KRR1

Summary

KRR1 (KRR1 small subunit processome component, HGNC:5176) is a protein-coding gene on chromosome 12q21.2, encoding KRR1 small subunit processome component homolog (Q13601). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. It is a common-essential gene (DepMap: required in 97.2% of cancer cell lines).

Enables RNA binding activity. Involved in ribosomal small subunit biogenesis. Located in chromosome; intercellular bridge; and nuclear lumen. Part of small-subunit processome.

Source: NCBI Gene 11103 — RefSeq curated summary.

At a glance

• GWAS associations: 12
• Clinical variants (ClinVar): 47 total
• Cancer dependency (DepMap): dependent in 97.2% of screened cell lines (common-essential)
• MANE Select transcript: NM_007043

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:5176
Approved symbol	KRR1
Name	KRR1 small subunit processome component
Location	12q21.2
Locus type	gene with protein product
Status	Approved
Aliases	RIP-1
Ensembl gene	ENSG00000111615
Ensembl biotype	protein_coding
OMIM	612817
Entrez	11103

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 7 protein_coding, 3 retained_intron

ENST00000229214, ENST00000438169, ENST00000550023, ENST00000550898, ENST00000551070, ENST00000907976, ENST00000907977, ENST00000935725, ENST00000935726, ENST00000935727

RefSeq mRNA: 1 — MANE Select: NM_007043 NM_007043

CCDS: CCDS9012

Canonical transcript exons

ENST00000229214 — 10 exons

Exon	Start	End
ENSE00000937320	75506484	75506609
ENSE00000937321	75506316	75506399
ENSE00000937322	75505198	75505254
ENSE00001239174	75503904	75504074
ENSE00001362565	75490863	75499951
ENSE00002376883	75511513	75511609
ENSE00003488836	75506782	75506916
ENSE00003595938	75501723	75501816
ENSE00003615577	75508274	75508446
ENSE00003653005	75501923	75502000

Expression profiles

Bgee: expression breadth ubiquitous, 291 present calls, max score 98.11.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 43.5581 / max 1085.8300, expressed in 1802 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
132164	43.5581	1802

Top tissues by expression

296 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	98.11	gold quality
oocyte	CL:0000023	97.73	gold quality
tendon	UBERON:0000043	95.93	gold quality
secondary oocyte	CL:0000655	95.78	gold quality
adrenal tissue	UBERON:0018303	94.49	gold quality
caput epididymis	UBERON:0004358	94.45	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	94.44	gold quality
cauda epididymis	UBERON:0004360	94.08	gold quality
mucosa of paranasal sinus	UBERON:0005030	93.67	gold quality
corpus epididymis	UBERON:0004359	93.24	gold quality
tonsil	UBERON:0002372	92.40	gold quality
islet of Langerhans	UBERON:0000006	92.38	gold quality
mammary duct	UBERON:0001765	92.36	gold quality
hair follicle	UBERON:0002073	92.29	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	92.20	gold quality
colonic epithelium	UBERON:0000397	92.15	gold quality
stromal cell of endometrium	CL:0002255	92.09	gold quality
epithelium of mammary gland	UBERON:0003244	92.06	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	92.03	gold quality
Brodmann (1909) area 23	UBERON:0013554	91.93	gold quality
biceps brachii	UBERON:0001507	91.85	gold quality
esophagus mucosa	UBERON:0002469	91.74	gold quality
medial globus pallidus	UBERON:0002477	91.52	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	91.48	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	91.38	gold quality
cranial nerve II	UBERON:0000941	91.30	gold quality
endometrium	UBERON:0001295	91.20	gold quality
minor salivary gland	UBERON:0001830	91.15	gold quality
synovial joint	UBERON:0002217	91.13	gold quality
bone marrow	UBERON:0002371	91.03	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-9543	yes	6.62
E-ENAD-17	no	382.14
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

