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KRT26

gene
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Summary

KRT26 (keratin 26, HGNC:30840) is a protein-coding gene on chromosome 17q21.2, encoding Keratin, type I cytoskeletal 26 (Q7Z3Y9).

The protein encoded by this gene is a member of the keratin superfamily. This keratin protein is a type I keratin that is specific for the inner root sheath of the hair follicle. This gene exists in a cluster with other keratin genes on chromosome 17q21.

Source: NCBI Gene 353288 — RefSeq curated summary.

At a glance

  • GWAS associations: 3
  • Clinical variants (ClinVar): 84 total
  • MANE Select transcript: NM_181539

Identifiers

Gene identifiers

FieldValue
HGNC IDHGNC:30840
Approved symbolKRT26
Namekeratin 26
Location17q21.2
Locus typegene with protein product
StatusApproved
Ensembl geneENSG00000186393
Ensembl biotypeprotein_coding
OMIM616675
Entrez353288

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000335552

RefSeq mRNA: 1 — MANE Select: NM_181539 NM_181539

CCDS: CCDS11374

Canonical transcript exons

ENST00000335552 — 8 exons

ExonStartEnd
ENSE000013321614076758640767653
ENSE000013321624076887940769096
ENSE000013321644076975440769879
ENSE000013321654076996140770122
ENSE000013321704077115440771236
ENSE000013321714076623840766666
ENSE000023665974077025340770409
ENSE000039782704077167340772201

Expression profiles

Bgee: expression breadth broad, 12 present calls, max score 85.67.

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

TissueAnatomy IDExpression scoreQuality
male germ line stem cell (sensu Vertebrata) in testisCL:0000089 ∩ UBERON:000047385.67gold quality
primordial germ cell in gonadCL:0000670 ∩ UBERON:000099158.85gold quality
skin of abdomenUBERON:000141642.09gold quality
zone of skinUBERON:000001441.35gold quality
skin of legUBERON:000151141.20gold quality
colonic epitheliumUBERON:000039737.20gold quality
ventricular zoneUBERON:000305336.48gold quality
cortical plateUBERON:000534336.47gold quality
bone marrow cellCL:000209236.16gold quality
sural nerveUBERON:001548835.97gold quality
ganglionic eminenceUBERON:000402335.49gold quality
granulocyteCL:000009435.46gold quality
testisUBERON:000047335.43gold quality
right testisUBERON:000453434.24silver quality
skeletal muscle tissueUBERON:000113433.38gold quality
left testisUBERON:000453333.17silver quality
urinary bladderUBERON:000125532.30gold quality
muscle tissueUBERON:000238532.15gold quality
hindlimb stylopod muscleUBERON:000425232.15gold quality
leukocyteCL:000073831.95gold quality
monocyteCL:000057631.81gold quality
bone marrowUBERON:000237131.74gold quality
stromal cell of endometriumCL:000225529.87gold quality
liverUBERON:000210729.33gold quality
prefrontal cortexUBERON:000045129.04gold quality
gall bladderUBERON:000211028.54gold quality
duodenumUBERON:000211428.14gold quality
bloodUBERON:000017827.80gold quality
lymph nodeUBERON:000002927.57gold quality
placentaUBERON:000198727.50gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

ExperimentMarker?Max mean expression
E-ANND-3yes3.45

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

32 targeting KRT26, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNAMax scoreAvg scoremiRNA target_count
HSA-MIR-7110-3P100.0073.182486
HSA-MIR-6873-3P100.0071.422626
HSA-MIR-607799.9968.042299
HSA-MIR-548AJ-3P99.9673.385345
HSA-MIR-548X-3P99.9673.385345
HSA-MIR-365899.9673.874379
HSA-MIR-9983-3P99.9471.483631
HSA-MIR-548AE-3P99.9372.664867
HSA-MIR-548AQ-3P99.9372.664867
HSA-MIR-450B-5P99.9271.483175
HSA-MIR-129-5P99.8870.263273
HSA-MIR-548AC99.8470.774351
HSA-MIR-548H-3P99.8470.804349
HSA-MIR-548Z99.8470.804349
HSA-MIR-6817-3P99.7968.352126
HSA-MIR-129999.7771.242389
HSA-MIR-1287-3P99.6366.93492
HSA-MIR-875-3P99.6369.472548
HSA-MIR-203A-3P99.4970.562806
HSA-MIR-4666A-5P99.4169.721887
HSA-MIR-10522-5P99.2668.502087
HSA-MIR-6770-5P98.9766.761853
HSA-MIR-153-3P98.9672.511644
HSA-MIR-154-5P98.9266.65733
HSA-MIR-129-1-3P98.8668.41779
HSA-MIR-129-2-3P98.8668.41779
HSA-MIR-518C-5P98.5369.201640
HSA-MIR-477398.3567.301710
HSA-MIR-541-5P98.2467.771181
HSA-MIR-315997.9466.791098

