDC7B divergent transcript, HGNC:53791) is a long non-coding RNA gene on chromosome 22q13.33.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53791
Approved symbol	KLHDC7B-DT
Name	KLHDC7B divergent transcript
Location	22q13.33
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000272666
Ensembl biotype	lncRNA
Entrez	105373098
RNAcentral	URS0002A18F03 — lncRNA, 1432 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 10 lncRNA

ENST00000609178, ENST00000796178, ENST00000796179, ENST00000796180, ENST00000796181, ENST00000796182, ENST00000796183, ENST00000796184, ENST00000796185, ENST00000796186

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000609178 — 1 exons

Exon	Start	End
ENSE00004181575	50542299	50542906

Expression profiles

Bgee: expression breadth ubiquitous, 147 present calls, max score 94.37.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.3805 / max 64.2028, expressed in 82 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
194782	0.3401	78
194781	0.0404	22

Top tissues by expression

236 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	94.37	gold quality
granulocyte	CL:0000094	85.51	gold quality
monocyte	CL:0000576	80.80	gold quality
leukocyte	CL:0000738	80.65	gold quality
bone marrow cell	CL:0002092	77.18	gold quality
vermiform appendix	UBERON:0001154	71.42	gold quality
blood	UBERON:0000178	69.52	gold quality
epithelium of nasopharynx	UBERON:0001951	69.17	gold quality
spleen	UBERON:0002106	68.09	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	67.30	gold quality
palpebral conjunctiva	UBERON:0001812	65.64	silver quality
ganglionic eminence	UBERON:0004023	65.34	gold quality
caecum	UBERON:0001153	64.70	gold quality
lymph node	UBERON:0000029	63.12	gold quality
right lobe of liver	UBERON:0001114	62.48	gold quality
tonsil	UBERON:0002372	62.34	gold quality
gingival epithelium	UBERON:0001949	61.94	gold quality
gall bladder	UBERON:0002110	61.74	gold quality
upper lobe of left lung	UBERON:0008952	61.19	gold quality
hindlimb stylopod muscle	UBERON:0004252	61.10	gold quality
islet of Langerhans	UBERON:0000006	60.37	gold quality
lower esophagus mucosa	UBERON:0035834	60.03	gold quality
right lung	UBERON:0002167	59.94	gold quality
upper lobe of lung	UBERON:0008948	59.53	gold quality
gingiva	UBERON:0001828	59.52	gold quality
rectum	UBERON:0001052	58.99	gold quality
esophagus mucosa	UBERON:0002469	58.43	gold quality
minor salivary gland	UBERON:0001830	58.19	gold quality
mucosa of transverse colon	UBERON:0004991	57.70	gold quality
bone marrow	UBERON:0002371	57.53	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.01

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• KLHDC7B-DT aggravates pancreatic ductal adenocarcinoma development via inducing cross-talk between cancer cells and macrophages. (PMID:33538300)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.