KLHL29

Summary

KLHL29 (kelch like family member 29, HGNC:29404) is a protein-coding gene on chromosome 2p24.1, encoding Kelch-like protein 29 (Q96CT2).

Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm.

Source: NCBI Gene 114818 — RefSeq curated summary.

At a glance

• GWAS associations: 37
• Clinical variants (ClinVar): 73 total
• MANE Select transcript: NM_052920

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:29404
Approved symbol	KLHL29
Name	kelch like family member 29
Location	2p24.1
Locus type	gene with protein product
Status	Approved
Aliases	KIAA1921
Ensembl gene	ENSG00000119771
Ensembl biotype	protein_coding
Entrez	114818

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 6 protein_coding, 2 retained_intron

ENST00000288548, ENST00000471654, ENST00000486442, ENST00000489446, ENST00000869654, ENST00000970997, ENST00000970998, ENST00000970999

RefSeq mRNA: 1 — MANE Select: NM_052920 NM_052920

CCDS: CCDS54335

Canonical transcript exons

ENST00000486442 — 14 exons

Exon	Start	End
ENSE00001034578	23684399	23684537
ENSE00001070703	23691674	23691876
ENSE00001821418	23642338	23642850
ENSE00001838941	23475560	23475667
ENSE00001877282	23706481	23708606
ENSE00001887860	23385179	23385780
ENSE00003482543	23695951	23696133
ENSE00003517832	23562152	23562481
ENSE00003545220	23695623	23695821
ENSE00003546964	23703719	23703863
ENSE00003604677	23639139	23639280
ENSE00003606781	23696333	23696513
ENSE00003618064	23693269	23693528
ENSE00003694119	23703186	23703379

Expression profiles

Bgee: expression breadth ubiquitous, 256 present calls, max score 91.98.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 4.1269 / max 51.3915, expressed in 1284 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
19153	2.1968	1105
19154	1.9301	836

Top tissues by expression

290 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
tibia	UBERON:0000979	91.98	gold quality
middle temporal gyrus	UBERON:0002771	90.71	gold quality
sural nerve	UBERON:0015488	90.56	gold quality
Brodmann (1909) area 23	UBERON:0013554	90.37	gold quality
synovial joint	UBERON:0002217	87.68	gold quality
pigmented layer of retina	UBERON:0001782	87.51	gold quality
trigeminal ganglion	UBERON:0001675	86.09	gold quality
lateral nuclear group of thalamus	UBERON:0002736	85.11	gold quality
skin of hip	UBERON:0001554	84.03	gold quality
cortical plate	UBERON:0005343	83.97	gold quality
endothelial cell	CL:0000115	83.61	silver quality
nerve	UBERON:0001021	83.60	gold quality
tibial nerve	UBERON:0001323	83.60	gold quality
lower esophagus muscularis layer	UBERON:0035833	83.06	gold quality
lower esophagus	UBERON:0013473	82.98	gold quality
calcaneal tendon	UBERON:0003701	82.73	gold quality
dorsal root ganglion	UBERON:0000044	82.48	gold quality
parietal pleura	UBERON:0002400	82.24	gold quality
adrenal cortex	UBERON:0001235	82.21	gold quality
left adrenal gland cortex	UBERON:0035825	81.58	gold quality
superior frontal gyrus	UBERON:0002661	81.49	gold quality
upper leg skin	UBERON:0004262	81.29	gold quality
urethra	UBERON:0000057	81.23	gold quality
saphenous vein	UBERON:0007318	81.18	gold quality
gastrocnemius	UBERON:0001388	81.05	gold quality
right adrenal gland cortex	UBERON:0035827	81.00	gold quality
left adrenal gland	UBERON:0001234	80.97	gold quality
primary visual cortex	UBERON:0002436	80.83	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	80.80	gold quality
postcentral gyrus	UBERON:0002581	80.75	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-CURD-119	yes	31.22
E-ANND-3	no	4.53

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): NR1I2

miRNA regulators (miRDB)

225 targeting KLHL29, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-5692B	100.00	71.32	2622
HSA-MIR-5692C	100.00	71.32	2622
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-3925-3P	100.00	69.95	1237
HSA-MIR-513A-5P	100.00	69.77	2465
HSA-MIR-188-3P	100.00	68.76	1240
HSA-MIR-7110-3P	100.00	73.18	2486
HSA-MIR-4673	100.00	66.64	1490
HSA-MIR-200B-3P	100.00	73.31	2693
HSA-MIR-200C-3P	100.00	73.35	2685
HSA-MIR-429	100.00	73.44	2698
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-6873-3P	100.00	71.42	2626
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-450A-1-3P	100.00	69.33	1837
HSA-MIR-1252-5P	100.00	69.80	2774
HSA-MIR-4510	100.00	66.60	2050
HSA-MIR-6127	100.00	66.76	2188
HSA-MIR-6129	100.00	66.46	2080
HSA-MIR-6130	100.00	66.69	2012
HSA-MIR-6133	100.00	66.48	2064
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997

