KMT2E-AS1

Summary

KMT2E-AS1 (KMT2E antisense RNA 1, HGNC:40845) is a long non-coding RNA gene on chromosome 7q22.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40845
Approved symbol	KMT2E-AS1
Name	KMT2E antisense RNA 1
Location	7q22.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	lncPENG, LOC100216545, RP11-325F22.5.1
Ensembl gene	ENSG00000239569
Ensembl biotype	lncRNA
Entrez	100216545
RNAcentral	URS000075E1F2 — lncRNA, 3615 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 64 — 64 lncRNA

ENST00000445184, ENST00000450686, ENST00000453666, ENST00000453677, ENST00000631061, ENST00000655204, ENST00000684821, ENST00000687367, ENST00000687790, ENST00000687813, ENST00000690482, ENST00000690819, ENST00000702542, ENST00000715773, ENST00000715774, ENST00000718398, ENST00000787479, ENST00000787480, ENST00000787481, ENST00000787482, ENST00000787483, ENST00000787484, ENST00000787485, ENST00000787486, ENST00000787487, ENST00000787488, ENST00000787489, ENST00000787490, ENST00000787491, ENST00000787492, ENST00000787493, ENST00000787494, ENST00000787495, ENST00000787496, ENST00000787497, ENST00000787498, ENST00000787499, ENST00000787500, ENST00000787501, ENST00000787502, ENST00000787503, ENST00000787504, ENST00000787505, ENST00000787506, ENST00000787507, ENST00000787508, ENST00000787509, ENST00000787510, ENST00000787511, ENST00000787512, ENST00000787513, ENST00000787514, ENST00000787515, ENST00000787516, ENST00000787517, ENST00000787518, ENST00000787519, ENST00000787520, ENST00000787521, ENST00000787522, ENST00000787523, ENST00000787524, ENST00000787525, ENST00000787526

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000445184 — 2 exons

Exon	Start	End
ENSE00001626031	105012932	105013024
ENSE00001736465	104982099	104982691

Expression profiles

Bgee: expression breadth ubiquitous, 136 present calls, max score 96.76.

FANTOM5 (CAGE): breadth broad, TPM avg 1.9216 / max 108.5483, expressed in 875 samples.

FANTOM5 promoters (10 alternative TSS)

Promoter ID	TPM avg	Samples expressed
85420	11.0918	1777
85419	5.6534	1511
85421	4.3902	1429
85414	0.8325	447
85412	0.6037	269
85413	0.3830	134
85405	0.2887	64
85404	0.1252	38
85411	0.1024	52
85403	0.0945	32

Top tissues by expression

138 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
thymus	UBERON:0002370	96.76	gold quality
quadriceps femoris	UBERON:0001377	90.88	gold quality
granulocyte	CL:0000094	90.56	gold quality
right hemisphere of cerebellum	UBERON:0014890	88.65	gold quality
cerebellar hemisphere	UBERON:0002245	88.31	gold quality
cerebellar cortex	UBERON:0002129	88.02	gold quality
cerebellum	UBERON:0002037	87.98	gold quality
cerebellar vermis	UBERON:0004720	87.73	gold quality
gastrocnemius	UBERON:0001388	86.11	gold quality
muscle of leg	UBERON:0001383	85.76	gold quality
spleen	UBERON:0002106	85.55	gold quality
right uterine tube	UBERON:0001302	85.40	gold quality
mucosa of transverse colon	UBERON:0004991	84.74	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	84.57	gold quality
apex of heart	UBERON:0002098	84.20	gold quality
lower esophagus mucosa	UBERON:0035834	83.80	gold quality
pituitary gland	UBERON:0000007	83.68	gold quality
hindlimb stylopod muscle	UBERON:0004252	83.13	gold quality
right lobe of liver	UBERON:0001114	83.09	gold quality
right lung	UBERON:0002167	83.09	gold quality
blood	UBERON:0000178	82.75	gold quality
adenohypophysis	UBERON:0002196	82.46	gold quality
monocyte	CL:0000576	82.31	gold quality
prostate gland	UBERON:0002367	82.23	gold quality
right lobe of thyroid gland	UBERON:0001119	82.20	gold quality
leukocyte	CL:0000738	82.07	gold quality
left lobe of thyroid gland	UBERON:0001120	81.90	gold quality
sural nerve	UBERON:0015488	81.34	gold quality
thyroid gland	UBERON:0002046	81.33	gold quality
small intestine Peyer’s patch	UBERON:0003454	81.05	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-9543	yes	18.82
E-ANND-3	yes	5.67

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Allele-specific control of rodent and human lncRNA KMT2E-AS1 promotes hypoxic endothelial pathology in pulmonary hypertension. (PMID:38198571)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.