KRT86

Summary

KRT86 (keratin 86, HGNC:6463) is a protein-coding gene on chromosome 12q13, encoding Keratin, type II cuticular Hb6 (O43790).

This gene encodes a type II keratin protein, which heterodimerizes with type I keratins to form hair and nails. This gene is present in a cluster of related genes and pseudogenes on chromosome 12. Mutations in this gene have been observed in patients with the hair disease monilethrix.

Source: NCBI Gene 3892 — RefSeq curated summary.

At a glance

• Gene–disease (curated): monilethrix (Strong, GenCC) — +1 more curated relationship
• GWAS associations: 4
• Clinical variants (ClinVar): 163 total — 5 pathogenic, 1 likely-pathogenic
• Phenotypes (HPO): 23
• Druggable target: yes
• MANE Select transcript: NM_001320198

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:6463
Approved symbol	KRT86
Name	keratin 86
Location	12q13
Locus type	gene with protein product
Status	Approved
Aliases	MNX, Hb6
Ensembl gene	ENSG00000170442
Ensembl biotype	protein_coding
OMIM	601928
Entrez	3892

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 protein_coding

ENST00000293525, ENST00000423955, ENST00000553310, ENST00000958042

RefSeq mRNA: 1 — MANE Select: NM_001320198 NM_001320198

CCDS: CCDS41785

Canonical transcript exons

ENST00000423955 — 11 exons

Exon	Start	End
ENSE00001192821	52308404	52309163
ENSE00003258183	52275821	52275946
ENSE00003291427	52303100	52303308
ENSE00003299386	52274645	52274722
ENSE00003324040	52304932	52305027
ENSE00003380886	52304111	52304171
ENSE00003390986	52305240	52305404
ENSE00003396590	52305663	52305788
ENSE00003401680	52308233	52308264
ENSE00003413101	52306060	52306280
ENSE00003702225	52301913	52302285

Expression profiles

Bgee: expression breadth ubiquitous, 160 present calls, max score 93.03.

FANTOM5 (CAGE): breadth broad, TPM avg 0.5886 / max 74.6373, expressed in 204 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
125609	0.3031	162
125610	0.1640	98
125615	0.0829	6
125611	0.0194	8
125612	0.0191	5

Top tissues by expression

285 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	93.03	gold quality
sperm	CL:0000019	84.91	silver quality
right coronary artery	UBERON:0001625	82.14	gold quality
male germ cell	CL:0000015	81.96	silver quality
upper arm skin	UBERON:0004263	79.65	silver quality
buccal mucosa cell	CL:0002336	76.00	silver quality
hair follicle	UBERON:0002073	74.10	silver quality
endometrium epithelium	UBERON:0004811	72.89	gold quality
coronary artery	UBERON:0001621	70.34	gold quality
ascending aorta	UBERON:0001496	70.05	gold quality
amniotic fluid	UBERON:0000173	70.04	gold quality
left coronary artery	UBERON:0001626	69.96	gold quality
thoracic aorta	UBERON:0001515	69.71	gold quality
tibialis anterior	UBERON:0001385	69.46	silver quality
pancreatic ductal cell	CL:0002079	69.09	silver quality
decidua	UBERON:0002450	68.12	silver quality
left lobe of thyroid gland	UBERON:0001120	65.97	gold quality
thyroid gland	UBERON:0002046	65.71	gold quality
placenta	UBERON:0001987	65.13	gold quality
body of pancreas	UBERON:0001150	64.79	gold quality
right lobe of thyroid gland	UBERON:0001119	64.42	gold quality
aorta	UBERON:0000947	64.35	gold quality
secondary oocyte	CL:0000655	63.29	gold quality
minor salivary gland	UBERON:0001830	63.29	gold quality
deltoid	UBERON:0001476	62.99	silver quality
C1 segment of cervical spinal cord	UBERON:0006469	62.96	gold quality
saliva-secreting gland	UBERON:0001044	62.93	gold quality
descending thoracic aorta	UBERON:0002345	62.87	gold quality
left testis	UBERON:0004533	62.36	gold quality
spinal cord	UBERON:0002240	62.11	gold quality

Single-cell (SCXA)

Detected in 6 experiment(s), a significant marker in 5.