Literature-anchored findings (GeneRIF, showing 3)

• The fusion transcript NR5A2-KLHL29FT was identified in normal and cancerous colonic epithelia. It is due to an uncharacterized polymorphic germline insertion of the NR5A2 sequence from chromosome 1 into the KLHL29 locus at chromosome 2, rather than a chromosomal rearrangement. NR5A2-KLH29FT expression levels were significantly lower in colon cancers than in matched normal colonic epithelia. (PMID:28081303)
• Brazilian Amerindian ancestry compared to Asian, European, and African Genomes.SNPs within or proximal to CIITA (rs6498115), SMC6 (rs1834619), and KLHL29 (rs2288697) were most differentiated in the Amerindian-specific branch. SNPs in ADAMTS9 (rs7631391), DOCK2 (rs77594147), SLC28A1 (rs28649017), ARHGAP5 (rs7151991), and CIITA (rs45601437) in the Asian comparison. (PMID:28100790)
• KLHL29-mediated DDX3X degradation promotes chemosensitivity by abrogating cell cycle checkpoint in triple-negative breast cancer. (PMID:37845393)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	KLHL29	ENSDARG00000043799
danio_rerio	klhl29	ENSDARG00000087688
mus_musculus	Klhl29	ENSMUSG00000020627
rattus_norvegicus	Klhl29	ENSRNOG00000005371

Paralogs (54): KLHL13 (ENSG00000003096), KLHL20 (ENSG00000076321), KEAP1 (ENSG00000079999), KLHL42 (ENSG00000087448), KLHL22 (ENSG00000099910), KLHL4 (ENSG00000102271), KLHL2 (ENSG00000109466), KLHL5 (ENSG00000109790), BACH2 (ENSG00000112182), KLHL18 (ENSG00000114648), KLHL24 (ENSG00000114796), IVNS1ABP (ENSG00000116679), KLHL12 (ENSG00000117153), KBTBD7 (ENSG00000120696), KLHL7 (ENSG00000122550), KLHL31 (ENSG00000124743), KLHDC7B (ENSG00000130487), KLHL36 (ENSG00000135686), KLHL8 (ENSG00000145332), KLHL3 (ENSG00000146021), KLHL35 (ENSG00000149243), KLHL1 (ENSG00000150361), BACH1 (ENSG00000156273), KLHL40 (ENSG00000157119), KLHL10 (ENSG00000161594), KLHL21 (ENSG00000162413), KLHDC8A (ENSG00000162873), KBTBD8 (ENSG00000163376), KBTBD6 (ENSG00000165572), KLHL26 (ENSG00000167487), KLHL30 (ENSG00000168427), KBTBD2 (ENSG00000170852), KLHL6 (ENSG00000172578), KLHL15 (ENSG00000174010), KLHL38 (ENSG00000175946), KBTBD11 (ENSG00000176595), KLHDC7A (ENSG00000179023), KLHL28 (ENSG00000179454), KBTBD3 (ENSG00000182359), KLHL33 (ENSG00000185271)

Protein

Protein identifiers

Kelch-like protein 29 — Q96CT2 (reviewed: Q96CT2)

Alternative names: Kelch repeat and BTB domain-containing protein 9

All UniProt accessions (2): Q96CT2, H0Y2P5

UniProt curated annotations — full annotation on UniProt →

Isoforms (2)

UniProt ID	Names	Canonical?
Q96CT2-1	1	yes
Q96CT2-2	2

RefSeq proteins (1): NP_443152* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000210	BTB/POZ_dom	Domain
IPR006652	Kelch_1	Repeat
IPR011333	SKP1/BTB/POZ_sf	Homologous_superfamily
IPR011705	BACK	Domain
IPR015915	Kelch-typ_b-propeller	Homologous_superfamily
IPR056737	Beta-prop_ATRN-MKLN-like	Domain

Pfam: PF00651, PF01344, PF07707, PF24981

UniProt features (14 total): repeat 6, compositionally biased region 2, region of interest 2, chain 1, domain 1, splice variant 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96CT2-F1	71.27	0.43

