KPNA7

Summary

KPNA7 (karyopherin subunit alpha 7, HGNC:21839) is a protein-coding gene on chromosome 7q22.1, encoding Importin subunit alpha-8 (A9QM74). Functions in nuclear protein import.

The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import, but exhibits different nuclear localization signal binding specificity compared to other members of the family. A pseudogene of this gene has been defined on chromosome 5.

Source: NCBI Gene 402569 — RefSeq curated summary.

At a glance

• Gene–disease (curated): oocyte/zygote/embryo maturation arrest 17 (Strong, GenCC) — +3 more curated relationships
• Clinical variants (ClinVar): 553 total — 2 pathogenic
• Phenotypes (HPO): 4
• MANE Select transcript: NM_001145715

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:21839
Approved symbol	KPNA7
Name	karyopherin subunit alpha 7
Location	7q22.1
Locus type	gene with protein product
Status	Approved
Aliases	IPOA8
Ensembl gene	ENSG00000185467
Ensembl biotype	protein_coding
OMIM	614107
Entrez	402569

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 protein_coding

ENST00000327442, ENST00000681060, ENST00000893183, ENST00000893184

RefSeq mRNA: 1 — MANE Select: NM_001145715 NM_001145715

CCDS: CCDS47651

Canonical transcript exons

ENST00000327442 — 11 exons

Exon	Start	End
ENSE00001293168	99195070	99195338
ENSE00001296710	99177920	99178066
ENSE00001302397	99196084	99196166
ENSE00001304989	99184929	99185162
ENSE00001311627	99207401	99207489
ENSE00001312636	99193019	99193101
ENSE00001316188	99181883	99182065
ENSE00001325308	99203106	99203240
ENSE00001328201	99188300	99188563
ENSE00001618379	99173572	99173794
ENSE00003912445	99208028	99208115

Expression profiles

Bgee: expression breadth broad, 52 present calls, max score 89.41.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0497 / max 10.1642, expressed in 17 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
85089	0.0279	8
85088	0.0218	7

Top tissues by expression

118 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	89.41	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	64.92	gold quality
islet of Langerhans	UBERON:0000006	64.21	gold quality
right uterine tube	UBERON:0001302	63.11	gold quality
gall bladder	UBERON:0002110	55.03	gold quality
esophagus mucosa	UBERON:0002469	53.35	gold quality
body of stomach	UBERON:0001161	52.62	gold quality
lower esophagus mucosa	UBERON:0035834	52.21	gold quality
stomach	UBERON:0000945	51.29	gold quality
fallopian tube	UBERON:0003889	49.96	gold quality
liver	UBERON:0002107	47.44	gold quality
pancreas	UBERON:0001264	47.35	gold quality
colonic epithelium	UBERON:0000397	45.23	gold quality
right lobe of liver	UBERON:0001114	44.88	silver quality
duodenum	UBERON:0002114	44.72	gold quality
mucosa of stomach	UBERON:0001199	44.07	gold quality
upper lobe of left lung	UBERON:0008952	43.47	gold quality
rectum	UBERON:0001052	42.24	gold quality
lung	UBERON:0002048	41.81	gold quality
minor salivary gland	UBERON:0001830	41.41	gold quality
placenta	UBERON:0001987	40.80	gold quality
saliva-secreting gland	UBERON:0001044	40.61	gold quality
urinary bladder	UBERON:0001255	40.49	silver quality
right lung	UBERON:0002167	40.31	silver quality
esophagus	UBERON:0001043	39.70	gold quality
mucosa of transverse colon	UBERON:0004991	39.56	silver quality
tonsil	UBERON:0002372	39.18	silver quality
transverse colon	UBERON:0001157	38.94	gold quality
smooth muscle tissue	UBERON:0001135	38.51	gold quality
vermiform appendix	UBERON:0001154	38.12	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.93

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

10 targeting KPNA7, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-23A-3P	99.95	74.24	3163
HSA-MIR-23B-3P	99.95	74.24	3163
HSA-MIR-23C	99.95	73.92	3192
HSA-MIR-103A-1-5P	99.39	67.78	1545
HSA-MIR-103A-2-5P	99.39	67.72	1577
HSA-MIR-3940-5P	99.14	65.26	493
HSA-MIR-4507	99.14	65.27	515
HSA-MIR-501-5P	98.77	68.88	1328
HSA-MIR-513B-3P	98.76	68.12	1577
HSA-MIR-4266	98.53	67.29	1035