Cross-species orthologs

2 orthologs

OrganismSymbolGene ID
mus_musculusKrt26ENSMUSG00000075570
rattus_norvegicusKrt26ENSRNOG00000033617

Paralogs (68): KRT33A (ENSG00000006059), VIM (ENSG00000026025), KRT31 (ENSG00000094796), NEFM (ENSG00000104722), KRT23 (ENSG00000108244), KRT37 (ENSG00000108417), KRT32 (ENSG00000108759), KRT18 (ENSG00000111057), LMNB1 (ENSG00000113368), KRT36 (ENSG00000126337), KRT17 (ENSG00000128422), GFAP (ENSG00000131095), KRT34 (ENSG00000131737), KRT33B (ENSG00000131738), NES (ENSG00000132688), PRPH (ENSG00000135406), KRT85 (ENSG00000135443), KRT7 (ENSG00000135480), KRT71 (ENSG00000139648), INA (ENSG00000148798), LMNTD1 (ENSG00000152936), LMNA (ENSG00000160789), KRT84 (ENSG00000161849), KRT82 (ENSG00000161850), KRT80 (ENSG00000167767), KRT1 (ENSG00000167768), KRT24 (ENSG00000167916), KRT8 (ENSG00000170421), KRT78 (ENSG00000170423), KRT86 (ENSG00000170442), KRT75 (ENSG00000170454), KRT6C (ENSG00000170465), KRT4 (ENSG00000170477), KRT74 (ENSG00000170484), KRT72 (ENSG00000170486), KRT83 (ENSG00000170523), BFSP2 (ENSG00000170819), KRT19 (ENSG00000171345), KRT15 (ENSG00000171346), KRT38 (ENSG00000171360)

Protein

Protein identifiers

Keratin, type I cytoskeletal 26 — Q7Z3Y9 (reviewed: Q7Z3Y9)

Alternative names: Cytokeratin-26, Keratin-25B, Keratin-26, Type I inner root sheath-specific keratin-K25irs2

All UniProt accessions (1): Q7Z3Y9

UniProt curated annotations — full annotation on UniProt →

Subunit / interactions. Heterotetramer of two type I and two type II keratins.

Tissue specificity. Strongly expressed in skin and scalp, and weak expression observed in thymus and tongue. In the hair follicle, expression is restricted to the mid- to upper inner root sheath cuticle, being present slightly above the apex of the dermal papilla (at protein level).

Miscellaneous. There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Similarity. Belongs to the intermediate filament family.

RefSeq proteins (1): NP_853517* (*=MANE)

Domains & families (InterPro)

IDNameType
IPR002957Keratin_IFamily
IPR039008IF_rod_domDomain

Pfam: PF00038

UniProt features (11 total): region of interest 7, chain 1, domain 1, sequence conflict 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

ModelpLDDTFraction very-high
AF-Q7Z3Y9-F175.830.54

Function

Pathways and Gene Ontology

Reactome pathways

3 pathways

IDPathway
R-HSA-6805567Keratinization
R-HSA-6809371Formation of the cornified envelope
R-HSA-1266738Developmental Biology

