LALTOP

Summary

LALTOP (lung cancer associated lncRNA targeting TOP2A, HGNC:58132) is a long non-coding RNA gene on chromosome 2p25.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:58132
Approved symbol	LALTOP
Name	lung cancer associated lncRNA targeting TOP2A
Location	2p25.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000228613
Ensembl biotype	lncRNA
Entrez	138842258
RNAcentral	URS0002A16661 — lncRNA, 1672 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 lncRNA

ENST00000438247, ENST00000816433, ENST00000816434

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000438247 — 3 exons

Exon	Start	End
ENSE00001644217	1619717	1620113
ENSE00001703386	1617167	1617284
ENSE00001791484	1546665	1546935

Expression profiles

Bgee: expression breadth ubiquitous, 108 present calls, max score 86.73.

Top tissues by expression

108 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right lobe of thyroid gland	UBERON:0001119	86.73	gold quality
left lobe of thyroid gland	UBERON:0001120	86.24	gold quality
thyroid gland	UBERON:0002046	84.18	gold quality
sural nerve	UBERON:0015488	75.90	gold quality
cortical plate	UBERON:0005343	66.60	gold quality
ventricular zone	UBERON:0003053	62.54	gold quality
monocyte	CL:0000576	59.13	gold quality
apex of heart	UBERON:0002098	58.24	gold quality
hindlimb stylopod muscle	UBERON:0004252	56.63	gold quality
skeletal muscle tissue	UBERON:0001134	56.03	gold quality
bone marrow	UBERON:0002371	54.99	gold quality
placenta	UBERON:0001987	54.12	gold quality
islet of Langerhans	UBERON:0000006	52.53	gold quality
spleen	UBERON:0002106	52.40	gold quality
prefrontal cortex	UBERON:0000451	52.37	gold quality
heart left ventricle	UBERON:0002084	52.20	gold quality
thoracic mammary gland	UBERON:0005200	52.16	gold quality
lymph node	UBERON:0000029	52.11	gold quality
calcaneal tendon	UBERON:0003701	52.05	silver quality
muscle of leg	UBERON:0001383	51.99	gold quality
mucosa of stomach	UBERON:0001199	51.64	gold quality
gastrocnemius	UBERON:0001388	51.52	gold quality
fallopian tube	UBERON:0003889	51.17	gold quality
liver	UBERON:0002107	51.00	silver quality
pancreas	UBERON:0001264	50.43	gold quality
right lobe of liver	UBERON:0001114	50.35	gold quality
heart	UBERON:0000948	50.12	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	49.99	gold quality
blood	UBERON:0000178	49.93	gold quality
gall bladder	UBERON:0002110	49.70	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.63

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.