Experiment	Marker?	Max mean expression
E-GEOD-70580	yes	916.28
E-MTAB-6678	yes	651.33
E-MTAB-6701	yes	95.04
E-CURD-46	yes	15.93
E-CURD-122	yes	10.16
E-ANND-3	no	1.71

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 10)

• The KRTHB6 expression uniformly occurred in the midcortex region. (PMID:15797458)
• The results emphasized the key role of hair keratin hHB6 in the pathogenesis of monilethrix and indicated that the common mutation of hHB6 was also a cause of monilethrix in Chinese. (PMID:18393232)
• Mutation E402K of the hHb6 in a Chinese Han family with monilethrix. (PMID:19505862)
• Congenital monilethrix and hereditary unilateral external auditory canal atresia are co-inherited in a Chinese pedigree with recurrent KRT86 mutation. (PMID:22568869)
• Results idntify a novel mutation of krt86 protein causing monilethrix located in a region other than the helix. (PMID:22670615)
• The mutation of extron 7 of KRT86 identified plays a major role in the pathogenesis of this pedigree with monilethrix. (PMID:23981620)
• Novel mutations causing monilethrix are reported in KRT81, KRT83, and KRT86. (PMID:25557232)
• Analysis of KRT86 revealed a novel mutation, c.1231G>T;p.Glu411*, in exon 7 in the three affected children and their mother with monilethrix. (PMID:25809918)
• Study reported here a three-generation Chinese family with autosomal dominant monilethrix carrying a novel missense mutation c.1223G>C in KRT86. (PMID:29701253)
• Autosomal dominant monilethrix with incomplete penetrance due to a novel KRT86 mutation in a Chinese family. (PMID:38594178)

Cross-species orthologs

0 orthologs

Paralogs (68): KRT33A (ENSG00000006059), VIM (ENSG00000026025), KRT31 (ENSG00000094796), NEFM (ENSG00000104722), KRT23 (ENSG00000108244), KRT37 (ENSG00000108417), KRT32 (ENSG00000108759), KRT18 (ENSG00000111057), LMNB1 (ENSG00000113368), KRT36 (ENSG00000126337), KRT17 (ENSG00000128422), GFAP (ENSG00000131095), KRT34 (ENSG00000131737), KRT33B (ENSG00000131738), NES (ENSG00000132688), PRPH (ENSG00000135406), KRT85 (ENSG00000135443), KRT7 (ENSG00000135480), KRT71 (ENSG00000139648), INA (ENSG00000148798), LMNTD1 (ENSG00000152936), LMNA (ENSG00000160789), KRT84 (ENSG00000161849), KRT82 (ENSG00000161850), KRT80 (ENSG00000167767), KRT1 (ENSG00000167768), KRT24 (ENSG00000167916), KRT8 (ENSG00000170421), KRT78 (ENSG00000170423), KRT75 (ENSG00000170454), KRT6C (ENSG00000170465), KRT4 (ENSG00000170477), KRT74 (ENSG00000170484), KRT72 (ENSG00000170486), KRT83 (ENSG00000170523), BFSP2 (ENSG00000170819), KRT19 (ENSG00000171345), KRT15 (ENSG00000171346), KRT38 (ENSG00000171360), KRT13 (ENSG00000171401)

Protein

Protein identifiers

Keratin, type II cuticular Hb6 — O43790 (reviewed: O43790)

Alternative names: Hair keratin K2.11, Keratin-86, Type II hair keratin Hb6, Type-II keratin Kb26

All UniProt accessions (2): O43790, U3KPR1

UniProt curated annotations — full annotation on UniProt →

Subunit / interactions. Heterotetramer of two type I and two type II keratins.