MSigDB gene sets: 60 (showing top): GOBP_MORPHOGENESIS_OF_AN_EPITHELIUM, GOBP_EPITHELIUM_DEVELOPMENT, GOBP_INTERMEDIATE_FILAMENT_BASED_PROCESS, GOBP_INTERMEDIATE_FILAMENT_ORGANIZATION, HNF1_Q6, NKX62_Q2, TATA_C, GFI1_01, HNF1_01, CART1_01, GOBP_TISSUE_MORPHOGENESIS, GOCC_INTERMEDIATE_FILAMENT_CYTOSKELETON, GOCC_KERATIN_FILAMENT, GOMF_STRUCTURAL_MOLECULE_ACTIVITY, TEF_Q6

GO Biological Process (3): morphogenesis of an epithelium (GO:0002009), epithelial cell differentiation (GO:0030855), intermediate filament organization (GO:0045109)

GO Molecular Function (3): structural constituent of skin epidermis (GO:0030280), structural molecule activity (GO:0005198), protein binding (GO:0005515)

GO Cellular Component (5): cytosol (GO:0005829), cytoskeleton (GO:0005856), keratin filament (GO:0045095), extracellular exosome (GO:0070062), intermediate filament (GO:0005882)

Reactome top-level categories

Rollup of top-2 pathways:

CategoryPathways
Developmental Biology1
Keratinization1

GO top-level categories

Rollup of top GO terms by namespace:

CategoryTerms
epithelium development2
tissue morphogenesis1
cell differentiation1
intermediate filament cytoskeleton organization1
supramolecular fiber organization1
structural molecule activity1
molecular_function1
binding1
cytoplasm1
cellular anatomical structure1
intracellular membraneless organelle1
intermediate filament1
extracellular vesicle1
intermediate filament cytoskeleton1
polymeric cytoskeletal fiber1

Protein interactions and networks

STRING

684 interactions, top by confidence (×1000):

Protein AProtein BPartner UniProtScore
KRT26KRTAP10-9P60411447
KRT26KRTAP10-3P60369417
KRT26KRTAP10-4P60372405
KRT26KRTAP10-11P60412399
KRT26KRTAP3-1Q9BYR8399
KRT26KRTAP10-5P60370370
KRT26KRTAP10-7P60409359
KRT26KRTAP10-8P60410352
KRT26KRTAP11-1Q8IUC1343
KRT26KRTAP1-1Q07627341
KRT26HSPB9Q9BQS6330
KRT26KRTAP26-1Q6PEX3323
KRT26KRTAP7-1Q8IUC3319
KRT26KRTAP6-2Q3LI66316
KRT26KRTAP4-5Q9BYR2292

IntAct

75 interactions, top by confidence:

ABTypeScore
KRT26TMCO1psi-mi:“MI:0915”(physical association)0.560
KRT26SNAPINpsi-mi:“MI:0915”(physical association)0.560
KRT26MCCD1psi-mi:“MI:0915”(physical association)0.560
SNAPINKRT26psi-mi:“MI:0915”(physical association)0.560
KRT26psi-mi:“MI:0915”(physical association)0.560
KRT3KRT26psi-mi:“MI:0915”(physical association)0.560
KRT1KRT26psi-mi:“MI:0915”(physical association)0.560
KRT71KRT26psi-mi:“MI:0915”(physical association)0.560
HGSKRT26psi-mi:“MI:0915”(physical association)0.560
KRT6CKRT26psi-mi:“MI:0915”(physical association)0.560
KRT75KRT26psi-mi:“MI:0915”(physical association)0.560
KRT6AKRT26psi-mi:“MI:0915”(physical association)0.560
KRT81KRT26psi-mi:“MI:0915”(physical association)0.560
KRT26CCDC146psi-mi:“MI:0915”(physical association)0.560
KRT26USHBP1psi-mi:“MI:0915”(physical association)0.560
KRT85KRT26psi-mi:“MI:0915”(physical association)0.560
KRT26KIFC3psi-mi:“MI:0915”(physical association)0.560
KRT26FAM86C1Ppsi-mi:“MI:0915”(physical association)0.560
SUOXKRT26psi-mi:“MI:0915”(physical association)0.560
KRT74KRT26psi-mi:“MI:0915”(physical association)0.560
KRT26TRIB3psi-mi:“MI:0915”(physical association)0.560
SLC19A1KRT26psi-mi:“MI:0915”(physical association)0.560
KRT26TXLNBpsi-mi:“MI:0915”(physical association)0.560
MCCD1KRT26psi-mi:“MI:0915”(physical association)0.560
BLOC1S2KRT26psi-mi:“MI:0915”(physical association)0.560
PDLIM7CRYBG2psi-mi:“MI:0914”(association)0.350

