KNDC1

Summary

KNDC1 (kinase non-catalytic C-lobe domain containing 1, HGNC:29374) is a protein-coding gene on chromosome 10q26.3, encoding Kinase non-catalytic C-lobe domain-containing protein 1 (Q76NI1). RAS-Guanine nucleotide exchange factor (GEF) that controls the negative regulation of neuronal dendrite growth by mediating a signaling pathway linking RAS and MAP2.

The protein encoded by this gene is a Ras guanine nucleotide exchange factor that appears to negatively regulate dendritic growth in the brain. Knockdown of this gene in senescent umbilical vein endothelial cells partially reversed the senescence, showing that this gene could potentially be targeted by anti-aging therapies.

Source: NCBI Gene 85442 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 385 total — 1 pathogenic
• MANE Select transcript: NM_152643

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:29374
Approved symbol	KNDC1
Name	kinase non-catalytic C-lobe domain containing 1
Location	10q26.3
Locus type	gene with protein product
Status	Approved
Aliases	KIAA1768, bB439H18.3, FLJ25027, Very-KIND, v-KIND
Ensembl gene	ENSG00000171798
Ensembl biotype	protein_coding
OMIM	616237
Entrez	85442

Gene structure

Transcript identifiers

Ensembl transcripts: 27 — 12 protein_coding, 9 nonsense_mediated_decay, 5 retained_intron, 1 protein_coding_CDS_not_defined

ENST00000304613, ENST00000368571, ENST00000478074, ENST00000485110, ENST00000530127, ENST00000682119, ENST00000682309, ENST00000682310, ENST00000682399, ENST00000682765, ENST00000683144, ENST00000683171, ENST00000683259, ENST00000683646, ENST00000683920, ENST00000684081, ENST00000684098, ENST00000684127, ENST00000684244, ENST00000684248, ENST00000684271, ENST00000684403, ENST00000684739, ENST00000684767, ENST00000919719, ENST00000946347, ENST00000946348

RefSeq mRNA: 4 — MANE Select: NM_152643 NM_001347864, NM_001347865, NM_001347866, NM_152643

CCDS: CCDS7674, CCDS91388, CCDS91389, CCDS91390

Canonical transcript exons

ENST00000304613 — 30 exons

Exon	Start	End
ENSE00001096949	133219031	133219090
ENSE00001096954	133219955	133220112
ENSE00001152990	133224659	133226412
ENSE00001152998	133206685	133206778
ENSE00001153056	133188539	133188653
ENSE00001323571	133206856	133206953
ENSE00001356846	133189598	133189669
ENSE00001409509	133207137	133207351
ENSE00001647099	133218831	133218953
ENSE00001669459	133211422	133211569
ENSE00001675307	133213645	133213727
ENSE00001680208	133212716	133212922
ENSE00001697341	133213972	133214122
ENSE00001801667	133211679	133211858
ENSE00001949770	133160219	133160569
ENSE00003243477	133201501	133201898
ENSE00003283928	133198578	133199266
ENSE00003313627	133189752	133189813
ENSE00003326058	133200375	133200460
ENSE00003342425	133183344	133183490
ENSE00003350272	133185974	133186674
ENSE00003369482	133197058	133197135
ENSE00003392339	133195663	133195821
ENSE00003401353	133198337	133198499
ENSE00003401489	133210611	133210724
ENSE00003421125	133183872	133183989
ENSE00003431146	133199458	133199602
ENSE00003437093	133197675	133197768
ENSE00003526294	133168254	133168312
ENSE00003691247	133167381	133167579

Expression profiles

Bgee: expression breadth ubiquitous, 190 present calls, max score 94.08.

