KRT83

Summary

KRT83 (keratin 83, HGNC:6460) is a protein-coding gene on chromosome 12q13.13, encoding Keratin, type II cuticular Hb3 (P78385).

The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB1 and KRTHB6, is found primarily in the hair cortex.

Source: NCBI Gene 3889 — RefSeq curated summary.

At a glance

• Gene–disease (curated): monilethrix (Strong, GenCC) — +3 more curated relationships
• Clinical variants (ClinVar): 252 total — 1 pathogenic, 2 likely-pathogenic
• Phenotypes (HPO): 30
• Druggable target: yes
• MANE Select transcript: NM_002282

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:6460
Approved symbol	KRT83
Name	keratin 83
Location	12q13.13
Locus type	gene with protein product
Status	Approved
Aliases	Hb-3
Ensembl gene	ENSG00000170523
Ensembl biotype	protein_coding
OMIM	602765
Entrez	3889

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000293670

RefSeq mRNA: 1 — MANE Select: NM_002282 NM_002282

CCDS: CCDS8823

Canonical transcript exons

ENST00000293670 — 9 exons

Exon	Start	End
ENSE00001192785	52314301	52314818
ENSE00001322910	52320952	52321398
ENSE00001627104	52317910	52317970
ENSE00001649134	52316859	52317023
ENSE00001659417	52316468	52316593
ENSE00001664486	52317681	52317776
ENSE00001666452	52319156	52319364
ENSE00001736409	52315312	52315343
ENSE00001782965	52315893	52316113

Expression profiles

Bgee: expression breadth broad, 73 present calls, max score 83.43.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0121 / max 15.1495, expressed in 2 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
131025	0.0121	2

Top tissues by expression

261 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
diaphragm	UBERON:0001103	83.43	gold quality
type B pancreatic cell	CL:0000169	80.34	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.02	gold quality
gluteal muscle	UBERON:0002000	79.87	silver quality
triceps brachii	UBERON:0001509	79.23	gold quality
olfactory bulb	UBERON:0002264	79.15	gold quality
vastus lateralis	UBERON:0001379	75.85	gold quality
heart right ventricle	UBERON:0002080	75.17	gold quality
quadriceps femoris	UBERON:0001377	74.78	gold quality
myocardium	UBERON:0002349	74.75	gold quality
endometrium epithelium	UBERON:0004811	72.74	gold quality
left ventricle myocardium	UBERON:0006566	72.68	gold quality
cardiac muscle of right atrium	UBERON:0003379	72.45	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	72.26	gold quality
nasal cavity epithelium	UBERON:0005384	71.38	gold quality
tongue squamous epithelium	UBERON:0006919	71.21	gold quality
CA1 field of hippocampus	UBERON:0003881	70.67	gold quality
hair follicle	UBERON:0002073	70.14	gold quality
orbitofrontal cortex	UBERON:0004167	69.85	gold quality
Brodmann (1909) area 46	UBERON:0006483	69.68	gold quality
biceps brachii	UBERON:0001507	69.14	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	69.02	gold quality
decidua	UBERON:0002450	68.86	gold quality
tendon of biceps brachii	UBERON:0008188	68.46	gold quality
thymus	UBERON:0002370	67.83	gold quality
layer of synovial tissue	UBERON:0007616	67.76	gold quality
frontal pole	UBERON:0002795	67.73	gold quality
middle frontal gyrus	UBERON:0002702	67.31	gold quality
paraflocculus	UBERON:0005351	67.29	gold quality
Brodmann (1909) area 10	UBERON:0013541	67.12	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.46