BioGRID (34): KRT26 (Affinity Capture-MS), KRT26 (Affinity Capture-MS), KRT26 (Affinity Capture-MS), KRT26 (Affinity Capture-MS), KRT26 (Two-hybrid), KRT26 (Two-hybrid), KRT26 (Two-hybrid), KRT26 (Two-hybrid), KRT26 (Two-hybrid), KRT26 (Two-hybrid), KRT26 (Two-hybrid), KRT26 (Two-hybrid), KRT26 (Two-hybrid), KRT26 (Two-hybrid), KRT26 (Two-hybrid)

ESM2 similar proteins: A0JND2, A3KN27, A6BLY7, A6H712, A6QNX5, A6QQJ3, A7YWK3, D3ZER2, E1AB55, O76014, O76015, P08552, P15331, P21807, P35617, P41219, P46660, P48670, Q0VBK2, Q13515, Q148H5, Q148H6, Q148H8, Q14CN4, Q28177, Q3SY84, Q3TRJ4, Q6A162, Q6IFW3, Q6IFW8, Q6IFX0, Q6IFX4, Q6IFZ9, Q6IG04, Q6IME9, Q6IMF1, Q6KB66, Q6NVD9, Q6NXH9, Q7RTS7

Diamond homologs: A1L317, A1L595, A5A6M0, A5A6M5, A5A6N2, A5A6P3, A6BLY7, A6H712, A6QQQ9, B0LKP1, B1AQ75, O18740, O57607, O57611, O76009, O76013, O77727, O93256, P02533, P02534, P02535, P02537, P05781, P05782, P05783, P05784, P06394, P08727, P08728, P08730, P08777, P08778, P08779, P08802, P13645, P13646, P19001, P19012, P25030, P25690

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 24 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

PathwayPartnersFoldFDR
Formation of the cornified envelope949.4×1e-12
Keratinization931.3×4e-11

GO biological processes:

GO termPartnersFoldFDR
intermediate filament organization9114.0×2e-15
keratinization9110.9×2e-15

Disease & clinical

Clinical variants and AI predictions

ClinVar

84 variants total. Per-class counts are floors (≥ shown; pagination cap):

ClassificationCount (floor)
Pathogenic0
Likely pathogenic0
Uncertain significance76
Likely benign8
Benign0

Top pathogenic / likely-pathogenic (0)

SpliceAI

740 predictions. Top by Δscore:

VariantEffectΔscore
17:40766664:AGTC:Aacceptor_loss1.0000
17:40766667:C:CCacceptor_gain1.0000
17:40767342:T:Adonor_gain1.0000
17:40767580:CTATA:Cdonor_loss1.0000
17:40767581:TATAC:Tdonor_loss1.0000
17:40767583:TA:Tdonor_loss1.0000
17:40767584:ACCTT:Adonor_loss1.0000
17:40767649:TTTTT:Tacceptor_gain1.0000
17:40767651:TTT:Tacceptor_gain1.0000
17:40767652:TT:Tacceptor_gain1.0000
17:40767652:TTCTG:Tacceptor_loss1.0000
17:40767653:TCTG:Tacceptor_loss1.0000
17:40767654:C:CCacceptor_gain1.0000
17:40767654:CTGT:Cacceptor_loss1.0000
17:40767655:T:Cacceptor_loss1.0000
17:40768958:A:ACdonor_gain1.0000
17:40768959:C:CCdonor_gain1.0000
17:40768961:C:CAdonor_gain1.0000
17:40769092:TGTTT:Tacceptor_gain1.0000
17:40769093:GTTT:Gacceptor_gain1.0000
17:40769094:TTT:Tacceptor_gain1.0000
17:40769095:TT:Tacceptor_gain1.0000
17:40769096:TCTG:Tacceptor_loss1.0000
17:40769097:C:Aacceptor_loss1.0000
17:40769097:C:CCacceptor_gain1.0000
17:40769878:CT:Cacceptor_gain1.0000
17:40769954:GACCT:Gdonor_loss1.0000
17:40769955:ACCT:Adonor_loss1.0000
17:40769956:CCTAC:Cdonor_loss1.0000
17:40769957:CTACC:Cdonor_loss1.0000

