LAMP5-AS1

Summary

LAMP5-AS1 (LAMP5 antisense RNA 1, HGNC:40754) is a long non-coding RNA gene on chromosome 20p12.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40754
Approved symbol	LAMP5-AS1
Name	LAMP5 antisense RNA 1
Location	20p12.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000225988
Ensembl biotype	lncRNA
Entrez	101929329
RNAcentral	URS0000058C9D — lncRNA, 1928 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 lncRNA

ENST00000443469, ENST00000772328, ENST00000772329

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000443469 — 5 exons

Exon	Start	End
ENSE00001626130	9508880	9509165
ENSE00001710061	9514764	9514998
ENSE00001753260	9506210	9506337
ENSE00001758930	9506925	9507259
ENSE00001803194	9505180	9506123

Expression profiles

Bgee: expression breadth broad, 51 present calls, max score 83.99.

Top tissues by expression

51 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow cell	CL:0002092	83.99	gold quality
blood	UBERON:0000178	81.32	gold quality
bone marrow	UBERON:0002371	64.13	gold quality
lung	UBERON:0002048	60.15	gold quality
nucleus accumbens	UBERON:0001882	58.50	gold quality
ventricular zone	UBERON:0003053	57.27	silver quality
ganglionic eminence	UBERON:0004023	54.53	silver quality
muscle of leg	UBERON:0001383	52.88	silver quality
prefrontal cortex	UBERON:0000451	51.49	gold quality
lymph node	UBERON:0000029	49.91	gold quality
caudate nucleus	UBERON:0001873	49.02	gold quality
duodenum	UBERON:0002114	48.77	gold quality
endometrium	UBERON:0001295	48.68	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	48.67	silver quality
putamen	UBERON:0001874	48.57	gold quality
gastrocnemius	UBERON:0001388	47.70	silver quality
brain	UBERON:0000955	46.20	gold quality
placenta	UBERON:0001987	45.94	silver quality
C1 segment of cervical spinal cord	UBERON:0006469	45.05	gold quality
frontal cortex	UBERON:0001870	45.03	gold quality
islet of Langerhans	UBERON:0000006	44.95	silver quality
primary visual cortex	UBERON:0002436	44.60	silver quality
left ovary	UBERON:0002119	44.44	gold quality
ovary	UBERON:0000992	43.87	gold quality
amygdala	UBERON:0001876	43.87	gold quality
right uterine tube	UBERON:0001302	43.67	silver quality
fallopian tube	UBERON:0003889	43.53	silver quality
thoracic aorta	UBERON:0001515	43.28	silver quality
Brodmann (1909) area 9	UBERON:0013540	42.88	silver quality
cerebral cortex	UBERON:0000956	42.64	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.48

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• The lncRNA LAMP5-AS1 drives leukemia cell stemness by directly modulating DOT1L methyltransferase activity in MLL leukemia. (PMID:32552847)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.