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 140 (showing top): GSE45365_CD8A_DC_VS_CD11B_DC_IFNAR_KO_UP, GSE37336_LY6C_POS_VS_NEG_NAIVE_CD4_TCELL_UP, GSE18804_SPLEEN_MACROPHAGE_VS_TUMORAL_MACROPHAGE_DN, PEREZ_TP63_TARGETS, GOBP_MACROMOLECULE_CATABOLIC_PROCESS, DAWSON_METHYLATED_IN_LYMPHOMA_TCL1, LIAO_METASTASIS, CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN, GOBP_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS, GRYDER_PAX3FOXO1_ENHANCERS_IN_TADS, GOBP_PROTEIN_CATABOLIC_PROCESS, GOCC_TRANSFERASE_COMPLEX, GOBP_PROTEOLYSIS, GOCC_CULLIN_RING_UBIQUITIN_LIGASE_COMPLEX, GOCC_CUL3_RING_UBIQUITIN_LIGASE_COMPLEX

GO Biological Process (1): proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)

GO Molecular Function (2): ubiquitin-like ligase-substrate adaptor activity (GO:1990756), protein binding (GO:0005515)

GO Cellular Component (2): cytoplasm (GO:0005737), Cul3-RING ubiquitin ligase complex (GO:0031463)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
ubiquitin-dependent protein catabolic process	1
proteasomal protein catabolic process	1
enzyme-substrate adaptor activity	1
binding	1
intracellular anatomical structure	1
cellular anatomical structure	1
cullin-RING ubiquitin ligase complex	1

Protein interactions and networks

STRING

526 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
KLHL29	FBXO46	Q6PJ61	479
KLHL29	ABHD15	Q6UXT9	463
KLHL29	A0A0G2JMU2	A0A0G2JMU2	435
KLHL29	POTEB3	A0JP26	423
KLHL29	CIMIP6	Q8N5S3	398
KLHL29	FRMD4A	Q9P2Q2	384
KLHL29	CIMAP1C	Q8IXM7	382
KLHL29	CFAP68	Q9H5F2	380
KLHL29	THOC7	Q6I9Y2	378
KLHL29	OR2C3	Q8N628	377
KLHL29	FBXW5	Q969U6	366
KLHL29	MINDY4	Q4G0A6	353
KLHL29	GPATCH11	Q8N954	349
KLHL29	DENND4C	Q5VZ89	344
KLHL29	CEACAM18	A8MTB9	342

IntAct

11 interactions, top by confidence:

A	B	Type	Score
KLHL29	NUDCD3	psi-mi:“MI:0915”(physical association)	0.670
KLHL9	ENC1	psi-mi:“MI:0914”(association)	0.640
KLHL29	HSP90AB1	psi-mi:“MI:0915”(physical association)	0.400
ZNF232	ZNF197	psi-mi:“MI:0914”(association)	0.350
KLHL29	NPHP3	psi-mi:“MI:0914”(association)	0.350
rep	VWA8	psi-mi:“MI:0914”(association)	0.350
ZBTB7C	ZBTB5	psi-mi:“MI:0914”(association)	0.350
KLHL29	TRIM32	psi-mi:“MI:0914”(association)	0.350

BioGRID (46): KBTBD8 (Affinity Capture-MS), ZBTB10 (Affinity Capture-MS), NPHP3 (Affinity Capture-MS), KLHL29 (Affinity Capture-MS), KLHL21 (Affinity Capture-MS), NUDCD3 (Affinity Capture-MS), KBTBD7 (Affinity Capture-MS), KLHL29 (Affinity Capture-RNA), KLHL29 (Affinity Capture-RNA), KLHL29 (Affinity Capture-Western), ZBTB10 (Affinity Capture-MS), KLHL29 (Affinity Capture-MS), NUDCD3 (Affinity Capture-MS), NPHP3 (Affinity Capture-MS), KBTBD7 (Affinity Capture-MS)

ESM2 similar proteins: D3ZB51, E9PZ19, M0RAS4, O60242, O60245, O70472, O75882, O94779, P13590, P13591, P13595, P13596, P15209, P24786, P31836, P51641, P68500, P78539, P97300, P97527, P97546, Q01973, Q03351, Q15223, Q16288, Q16620, Q5IFJ9, Q5IS37, Q5IS82, Q63604, Q63769, Q6A051, Q6AZB0, Q6P1D5, Q6VNS1, Q7TNR6, Q80T74, Q80ZF8, Q8R4I7, Q8TDF5