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

17 targeting KRT83, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4747-5P	100.00	67.90	2681
HSA-MIR-5196-5P	100.00	67.98	2761
HSA-MIR-4533	100.00	69.48	2758
HSA-MIR-589-3P	99.91	69.62	2088
HSA-MIR-92A-2-5P	99.75	67.01	2164
HSA-MIR-3175	99.65	66.30	2031
HSA-MIR-6716-5P	99.56	68.62	1244
HSA-MIR-6868-5P	99.06	65.69	1284
HSA-MIR-1207-3P	98.99	66.22	1532
HSA-MIR-331-3P	98.76	64.91	793
HSA-MIR-5187-5P	98.54	67.94	952
HSA-MIR-10526-3P	97.86	64.97	1342
HSA-MIR-6728-5P	97.79	66.33	891
HSA-MIR-8057	97.64	66.54	897
HSA-MIR-4456	97.50	64.88	1678
HSA-MIR-4537	85.08	60.32	148
HSA-MIR-5587-3P	82.90	60.79	138

Literature-anchored findings (GeneRIF, showing 4)

• A heterozygous missense mutation in hHb3 causing the substitution of a glutamic acid by a lysine at position 407 in the helix termination motif defines this particular residue as a trichocyte keratin mutational hotspot associated with monilethrix. (PMID:15744029)
• The KRTHB3 expression uniformly occurred in the midcortex region. (PMID:15797458)
• Novel mutations causing monilethrix are reported in KRT81, KRT83, and KRT86. (PMID:25557232)
• Our findings indicate that at least some cases of autosomal recessive Progressive symmetric erythrokeratoderma (PSEK)and autosomal dominant monilethrix are allelic, respectively resulting from loss-of-function and missense mutations in the KRT83 gene (PMID:27965375)

Cross-species orthologs

0 orthologs

Paralogs (68): KRT33A (ENSG00000006059), VIM (ENSG00000026025), KRT31 (ENSG00000094796), NEFM (ENSG00000104722), KRT23 (ENSG00000108244), KRT37 (ENSG00000108417), KRT32 (ENSG00000108759), KRT18 (ENSG00000111057), LMNB1 (ENSG00000113368), KRT36 (ENSG00000126337), KRT17 (ENSG00000128422), GFAP (ENSG00000131095), KRT34 (ENSG00000131737), KRT33B (ENSG00000131738), NES (ENSG00000132688), PRPH (ENSG00000135406), KRT85 (ENSG00000135443), KRT7 (ENSG00000135480), KRT71 (ENSG00000139648), INA (ENSG00000148798), LMNTD1 (ENSG00000152936), LMNA (ENSG00000160789), KRT84 (ENSG00000161849), KRT82 (ENSG00000161850), KRT80 (ENSG00000167767), KRT1 (ENSG00000167768), KRT24 (ENSG00000167916), KRT8 (ENSG00000170421), KRT78 (ENSG00000170423), KRT86 (ENSG00000170442), KRT75 (ENSG00000170454), KRT6C (ENSG00000170465), KRT4 (ENSG00000170477), KRT74 (ENSG00000170484), KRT72 (ENSG00000170486), BFSP2 (ENSG00000170819), KRT19 (ENSG00000171345), KRT15 (ENSG00000171346), KRT38 (ENSG00000171360), KRT13 (ENSG00000171401)

Protein

Protein identifiers

Keratin, type II cuticular Hb3 — P78385 (reviewed: P78385)

Alternative names: Hair keratin K2.10, Keratin-83, Type II hair keratin Hb3, Type-II keratin Kb23

All UniProt accessions (1): P78385

UniProt curated annotations — full annotation on UniProt →

Subunit / interactions. Heterotetramer of two type I and two type II keratins.

Tissue specificity. Synthesis begins in the cortex 10-15 cell layers above the apex of the dermal papilla and ends abruptly in the middle of the cortex.

