LACTB2-AS1

Summary

LACTB2-AS1 (LACTB2 antisense RNA 1, HGNC:27841) is a long non-coding RNA gene on chromosome 8q13.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27841
Approved symbol	LACTB2-AS1
Name	LACTB2 antisense RNA 1
Location	8q13.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000246366
Ensembl biotype	lncRNA
Entrez	286190
RNAcentral	URS000075D2DF — lncRNA, 3727 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 18 — 18 lncRNA

ENST00000499227, ENST00000518152, ENST00000518553, ENST00000519167, ENST00000519358, ENST00000703251, ENST00000756119, ENST00000756120, ENST00000756121, ENST00000756122, ENST00000756123, ENST00000756124, ENST00000756125, ENST00000756126, ENST00000756127, ENST00000756128, ENST00000756129, ENST00000756130

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000499227 — 4 exons

Exon	Start	End
ENSE00001962917	70652511	70652752
ENSE00001983346	70660145	70663279
ENSE00001987006	70608577	70608833
ENSE00001991548	70651813	70651894

Expression profiles

Bgee: expression breadth ubiquitous, 159 present calls, max score 93.38.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0731 / max 16.6901, expressed in 14 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
89314	0.0731	14

Top tissues by expression

246 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	93.38	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.81	gold quality
bone marrow cell	CL:0002092	81.47	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	73.35	gold quality
left testis	UBERON:0004533	70.43	gold quality
testis	UBERON:0000473	69.47	gold quality
tonsil	UBERON:0002372	68.80	gold quality
buccal mucosa cell	CL:0002336	68.16	gold quality
right testis	UBERON:0004534	67.43	gold quality
right lobe of liver	UBERON:0001114	66.08	gold quality
ventricular zone	UBERON:0003053	65.73	gold quality
granulocyte	CL:0000094	65.17	gold quality
cortical plate	UBERON:0005343	64.29	gold quality
stromal cell of endometrium	CL:0002255	62.97	gold quality
lymph node	UBERON:0000029	61.99	gold quality
calcaneal tendon	UBERON:0003701	61.97	gold quality
hindlimb stylopod muscle	UBERON:0004252	61.27	gold quality
ganglionic eminence	UBERON:0004023	61.02	gold quality
liver	UBERON:0002107	60.84	gold quality
spleen	UBERON:0002106	59.94	gold quality
small intestine Peyer’s patch	UBERON:0003454	59.33	gold quality
apex of heart	UBERON:0002098	59.01	gold quality
small intestine	UBERON:0002108	58.36	gold quality
right adrenal gland	UBERON:0001233	57.96	gold quality
sural nerve	UBERON:0015488	57.94	silver quality
leukocyte	CL:0000738	57.72	gold quality
metanephros cortex	UBERON:0010533	57.36	gold quality
pituitary gland	UBERON:0000007	57.34	gold quality
adenohypophysis	UBERON:0002196	57.32	gold quality
vermiform appendix	UBERON:0001154	57.17	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.59

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.