FANTOM5 (CAGE): breadth broad, TPM avg 2.6135 / max 101.4175, expressed in 574 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
107750	1.7222	497
107751	0.7355	244
107749	0.1558	84

Top tissues by expression

252 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right hemisphere of cerebellum	UBERON:0014890	94.08	gold quality
cerebellar hemisphere	UBERON:0002245	93.69	gold quality
cerebellar cortex	UBERON:0002129	93.63	gold quality
lateral nuclear group of thalamus	UBERON:0002736	93.43	gold quality
right uterine tube	UBERON:0001302	93.28	gold quality
cerebellum	UBERON:0002037	93.12	gold quality
right frontal lobe	UBERON:0002810	92.46	gold quality
Brodmann (1909) area 9	UBERON:0013540	90.49	gold quality
pituitary gland	UBERON:0000007	90.33	gold quality
left adrenal gland cortex	UBERON:0035825	90.24	gold quality
anterior cingulate cortex	UBERON:0009835	90.12	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	90.10	gold quality
left adrenal gland	UBERON:0001234	89.76	gold quality
bronchial epithelial cell	CL:0002328	89.72	gold quality
amygdala	UBERON:0001876	89.58	gold quality
primary visual cortex	UBERON:0002436	89.58	gold quality
right adrenal gland	UBERON:0001233	89.55	gold quality
adenohypophysis	UBERON:0002196	89.46	gold quality
frontal cortex	UBERON:0001870	89.15	gold quality
entorhinal cortex	UBERON:0002728	89.10	gold quality
temporal lobe	UBERON:0001871	89.03	gold quality
cerebellar vermis	UBERON:0004720	89.01	gold quality
neocortex	UBERON:0001950	88.89	gold quality
bronchus	UBERON:0002185	88.69	gold quality
postcentral gyrus	UBERON:0002581	88.68	gold quality
right adrenal gland cortex	UBERON:0035827	88.45	gold quality
cerebral cortex	UBERON:0000956	88.40	gold quality
adrenal cortex	UBERON:0001235	88.38	gold quality
hypothalamus	UBERON:0001898	88.38	gold quality
superior frontal gyrus	UBERON:0002661	88.38	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	7.89

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

33 targeting KNDC1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6867-5P	100.00	82.21	3464
HSA-MIR-4723-5P	99.97	68.70	2034
HSA-MIR-1250-3P	99.96	70.04	4038
HSA-MIR-545-3P	99.95	70.74	2783
HSA-MIR-153-5P	99.89	73.86	6317
HSA-MIR-4731-5P	99.89	67.23	2537
HSA-MIR-4447	99.85	67.81	2900
HSA-MIR-12130	99.75	65.47	452
HSA-MIR-6762-3P	99.66	66.94	1188
HSA-MIR-4472	99.56	66.08	1478
HSA-MIR-1207-5P	99.49	69.11	2983
HSA-MIR-3612	99.45	66.02	1333
HSA-MIR-650	99.45	65.77	1309
HSA-MIR-3692-5P	99.29	67.04	1421
HSA-MIR-6852-5P	99.17	66.69	2073
HSA-MIR-892C-5P	99.16	70.56	2116
HSA-MIR-6791-5P	99.16	65.92	1844
HSA-MIR-4292	99.16	65.57	1767
HSA-MIR-4763-3P	99.10	67.83	2649
HSA-MIR-4650-3P	99.01	68.39	1062
HSA-MIR-4744	99.01	69.91	1581
HSA-MIR-4451	98.82	68.17	1455
HSA-MIR-384	98.71	67.34	1229
HSA-MIR-6830-3P	98.62	68.07	1760
HSA-MIR-4443	98.02	66.25	1928
HSA-MIR-637	97.91	64.05	1517
HSA-MIR-7111-3P	97.80	66.75	1467
HSA-MIR-299-3P	97.73	66.67	773
HSA-MIR-4714-5P	97.04	67.76	955
HSA-MIR-7847-3P	96.63	64.58	952

Literature-anchored findings (GeneRIF, showing 2)