Disease relevance. Erythrokeratodermia variabilis et progressiva 5 (EKVP5) [MIM:617756] A form of erythrokeratodermia variabilis et progressiva, a genodermatosis characterized by the coexistence of two independent skin lesions: transient erythema and hyperkeratosis that is usually localized but occasionally occurs in its generalized form. Clinical presentation varies significantly within a family and from one family to another. Palmoplantar keratoderma is present in around 50% of cases. EKVP5 inheritance is autosomal recessive. The disease is caused by variants affecting the gene represented in this entry. Monilethrix 3 (MNLIX3) [MIM:621170] A form of monilethrix, a disorder of the hair shaft characterized by brittle hair, follicular papules, and varying degrees of alopecia. Affected hairs have uniform elliptical nodes of normal thickness and intermittent constrictions, internodes at which the hair easily breaks. Usually only the scalp is involved, but in severe forms, the secondary sexual hair, eyebrows, eyelashes, and nails may also be affected. Inheritance is autosomal dominant. The disease is caused by variants affecting the gene represented in this entry.

Miscellaneous. There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Similarity. Belongs to the intermediate filament family.

RefSeq proteins (1): NP_002273* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR003054	Keratin_II	Family
IPR009030	Growth_fac_rcpt_cys_sf	Homologous_superfamily
IPR018039	IF_conserved	Conserved_site
IPR032444	Keratin_2_head	Domain
IPR039008	IF_rod_dom	Domain

Pfam: PF00038, PF16208

UniProt features (18 total): region of interest 7, sequence variant 5, sequence conflict 3, chain 1, domain 1, cross-link 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P78385-F1	74.81	0.53

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 217

Function

Pathways and Gene Ontology

Reactome pathways

3 pathways

ID	Pathway
R-HSA-6805567	Keratinization
R-HSA-6809371	Formation of the cornified envelope
R-HSA-1266738	Developmental Biology

MSigDB gene sets: 107 (showing top): GOBP_EPITHELIUM_DEVELOPMENT, GOBP_INTERMEDIATE_FILAMENT_BASED_PROCESS, GOBP_INTERMEDIATE_FILAMENT_ORGANIZATION, GCM_MYCL1, GOBP_EPIDERMAL_CELL_DIFFERENTIATION, MARTINEZ_RB1_TARGETS_DN, GOBP_MOLTING_CYCLE, GOBP_EPIDERMIS_DEVELOPMENT, GCM_TEC, POU3F2_02, GOBP_KERATINIZATION, MORF_ATF2, GOBP_SKIN_DEVELOPMENT, ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN, GOCC_INTERMEDIATE_FILAMENT_CYTOSKELETON

GO Biological Process (4): epidermis development (GO:0008544), keratinization (GO:0031424), hair cycle (GO:0042633), intermediate filament organization (GO:0045109)

GO Molecular Function (2): structural constituent of skin epidermis (GO:0030280), protein binding (GO:0005515)

GO Cellular Component (4): obsolete extracellular space (GO:0005615), cytosol (GO:0005829), keratin filament (GO:0045095), intermediate filament (GO:0005882)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Developmental Biology	1
Keratinization	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
tissue development	1
keratinocyte differentiation	1
multicellular organismal process	1
molting cycle	1
intermediate filament cytoskeleton organization	1
supramolecular fiber organization	1
structural molecule activity	1
binding	1
cytoplasm	1
cellular anatomical structure	1
intermediate filament	1
intermediate filament cytoskeleton	1
polymeric cytoskeletal fiber	1

Protein interactions and networks

STRING

830 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
KRT83	DSG4	Q86SJ6	887
KRT83	KRT25	Q7Z3Z0	460
KRT83	KRTAP3-1	Q9BYR8	455
KRT83	FAM187B	Q17R55	453
KRT83	ZNF546	Q86UE3	450
KRT83	KRTAP4-16	G5E9R7	446
KRT83	KRTAP6-1	Q3LI64	435
KRT83	OR7G3	Q8NG95	429
KRT83	KRTAP16-1	A8MUX0	423
KRT83	MAGEB16	A2A368	406
KRT83	TCHH	Q07283	403
KRT83	CCHCR1	Q8TD31	398
KRT83	SLC22A24	Q8N4F4	396
KRT83	PRR27	Q6MZM9	394
KRT83	CBY2	Q8NA61	387