Tissue specificity. Synthesis begins slightly higher in the hair shaft than HB1 and HB3 and continues much farther up, ending in the keratogeneous zone.

Disease relevance. Monilethrix 1 (MNLIX1) [MIM:158000] A form of monilethrix, a disorder of the hair shaft characterized by brittle hair, follicular papules, and varying degrees of alopecia. Affected hairs have uniform elliptical nodes of normal thickness and intermittent constrictions, internodes at which the hair easily breaks. Usually only the scalp is involved, but in severe forms, the secondary sexual hair, eyebrows, eyelashes, and nails may also be affected. Inheritance is autosomal dominant. The disease is caused by variants affecting the gene represented in this entry.

Miscellaneous. There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Similarity. Belongs to the intermediate filament family.

RefSeq proteins (1): NP_001307127* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR003054	Keratin_II	Family
IPR018039	IF_conserved	Conserved_site
IPR032444	Keratin_2_head	Domain
IPR039008	IF_rod_dom	Domain

Pfam: PF00038, PF16208

UniProt features (19 total): sequence variant 8, region of interest 7, chain 1, domain 1, sequence conflict 1, cross-link 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O43790-F1	75.50	0.53

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 212

Function

Pathways and Gene Ontology

Reactome pathways

3 pathways

ID	Pathway
R-HSA-6805567	Keratinization
R-HSA-6809371	Formation of the cornified envelope
R-HSA-1266738	Developmental Biology

MSigDB gene sets: 198 (showing top): GSE45365_CD8A_DC_VS_CD11B_DC_IFNAR_KO_MCMV_INFECTION_UP, GSE45365_NK_CELL_VS_CD11B_DC_UP, MODULE_52, GOBP_EPITHELIUM_DEVELOPMENT, MORF_FLT1, CAR_TNFRSF25, GOBP_INTERMEDIATE_FILAMENT_BASED_PROCESS, MORF_MSH3, GOBP_INTERMEDIATE_FILAMENT_ORGANIZATION, MODULE_45, MORF_BRCA1, MORF_ATRX, FOXO4_01, MORF_ESR1, MODULE_16

GO Biological Process (2): keratinization (GO:0031424), intermediate filament organization (GO:0045109)

GO Molecular Function (2): structural constituent of skin epidermis (GO:0030280), protein binding (GO:0005515)

GO Cellular Component (4): obsolete extracellular space (GO:0005615), cytosol (GO:0005829), keratin filament (GO:0045095), intermediate filament (GO:0005882)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Developmental Biology	1
Keratinization	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
keratinocyte differentiation	1
multicellular organismal process	1
intermediate filament cytoskeleton organization	1
supramolecular fiber organization	1
structural molecule activity	1
binding	1
cytoplasm	1
cellular anatomical structure	1
intermediate filament	1
intermediate filament cytoskeleton	1
polymeric cytoskeletal fiber	1

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

155 interactions, top by confidence:

A	B	Type	Score
KRT86	KRT15	psi-mi:“MI:0915”(physical association)	0.780
KRT15	KRT86	psi-mi:“MI:0915”(physical association)	0.780
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
KRT86	KRT39	psi-mi:“MI:0915”(physical association)	0.630
MEOX2	KRT86	psi-mi:“MI:0915”(physical association)	0.560
KRT86	MEOX2	psi-mi:“MI:0915”(physical association)	0.560
KRT86	KRT37	psi-mi:“MI:0915”(physical association)	0.560
KRT86	KRT19	psi-mi:“MI:0915”(physical association)	0.560
KRT86	KRT31	psi-mi:“MI:0915”(physical association)	0.560
KRT86	KRT36	psi-mi:“MI:0915”(physical association)	0.560
KRT86	KRT34	psi-mi:“MI:0915”(physical association)	0.560
KRT86	KRT16	psi-mi:“MI:0915”(physical association)	0.560
KRT86	KRT35	psi-mi:“MI:0915”(physical association)	0.560
KRT86	KRT38	psi-mi:“MI:0915”(physical association)	0.560
KRT86	KRT33B	psi-mi:“MI:0915”(physical association)	0.560
KRT86	KRT25	psi-mi:“MI:0915”(physical association)	0.560
KRT86	KRT40	psi-mi:“MI:0915”(physical association)	0.560
KRT86	KRT27	psi-mi:“MI:0915”(physical association)	0.560
CYSRT1	KRT86	psi-mi:“MI:0915”(physical association)	0.560
KRT86	ODF1	psi-mi:“MI:0915”(physical association)	0.560
KRT86	KRT14	psi-mi:“MI:0915”(physical association)	0.560
KRT86	KRT32	psi-mi:“MI:0915”(physical association)	0.560
KRT86	ZNF414	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (89): KRT86 (Two-hybrid), MEOX2 (Two-hybrid), KRT86 (Affinity Capture-MS), KRT86 (Affinity Capture-MS), KRT86 (Affinity Capture-MS), KRT86 (Affinity Capture-MS), KRT86 (Two-hybrid), KRT86 (Two-hybrid), KRT86 (Two-hybrid), KRT86 (Two-hybrid), KRT86 (Two-hybrid), KRT86 (Two-hybrid), KRT86 (Two-hybrid), KRT86 (Two-hybrid), KRT86 (Two-hybrid)

ESM2 similar proteins: A4FUZ0, A5A6M5, A5A6P3, A6QNX5, A7YWK3, B0LKP1, B1AQ75, E1AB55, O43790, O76009, O76013, P02534, P15241, P19013, P25690, P25691, P78385, P78386, P97861, Q0P5J7, Q14525, Q14532, Q14533, Q148H4, Q148H5, Q148H7, Q148H8, Q14CN4, Q15323, Q3SY84, Q497I4, Q61765, Q61897, Q62168, Q6IG03, Q6IG04, Q6IME9, Q6IMF0, Q6NXH9, Q86Y46

Diamond homologs: A0A125S9M6, A0JND2, A4FUZ0, A5A6M8, A6NCN2, A7YWK3, O43790, P02542, P02545, P02547, P02548, P04104, P04260, P04261, P04262, P04263, P07196, P07744, P08551, P08928, P09010, P10999, P12035, P12036, P13647, P13648, P15241, P16884, P19013, P19246, P19527, P21619, P21910, P25691, P35908, P48671, P48672, P48678, P48679, P78385

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 60 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Formation of the cornified envelope	18	42.7×	1e-23
Keratinization	18	27.1×	3e-20

GO biological processes:

GO term	Partners	Fold	FDR
morphogenesis of an epithelium	17	106.3×	5e-29
intermediate filament organization	18	78.8×	2e-28
epithelial cell differentiation	15	47.9×	5e-20
epidermis development	5	19.1×	3e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

163 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	5
Likely pathogenic	1
Uncertain significance	86
Likely benign	21
Benign	34

Top pathogenic / likely-pathogenic (6)

Variant ID	HGVS	Classification
7609	NM_001320198.2(KRT86):c.1237G>A (p.Glu413Lys)	Pathogenic
7610	NM_001320198.2(KRT86):c.1239G>T (p.Glu413Asp)	Pathogenic
7612	NM_001320198.2(KRT86):c.340A>G (p.Asn114Asp)	Pathogenic
7613	NM_001320198.2(KRT86):c.1204G>C (p.Glu402Gln)	Pathogenic
7614	NM_001320198.2(KRT86):c.353C>A (p.Ala118Glu)	Pathogenic
7611	NM_001320198.2(KRT86):c.1204G>A (p.Glu402Lys)	Likely pathogenic

SpliceAI

2577 predictions. Top by Δscore:

Variant	Effect	Δscore
12:52286789:A:AC	donor_gain	1.0000
12:52286790:C:CC	donor_gain	1.0000
12:52287097:CCCA:C	donor_loss	1.0000
12:52287099:CA:C	donor_loss	1.0000
12:52287100:A:AC	donor_gain	1.0000
12:52287100:ACC:A	donor_loss	1.0000
12:52287101:C:CA	donor_loss	1.0000
12:52287101:C:CC	donor_gain	1.0000
12:52287101:CCT:C	donor_gain	1.0000
12:52287187:C:CA	donor_gain	1.0000
12:52287318:GAGTT:G	acceptor_gain	1.0000
12:52287319:AGTT:A	acceptor_gain	1.0000
12:52287319:AGTTC:A	acceptor_gain	1.0000
12:52287320:GTT:G	acceptor_gain	1.0000
12:52287320:GTTCT:G	acceptor_gain	1.0000
12:52287321:TT:T	acceptor_gain	1.0000
12:52287321:TTCT:T	acceptor_gain	1.0000
12:52287322:TCTGA:T	acceptor_gain	1.0000
12:52287323:C:CC	acceptor_gain	1.0000
12:52287323:CTG:C	acceptor_gain	1.0000
12:52287324:T:A	acceptor_gain	1.0000
12:52287324:T:C	acceptor_loss	1.0000
12:52287333:C:CT	acceptor_gain	1.0000
12:52287334:A:T	acceptor_gain	1.0000
12:52287594:A:T	donor_loss	1.0000
12:52287595:CCTG:C	donor_gain	1.0000
12:52287597:TGGC:T	donor_gain	1.0000
12:52287613:C:CT	donor_gain	1.0000
12:52287614:C:CT	donor_gain	1.0000
12:52287717:TCAC:T	acceptor_gain	1.0000

AlphaMissense

3178 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
12:52304168:G:C	K212N	0.995
12:52304168:G:T	K212N	0.995
12:52306259:T:C	L409P	0.995
12:52302265:T:C	F117L	0.994
12:52302267:C:A	F117L	0.994
12:52302267:C:G	F117L	0.994
12:52302266:T:C	F117S	0.993
12:52305757:T:C	L332P	0.993
12:52305777:G:C	A339P	0.993
12:52306221:G:C	K396N	0.993
12:52306221:G:T	K396N	0.993
12:52306249:T:C	Y406H	0.993
12:52306229:T:C	L399P	0.991
12:52306239:G:C	E402D	0.991
12:52306239:G:T	E402D	0.991
12:52306243:G:C	A404P	0.991
12:52306249:T:G	Y406D	0.991
12:52306241:T:G	I403S	0.990
12:52302258:C:A	N114K	0.989
12:52302258:C:G	N114K	0.989
12:52303119:A:C	Q130P	0.989
12:52306165:G:C	A378P	0.989
12:52302254:T:C	L113P	0.988
12:52303110:T:C	L127P	0.988
12:52302266:T:G	F117C	0.987
12:52302274:T:C	F120L	0.987
12:52302276:C:A	F120L	0.987
12:52302276:C:G	F120L	0.987
12:52304154:T:C	F208L	0.987
12:52304156:T:A	F208L	0.987

dbSNP variants (sampled 300 via entrez): RS1000437601 (12:52288662 C>T), RS1000599780 (12:52282815 T>C), RS1000746592 (12:52289181 A>G), RS1000833401 (12:52295813 A>G), RS1000869663 (12:52276868 G>A,C), RS1000922207 (12:52277128 G>A), RS1000994955 (12:52291963 T>G), RS1001067984 (12:52301963 C>G,T), RS1001178166 (12:52287906 A>T), RS1001452533 (12:52283682 A>G,T), RS1001470675 (12:52273156 A>G), RS1001595314 (12:52279580 A>G,T), RS1001666387 (12:52295098 G>A), RS1001870986 (12:52282063 C>G,T), RS1001996880 (12:52293424 T>C)

