KLHL5

Summary

KLHL5 (kelch like family member 5, HGNC:6356) is a protein-coding gene on chromosome 4p14, encoding Kelch-like protein 5 (Q96PQ7).

Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Located in microtubule cytoskeleton and plasma membrane. Implicated in cocaine dependence.

Source: NCBI Gene 51088 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 112 total
• MANE Select transcript: NM_015990

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:6356
Approved symbol	KLHL5
Name	kelch like family member 5
Location	4p14
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000109790
Ensembl biotype	protein_coding
OMIM	608064
Entrez	51088

Gene structure

Transcript identifiers

Ensembl transcripts: 13 — 12 protein_coding, 1 nonsense_mediated_decay

ENST00000261425, ENST00000261426, ENST00000381930, ENST00000504108, ENST00000508137, ENST00000514399, ENST00000515612, ENST00000891918, ENST00000891919, ENST00000891920, ENST00000891921, ENST00000919279, ENST00000962795

RefSeq mRNA: 4 — MANE Select: NM_015990 NM_001007075, NM_001171654, NM_015990, NM_199039

CCDS: CCDS33975, CCDS3449, CCDS54756

Canonical transcript exons

ENST00000504108 — 11 exons

Exon	Start	End
ENSE00000710663	39113020	39113232
ENSE00000826443	39107569	39107731
ENSE00001077191	39115159	39115330
ENSE00001171492	39081103	39081239
ENSE00001301206	39096692	39096878
ENSE00001304952	39081963	39082159
ENSE00001305394	39103287	39103511
ENSE00001326701	39086515	39086727
ENSE00002049201	39062232	39063035
ENSE00002071317	39121010	39126233
ENSE00003477265	39075965	39076147

Expression profiles

Bgee: expression breadth ubiquitous, 256 present calls, max score 96.52.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 37.2748 / max 426.3441, expressed in 1803 samples.

FANTOM5 promoters (8 alternative TSS)

Promoter ID	TPM avg	Samples expressed
47357	16.6540	1772
47358	14.6234	1754
47356	5.1483	1610
47359	0.2644	116
47360	0.2176	81
203142	0.1342	52
47361	0.1306	51
47362	0.1023	52

Top tissues by expression

258 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
stromal cell of endometrium	CL:0002255	96.52	gold quality
seminal vesicle	UBERON:0000998	96.32	gold quality
corpus callosum	UBERON:0002336	95.11	gold quality
cauda epididymis	UBERON:0004360	94.84	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	94.81	gold quality
spinal cord	UBERON:0002240	94.78	gold quality
smooth muscle tissue	UBERON:0001135	94.57	gold quality
subthalamic nucleus	UBERON:0001906	94.20	gold quality
substantia nigra	UBERON:0002038	93.85	gold quality
amygdala	UBERON:0001876	93.76	gold quality
Ammon’s horn	UBERON:0001954	93.67	gold quality
placenta	UBERON:0001987	93.65	gold quality
colonic epithelium	UBERON:0000397	93.49	gold quality
midbrain	UBERON:0001891	93.43	gold quality
Brodmann (1909) area 46	UBERON:0006483	93.34	gold quality
muscle layer of sigmoid colon	UBERON:0035805	93.26	gold quality
postcentral gyrus	UBERON:0002581	93.17	gold quality
inferior vagus X ganglion	UBERON:0005363	92.84	gold quality
hypothalamus	UBERON:0001898	92.82	gold quality
islet of Langerhans	UBERON:0000006	92.78	gold quality
medulla oblongata	UBERON:0001896	92.76	gold quality
dorsal plus ventral thalamus	UBERON:0001897	92.70	gold quality
lower esophagus muscularis layer	UBERON:0035833	92.45	gold quality
lower esophagus	UBERON:0013473	92.43	gold quality
cortical plate	UBERON:0005343	92.36	gold quality
vermiform appendix	UBERON:0001154	92.30	gold quality
monocyte	CL:0000576	92.24	gold quality
superficial temporal artery	UBERON:0001614	92.21	gold quality
parietal lobe	UBERON:0001872	92.13	gold quality
temporal lobe	UBERON:0001871	92.05	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-GEOD-137537	yes	7.58
E-ANND-3	yes	5.57
E-GEOD-99795	no	76.04