• KNDC1 knockdown promoted HUVEC proliferation via the extracellular signal-regulated kinase signaling pathway and delayed HUVEC senescence by inhibiting the p53-p21-p16 transduction cascade. (PMID:24788352)
• The results demonstrated that KNDC1 overexpression possibly inhibited HUVEC activity and function and promoted HUVEC senescence. Mechanistic studies demonstrated that KNDC1 triggered a p53ROS positive feedback loop, which serves a crucial role in regulating senescence. (PMID:29568929)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio		ENSDARG00000116483
mus_musculus	Kndc1	ENSMUSG00000066129
rattus_norvegicus	Kndc1	ENSRNOG00000027240

Protein

Protein identifiers

Kinase non-catalytic C-lobe domain-containing protein 1 — Q76NI1 (reviewed: Q76NI1)

Alternative names: Cerebral protein 9, Protein very KIND, Ras-GEF domain-containing family member 2

All UniProt accessions (14): Q76NI1, A0A7I2PM36, A0A804HHZ0, A0A804HI19, A0A804HI34, A0A804HID6, A0A804HIF7, A0A804HIR2, A0A804HIR7, A0A804HIZ4, A0A804HJH2, A0A804HKE4, A0A804HKF6, A0A804HKW7

UniProt curated annotations — full annotation on UniProt →

Function. RAS-Guanine nucleotide exchange factor (GEF) that controls the negative regulation of neuronal dendrite growth by mediating a signaling pathway linking RAS and MAP2. May be involved in cellular senescence.

Subunit / interactions. Interacts (via KIND2) with MAP2; the interaction enhances MAP2 phosphorylation and localizes KNDC1 to dendrites.

Subcellular location. Cell projection. Dendrite. Perikaryon.

Tissue specificity. Expressed specifically in the cerebral cortex.

Isoforms (2)

UniProt ID	Names	Canonical?
Q76NI1-1	1	yes
Q76NI1-4	2

RefSeq proteins (4): NP_001334793, NP_001334794, NP_001334795, NP_689856* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000651	Ras-like_Gua-exchang_fac_N	Domain
IPR001895	RASGEF_cat_dom	Domain
IPR011009	Kinase-like_dom_sf	Homologous_superfamily
IPR011019	KIND_dom	Domain
IPR023578	Ras_GEF_dom_sf	Homologous_superfamily
IPR029899	KNDC1	Family
IPR036964	RASGEF_cat_dom_sf	Homologous_superfamily

Pfam: PF00617, PF00618, PF16474

UniProt features (38 total): compositionally biased region 10, sequence conflict 10, sequence variant 5, domain 4, region of interest 4, splice variant 2, chain 1, modified residue 1, coiled-coil region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q76NI1-F1	61.25	0.22

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 964

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 79 (showing top): GOBP_DENDRITE_DEVELOPMENT, GOBP_HINDBRAIN_DEVELOPMENT, GOBP_METENCEPHALON_DEVELOPMENT, GOBP_REGULATION_OF_DENDRITE_MORPHOGENESIS, GOBP_CEREBELLAR_CORTEX_MORPHOGENESIS, GOBP_NEUROGENESIS, GOBP_REGULATION_OF_CELL_PROJECTION_ORGANIZATION, GOBP_CEREBELLAR_GRANULAR_LAYER_DEVELOPMENT, GOBP_CEREBELLAR_CORTEX_DEVELOPMENT, GOBP_DENDRITE_MORPHOGENESIS, GOBP_CELL_DIFFERENTIATION_IN_HINDBRAIN, GOBP_CENTRAL_NERVOUS_SYSTEM_NEURON_DIFFERENTIATION, SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_DN, GOBP_HEAD_DEVELOPMENT, GOBP_REGULATION_OF_NEURON_PROJECTION_DEVELOPMENT

GO Biological Process (4): small GTPase-mediated signal transduction (GO:0007264), cerebellar granule cell differentiation (GO:0021707), regulation of dendrite morphogenesis (GO:0048814), regulation of dendrite development (GO:0050773)

