KLRK1-AS1

Summary

KLRK1-AS1 (KLRK1 antisense RNA 1, HGNC:54868) is a long non-coding RNA gene on chromosome 12p13.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:54868
Approved symbol	KLRK1-AS1
Name	KLRK1 antisense RNA 1
Location	12p13.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	LOC101928100, TP53LC04
Ensembl gene	ENSG00000245648
Ensembl biotype	lncRNA
Entrez	101928100
RNAcentral	URS000059E32C — lncRNA, 2830 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 37 — 37 lncRNA

ENST00000500682, ENST00000654540, ENST00000663376, ENST00000665123, ENST00000666750, ENST00000671087, ENST00000816480, ENST00000816481, ENST00000816482, ENST00000816483, ENST00000816484, ENST00000816485, ENST00000816486, ENST00000816487, ENST00000816488, ENST00000816489, ENST00000816490, ENST00000816491, ENST00000816492, ENST00000816493, ENST00000816494, ENST00000816495, ENST00000816496, ENST00000816497, ENST00000816498, ENST00000816499, ENST00000816500, ENST00000816501, ENST00000816502, ENST00000816503, ENST00000816504, ENST00000816505, ENST00000816506, ENST00000816507, ENST00000816508, ENST00000816509, ENST00000816510

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000500682 — 4 exons

Exon	Start	End
ENSE00001962648	10374035	10374136
ENSE00001969973	10396179	10398506
ENSE00001970789	10379702	10379836
ENSE00001975845	10363769	10364033

Expression profiles

Bgee: expression breadth ubiquitous, 168 present calls, max score 89.24.

FANTOM5 (CAGE): breadth broad, TPM avg 0.8697 / max 57.4153, expressed in 299 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
124164	0.7101	230
124165	0.1596	70

Top tissues by expression

246 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	89.24	gold quality
minor salivary gland	UBERON:0001830	82.07	gold quality
granulocyte	CL:0000094	81.93	gold quality
mouth mucosa	UBERON:0003729	79.42	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	77.17	gold quality
left testis	UBERON:0004533	76.89	gold quality
right testis	UBERON:0004534	76.68	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	76.36	gold quality
islet of Langerhans	UBERON:0000006	76.19	gold quality
testis	UBERON:0000473	76.19	gold quality
esophagus mucosa	UBERON:0002469	76.08	gold quality
saliva-secreting gland	UBERON:0001044	76.04	gold quality
oocyte	CL:0000023	75.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	75.57	gold quality
colonic epithelium	UBERON:0000397	74.79	gold quality
right adrenal gland	UBERON:0001233	73.86	gold quality
left adrenal gland	UBERON:0001234	73.82	gold quality
urinary bladder	UBERON:0001255	73.75	gold quality
right uterine tube	UBERON:0001302	73.48	gold quality
adrenal gland	UBERON:0002369	72.98	gold quality
epithelial cell of pancreas	CL:0000083	72.86	gold quality
bone marrow cell	CL:0002092	72.78	gold quality
left adrenal gland cortex	UBERON:0035825	72.76	gold quality
left ovary	UBERON:0002119	72.35	gold quality
skin of abdomen	UBERON:0001416	72.20	gold quality
right adrenal gland cortex	UBERON:0035827	72.00	gold quality
right ovary	UBERON:0002118	71.46	gold quality
adrenal cortex	UBERON:0001235	71.17	gold quality
ovary	UBERON:0000992	71.05	gold quality
vagina	UBERON:0000996	70.86	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.57

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.