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

203 targeting KLHL5, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-656-3P	100.00	72.15	2788
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-5696	99.98	72.36	4487
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-433-3P	99.98	69.37	1203
HSA-MIR-4803	99.98	71.99	3117
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-4482-3P	99.98	72.50	3147
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-6793-5P	99.97	65.95	758
HSA-MIR-507	99.97	70.11	1915
HSA-MIR-551B-5P	99.96	71.28	3493
HSA-MIR-548AJ-3P	99.96	73.38	5345
HSA-MIR-548X-3P	99.96	73.38	5345
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-1250-3P	99.96	70.04	4038

Literature-anchored findings (GeneRIF, showing 2)

• Data report a novel splicing variant of KLHL5, named KLHL5b, and describe its expression pattern in many tissues. (PMID:14672410)
• KLHL5/Cul3-based E3 ubiquitin ligase complex is important for regulation of SK1 protein stability via Lys183 ubiquitination. (PMID:31652307)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	klhl5	ENSDARG00000062122
mus_musculus	Klhl5	ENSMUSG00000054920
rattus_norvegicus	Klhl5	ENSRNOG00000008421
drosophila_melanogaster	CG17754	FBGN0030114

Paralogs (54): KLHL13 (ENSG00000003096), KLHL20 (ENSG00000076321), KEAP1 (ENSG00000079999), KLHL42 (ENSG00000087448), KLHL22 (ENSG00000099910), KLHL4 (ENSG00000102271), KLHL2 (ENSG00000109466), BACH2 (ENSG00000112182), KLHL18 (ENSG00000114648), KLHL24 (ENSG00000114796), IVNS1ABP (ENSG00000116679), KLHL12 (ENSG00000117153), KLHL29 (ENSG00000119771), KBTBD7 (ENSG00000120696), KLHL7 (ENSG00000122550), KLHL31 (ENSG00000124743), KLHDC7B (ENSG00000130487), KLHL36 (ENSG00000135686), KLHL8 (ENSG00000145332), KLHL3 (ENSG00000146021), KLHL35 (ENSG00000149243), KLHL1 (ENSG00000150361), BACH1 (ENSG00000156273), KLHL40 (ENSG00000157119), KLHL10 (ENSG00000161594), KLHL21 (ENSG00000162413), KLHDC8A (ENSG00000162873), KBTBD8 (ENSG00000163376), KBTBD6 (ENSG00000165572), KLHL26 (ENSG00000167487), KLHL30 (ENSG00000168427), KBTBD2 (ENSG00000170852), KLHL6 (ENSG00000172578), KLHL15 (ENSG00000174010), KLHL38 (ENSG00000175946), KBTBD11 (ENSG00000176595), KLHDC7A (ENSG00000179023), KLHL28 (ENSG00000179454), KBTBD3 (ENSG00000182359), KLHL33 (ENSG00000185271)

Protein

Protein identifiers

Kelch-like protein 5 — Q96PQ7 (reviewed: Q96PQ7)

All UniProt accessions (5): Q96PQ7, A0A804C9D6, A0A804CHP1, H0Y9Y5, H0YAF6

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Cytoplasm. Cytoskeleton.

Tissue specificity. Expressed in adrenal gland, ovary and thyroid gland and less abundantly in lymph node, prostate, spinal cord, testis and trachea.

Miscellaneous. May be due to intron retention. Ubiquitous expression, differentially expressed in kidney and pancreas relatively to isoform 1.

Isoforms (6)

UniProt ID	Names	Canonical?
Q96PQ7-1	1, KLHL5a	yes
Q96PQ7-2	2
Q96PQ7-3	3
Q96PQ7-4	4, KLHL5b
Q96PQ7-5	5
Q96PQ7-6	6

RefSeq proteins (4): NP_001007076, NP_001165125, NP_057074, NP_950240 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000210	BTB/POZ_dom	Domain
IPR006652	Kelch_1	Repeat
IPR011333	SKP1/BTB/POZ_sf	Homologous_superfamily
IPR011705	BACK	Domain
IPR015915	Kelch-typ_b-propeller	Homologous_superfamily
IPR030606	KLHL5_BTB/POZ	Domain
IPR056737	Beta-prop_ATRN-MKLN-like	Domain

