L3MBTL2-AS1

Summary

L3MBTL2-AS1 (L3MBTL2 antisense RNA 1, HGNC:40847) is a long non-coding RNA gene on chromosome 22q13.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40847
Approved symbol	L3MBTL2-AS1
Name	L3MBTL2 antisense RNA 1
Location	22q13.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000235513
Ensembl biotype	lncRNA
Entrez	100506544
RNAcentral	URS00004A8CFE — lncRNA, 2500 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 lncRNA

ENST00000441316, ENST00000451176, ENST00000657161, ENST00000658453

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000441316 — 4 exons

Exon	Start	End
ENSE00001784230	41217032	41217310
ENSE00003867134	41208552	41209951
ENSE00003886507	41213796	41214703
ENSE00003886769	41217393	41217646

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 80.46.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.3406 / max 11.4203, expressed in 176 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
194344	0.2780	145
194343	0.0626	28

Top tissues by expression

136 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
thymus	UBERON:0002370	80.46	silver quality
cerebellar vermis	UBERON:0004720	80.31	gold quality
quadriceps femoris	UBERON:0001377	79.79	gold quality
spinal cord	UBERON:0002240	74.68	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	74.65	gold quality
substantia nigra	UBERON:0002038	70.72	gold quality
monocyte	CL:0000576	70.65	gold quality
sural nerve	UBERON:0015488	70.48	gold quality
leukocyte	CL:0000738	70.27	gold quality
bone marrow cell	CL:0002092	69.95	silver quality
mucosa of stomach	UBERON:0001199	69.16	gold quality
colonic epithelium	UBERON:0000397	68.72	silver quality
corpus callosum	UBERON:0002336	67.76	gold quality
stromal cell of endometrium	CL:0002255	67.39	gold quality
Ammon’s horn	UBERON:0001954	67.36	gold quality
caudate nucleus	UBERON:0001873	66.65	gold quality
apex of heart	UBERON:0002098	66.07	gold quality
nucleus accumbens	UBERON:0001882	65.89	gold quality
putamen	UBERON:0001874	65.76	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	65.74	gold quality
tibial nerve	UBERON:0001323	65.28	gold quality
heart left ventricle	UBERON:0002084	65.25	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.17	gold quality
hypothalamus	UBERON:0001898	65.10	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.08	gold quality
lower esophagus	UBERON:0013473	65.06	gold quality
right atrium auricular region	UBERON:0006631	65.01	gold quality
amygdala	UBERON:0001876	65.00	gold quality
temporal lobe	UBERON:0001871	64.99	gold quality
cerebellum	UBERON:0002037	64.96	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	2.66

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.