AlphaMissense

3071 scored. Top likely-pathogenic:

VariantProtein changeam_pathogenicity
17:40769773:A:GL317P0.943
17:40769992:C:GR271P0.942
17:40771836:C:GR93P0.938
17:40769041:A:GL342P0.929
17:40771683:A:GL144P0.927
17:40771185:C:GA165P0.925
17:40768987:C:GR360P0.913
17:40769970:G:CF278L0.911
17:40769970:G:TF278L0.911
17:40769972:A:GF278L0.911
17:40768999:A:GL356P0.909
17:40769794:A:GL310P0.906
17:40769984:C:GA274P0.905
17:40769800:C:GR308P0.898
17:40770037:A:GL256S0.897
17:40768948:A:GL373P0.894
17:40771795:C:GA107P0.893
17:40771173:C:GA169P0.891
17:40770024:C:AR260S0.884
17:40770024:C:GR260S0.884
17:40771212:C:GA156P0.878
17:40770409:C:AK175N0.874
17:40770409:C:GK175N0.874
17:40768935:T:AK377N0.871
17:40768935:T:GK377N0.871
17:40771178:A:GL167P0.871
17:40769759:C:GA322P0.870
17:40771162:G:CF172L0.870
17:40771162:G:TF172L0.870
17:40771164:A:GF172L0.870

dbSNP variants (sampled 300 via entrez): RS1000088128 (17:40773923 T>C), RS1000277020 (17:40769206 T>C), RS1000529524 (17:40770801 C>A,T), RS1000824915 (17:40769536 C>T), RS1002823650 (17:40772249 A>G), RS1003195785 (17:40767813 A>C,G), RS1003223991 (17:40767764 A>C,G), RS1003582488 (17:40768046 C>A), RS1003804350 (17:40771927 A>C,G), RS1004275268 (17:40771514 T>C), RS1004402523 (17:40766001 T>C), RS1004539280 (17:40772993 T>C), RS1005024751 (17:40766334 A>G,T), RS1005181412 (17:40771928 C>T), RS1005361772 (17:40767983 A>G)

Disease associations

OMIM: gene MIM:616675 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

StudyTraitp-value
GCST003075_26Cognitive decline rate in late mild cognitive impairment2.000000e-07
GCST003075_59Cognitive decline rate in late mild cognitive impairment2.000000e-07
GCST009798_41Asthma3.000000e-08

EFO canonical traits (1, from GWAS)

EFO IDTrait name
EFO:0007710cognitive decline measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

7 total (human), top 7 by PubMed support.

ChemicalActions (top 5)PubMed papers
sodium arsenitedecreases expression1
CGP 52608affects binding, increases reaction1
bisphenol Sincreases methylation1
Fulvestrantincreases methylation1
Air Pollutantsdecreases expression, increases abundance1
Benzo(a)pyreneaffects methylation1
Particulate Matterincreases abundance, decreases expression1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.

No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.4
BioBTree
v2.0.2

Sources 75

This page pulls from 75 datasets indexed by BioBTree:

alphafoldalphamissenseantibodybgeebgee_evidencebindingdbbiogrid_interactionbrendabrenda_kineticsccdscellosauruschembl_activitychembl_targetciviccivic_evidenceclingen_dosageclingen_gene_validityclinical_trialsclinvarcollectrictd_gene_interactiondbsnpdepmapdiamond_similarityefoensemblentrezesm2_similarityexonfantom5_genefantom5_promotergenccgenerifgogoparentgtopdbgwasgwas_studyhgnchpointactinterprointogenjasparmeshmimmirdbmondomsigdborphanetorthologparalogpdbpfampharmgkb_clinicalpharmgkb_genepharmgkb_guidelinepharmgkb_variantpubchempubchem_activitypubchem_assaypubmedreactomereactomeparentrefseqrhearnacentralscxa_expressionscxa_gene_experimentsignorspliceaistring_interactiontranscriptufeatureuniprot