Pfam: PF00651, PF07707, PF24981

UniProt features (26 total): sequence conflict 8, repeat 6, splice variant 5, compositionally biased region 2, sequence variant 2, chain 1, domain 1, region of interest 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96PQ7-F1	77.74	0.66

Function

Pathways and Gene Ontology

Reactome pathways

7 pathways

ID	Pathway
R-HSA-8951664	Neddylation
R-HSA-983168	Antigen processing: Ubiquitination & Proteasome degradation
R-HSA-1280218	Adaptive Immune System
R-HSA-168256	Immune System
R-HSA-392499	Metabolism of proteins
R-HSA-597592	Post-translational protein modification
R-HSA-983169	Class I MHC mediated antigen processing & presentation

MSigDB gene sets: 162 (showing top): GSE18804_SPLEEN_MACROPHAGE_VS_TUMORAL_MACROPHAGE_UP, RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP, REACTOME_ADAPTIVE_IMMUNE_SYSTEM, REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION, REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN, GOBP_MACROMOLECULE_CATABOLIC_PROCESS, LHX3_01, NKX61_01, WTGAAAT_UNKNOWN, DODD_NASOPHARYNGEAL_CARCINOMA_UP, GATA2_01, BENPORATH_NOS_TARGETS, GOMF_ACTIN_BINDING

GO Biological Process (1): proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)

GO Molecular Function (3): actin binding (GO:0003779), ubiquitin-like ligase-substrate adaptor activity (GO:1990756), protein binding (GO:0005515)

GO Cellular Component (6): cytoplasm (GO:0005737), cytosol (GO:0005829), plasma membrane (GO:0005886), microtubule cytoskeleton (GO:0015630), Cul3-RING ubiquitin ligase complex (GO:0031463), cytoskeleton (GO:0005856)

Reactome top-level categories

Rollup of top-5 pathways:

Category	Pathways
Post-translational protein modification	1
Class I MHC mediated antigen processing & presentation	1
Immune System	1
Metabolism of proteins	1
Adaptive Immune System	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
ubiquitin-dependent protein catabolic process	1
proteasomal protein catabolic process	1
cytoskeletal protein binding	1
enzyme-substrate adaptor activity	1
binding	1
intracellular anatomical structure	1
cytoplasm	1
membrane	1
cell periphery	1
cytoskeleton	1
cullin-RING ubiquitin ligase complex	1
intracellular membraneless organelle	1

Protein interactions and networks

STRING

764 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
KLHL5	TMEM156	Q8N614	636
KLHL5	PRKAR2B	P31323	571
KLHL5	ANAPC7	Q9UJX3	539
KLHL5	N4BP2	Q86UW6	489
KLHL5	WDR19	Q8NEZ3	489
KLHL5	NEDD4L	Q96PU5	481
KLHL5	LIAS	O43766	476
KLHL5	SIAH2	O43255	467
KLHL5	RFC1	P35251	449
KLHL5	ZNF684	Q5T5D7	442
KLHL5	FBXO48	Q5FWF7	439
KLHL5	OR8B4	Q96RC9	429
KLHL5	SOCS3	O14543	424
KLHL5	OR5AP2	Q8NGF4	417
KLHL5	RPL9	P32969	414

IntAct

29 interactions, top by confidence:

A	B	Type	Score
CUL3	KLHL5	psi-mi:“MI:0915”(physical association)	0.800
KLHL5	CUL3	psi-mi:“MI:0914”(association)	0.800
TRIM2	TRIM3	psi-mi:“MI:0914”(association)	0.770
KLHL1	CUL3	psi-mi:“MI:0914”(association)	0.560
CUL3	RHOBTB1	psi-mi:“MI:0914”(association)	0.530
CUL3	ZSWIM8	psi-mi:“MI:0914”(association)	0.530
SKA2	VSIG8	psi-mi:“MI:0914”(association)	0.530
SPHK1	KLHL5	psi-mi:“MI:0915”(physical association)	0.480
GABARAPL2	KLHL5	psi-mi:“MI:0915”(physical association)	0.370
KLHL5	MAP1LC3B	psi-mi:“MI:0915”(physical association)	0.370
SMN1	KLHL5	psi-mi:“MI:0915”(physical association)	0.370
TK1	KLHL5	psi-mi:“MI:0915”(physical association)	0.370
CUL3	PXDNL	psi-mi:“MI:0914”(association)	0.350
KLHL4	CUL1	psi-mi:“MI:0914”(association)	0.350
SKA2	CORO1A	psi-mi:“MI:0914”(association)	0.350
KLHL1	SNX2	psi-mi:“MI:0914”(association)	0.350
CAMK2D	PPM1D	psi-mi:“MI:0914”(association)	0.350
MYC	KLHL5	psi-mi:“MI:0915”(physical association)	0.000
KLHL5		psi-mi:“MI:0915”(physical association)	0.000
	KLHL5	psi-mi:“MI:0915”(physical association)	0.000
KLHL5	hscC	psi-mi:“MI:0915”(physical association)	0.000
fliH	KLHL5	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (28): KLHL5 (Affinity Capture-MS), KLHL5 (Two-hybrid), SPHK1 (Affinity Capture-Western), CUL3 (Affinity Capture-Western), KLHL5 (Affinity Capture-MS), KLHL5 (Affinity Capture-MS), KLHL5 (Affinity Capture-MS), KLHL5 (Affinity Capture-MS), KLHL5 (Affinity Capture-MS), KLHL5 (Reconstituted Complex), KLHL5 (Affinity Capture-MS), KLHL5 (Negative Genetic), KLHL5 (Negative Genetic), KLHL5 (Affinity Capture-MS), CUL3 (Affinity Capture-Western)

ESM2 similar proteins: A4FUN7, A5D9H7, A5PKA5, A5WWB0, A6H8I0, A6NNY8, C0HB46, D0RB01, F1M625, O75317, O89050, P0C8Z3, P50876, P50904, P62068, P62069, Q09LZ8, Q3TIX9, Q3UHD6, Q52KZ6, Q53GS9, Q5DU02, Q5F415, Q5F450, Q5IFJ9, Q5IS37, Q5IS82, Q5M981, Q5R4Q7, Q5R573, Q5R761, Q5RB35, Q5RBQ4, Q5RDP3, Q5VU57, Q60969, Q6DCJ1, Q6GNI6, Q8CEG8, Q8K4V4

Diamond homologs: A0A1B8YAB1, A1YPR0, B0WWP2, B1H285, B3M9V8, B3NDN0, B4GRJ2, B4HIK1, B4J045, B4L0G9, B4LIG6, B4MXW3, B4PD06, B4QLQ2, C9JR72, D3Z8N4, E0CZ16, G3X9X1, O15062, O88939, O93567, O95365, P28575, P41182, P41183, Q08CL3, Q08DK3, Q13105, Q16RL8, Q2M0J9, Q3UQV5, Q52KB5, Q5EXX3, Q5R7B8, Q5RDY3, Q5TC79, Q5ZI33, Q5ZKD9, Q5ZM39, Q60821

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 23 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

GO biological processes:

GO term	Partners	Fold	FDR
proteasome-mediated ubiquitin-dependent protein catabolic process	7	18.3×	1e-05

Disease & clinical

Clinical variants and AI predictions

ClinVar

112 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	91
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1961 predictions. Top by Δscore:

Variant	Effect	Δscore
4:39045094:GCG:G	donor_gain	1.0000
4:39045095:CGGTA:C	donor_loss	1.0000
4:39045097:G:GG	donor_gain	1.0000
4:39045097:GT:G	donor_loss	1.0000
4:39045098:T:G	donor_loss	1.0000
4:39075959:TTTCA:T	acceptor_loss	1.0000
4:39075961:TCAG:T	acceptor_loss	1.0000
4:39075962:CA:C	acceptor_loss	1.0000
4:39081099:ACAG:A	acceptor_loss	1.0000
4:39081100:CA:C	acceptor_loss	1.0000
4:39081101:A:AC	acceptor_loss	1.0000
4:39081101:A:AG	acceptor_gain	1.0000
4:39081101:AGATT:A	acceptor_gain	1.0000
4:39081102:G:GG	acceptor_gain	1.0000
4:39081102:G:GT	acceptor_loss	1.0000
4:39081102:GATTG:G	acceptor_gain	1.0000
4:39081236:ACAG:A	donor_loss	1.0000
4:39081238:AG:A	donor_loss	1.0000
4:39081239:GGTAA:G	donor_loss	1.0000
4:39081241:T:G	donor_loss	1.0000
4:39081961:A:G	acceptor_gain	1.0000
4:39086674:A:T	donor_gain	1.0000
4:39086677:GATC:G	donor_gain	1.0000
4:39086680:C:CG	donor_gain	1.0000
4:39086680:C:G	donor_gain	1.0000
4:39086684:G:GG	donor_gain	1.0000
4:39088169:T:TG	donor_gain	1.0000
4:39096690:A:AG	acceptor_gain	1.0000
4:39096691:G:GG	acceptor_gain	1.0000
4:39096826:G:GT	donor_gain	1.0000

