KRT7-AS

Summary

KRT7-AS (KRT7 antisense RNA 1, HGNC:52643) is a long non-coding RNA gene on chromosome 12q13.13.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:52643
Approved symbol	KRT7-AS
Name	KRT7 antisense RNA 1
Location	12q13.13
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000257671
Ensembl biotype	lncRNA
Entrez	109729127
RNAcentral	URS0000BC43E1 — lncRNA, 1698 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000546686

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000546686 — 2 exons

Exon	Start	End
ENSE00002386899	52245048	52246468
ENSE00002399070	52247177	52247448

Expression profiles

Bgee: expression breadth ubiquitous, 125 present calls, max score 88.16.

Top tissues by expression

216 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
minor salivary gland	UBERON:0001830	88.16	gold quality
left lobe of thyroid gland	UBERON:0001120	88.05	gold quality
right lobe of thyroid gland	UBERON:0001119	87.09	gold quality
thyroid gland	UBERON:0002046	86.05	gold quality
upper lobe of left lung	UBERON:0008952	85.65	gold quality
upper lobe of lung	UBERON:0008948	83.59	gold quality
mouth mucosa	UBERON:0003729	82.04	gold quality
saliva-secreting gland	UBERON:0001044	81.13	gold quality
right lung	UBERON:0002167	79.27	gold quality
metanephros cortex	UBERON:0010533	78.04	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	77.94	gold quality
hindlimb stylopod muscle	UBERON:0004252	76.01	gold quality
right uterine tube	UBERON:0001302	71.79	gold quality
skin of leg	UBERON:0001511	71.53	gold quality
lower esophagus mucosa	UBERON:0035834	71.27	gold quality
body of pancreas	UBERON:0001150	71.23	gold quality
lung	UBERON:0002048	70.55	gold quality
gall bladder	UBERON:0002110	68.64	gold quality
pancreas	UBERON:0001264	68.50	gold quality
skin of abdomen	UBERON:0001416	68.14	gold quality
metanephros	UBERON:0000081	66.95	gold quality
zone of skin	UBERON:0000014	66.56	gold quality
cortex of kidney	UBERON:0001225	66.48	gold quality
islet of Langerhans	UBERON:0000006	65.83	gold quality
right coronary artery	UBERON:0001625	65.39	gold quality
prostate gland	UBERON:0002367	64.82	gold quality
esophagus mucosa	UBERON:0002469	64.74	gold quality
left uterine tube	UBERON:0001303	64.03	gold quality
buccal mucosa cell	CL:0002336	63.82	gold quality
upper leg skin	UBERON:0004262	62.81	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.40

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• KRT7-AS formed an RNA-RNA hybrid with KRT7 and controlled KRT7 expression at both the mRNA and the post-transcriptional levels. forced overexpression of the KRT7-overlapping region (OL) of KRT7-AS (but not its non-KRT7-OL portions) increased keratin 7 protein levels in cells. Finally, forced overexpression of full-length KRT7-AS or OL KRT7-AS (but not its non-KRT7-OL regions) promoted GC cell proliferation (PMID:26876208)
• Fusobacterium nucleatum promotes colorectal cancer metastasis by modulating KRT7-AS/KRT7. (PMID:31910722)
• The long non-coding RNA keratin-7 antisense acts as a new tumor suppressor to inhibit tumorigenesis and enhance apoptosis in lung and breast cancers. (PMID:37185462)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.