Literature-anchored findings (GeneRIF, showing 7)

• Our data show that compound heterozygous mutations in KPNA7 are associated with a human neurodevelopmental disease, and provide the first example of a human disease associated with mutation of a nuclear transport receptor. (PMID:24045845)
• KPNA7 silencing inhibits the malignant properties of pancreatic cancer cells in vitro and thereby provide the first evidence on the functional role for KPNA7 in human cancer. (PMID:24275456)
• Bel1 fragment with residues 215-223, which bears the NLS, interacts with KPNA1, KPNA6, and KPNA7. (PMID:25272585)
• KPNA7 binding and nuclear transfer was validated for two proteins, MVP and ZNF414. MVP and ZNF414 have a key role in the regulation of pancreatic cancer cell growth. (PMID:27664836)
• KPNA7 has a critical role in the regulation of mitosis through the proper organization of the mitotic spindle and acts in the maintenance of the nuclear envelope structure and nuclear morphology. (PMID:29580221)
• KPNA7, an isoform with expression mostly limited to early development, can bind Importin-beta (Imp-beta) in the absence of NLS cargo. (PMID:31642884)
• An epilepsy-associated mutation in the nuclear import receptor KPNA7 reduces nuclear localization signal binding. (PMID:32179771)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	kpna7	ENSDARG00000027169
mus_musculus	Kpna7	ENSMUSG00000038770
rattus_norvegicus	Kpna7	ENSRNOG00000042296
caenorhabditis_elegans		WBGENE00002072
caenorhabditis_elegans		WBGENE00009956

Paralogs (6): KPNA6 (ENSG00000025800), KPNA3 (ENSG00000102753), KPNA1 (ENSG00000114030), KPNA2 (ENSG00000182481), KPNA4 (ENSG00000186432), KPNA5 (ENSG00000196911)

Protein

Protein identifiers

Importin subunit alpha-8 — A9QM74 (reviewed: A9QM74)

Alternative names: Karyopherin subunit alpha-7

All UniProt accessions (1): A9QM74

UniProt curated annotations — full annotation on UniProt →

Function. Functions in nuclear protein import.

Subunit / interactions. Binds very efficiently to importin subunit beta-1/KPNB1 via the IBB domain; this complex dissociates in the presence of RAN-GTP. Shows a limited binding to the RB1 nuclear localization signal (NLS), but not to the SV40, nor NPM1 NLSs. Interacts with RSL1D1.

Subcellular location. Nucleus.

Disease relevance. Oocyte/zygote/embryo maturation arrest 17 (OZEMA17) [MIM:620319] A rare cause of female primary infertility. In affected women, ovulation and fertilization proceed normally but embryos are arrested at early stages of development or cannot establish pregnancy after implantation. Inheritance is autosomal recessive. The disease is caused by variants affecting the gene represented in this entry.

Similarity. Belongs to the importin alpha family.

RefSeq proteins (1): NP_001139187* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000225	Armadillo	Repeat
IPR002652	Importin-a_IBB	Domain
IPR011989	ARM-like	Homologous_superfamily
IPR016024	ARM-type_fold	Homologous_superfamily
IPR024931	Importin_alpha	Family
IPR032413	Arm_3	Repeat
IPR036975	Importin-a_IBB_sf	Homologous_superfamily

Pfam: PF00514, PF01749, PF16186

UniProt features (14 total): repeat 8, sequence variant 4, chain 1, domain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A9QM74-F1	85.26	0.75

Function

Pathways and Gene Ontology

Reactome pathways

11 pathways

ID	Pathway
R-HSA-1169408	ISG15 antiviral mechanism
R-HSA-168276	NS1 Mediated Effects on Host Pathways
R-HSA-9918432	Maturation of DENV proteins
R-HSA-1169410	Antimicrobial mechanism of IFN-stimulated genes
R-HSA-1280215	Cytokine Signaling in Immune system
R-HSA-1643685	Disease
R-HSA-168255	Influenza Infection
R-HSA-168256	Immune System
R-HSA-5663205	Infectious disease
R-HSA-913531	Interferon Signaling
R-HSA-9824446	Viral Infection Pathways