AlphaMissense

4959 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
4:39076104:G:C	D221H	1.000
4:39076105:A:C	D221A	1.000
4:39076105:A:G	D221G	1.000
4:39076105:A:T	D221V	1.000
4:39076114:T:C	L224S	1.000
4:39076141:C:A	A233D	1.000
4:39076143:C:G	H234D	1.000
4:39076144:A:G	H234R	1.000
4:39076147:G:C	R235T	1.000
4:39081103:A:C	R235S	1.000
4:39081103:A:T	R235S	1.000
4:39081105:T:G	L236W	1.000
4:39081108:T:A	V237E	1.000
4:39081111:T:A	L238H	1.000
4:39081111:T:C	L238P	1.000
4:39081111:T:G	L238R	1.000
4:39081128:T:C	Y244H	1.000
4:39081131:T:C	F245L	1.000
4:39081132:T:C	F245S	1.000
4:39081133:T:A	F245L	1.000
4:39081133:T:G	F245L	1.000
4:39081141:T:C	M248T	1.000
4:39081142:G:A	M248I	1.000
4:39081142:G:C	M248I	1.000
4:39081142:G:T	M248I	1.000
4:39081143:T:A	F249I	1.000
4:39081143:T:C	F249L	1.000
4:39081143:T:G	F249V	1.000
4:39081144:T:C	F249S	1.000
4:39081144:T:G	F249C	1.000

dbSNP variants (sampled 300 via entrez): RS1000033272 (4:39127487 G>A), RS1000048856 (4:39052640 C>G), RS1000066156 (4:39130532 T>G), RS1000112032 (4:39079851 G>C), RS1000124415 (4:39072991 T>A), RS1000160367 (4:39130828 G>A), RS1000225942 (4:39113588 A>G), RS1000226967 (4:39094342 G>T), RS1000233297 (4:39065575 A>G), RS1000234354 (4:39073277 A>G), RS10002441 (4:39096149 T>C), RS1000251037 (4:39073272 T>A,C), RS1000320211 (4:39137038 A>G), RS1000336059 (4:39058371 A>G), RS1000339285 (4:39115526 A>G,T)

Disease associations

OMIM: gene MIM:608064 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST002088_4	Asthma (childhood onset)	3.000000e-07

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

52 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, increases expression	5
sodium arsenite	decreases expression, increases expression	2
Acetaminophen	decreases expression	2
Benzo(a)pyrene	affects methylation, increases expression	2
Cisplatin	affects expression, increases expression	2
Phenylmercuric Acetate	affects cotreatment, increases expression	2
Smoke	decreases expression, increases abundance	2
Cyclosporine	decreases expression	2
aristolochic acid I	decreases expression	1
dicrotophos	decreases expression	1
methylmercuric chloride	decreases expression	1
benzo(e)pyrene	increases methylation	1
potassium chromate(VI)	decreases expression	1
2,3-bis(3’-hydroxybenzyl)butyrolactone	affects cotreatment, decreases expression	1
mercuric bromide	affects cotreatment, decreases expression	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
perfluoro-n-nonanoic acid	increases expression	1
entinostat	increases expression	1
K 7174	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	decreases expression, increases expression, affects cotreatment	1
dorsomorphin	affects cotreatment, decreases expression, increases expression	1
MT19c compound	increases expression	1
Resveratrol	affects cotreatment, increases expression	1
Temozolomide	decreases expression	1
Decitabine	affects expression	1
Troglitazone	increases expression	1
Vorinostat	increases expression	1
Leflunomide	increases expression	1
Air Pollutants	decreases expression, increases abundance	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.