Disease associations

OMIM: gene MIM:601928 | disease phenotypes: MIM:158000

GenCC curated gene-disease

Disease	Classification	Inheritance
monilethrix	Strong	Autosomal dominant
monilethrix-1	Strong	Autosomal dominant

Mondo (2): monilethrix (MONDO:0008009), monilethrix-1 (MONDO:0700343)

Orphanet (1): Monilethrix (Orphanet:573)

HPO phenotypes

23 total (23 of 23 shown, HPO-id order):

HPO	Term
HP:0000006	Autosomal dominant inheritance
HP:0000164	Abnormality of the dentition
HP:0000499	Abnormal eyelash morphology
HP:0000518	Cataract
HP:0000534	Abnormal eyebrow morphology
HP:0001249	Intellectual disability
HP:0001596	Alopecia
HP:0001597	Abnormal nail morphology
HP:0002164	Nail dysplasia
HP:0002213	Fine hair
HP:0002217	Slow-growing hair
HP:0002232	Patchy alopecia
HP:0002299	Brittle hair
HP:0003593	Infantile onset
HP:0003828	Variable expressivity
HP:0007468	Perifollicular hyperkeratosis
HP:0007502	Follicular hyperkeratosis
HP:0008070	Sparse hair
HP:0008404	Nail dystrophy
HP:0010719	Abnormality of hair texture
HP:0032152	Keratosis pilaris
HP:0100543	Cognitive impairment
HP:0100753	Schizophrenia

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST002359_4	Plasma amyloid beta peptide concentrations (ABx-42)	2.000000e-06
GCST002875_23	Diisocyanate-induced asthma	1.000000e-06
GCST006988_173	Blond vs. brown/black hair color	2.000000e-12
GCST007637_15	Diffusing capacity of carbon monoxide	7.000000e-06

EFO canonical traits (4, from GWAS)

EFO ID	Trait name
EFO:0005660	plasma beta-amyloid 1-42 measurement
EFO:0006995	response to diisocyanate
EFO:0003924	hair color
EFO:0009369	diffusing capacity of the lung for carbon monoxide

MeSH disease descriptors (1)

Descriptor	Name	Tree numbers
D056734	Monilethrix	C16.131.077.592; C16.320.850.647; C17.800.329.984; C17.800.827.602

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL4523139 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

31 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Acetaminophen	decreases expression, increases expression	2
Estradiol	affects expression, increases reaction, decreases expression	2
Cyclosporine	decreases expression, increases expression	2
GSK-J4	decreases expression	1
afuresertib	increases expression	1
sotorasib	affects cotreatment, increases expression	1
propionaldehyde	increases expression	1
sulforaphane	decreases expression	1
sodium arsenite	decreases expression	1
butylbenzyl phthalate	increases expression	1
vanadyl sulfate	increases expression	1
homosalate	affects cotreatment, decreases expression	1
abrine	decreases expression	1
jinfukang	affects cotreatment, decreases expression	1
trametinib	affects cotreatment, increases expression	1
NVP-BKM120	affects cotreatment, increases expression	1
Temozolomide	increases expression	1
Air Pollutants	decreases expression, increases abundance	1
Benzo(a)pyrene	affects methylation	1
Cisplatin	affects cotreatment, decreases expression	1
Fluorouracil	decreases expression, affects response to substance	1
Hydrogen Peroxide	increases expression	1
Polystyrenes	affects cotreatment, decreases expression	1
Progesterone	increases expression	1
Silicon Dioxide	decreases expression	1
Smoke	decreases expression	1
Tamoxifen	decreases expression	1
Tretinoin	increases expression	1
Vitallium	decreases expression	1
Aflatoxin B1	decreases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL4341411	Binding	Binding affinity to KRT86 in human A549 cells lysates grown on SILAC media at 10 uM incubated for 1 hr by LC-MS/MS analysis relative to untreated control	Profiling withanolide A for therapeutic targets in neurodegenerative diseases. — Bioorg Med Chem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.