MSigDB gene sets: 79 (showing top): GOBP_EMBRYO_DEVELOPMENT_ENDING_IN_BIRTH_OR_EGG_HATCHING, GOBP_INTRACELLULAR_PROTEIN_TRANSPORT, REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM, GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ORGANELLE, GOBP_NUCLEAR_TRANSPORT, GOBP_IN_UTERO_EMBRYONIC_DEVELOPMENT, GOBP_BLASTOCYST_DEVELOPMENT, GOBP_PROTEIN_LOCALIZATION_TO_ORGANELLE, GOBP_NLS_BEARING_PROTEIN_IMPORT_INTO_NUCLEUS, GOBP_EMBRYO_DEVELOPMENT, GOBP_CHROMATIN_REMODELING, GOBP_PROTEIN_LOCALIZATION_TO_NUCLEUS, GOBP_EPIGENETIC_REGULATION_OF_GENE_EXPRESSION, GOCC_SPINDLE, GOMF_SIGNAL_SEQUENCE_BINDING

GO Biological Process (7): blastocyst development (GO:0001824), protein import into nucleus (GO:0006606), NLS-bearing protein import into nucleus (GO:0006607), positive regulation of gene expression (GO:0010628), negative regulation of gene expression (GO:0010629), epigenetic regulation of gene expression (GO:0040029), protein transport (GO:0015031)

GO Molecular Function (3): nuclear localization sequence binding (GO:0008139), nuclear import signal receptor activity (GO:0061608), protein binding (GO:0005515)

GO Cellular Component (7): female germ cell nucleus (GO:0001674), nucleus (GO:0005634), nucleoplasm (GO:0005654), spindle (GO:0005819), cytosol (GO:0005829), NLS-dependent protein nuclear import complex (GO:0042564), cytoplasm (GO:0005737)

Reactome top-level categories

Rollup of top-9 pathways:

Category	Pathways
Antimicrobial mechanism of IFN-stimulated genes	1
Influenza Infection	1
Dengue Virus Genome Translation and Replication	1
Interferon Signaling	1
Immune System	1
Viral Infection Pathways	1
Disease	1
Cytokine Signaling in Immune system	1
Infectious disease	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of gene expression	3
cellular anatomical structure	3
import into nucleus	2
gene expression	2
in utero embryonic development	1
anatomical structure development	1
intracellular protein transport	1
protein localization to nucleus	1
establishment of protein localization to organelle	1
protein import into nucleus	1
positive regulation of macromolecule biosynthetic process	1
negative regulation of macromolecule biosynthetic process	1
chromatin remodeling	1
transport	1
intracellular protein localization	1
establishment of protein localization	1
signal sequence receptor activity	1
nucleocytoplasmic carrier activity	1
binding	1
germ cell nucleus	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
microtubule cytoskeleton	1
intracellular membraneless organelle	1
cytoplasm	1
nucleocytoplasmic transport complex	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

2109 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
KPNA7	IL1F10	Q8WWZ1	838
KPNA7	BTN3A1	O00481	777
KPNA7	MUC3A	Q02505	712
KPNA7	FOXP1	Q9H334	695
KPNA7	SMURF1	Q9HCE7	676
KPNA7	A0A3B3IT14	A0A3B3IT14	654
KPNA7	NPM2	Q86SE8	622
KPNA7	KPNB1	Q14974	575
KPNA7	IPO13	O94829	485
KPNA7	TNPO2	O14787	472
KPNA7	CSE1L	P55060	437
KPNA7	IPO4	Q8TEX9	436
KPNA7	TNPO1	Q92973	435
KPNA7	IPO11	Q9UI26	433
KPNA7	XPO1	O14980	432
KPNA7	IPO7	O95373	432

IntAct

4 interactions, top by confidence:

A	B	Type	Score
KPNB1	KPNA7	psi-mi:“MI:0407”(direct interaction)	0.440
CDC45	KPNA7	psi-mi:“MI:0915”(physical association)	0.400

BioGRID (10): KPNA7 (Affinity Capture-Western), KPNA7 (Reconstituted Complex), USP1 (Affinity Capture-Western), KPNA7 (Affinity Capture-MS), KPNA7 (Affinity Capture-MS), KPNA7 (Affinity Capture-MS), KPNA7 (Cross-Linking-MS (XL-MS)), KPNA7 (Affinity Capture-MS), KPNA7 (Affinity Capture-Western), KPNA7 (Reconstituted Complex)

ESM2 similar proteins: A2BFL2, A9QM74, B6HJ92, B8ARW2, B9FDR3, C0LLJ0, C1JZ66, C6K7I2, F4JL11, G5EB89, O00505, O00629, O04294, O14063, O14089, O22478, O35343, O35344, O43747, O60518, O75843, O80480, O88512, O94374, P22892, P52170, P52171, P52292, P52293, P52295, P91276, Q02821, Q19969, Q23924, Q557F4, Q5R5M2, Q5RAG3, Q6DGR4, Q71VM4, Q76P29

Diamond homologs: A2VE08, A9QM74, B6HJ92, C0LLJ0, C1JZ66, C6K7I2, F4JL11, G5EB89, O00505, O00629, O04294, O14063, O15131, O22478, O35343, O35344, O35345, O60684, O80480, O94374, P52170, P52171, P52292, P52293, P52294, P52295, P83953, P91276, Q02821, Q0V7M0, Q19969, Q503E9, Q557F4, Q56R16, Q5R909, Q5RBV0, Q5ZML1, Q60960, Q71VM4, Q76P29

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

553 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	2
Likely pathogenic	0
Uncertain significance	299
Likely benign	227
Benign	17

Top pathogenic / likely-pathogenic (2)

Variant ID	HGVS	Classification
2498074	NM_001145715.3(KPNA7):c.523C>A (p.Gln175Lys)	Pathogenic
2498075	NM_001145715.3(KPNA7):c.1350_1356del (p.Leu450_Cys451insTer)	Pathogenic

SpliceAI

1975 predictions. Top by Δscore:

Variant	Effect	Δscore
7:99177915:CTTA:C	donor_loss	1.0000
7:99177916:TTA:T	donor_loss	1.0000
7:99177917:TACCT:T	donor_loss	1.0000
7:99177918:A:AC	donor_gain	1.0000
7:99177918:A:T	donor_loss	1.0000
7:99177918:ACCT:A	donor_gain	1.0000
7:99177919:C:CC	donor_gain	1.0000
7:99177919:C:CG	donor_loss	1.0000
7:99177919:CCT:C	donor_gain	1.0000
7:99177919:CCTC:C	donor_gain	1.0000
7:99177919:CCTCA:C	donor_gain	1.0000
7:99178063:CCGC:C	acceptor_gain	1.0000
7:99178064:CGC:C	acceptor_gain	1.0000
7:99178064:CGCC:C	acceptor_gain	1.0000
7:99178067:C:CA	acceptor_loss	1.0000
7:99178068:T:G	acceptor_loss	1.0000
7:99181881:A:C	donor_loss	1.0000
7:99181882:C:CA	donor_loss	1.0000
7:99184927:A:AC	donor_gain	1.0000
7:99184928:C:CC	donor_gain	1.0000
7:99193014:CTTA:C	donor_loss	1.0000
7:99193015:TTA:T	donor_loss	1.0000
7:99193016:TA:T	donor_loss	1.0000
7:99193017:A:AC	donor_gain	1.0000
7:99193018:C:CC	donor_gain	1.0000
7:99193018:C:CT	donor_loss	1.0000
7:99193018:CCGG:C	donor_gain	1.0000
7:99193098:TCAC:T	acceptor_gain	1.0000
7:99193099:CAC:C	acceptor_gain	1.0000
7:99193099:CACC:C	acceptor_gain	1.0000