Diamond homologs: A0JN76, A1L2U9, A1YPR0, B1WAZ8, B1WBS3, B1WBU4, B2RXF5, E1B932, G5E8B9, O14867, O15062, O43167, O43298, O88282, O88939, O93567, O95365, O95625, P10074, P28575, P41182, P41183, P52739, P97302, P97303, Q0IH98, Q0IJ29, Q0P4X6, Q0VCJ6, Q13105, Q14526, Q1H9T6, Q1L8W0, Q3B725, Q3B7M1, Q3B7N9, Q3SWU4, Q3ZB90, Q503R4, Q53G59

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

73 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	70
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

4573 predictions. Top by Δscore:

Variant	Effect	Δscore
2:23445146:GGCAT:G	donor_gain	1.0000
2:23475558:A:AG	acceptor_gain	1.0000
2:23475559:G:GG	acceptor_gain	1.0000
2:23475664:CAAG:C	donor_loss	1.0000
2:23475665:AAGG:A	donor_loss	1.0000
2:23475667:GGT:G	donor_loss	1.0000
2:23475668:G:GA	donor_loss	1.0000
2:23475669:T:A	donor_loss	1.0000
2:23562147:CACA:C	acceptor_loss	1.0000
2:23562149:CAG:C	acceptor_loss	1.0000
2:23562150:A:AT	acceptor_loss	1.0000
2:23562478:CAAGG:C	donor_loss	1.0000
2:23562479:AAGG:A	donor_loss	1.0000
2:23562481:GGT:G	donor_loss	1.0000
2:23562482:GT:G	donor_loss	1.0000
2:23562483:T:A	donor_loss	1.0000
2:23691875:CGG:C	donor_loss	1.0000
2:23691877:G:A	donor_loss	1.0000
2:23691877:G:GG	donor_gain	1.0000
2:23691878:T:A	donor_loss	1.0000
2:23693524:CACAG:C	donor_loss	1.0000
2:23693526:CAGG:C	donor_loss	1.0000
2:23693527:AGG:A	donor_loss	1.0000
2:23693528:GG:G	donor_loss	1.0000
2:23693529:GT:G	donor_loss	1.0000
2:23693530:T:G	donor_loss	1.0000
2:23695614:A:AG	acceptor_gain	1.0000
2:23695617:CTGCA:C	acceptor_loss	1.0000
2:23695618:TGCA:T	acceptor_loss	1.0000
2:23695619:GCA:G	acceptor_loss	1.0000

AlphaMissense

5688 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:23642826:T:C	F306L	1.000
2:23642827:T:C	F306S	1.000
2:23642828:C:A	F306L	1.000
2:23642828:C:G	F306L	1.000
2:23684425:C:A	R323S	1.000
2:23684426:G:C	R323P	1.000
2:23684450:T:C	L331P	1.000
2:23684485:C:G	H343D	1.000
2:23684495:T:A	V346D	1.000
2:23684509:A:C	S351R	1.000
2:23684511:C:A	S351R	1.000
2:23684511:C:G	S351R	1.000
2:23691765:T:C	F391L	1.000
2:23691767:T:A	F391L	1.000
2:23691767:T:G	F391L	1.000
2:23691870:T:C	F426L	1.000
2:23691872:T:A	F426L	1.000
2:23691872:T:G	F426L	1.000
2:23693313:G:C	A443P	1.000
2:23693496:T:A	W504R	1.000
2:23693496:T:C	W504R	1.000
2:23695648:T:A	V523D	1.000
2:23695650:C:A	R524S	1.000
2:23695678:T:C	L533P	1.000
2:23695681:T:C	L534P	1.000
2:23695690:T:A	V537D	1.000
2:23695729:G:C	R550P	1.000
2:23695735:T:C	L552P	1.000
2:23695746:G:C	A556P	1.000
2:23695747:C:A	A556D	1.000

dbSNP variants (sampled 300 via entrez): RS1000005592 (2:23603894 G>A), RS1000008316 (2:23589054 C>A,G,T), RS1000011375 (2:23471710 T>G), RS1000028249 (2:23461268 G>A), RS1000028844 (2:23668973 G>A), RS1000036189 (2:23640654 C>T), RS1000040584 (2:23686261 G>A), RS1000057867 (2:23554116 G>A), RS1000059878 (2:23668680 G>A), RS1000071940 (2:23478443 T>C), RS1000072094 (2:23391852 A>G), RS1000075843 (2:23697369 G>A), RS1000082549 (2:23626829 T>G), RS1000089104 (2:23519079 G>T), RS1000089804 (2:23460115 T>C,G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

37 associations (top):