100 targeting KRR1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-513A-5P	100.00	69.77	2465
HSA-MIR-12118	100.00	65.88	1270
HSA-MIR-5692B	100.00	71.32	2622
HSA-MIR-5692C	100.00	71.32	2622
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-4482-3P	99.98	72.50	3147
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-3173-3P	99.98	66.49	1217
HSA-MIR-6891-5P	99.98	66.53	1372
HSA-MIR-548AN	99.97	70.91	2817
HSA-MIR-4666A-3P	99.96	71.71	3434
HSA-MIR-548AA	99.96	70.64	3753
HSA-MIR-548AP-3P	99.96	70.64	3753
HSA-MIR-548T-3P	99.96	70.64	3753
HSA-MIR-9983-3P	99.94	71.48	3631
HSA-MIR-552-5P	99.93	68.56	1583
HSA-MIR-3682-5P	99.93	67.97	1163
HSA-MIR-4760-3P	99.93	70.50	2385
HSA-MIR-3119	99.92	71.34	2390
HSA-MIR-8063	99.91	69.76	3146
HSA-MIR-219A-5P	99.91	73.36	735

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 97.2% of screened cell lines, common-essential.

Literature-anchored findings (GeneRIF, showing 1)

• The antibody response to KRR1 was higher in sera of patients with invasive ductal carcinoma than in sera of patients with other histological types of breast tumors. (PMID:27847402)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	krr1	ENSDARG00000011246
mus_musculus	Krr1	ENSMUSG00000063334
rattus_norvegicus	Krr1	ENSRNOG00000004035
drosophila_melanogaster	dbe	FBGN0020305
caenorhabditis_elegans		WBGENE00015461

Protein

Protein identifiers

KRR1 small subunit processome component homolog — Q13601 (reviewed: Q13601)

Alternative names: HIV-1 Rev-binding protein 2, KRR-R motif-containing protein 1, Rev-interacting protein 1

All UniProt accessions (1): Q13601

UniProt curated annotations — full annotation on UniProt →

Function. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.

Subunit / interactions. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3. (Microbial infection) Directly interacts with HIV-1 protein VPR. Also identified in a complex with NR3C1 and HIV-1 protein VPR.

Subcellular location. Nucleus. Nucleolus Nucleus. Cytoplasm.

Similarity. Belongs to the KRR1 family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q13601-1	1	yes
Q13601-2	2

RefSeq proteins (1): NP_008974* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR004087	KH_dom	Domain
IPR024166	rRNA_assembly_KRR1	Family
IPR036612	KH_dom_type_1_sf	Homologous_superfamily
IPR041174	KRR1-like_KH1	Domain
IPR048548	KRR1-like_KH2	Domain
IPR048549	KRR1-like_KH2_euk	Domain
IPR048550	KRR1-like_KH1_euk	Domain

Pfam: PF17903, PF21800

UniProt features (26 total): sequence conflict 9, modified residue 3, cross-link 3, region of interest 3, compositionally biased region 3, initiator methionine 1, chain 1, splice variant 1, sequence variant 1, domain 1

Structure

Experimental structures (PDB)

2 structures.

PDB	Method	Resolution (Å)
7MQ8	ELECTRON MICROSCOPY	3.6
7MQ9	ELECTRON MICROSCOPY	3.87

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q13601-F1	81.24	0.48

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (6): 3, 5, 24, 340, 369, 2

Function

Pathways and Gene Ontology

Reactome pathways

5 pathways

ID	Pathway
R-HSA-6790901	rRNA modification in the nucleus and cytosol
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72312	rRNA processing
R-HSA-8868773	rRNA processing in the nucleus and cytosol
R-HSA-8953854	Metabolism of RNA

MSigDB gene sets: 174 (showing top): GOBP_RIBOSOME_BIOGENESIS, MORF_FLT1, YAGI_AML_WITH_INV_16_TRANSLOCATION, MORF_MSH3, GOBP_MATURATION_OF_SSU_RRNA, MORF_BRCA1, MORF_ESR1, MORF_RAD51L3, MILI_PSEUDOPODIA_HAPTOTAXIS_UP, chr12q21, GOBP_RIBOSOMAL_SMALL_SUBUNIT_BIOGENESIS, DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_UP, NOUZOVA_TRETINOIN_AND_H4_ACETYLATION, MORF_ATF2, MORF_BCL2L11

GO Biological Process (3): rRNA processing (GO:0006364), ribosomal small subunit biogenesis (GO:0042274), ribosome biogenesis (GO:0042254)

GO Molecular Function (3): RNA binding (GO:0003723), nucleic acid binding (GO:0003676), protein binding (GO:0005515)