GO Molecular Function (1): guanyl-nucleotide exchange factor activity (GO:0005085)

GO Cellular Component (5): dendrite (GO:0030425), guanyl-nucleotide exchange factor complex (GO:0032045), neuronal cell body (GO:0043025), perikaryon (GO:0043204), cell projection (GO:0042995)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
intracellular signaling cassette	1
cell differentiation in hindbrain	1
cerebellar granular layer formation	1
central nervous system neuron differentiation	1
glutamatergic neuron differentiation	1
regulation of anatomical structure morphogenesis	1
dendrite morphogenesis	1
regulation of dendrite development	1
regulation of neuron projection development	1
dendrite development	1
regulation of developmental process	1
GTP binding	1
GDP binding	1
GTPase regulator activity	1
neuron projection	1
dendritic tree	1
intracellular protein-containing complex	1
somatodendritic compartment	1
cell body	1
neuronal cell body	1

Protein interactions and networks

STRING

776 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
KNDC1	ADGRA1	Q86SQ6	665
KNDC1	CDH24	Q86UP0	579
KNDC1	ZSCAN29	Q8IWY8	518
KNDC1	CDHR2	Q9BYE9	518
KNDC1	ITM2C	Q9NQX7	513
KNDC1	ZSCAN20	P17040	490
KNDC1	LRRC71	Q8N4P6	480
KNDC1	CDH18	Q13634	446
KNDC1	SLC36A4	Q6YBV0	434
KNDC1	PTPRT	O14522	429
KNDC1	FRMPD2	Q68DX3	419
KNDC1	GPR183	P32249	386
KNDC1	VENTX	O95231	376
KNDC1	SLC15A1	P46059	368
KNDC1	SHISAL2A	Q6UWV7	365

IntAct

9 interactions, top by confidence:

A	B	Type	Score
P/V	IRS4	psi-mi:“MI:0914”(association)	0.530
KNDC1	LMNA	psi-mi:“MI:0915”(physical association)	0.400
KNDC1	ATP5PO	psi-mi:“MI:0915”(physical association)	0.400
Xpo1	IFT56	psi-mi:“MI:0914”(association)	0.350
Prdm16	ESYT2	psi-mi:“MI:0914”(association)	0.350
CUL3	PXDNL	psi-mi:“MI:0914”(association)	0.350
MYC	PDZD2	psi-mi:“MI:0914”(association)	0.350
KNDC1	ASAP2	psi-mi:“MI:0914”(association)	0.350

BioGRID (26): KNDC1 (Affinity Capture-MS), KNDC1 (Affinity Capture-RNA), KNDC1 (Affinity Capture-MS), KNDC1 (Proximity Label-MS), KNDC1 (Proximity Label-MS), KNDC1 (Affinity Capture-MS), ANAPC4 (Affinity Capture-MS), DYRK1A (Affinity Capture-MS), EPDR1 (Affinity Capture-MS), NDUFS1 (Affinity Capture-MS), PPP2R5B (Affinity Capture-MS), PPP2R5E (Affinity Capture-MS), PPP2R5A (Affinity Capture-MS), AHCYL2 (Affinity Capture-MS), DCAF7 (Affinity Capture-MS)

ESM2 similar proteins: A0A0U1RRK4, A0A1W2PPE3, A0A1W2PR82, A0A2Z4LIS9, A2VE02, A4D1S0, A5PKC7, A5PL33, A6H7B4, A6NEL2, A6QP24, A6QPM6, A8MTW9, A8MYA2, D3ZAQ5, D4AAA5, E7EW31, O75474, O75638, O89113, O94850, P0C7X2, P14652, P50617, P70339, Q2KIS6, Q3UN58, Q5JPB2, Q5VZ46, Q6GQX2, Q6NZ36, Q6ZSJ8, Q6ZW13, Q76NI1, Q7TNS8, Q80TS7, Q86UU5, Q8IWN7, Q8N6K4, Q8N944