AlphaMissense

3354 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
7:99188517:C:G	R228P	0.998
7:99195091:A:G	W178R	0.998
7:99195091:A:T	W178R	0.998
7:99195198:G:T	A142D	0.998
7:99195203:G:C	N140K	0.998
7:99195203:G:T	N140K	0.998
7:99195217:A:G	W136R	0.998
7:99195217:A:T	W136R	0.998
7:99196084:C:A	R95M	0.998
7:99188539:A:G	W221R	0.997
7:99188539:A:T	W221R	0.997
7:99195077:A:C	N182K	0.997
7:99195077:A:T	N182K	0.997
7:99195089:C:A	W178C	0.997
7:99195089:C:G	W178C	0.997
7:99195210:A:G	L138P	0.997
7:99195215:C:A	W136C	0.997
7:99195215:C:G	W136C	0.997
7:99196084:C:G	R95T	0.997
7:99195081:C:A	G181V	0.996
7:99195081:C:T	G181D	0.996
7:99195207:G:A	T139I	0.996
7:99195223:C:G	A134P	0.996
7:99195338:C:A	R95S	0.996
7:99195338:C:G	R95S	0.996
7:99188523:A:G	L226P	0.995
7:99188537:C:A	W221C	0.995
7:99188537:C:G	W221C	0.995
7:99193082:T:A	R191S	0.995
7:99193082:T:G	R191S	0.995

dbSNP variants (sampled 300 via entrez): RS1000056042 (7:99177718 G>A,C), RS1000061479 (7:99146045 C>T), RS1000092358 (7:99155858 C>T), RS1000114036 (7:99193099 C>T), RS1000150910 (7:99155541 G>A), RS1000161853 (7:99219466 T>A), RS1000185854 (7:99204449 T>C), RS1000248931 (7:99198705 C>A), RS1000254627 (7:99161801 C>T), RS1000274577 (7:99216925 G>A), RS1000280057 (7:99145793 T>C), RS1000317477 (7:99209557 C>G,T), RS1000335137 (7:99187616 C>A,T), RS1000363290 (7:99167021 T>G), RS1000372701 (7:99172890 C>T)

Disease associations

OMIM: gene MIM:614107 | disease phenotypes: MIM:620319

GenCC curated gene-disease

Disease	Classification	Inheritance
oocyte/zygote/embryo maturation arrest 17	Strong	Autosomal recessive
neurodevelopmental disorder	Moderate	Autosomal recessive
partial corpus callosum agenesis-cerebellar vermis hypoplasia with posterior fossa cysts syndrome	Supportive	Autosomal recessive

ClinGen Gene-Disease Validity (1)

Expert-panel classifications — Definitive > Strong > Moderate > Limited > Disputed > Refuted.

Disease	Classification	Inheritance
epilepsy	Limited	AR

Mondo (3): oocyte/zygote/embryo maturation arrest 17 (MONDO:0957220), partial corpus callosum agenesis-cerebellar vermis hypoplasia with posterior fossa cysts syndrome (MONDO:0018430), neurodevelopmental disorder (MONDO:0700092)

Orphanet (0):

HPO phenotypes

4 total (4 of 4 shown, HPO-id order):

HPO	Term
HP:0000007	Autosomal recessive inheritance
HP:0000141	Amenorrhea
HP:0008222	Female infertility
HP:0011462	Young adult onset

GWAS associations

0 associations (top):

MeSH disease descriptors (1)

Descriptor	Name	Tree numbers
D065886	Neurodevelopmental Disorders	F03.625

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

13 total (human), top 13 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
fluorene-9-bisphenol	decreases expression	1
2-methyl-4-isothiazolin-3-one	increases expression	1
beta-lapachone	increases expression	1
sodium arsenite	increases expression	1
jinfukang	increases expression	1
Atorvastatin	decreases reaction, increases expression	1
Cadmium	increases expression	1
Ivermectin	decreases reaction, increases expression	1
Mustard Gas	increases expression	1
Poly I-C	decreases reaction, increases expression	1
Tobacco Smoke Pollution	increases expression	1
Cadmium Chloride	decreases expression	1
Okadaic Acid	increases expression	1

Clinical trials (associated diseases)

202 trials via MONDO — disease-level, not drug-specific.

