KTN1-AS1

Summary

KTN1-AS1 (KTN1 antisense RNA 1, HGNC:19842) is a long non-coding RNA gene on chromosome 14q22.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:19842
Approved symbol	KTN1-AS1
Name	KTN1 antisense RNA 1
Location	14q22.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	MYCLo-3
Ensembl gene	ENSG00000186615
Ensembl biotype	lncRNA
Entrez	100129075
RNAcentral	URS000075BA48 — lncRNA, 1512 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 12 lncRNA

ENST00000335142, ENST00000412224, ENST00000535211, ENST00000554558, ENST00000653613, ENST00000663686, ENST00000663990, ENST00000743879, ENST00000743880, ENST00000743881, ENST00000743882, ENST00000743883

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000335142 — 3 exons

Exon	Start	End
ENSE00001340609	55578606	55578737
ENSE00004082676	55576186	55577379
ENSE00004082679	55579936	55580150

Expression profiles

Bgee: expression breadth ubiquitous, 135 present calls, max score 82.79.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 4.9461 / max 62.5457, expressed in 1509 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
143374	4.9461	1509

Top tissues by expression

138 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.79	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	76.62	gold quality
adrenal tissue	UBERON:0018303	72.94	gold quality
apex of heart	UBERON:0002098	72.63	gold quality
skin of abdomen	UBERON:0001416	72.55	gold quality
skeletal muscle tissue	UBERON:0001134	72.31	gold quality
ovary	UBERON:0000992	72.10	gold quality
left ovary	UBERON:0002119	72.08	gold quality
zone of skin	UBERON:0000014	72.04	gold quality
body of pancreas	UBERON:0001150	72.01	gold quality
skin of leg	UBERON:0001511	71.49	gold quality
gastrocnemius	UBERON:0001388	71.36	gold quality
muscle of leg	UBERON:0001383	71.27	gold quality
left adrenal gland	UBERON:0001234	71.23	gold quality
ventricular zone	UBERON:0003053	71.23	gold quality
stromal cell of endometrium	CL:0002255	71.16	gold quality
pancreas	UBERON:0001264	71.15	gold quality
adrenal gland	UBERON:0002369	71.01	gold quality
right ovary	UBERON:0002118	70.85	gold quality
left adrenal gland cortex	UBERON:0035825	70.54	gold quality
right adrenal gland	UBERON:0001233	70.42	gold quality
muscle tissue	UBERON:0002385	70.42	gold quality
hindlimb stylopod muscle	UBERON:0004252	70.40	gold quality
heart left ventricle	UBERON:0002084	70.05	gold quality
heart	UBERON:0000948	69.99	gold quality
islet of Langerhans	UBERON:0000006	69.82	gold quality
popliteal artery	UBERON:0002250	69.80	gold quality
tibial artery	UBERON:0007610	69.79	gold quality
endometrium	UBERON:0001295	69.65	gold quality
right atrium auricular region	UBERON:0006631	69.35	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.55

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 9)

• Long noncoding RNA KTN1-AS1 promotes head and neck squamous cell carcinoma cell epithelial-mesenchymal transition by targeting miR-153-3p. (PMID:32267161)
• STAT1-induced upregulation of lncRNA KTN1-AS1 predicts poor prognosis and facilitates non-small cell lung cancer progression via miR-23b/DEPDC1 axis. (PMID:32396871)
• LncRNA KTN1-AS1 promotes the progression of non-small cell lung cancer via sponging of miR-130a-5p and activation of PDPK1. (PMID:32820252)
• lncRNA KTN1AS1 promotes glioma cell proliferation and invasion by negatively regulating miR5053p. (PMID:33125151)
• The long noncoding RNA KTN1-AS1 promotes bladder cancer tumorigenesis via KTN1 cis-activation and the consequent initiation of Rho GTPase-mediated signaling. (PMID:33480975)
• Long noncoding RNA KTN1 antisense RNA 1exerts an oncogenic function in lung adenocarcinoma by regulating DEP domain containing 1 expression via activating epithelial-mesenchymal transition. (PMID:33491970)
• IncRNA KTN1-AS1 Silencing Inhibits Non-Small-Cell Lung Cancer Cell Proliferation and KTN1-AS1 Expression Predicts Survival. (PMID:35381130)
• The lncRNA KTN1-AS1 co-regulates a variety of Myc-target genes and enhances proliferation of Burkitt lymphoma cells. (PMID:35866590)
• Long Non-coding RNA KTN1-AS1 Targets miR-505 to Promote Glioblastoma Progression. (PMID:36762036)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.