IntAct

144 interactions, top by confidence:

A	B	Type	Score
KRT83	KRT38	psi-mi:“MI:0915”(physical association)	0.780
KRT38	KRT83	psi-mi:“MI:0915”(physical association)	0.780
KRT31	KRT83	psi-mi:“MI:0915”(physical association)	0.720
KRT83	KRT31	psi-mi:“MI:0915”(physical association)	0.720
KRT83	KRTAP3-3	psi-mi:“MI:0915”(physical association)	0.630
	KRT83	psi-mi:“MI:0915”(physical association)	0.560
KRTAP10-7	KRT83	psi-mi:“MI:0915”(physical association)	0.560
KRTAP10-8	KRT83	psi-mi:“MI:0915”(physical association)	0.560
KRTAP10-9	KRT83	psi-mi:“MI:0915”(physical association)	0.560
NOTCH2NLA	KRT83	psi-mi:“MI:0915”(physical association)	0.560
KRT83	KRTAP10-7	psi-mi:“MI:0915”(physical association)	0.560
KRT83	KRTAP10-9	psi-mi:“MI:0915”(physical association)	0.560
KRT83	OTX1	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (79): KRT83 (Two-hybrid), KRT38 (Two-hybrid), KRTAP10-7 (Two-hybrid), KRTAP10-9 (Two-hybrid), KRTAP10-8 (Two-hybrid), KRTAP10-3 (Two-hybrid), NOTCH2NL (Two-hybrid), KRT83 (Affinity Capture-MS), KRT83 (Affinity Capture-MS), KRT83 (Two-hybrid), KRT83 (Two-hybrid), KRT83 (Two-hybrid), KRT83 (Two-hybrid), KRT83 (Two-hybrid), KRT83 (Two-hybrid)

ESM2 similar proteins: A4FUZ0, A5A6M5, A5A6P3, A6QNX5, A7YWK3, B0LKP1, B1AQ75, E1AB55, O43790, O76009, O76013, P02534, P15241, P19013, P25690, P25691, P78385, P78386, P97861, Q0P5J7, Q14525, Q14532, Q14533, Q148H4, Q148H5, Q148H7, Q148H8, Q14CN4, Q15323, Q3SY84, Q497I4, Q61765, Q61897, Q62168, Q6IG03, Q6IG04, Q6IME9, Q6IMF0, Q6NXH9, Q86Y46

Diamond homologs: A0A125S9M6, A0JND2, A4FUZ0, A5A6M8, A6NCN2, A7YWK3, O43790, P02542, P02545, P02547, P02548, P04104, P04260, P04261, P04262, P04263, P07196, P07744, P08551, P08928, P09010, P10999, P12035, P12036, P13647, P13648, P15241, P16884, P19013, P19246, P19527, P21619, P21910, P25691, P35908, P48671, P48672, P48678, P48679, P78385

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 48 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Formation of the cornified envelope	13	32.6×	2e-15
Keratinization	20	31.8×	1e-24

GO biological processes:

GO term	Partners	Fold	FDR
morphogenesis of an epithelium	13	117.7×	3e-22
intermediate filament organization	13	82.4×	2e-20
epithelial cell differentiation	12	55.4×	1e-16

Disease & clinical

Clinical variants and AI predictions

ClinVar

252 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	2
Uncertain significance	131
Likely benign	28
Benign	69

Top pathogenic / likely-pathogenic (3)

Variant ID	HGVS	Classification
446110	NM_002282.3(KRT83):c.1252G>A (p.Glu418Lys)	Pathogenic
191039	NM_002282.3(KRT83):c.1244T>G (p.Leu415Arg)	Likely pathogenic
6837	NM_002282.3(KRT83):c.1219G>A (p.Glu407Lys)	Likely pathogenic

SpliceAI

1199 predictions. Top by Δscore:

Variant	Effect	Δscore
12:52315890:CA:C	donor_loss	1.0000
12:52315892:C:CT	donor_loss	1.0000
12:52315892:CCT:C	donor_gain	1.0000
12:52316109:GAGTT:G	acceptor_gain	1.0000
12:52316110:AGTT:A	acceptor_gain	1.0000
12:52316110:AGTTC:A	acceptor_gain	1.0000
12:52316111:GTT:G	acceptor_gain	1.0000
12:52316111:GTTC:G	acceptor_gain	1.0000
12:52316112:TT:T	acceptor_gain	1.0000
12:52316112:TTCTG:T	acceptor_gain	1.0000
12:52316114:C:CC	acceptor_gain	1.0000
12:52316121:G:C	acceptor_gain	1.0000
12:52316121:G:GC	acceptor_gain	1.0000
12:52316130:A:AC	acceptor_gain	1.0000
12:52316130:A:C	acceptor_gain	1.0000
12:52316132:A:AC	acceptor_gain	1.0000
12:52316132:A:C	acceptor_gain	1.0000
12:52316463:GGTAC:G	donor_loss	1.0000
12:52316465:TA:T	donor_loss	1.0000
12:52316466:A:C	donor_loss	1.0000
12:52316467:C:CG	donor_loss	1.0000
12:52316467:CCTG:C	donor_gain	1.0000
12:52316468:CTGG:C	donor_gain	1.0000
12:52316469:TGGC:T	donor_gain	1.0000
12:52316589:TCACA:T	acceptor_gain	1.0000
12:52316590:CACA:C	acceptor_gain	1.0000
12:52316590:CACAC:C	acceptor_gain	1.0000
12:52316591:ACA:A	acceptor_gain	1.0000
12:52316592:CA:C	acceptor_gain	1.0000
12:52316592:CAC:C	acceptor_gain	1.0000

AlphaMissense

3227 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
12:52317913:C:A	K217N	0.990
12:52317913:C:G	K217N	0.990
12:52316882:C:G	A298P	0.987
12:52320970:G:C	F122L	0.986
12:52320970:G:T	F122L	0.986
12:52320972:A:G	F122L	0.986
12:52316479:C:G	A344P	0.983
12:52316499:A:G	L337P	0.983
12:52316520:A:G	L330P	0.983
12:52320971:A:G	F122S	0.982
12:52315952:C:A	K401N	0.980
12:52315952:C:G	K401N	0.980
12:52316050:C:G	A369P	0.976
12:52316003:C:A	K384N	0.975
12:52316003:C:G	K384N	0.975
12:52316890:C:G	R295P	0.975
12:52316514:C:G	R332P	0.974
12:52316550:A:G	L320P	0.974
12:52320971:A:C	F122C	0.973
12:52320979:G:C	N119K	0.972
12:52320979:G:T	N119K	0.972
12:52317925:A:C	F213L	0.969
12:52317925:A:T	F213L	0.969
12:52317927:A:G	F213L	0.969
12:52317939:C:G	A209P	0.969
12:52315944:A:G	L404P	0.967
12:52320961:G:C	F125L	0.967
12:52320961:G:T	F125L	0.967
12:52320963:A:G	F125L	0.967
12:52319345:T:G	Q135P	0.966

dbSNP variants (sampled 300 via entrez): RS1000154181 (12:52320424 G>A), RS1000243240 (12:52314479 G>A,C,T), RS1000810122 (12:52318806 G>A), RS1001331106 (12:52316058 A>C,G), RS1001481516 (12:52321488 C>A,T), RS1002930395 (12:52318435 T>C), RS1003497880 (12:52323062 T>C), RS1003792586 (12:52322486 A>G), RS1003824933 (12:52322737 C>T), RS1004106949 (12:52318172 GT>G,GTT), RS1004555621 (12:52316762 A>T), RS1004569594 (12:52322497 A>G), RS1004592659 (12:52322117 G>A), RS1004692256 (12:52322103 A>G,T), RS1006356570 (12:52318165 C>G,T)