Trial	Phase	Status	Title
NCT04586348	PHASE4	UNKNOWN	Prenatal Iodine Supplementation and Early Childhood Neurodevelopment
NCT04873115	PHASE4	UNKNOWN	Double-blind, Placebo-controlled, Randomized Clinical Trial Comparing the Efficacy and Safety of Sialanar Plus orAl rehabiLitation Against Placebo Plus Oral Rehabilitation for chIldren and Adolescents With seVere Sialorrhoea and Neurodisabilties,
NCT02559102	PHASE3	COMPLETED	Dexmedetomidine Sedation Versus General Anaesthesia for Inguinal Hernia Surgery in Infants
NCT02757079	PHASE3	COMPLETED	Study of the Efficacy and Safety of NPC-15 for Sleep Disorders of Children With Neurodevelopmental Disorders
NCT06915480	PHASE3	RECRUITING	Reducing Missed Appointments
NCT07377032	PHASE3	RECRUITING	TAP-GRIN: Interventional Study on Patients With GRIN-related Neurodevelopmental Disorders
NCT02909959	PHASE2	COMPLETED	Sulforaphane for the Treatment of Young Men With Autism Spectrum Disorder
NCT06081348	PHASE2	RECRUITING	Sertraline vs. Placebo in the Treatment of Anxiety in Children and AdoLescents With NeurodevelopMental Disorders
NCT06352372	PHASE2	COMPLETED	Safety and Efficacy of tPBM for Epileptiform Activity in Autism
NCT00503191	PHASE1	COMPLETED	NeuroModulation Technique Treatment of Autism
NCT04475848	PHASE1	COMPLETED	A Study to Investigate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Food Effect of RO6953958 in Healthy Participants
NCT06300398	PHASE1	COMPLETED	IAMA-6 Oral Dose Study in Healthy Adults
NCT01783041	PHASE2/PHASE3	COMPLETED	Effect of Early L-Carnitine Supplementation on Neurodevelopmental Outcomes in Very Preterm Infants
NCT05767385	PHASE2/PHASE3	RECRUITING	Fetal Cerebrovascular Autoregulation in Congenital Heart Disease and Association With Neonatal Neurobehavior
NCT05675098	EARLY_PHASE1	NOT_YET_RECRUITING	Central Nervous System Stimulants and Physical Function in Children With Cerebral Palsy
NCT00783783	Not specified	COMPLETED	CYP2D6 Pharmacogenetics in Risperidone-Treated Children
NCT01778504	Not specified	RECRUITING	Studying Childhood-onset Behavioral, Psychiatric, and Developmental Disorders
NCT01850784	Not specified	UNKNOWN	High Energy Formula Feeding in Infants With Congenital Heart Disease
NCT01922791	Not specified	COMPLETED	Nutrition and Pregnancy Intervention Study
NCT01942525	Not specified	UNKNOWN	Influence of Intrauterine Growth Restriction on Amplitude-integrated EEG in Preterm Infants
NCT02003170	Not specified	COMPLETED	Etiology and Early Diagnosis of Neurodevelopmental Disorders
NCT02118649	Not specified	ACTIVE_NOT_RECRUITING	Enhancing Behavior and Brain Response to Visual Targets Using a Computer Game
NCT02557191	Not specified	TERMINATED	Biomarkers, Neurodevelopment and Preterm Infants
NCT02690675	Not specified	COMPLETED	Iron Supplement Effect on Child Development
NCT02694003	Not specified	COMPLETED	Better Nights, Better Days for Children With Neurodevelopment Disorders
NCT02792894	Not specified	COMPLETED	Family Networks (FaNs) for Children With Developmental Disorders and Delays
NCT02871674	Not specified	UNKNOWN	Good Night Project: Behavioural Sleep Interventions for Children With ADHD: A Randomised Controlled Trial
NCT02887157	Not specified	COMPLETED	Analyzing Retinal Microanatomy in ROP
NCT02898298	Not specified	COMPLETED	Positive Emotion Regulation Training in Children, Adolescents and Young Adults With and Without Developmental Disorder
NCT02912780	Not specified	UNKNOWN	Introduction of Microsystems in a Level 3 Neonatal Intensive Care Unit
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