Diamond homologs: Q0KK55, Q76NI1, Q8IS18

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
KNDC1	“up-regulates activity”	MAP2	phosphorylation

Disease & clinical

Clinical variants and AI predictions

ClinVar

385 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	324
Likely benign	34
Benign	8

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
2574693	GRCh37/hg19 10q26.13-26.3(chr10:123477898-135427143)	Pathogenic

SpliceAI

6779 predictions. Top by Δscore:

Variant	Effect	Δscore
10:133160566:CGAGG:C	donor_loss	1.0000
10:133160567:GAG:G	donor_gain	1.0000
10:133160567:GAGGT:G	donor_loss	1.0000
10:133160568:AGGTG:A	donor_loss	1.0000
10:133160569:GGTG:G	donor_loss	1.0000
10:133160570:G:C	donor_loss	1.0000
10:133160570:G:GG	donor_gain	1.0000
10:133160571:T:G	donor_loss	1.0000
10:133167577:GCG:G	donor_gain	1.0000
10:133168252:A:G	acceptor_gain	1.0000
10:133168253:G:GG	acceptor_gain	1.0000
10:133183338:CCACA:C	acceptor_loss	1.0000
10:133183341:CA:C	acceptor_loss	1.0000
10:133183342:A:AG	acceptor_gain	1.0000
10:133183342:A:C	acceptor_loss	1.0000
10:133183343:G:GG	acceptor_gain	1.0000
10:133183343:GGC:G	acceptor_gain	1.0000
10:133183343:GGCGC:G	acceptor_gain	1.0000
10:133183488:GAG:G	donor_gain	1.0000
10:133183488:GAGGT:G	donor_loss	1.0000
10:133183489:AGG:A	donor_loss	1.0000
10:133183490:GGT:G	donor_loss	1.0000
10:133183491:G:GG	donor_gain	1.0000
10:133183491:GT:G	donor_loss	1.0000
10:133188537:AGTG:A	acceptor_gain	1.0000
10:133188538:GTGG:G	acceptor_gain	1.0000
10:133198497:CAGGT:C	donor_loss	1.0000
10:133198498:AGGT:A	donor_loss	1.0000
10:133198501:T:A	donor_loss	1.0000
10:133199450:A:AG	acceptor_gain	1.0000

AlphaMissense

11365 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
10:133167538:T:C	F87S	0.999
10:133220099:T:A	W1669R	0.999
10:133220099:T:C	W1669R	0.999
10:133206752:T:C	L1152P	0.998
10:133211468:A:C	S1319R	0.998
10:133211470:C:A	S1319R	0.998
10:133211470:C:G	S1319R	0.998
10:133211489:T:A	W1326R	0.998
10:133211489:T:C	W1326R	0.998
10:133214084:T:A	W1547R	0.998
10:133214084:T:C	W1547R	0.998
10:133214093:G:C	A1550P	0.998
10:133219077:T:C	L1616P	0.998
10:133167532:T:C	L85P	0.997
10:133206739:T:C	F1148L	0.997
10:133206741:C:A	F1148L	0.997
10:133206741:C:G	F1148L	0.997
10:133207330:T:C	L1258P	0.997
10:133167562:T:C	F95S	0.996
10:133183372:T:C	L130P	0.996
10:133199538:T:A	W947R	0.996
10:133199538:T:C	W947R	0.996
10:133199563:T:C	L955P	0.996
10:133206886:T:C	L1171P	0.996
10:133212906:T:C	L1476P	0.996
10:133167444:T:A	W56R	0.995
10:133167444:T:C	W56R	0.995
10:133167453:T:C	C59R	0.995
10:133167517:T:A	I80N	0.995
10:133183362:G:T	G127W	0.995