GO Cellular Component (9): nucleoplasm (GO:0005654), chromosome (GO:0005694), nucleolus (GO:0005730), cytoplasm (GO:0005737), membrane (GO:0016020), small-subunit processome (GO:0032040), intercellular bridge (GO:0045171), nucleus (GO:0005634), ribonucleoprotein complex (GO:1990904)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
rRNA processing in the nucleus and cytosol	2
Metabolism of RNA	1
rRNA processing	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	4
ribosome biogenesis	2
ribonucleoprotein complex biogenesis	2
binding	2
nuclear lumen	2
intracellular membraneless organelle	2
RNA processing	1
rRNA metabolic process	1
nucleic acid binding	1
intracellular anatomical structure	1
nucleolus	1
preribosome	1
t-UTP complex	1
nuclear protein-containing complex	1
intracellular membrane-bounded organelle	1
protein-containing complex	1

Protein interactions and networks

STRING

2873 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
KRR1	KRI1	Q8N9T8	784
KRR1	HNRNPK	P61978	753
KRR1	PDCD11	Q14690	737
KRR1	BYSL	Q13895	710
KRR1	BMS1	Q14692	696
KRR1	RRP7A	Q9Y3A4	692
KRR1	UTP20	O75691	678
KRR1	NOL6	Q9H6R4	678
KRR1	DDX52	Q9Y2R4	665
KRR1	WDR46	O15213	664
KRR1	SUOX	P51687	649
KRR1	DENND1A	Q8TEH3	642
KRR1	FCF1	Q9Y324	627
KRR1	HEATR1	Q9H583	625
KRR1	PNO1	Q9NRX1	617

IntAct

218 interactions, top by confidence:

A	B	Type	Score
NOP10	DKC1	psi-mi:“MI:0914”(association)	0.890
LARP7	CCNT1	psi-mi:“MI:0914”(association)	0.850
RPS14	KRR1	psi-mi:“MI:0915”(physical association)	0.740
H2AX	PPM1G	psi-mi:“MI:0914”(association)	0.730
USP44	CETN2	psi-mi:“MI:0914”(association)	0.690
H1-1	RRP8	psi-mi:“MI:0914”(association)	0.640
SNRPA1	HTATSF1	psi-mi:“MI:0914”(association)	0.640
LIN28A	IGF2BP3	psi-mi:“MI:0914”(association)	0.640
RPS14	MAGEB2	psi-mi:“MI:0914”(association)	0.560
H1-6	ZNF724	psi-mi:“MI:0914”(association)	0.530
H1-4	IGF2BP3	psi-mi:“MI:0914”(association)	0.530
RPS2	MPHOSPH10	psi-mi:“MI:0914”(association)	0.530
MAK16	NVL	psi-mi:“MI:0914”(association)	0.530
RPL7	ZBTB24	psi-mi:“MI:0914”(association)	0.530
RPSA	DKC1	psi-mi:“MI:0914”(association)	0.530
ZCRB1	DKC1	psi-mi:“MI:0914”(association)	0.530
N	NOP56	psi-mi:“MI:0914”(association)	0.530
N	RBM47	psi-mi:“MI:0914”(association)	0.530
NSA2	TYW5	psi-mi:“MI:0914”(association)	0.530
RPS3	ZNF316	psi-mi:“MI:0914”(association)	0.530
MAGEB2	POLRMT	psi-mi:“MI:0914”(association)	0.530
CCDC59	GAPDHS	psi-mi:“MI:0914”(association)	0.530

BioGRID (475): KRR1 (Affinity Capture-RNA), KRR1 (Affinity Capture-MS), KRR1 (Affinity Capture-MS), KRR1 (Affinity Capture-MS), KRR1 (Affinity Capture-MS), KRR1 (Affinity Capture-MS), KRR1 (Affinity Capture-MS), KRR1 (Affinity Capture-MS), KRR1 (Affinity Capture-MS), KRR1 (Affinity Capture-MS), KRR1 (Affinity Capture-MS), KRR1 (Affinity Capture-MS), KRR1 (Affinity Capture-MS), KRR1 (Two-hybrid), AATF (Co-fractionation)