Disease associations

OMIM: gene MIM:602765 | disease phenotypes: MIM:158000, MIM:617756, MIM:621170

GenCC curated gene-disease

Disease	Classification	Inheritance
monilethrix	Strong	Autosomal dominant
monilethrix-3	Moderate	Autosomal dominant
erythrokeratodermia variabilis	Supportive	Autosomal dominant
erythrokeratodermia variabilis et progressiva 5	Limited	Autosomal recessive

Mondo (5): monilethrix (MONDO:0008009), erythrokeratodermia variabilis et progressiva 5 (MONDO:0033015), monilethrix-1 (MONDO:0700343), monilethrix-3 (MONDO:0700342), erythrokeratodermia variabilis (MONDO:0017851)

Orphanet (1): Monilethrix (Orphanet:573)

HPO phenotypes

30 total (30 of 30 shown, HPO-id order):

HPO	Term
HP:0000006	Autosomal dominant inheritance
HP:0000007	Autosomal recessive inheritance
HP:0000164	Abnormality of the dentition
HP:0000499	Abnormal eyelash morphology
HP:0000518	Cataract
HP:0000534	Abnormal eyebrow morphology
HP:0000962	Hyperkeratosis
HP:0000972	Palmoplantar hyperkeratosis
HP:0000982	Palmoplantar keratoderma
HP:0001249	Intellectual disability
HP:0001387	Joint stiffness
HP:0001595	Abnormal hair morphology
HP:0001596	Alopecia
HP:0001597	Abnormal nail morphology
HP:0001805	Onychogryphosis
HP:0002213	Fine hair
HP:0002217	Slow-growing hair
HP:0002232	Patchy alopecia
HP:0002293	Alopecia of scalp
HP:0002299	Brittle hair
HP:0003593	Infantile onset
HP:0007502	Follicular hyperkeratosis
HP:0008070	Sparse hair
HP:0010783	Erythema
HP:0011463	Childhood onset
HP:0032470	Monilethrix
HP:0100543	Cognitive impairment
HP:0100699	Scarring
HP:0100753	Schizophrenia
HP:0200035	Skin plaque

GWAS associations

0 associations (top):

MeSH disease descriptors (3)

Descriptor	Name	Tree numbers
D056266	Erythrokeratodermia Variabilis	C16.320.850.337; C17.800.229.606; C17.800.428.304; C17.800.827.337
D056734	Monilethrix	C16.131.077.592; C16.320.850.647; C17.800.329.984; C17.800.827.602
C536154	Keratoderma palmoplantaris transgrediens (supp.)

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL4523262 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

16 total (human), top 16 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Cadmium Chloride	decreases reaction, increases abundance, increases palmitoylation, decreases expression	2
butyraldehyde	increases expression	1
2-bromopalmitate	decreases reaction, increases abundance, increases palmitoylation	1
zinc chromate	decreases expression, increases abundance	1
chromium hexavalent ion	decreases expression, increases abundance	1
CGP 52608	affects binding, increases reaction	1
abrine	decreases expression	1
jinfukang	affects cotreatment, decreases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Arsenic	increases methylation	1
Benzo(a)pyrene	increases methylation	1
Cadmium	decreases reaction, increases abundance, increases palmitoylation	1
Cisplatin	affects cotreatment, decreases expression	1
Diethylhexyl Phthalate	increases expression	1
Plant Extracts	affects cotreatment, decreases expression	1
Tobacco Smoke Pollution	decreases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL4341412	Binding	Binding affinity to KRT83 in human A549 cells lysates grown on SILAC media at 10 uM incubated for 1 hr by LC-MS/MS analysis relative to untreated control	Profiling withanolide A for therapeutic targets in neurodegenerative diseases. — Bioorg Med Chem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.