LAMC1-AS1

Summary

LAMC1-AS1 (LAMC1 antisense RNA 1, HGNC:52645) is a long non-coding RNA gene on chromosome 1q25.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:52645
Approved symbol	LAMC1-AS1
Name	LAMC1 antisense RNA 1
Location	1q25.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	lnc-LAMC2-1:1
Ensembl gene	ENSG00000224468
Ensembl biotype	lncRNA
Entrez	110841583
RNAcentral	URS0000BC460C — lncRNA, 467 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000457852

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000457852 — 3 exons

Exon	Start	End
ENSE00001630776	183138402	183138580
ENSE00001753607	183140811	183140969
ENSE00001760655	183141142	183141282

Expression profiles

Bgee: expression breadth ubiquitous, 125 present calls, max score 92.86.

Top tissues by expression

125 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	92.86	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	90.73	gold quality
subcutaneous adipose tissue	UBERON:0002190	86.55	gold quality
adipose tissue	UBERON:0001013	83.37	gold quality
mucosa of stomach	UBERON:0001199	82.22	gold quality
tibial nerve	UBERON:0001323	82.21	gold quality
left uterine tube	UBERON:0001303	80.68	gold quality
thoracic mammary gland	UBERON:0005200	80.23	gold quality
omental fat pad	UBERON:0010414	79.83	gold quality
right lung	UBERON:0002167	78.94	gold quality
popliteal artery	UBERON:0002250	78.91	gold quality
tibial artery	UBERON:0007610	78.90	gold quality
ectocervix	UBERON:0012249	78.76	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	78.41	gold quality
gastrocnemius	UBERON:0001388	76.99	gold quality
lower esophagus muscularis layer	UBERON:0035833	76.94	gold quality
body of uterus	UBERON:0009853	76.90	gold quality
ascending aorta	UBERON:0001496	76.84	gold quality
lower esophagus	UBERON:0013473	76.84	gold quality
skin of leg	UBERON:0001511	76.64	gold quality
thoracic aorta	UBERON:0001515	76.59	gold quality
endocervix	UBERON:0000458	76.51	gold quality
gall bladder	UBERON:0002110	76.49	gold quality
left coronary artery	UBERON:0001626	76.44	gold quality
muscle layer of sigmoid colon	UBERON:0035805	76.39	gold quality
zone of skin	UBERON:0000014	76.00	gold quality
muscle of leg	UBERON:0001383	76.00	gold quality
uterine cervix	UBERON:0000002	75.90	gold quality
calcaneal tendon	UBERON:0003701	75.75	gold quality
vagina	UBERON:0000996	75.51	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.17

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• rs2147578 in lnc-LAMC2-1:1 might be a genetic modifier for the development of colorectal cancer. [lnc-LAMC2-1:1] (PMID:26905585)
• The Lnc-LAMC2-1:1 rs2147578 C > G polymorphism is associated with increased neuroblastoma susceptibility in Han populations of Northern China. (PMID:30285664)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.