ESM2 similar proteins: A5IQE7, A6QEP6, A6TZ71, A7WZ38, A8YZU0, A9GI17, B3LU25, B3MM49, B3N899, B4G9L6, B4JDU5, B4KF66, B4LTY6, B4N0P7, B4P2Y8, B4U4H7, B5VEQ2, B9DKS1, C0MH28, C8Z430, E7LRT8, E7QBZ1, O07633, O74777, P0C1E7, P17531, P18333, P25586, P56835, Q13601, Q2FJ50, Q2G0I5, Q2YS71, Q3B7L9, Q49VE6, Q4L3R9, Q54UU6, Q5FJL5, Q5HI83, Q5HRF2

Diamond homologs: B3LU25, B3MM49, B3N899, B4G9L6, B4JDU5, B4KF66, B4LTY6, B4N0P7, B4P2Y8, B5VEQ2, C8Z430, E7LRT8, E7QBZ1, O74777, P25586, Q13601, Q3B7L9, Q54UU6, Q8BGA5, Q9VPU8

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 187 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Eukaryotic Translation Initiation	13	33.4×	8e-16
Cap-dependent Translation Initiation	13	33.4×	8e-16
SARS-CoV-1 modulates host translation machinery	13	33.4×	8e-16
Eukaryotic Translation Elongation	13	30.2×	4e-15
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	13	29.5×	5e-15
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	5	28.0×	7e-06
Nonsense-Mediated Decay (NMD)	14	27.2×	1e-15
Influenza Viral RNA Transcription and Replication	14	25.1×	4e-15

GO biological processes:

GO term	Partners	Fold	FDR
negative regulation of DNA recombination	7	46.0×	1e-08
chromosome condensation	7	34.5×	9e-08
maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	5	27.4×	6e-05
regulation of mRNA splicing, via spliceosome	5	25.9×	7e-05
cytoplasmic translation	23	24.9×	3e-23
ribosomal small subunit biogenesis	15	20.0×	2e-13
ribosomal large subunit biogenesis	7	18.1×	9e-06
translation	23	13.8×	3e-17

Disease & clinical

Clinical variants and AI predictions

ClinVar

47 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	24
Likely benign	8
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

1948 predictions. Top by Δscore:

Variant	Effect	Δscore
12:75495571:TTACA:T	acceptor_loss	1.0000
12:75495572:TACA:T	acceptor_loss	1.0000
12:75495572:TACAG:T	acceptor_gain	1.0000
12:75495573:ACAG:A	acceptor_loss	1.0000
12:75495573:ACAGA:A	acceptor_gain	1.0000
12:75495574:CAG:C	acceptor_gain	1.0000
12:75495574:CAGA:C	acceptor_loss	1.0000
12:75495575:A:AG	acceptor_gain	1.0000
12:75495575:A:C	acceptor_loss	1.0000
12:75495575:AGA:A	acceptor_gain	1.0000
12:75495575:AGAG:A	acceptor_gain	1.0000
12:75495575:AGAGG:A	acceptor_gain	1.0000
12:75495576:G:GA	acceptor_gain	1.0000
12:75495576:GA:G	acceptor_gain	1.0000
12:75495576:GAG:G	acceptor_gain	1.0000
12:75495576:GAGG:G	acceptor_gain	1.0000
12:75495576:GAGGG:G	acceptor_gain	1.0000
12:75495659:TGTGG:T	donor_loss	1.0000
12:75495660:GTG:G	donor_gain	1.0000
12:75495660:GTGGT:G	donor_loss	1.0000
12:75495661:TGGTG:T	donor_loss	1.0000
12:75495663:G:GG	donor_gain	1.0000
12:75495664:T:G	donor_loss	1.0000
12:75495665:G:GT	donor_loss	1.0000
12:75495666:AGTAA:A	donor_loss	1.0000
12:75498684:A:AG	acceptor_gain	1.0000
12:75498685:A:G	acceptor_gain	1.0000
12:75498692:A:AG	acceptor_gain	1.0000
12:75498693:G:GG	acceptor_gain	1.0000
12:75498721:G:GG	donor_gain	1.0000