dbSNP variants (sampled 300 via entrez): RS1000015295 (10:133170226 C>T), RS1000089431 (10:133178596 G>A), RS1000096301 (10:133161899 G>A,T), RS1000126885 (10:133200868 T>C), RS1000167809 (10:133196359 C>T), RS1000177906 (10:133211126 G>A), RS1000234290 (10:133204496 C>T), RS1000268903 (10:133165322 G>A), RS1000318661 (10:133192342 G>C,T), RS1000375060 (10:133173731 C>T), RS1000391039 (10:133200373 AGCACGGC>A), RS1000411933 (10:133200702 G>A), RS1000453167 (10:133216860 G>A), RS1000480869 (10:133189067 G>A,T), RS1000494824 (10:133168763 G>T)

Disease associations

OMIM: gene MIM:616237 | disease phenotypes: MIM:609625

GenCC curated gene-disease

Mondo (2): breast ductal adenocarcinoma (MONDO:0005590), distal 10q deletion syndrome (MONDO:0012315)

Orphanet (1): Distal deletion 10q syndrome (Orphanet:96148)

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST008512_29	Multisite chronic pain	4.000000e-08
GCST009514_3	Recurrence of mild malaria attacks	8.000000e-07
GCST90000514_15	Gastroesophageal reflux disease	5.000000e-10

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0010100	multisite chronic pain
EFO:0004952	disease recurrence

MeSH disease descriptors (2)

Descriptor	Name	Tree numbers
D018270	Carcinoma, Ductal, Breast	C04.557.470.200.025.232.500; C04.557.470.615.132.500; C04.588.180.390; C17.800.090.500.390
C567182	Chromosome 10q26 Deletion Syndrome (supp.)

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

33 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
mercuric bromide	decreases expression, affects cotreatment	2
Benzo(a)pyrene	affects methylation, increases methylation	2
Phenylmercuric Acetate	affects cotreatment, decreases expression	2
Tobacco Smoke Pollution	decreases methylation, decreases expression	2
Valproic Acid	increases methylation, affects expression	2
fluorene-9-bisphenol	decreases expression	1
bisphenol A	decreases methylation	1
ethyl-p-hydroxybenzoate	decreases expression	1
sodium arsenite	affects binding, increases reaction	1
butyraldehyde	decreases expression	1
benzo(e)pyrene	increases methylation	1
aflatoxin B2	affects methylation	1
CGP 52608	increases reaction, affects binding	1
entinostat	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
abrine	decreases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
licochalcone B	decreases expression	1
bisphenol S	decreases methylation	1
jinfukang	increases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Sunitinib	increases expression	1
Acetaminophen	increases expression	1
Air Pollutants	affects methylation, increases abundance	1
Cadmium	increases abundance, decreases expression	1
Copper	affects cotreatment, decreases expression	1
Diazinon	increases methylation	1
Diethylhexyl Phthalate	decreases expression	1
Methapyrilene	increases methylation	1
Silicon Dioxide	decreases expression	1

Clinical trials (associated diseases)

11 trials via MONDO — disease-level, not drug-specific.

Trial	Phase	Status	Title
NCT03414970	PHASE3	ACTIVE_NOT_RECRUITING	Hypofractionated Radiation Therapy After Mastectomy in Preventing Recurrence in Patients With Stage IIa-IIIa Breast Cancer
NCT00461344	PHASE2	TERMINATED	Docetaxel + Doxorubicin as Neoadjuvant Chemotherapy in Patients With Breast Cancer
NCT07499999	PHASE2	NOT_YET_RECRUITING	Randomized Double-Blind Phase II Trial of Baby Exemestane Versus Baby Tamoxifen in Post-Menopausal Women at High Risk for Breast Cancer
NCT00637364	PHASE1/PHASE2	SUSPENDED	High Intensity Focused Ultrasound Tumor Treatment for Pancreatic Cancer Pain
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