Study	Trait	p-value
GCST000973_4	Hypertension	1.000000e-07
GCST001066_1	Dialysis-related mortality	8.000000e-08
GCST001762_398	Obesity-related traits	6.000000e-07
GCST001762_415	Obesity-related traits	4.000000e-06
GCST003542_1	Night sleep phenotypes	6.000000e-06
GCST004601_16	Red blood cell count	2.000000e-21
GCST004604_20	Hematocrit	6.000000e-09
GCST004607_212	Plateletcrit	7.000000e-11
GCST004608_50	Granulocyte percentage of myeloid white cells	2.000000e-10
GCST004615_89	Hemoglobin concentration	2.000000e-10
GCST004723_20	Conotruncal heart defects (maternal effects)	7.000000e-06
GCST006626_27	Pulse pressure	1.000000e-11
GCST006631_32	Nicotine dependence and major depression (severity of comorbidity)	8.000000e-07
GCST006922_5	Regular attendance at a religious group	8.000000e-09
GCST006943_64	Feeling miserable	3.000000e-08
GCST006945_25	Feeling guilty	2.000000e-09
GCST006947_34	Feeling fed-up	2.000000e-12
GCST007325_177	General risk tolerance (MTAG)	1.000000e-08
GCST007325_29	General risk tolerance (MTAG)	4.000000e-08
GCST007326_92	Number of sexual partners	7.000000e-13
GCST007709_5	General factor of neuroticism	1.000000e-08
GCST008034_16	Hemoglobin A1c levels	5.000000e-09
GCST008034_7	Hemoglobin A1c levels	4.000000e-11
GCST008362_99	Birth weight	2.000000e-16
GCST008749_1	Systolic blood pressure	7.000000e-07
GCST010083_273	Hemoglobin levels	3.000000e-12
GCST010480_2	Coronary artery disease	1.000000e-10
GCST011038_4	Parkinson’s disease progression (motor)	3.000000e-06
GCST011494_91	Daytime nap	4.000000e-20
GCST90000025_797	Appendicular lean mass	2.000000e-68

EFO canonical traits (25, from GWAS)

EFO ID	Trait name
EFO:0004730	hormone measurement
EFO:0003940	physical activity
EFO:0004305	erythrocyte count
EFO:0004348	hematocrit
EFO:0007985	platelet crit
EFO:0007997	granulocyte percentage of myeloid white cells
EFO:0004509	hemoglobin measurement
EFO:0005763	pulse pressure measurement
EFO:0007006	depressive symptom measurement
EFO:0009262	nicotine dependence symptom count
EFO:0009592	social interaction measurement
EFO:0009598	feeling miserable measurement
EFO:0009595	guilt measurement
EFO:0009588	feeling “fed-up” measurement
EFO:0008579	risk-taking behaviour
EFO:0007660	neuroticism measurement
EFO:0004541	HbA1c measurement
EFO:0004344	birth weight
EFO:0006335	systolic blood pressure
EFO:0008336	disease progression measurement
EFO:0007828	daytime rest measurement
EFO:0004980	appendicular lean mass
EFO:0004527	mean corpuscular hemoglobin
EFO:0008039	BMI-adjusted hip circumference
EFO:0007789	BMI-adjusted waist circumference

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

51 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, increases expression, affects expression, increases methylation	9
Benzo(a)pyrene	affects methylation, decreases expression	3
bisphenol A	decreases methylation, affects cotreatment, increases expression	2
sodium arsenite	decreases expression	2
Estradiol	affects cotreatment, increases expression	2
p-Chloromercuribenzoic Acid	affects cotreatment, decreases expression	2
aristolochic acid I	decreases expression	1
trichostatin A	increases expression	1
tris(2-butoxyethyl) phosphate	affects expression	1
sulforaphane	decreases expression	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
perfluorooctanoic acid	increases expression	1
zinc chromate	decreases expression, increases abundance	1
benzo(e)pyrene	increases methylation	1
aflatoxin B2	increases methylation	1
chromium hexavalent ion	decreases expression, increases abundance	1
perfluorooctane sulfonic acid	increases expression	1
CGP 52608	affects binding, increases reaction	1
2-palmitoylglycerol	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression, increases expression	1
ICG 001	increases expression	1
dorsomorphin	affects cotreatment, decreases expression, increases expression	1
bisphenol S	decreases methylation	1
jinfukang	affects cotreatment, decreases expression	1
(+)-JQ1 compound	increases expression	1
Acetaminophen	increases expression	1
Air Pollutants	decreases expression, increases abundance	1
Arsenic	affects methylation	1
Vehicle Emissions	decreases methylation	1
Cisplatin	affects cotreatment, decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.