AlphaMissense

2526 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
12:75504009:A:C	F242L	1.000
12:75504009:A:T	F242L	1.000
12:75504011:A:G	F242L	1.000
12:75504018:C:A	W239C	1.000
12:75504018:C:G	W239C	1.000
12:75504020:A:G	W239R	1.000
12:75504020:A:T	W239R	1.000
12:75504052:A:G	L228S	1.000
12:75504067:A:G	M223T	1.000
12:75505198:T:A	K220N	1.000
12:75505198:T:G	K220N	1.000
12:75505214:G:T	P215Q	1.000
12:75505216:A:C	H214Q	1.000
12:75505216:A:T	H214Q	1.000
12:75505217:T:C	H214R	1.000
12:75505218:G:C	H214D	1.000
12:75506338:C:T	G194E	1.000
12:75506339:C:G	G194R	1.000
12:75506339:C:T	G194R	1.000
12:75506350:A:T	V190D	1.000
12:75506359:C:T	G187E	1.000
12:75506360:C:G	G187R	1.000
12:75506360:C:T	G187R	1.000
12:75506376:A:C	C181W	1.000
12:75506389:A:G	L177P	1.000
12:75506506:C:T	G166D	1.000
12:75506507:C:G	G166R	1.000
12:75506520:T:A	R161S	1.000
12:75506520:T:G	R161S	1.000
12:75506521:C:G	R161T	1.000

dbSNP variants (sampled 300 via entrez): RS1000708245 (12:75500374 C>CTCAATA), RS1000779003 (12:75506811 G>A), RS1000806805 (12:75497266 T>C), RS1000972255 (12:75510896 G>A), RS1000984369 (12:75503724 C>A,T), RS1001076824 (12:75491034 T>C), RS1001321188 (12:75492412 A>G), RS1001602953 (12:75505398 G>A), RS1001826806 (12:75498410 T>G), RS1001944167 (12:75512035 T>C), RS1001987913 (12:75512076 A>G,T), RS1002019025 (12:75511857 G>A), RS1002205769 (12:75500011 A>G), RS1002288375 (12:75494253 A>G), RS1002297888 (12:75495877 AAAC>A,AAACAAC)

Disease associations

OMIM: gene MIM:612817 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

12 associations (top):

Study	Trait	p-value
GCST002041_7	Blood trace element (Cu levels)	3.000000e-06
GCST003144_6	Polycystic ovary syndrome	2.000000e-08
GCST003518_77	Daytime sleep phenotypes	8.000000e-06
GCST005984_58	Glomerular filtration rate	1.000000e-11
GCST005985_38	Creatinine levels	1.000000e-12
GCST005986_15	Blood urea nitrogen levels	6.000000e-09
GCST006061_120	Atrial fibrillation	4.000000e-10
GCST006061_121	Atrial fibrillation	8.000000e-09
GCST007089_12	Polycystic ovary syndrome	2.000000e-09
GCST007344_10	Estimated glomerular filtration rate	1.000000e-08
GCST009723_31	Vertical cup-disc ratio (adjusted for vertical disc diameter)	3.000000e-08
GCST010396_209	Gut microbiota (bacterial taxa, hurdle binary method)	4.000000e-06

EFO canonical traits (4, from GWAS)

EFO ID	Trait name
EFO:0005267	serum copper measurement
EFO:0007828	daytime rest measurement
EFO:0006939	cup-to-disc ratio measurement
EFO:0007874	gut microbiome measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

32 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
FR900359	increases phosphorylation	1
TAK-243	decreases sumoylation	1
dicrotophos	decreases expression	1
methylmercuric chloride	decreases expression	1
triphenyl phosphate	affects expression	1
deoxynivalenol	increases expression	1
nickel sulfate	decreases expression	1
nivalenol	increases expression	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	increases reaction, affects binding	1
ICG 001	decreases expression	1
jinfukang	decreases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	decreases expression	1
Vorinostat	increases expression	1
Air Pollutants	decreases expression, increases abundance	1
Arsenic	increases methylation	1
Benzo(a)pyrene	affects methylation	1
Coal	decreases expression, increases abundance	1
Dinitrochlorobenzene	affects binding	1
Estradiol	affects expression	1
Gold	decreases expression	1
Ivermectin	decreases expression	1
Methotrexate	affects response to substance	1
Mitoxantrone	affects response to substance	1
Piroxicam	increases expression	1
Ribonucleotides	affects binding	1
Selenium	decreases expression	1
Smoke	decreases expression, increases abundance	1
Thimerosal	increases expression	1
Valproic Acid	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.