LAMTOR5-AS1

Summary

LAMTOR5-AS1 (LAMTOR5 and SLC16A4 antisense RNA 1, HGNC:40823) is a long non-coding RNA gene on chromosome 1p13.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40823
Approved symbol	LAMTOR5-AS1
Name	LAMTOR5 and SLC16A4 antisense RNA 1
Location	1p13.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000224699
Ensembl biotype	lncRNA
Entrez	101410535
RNAcentral	URS000075B6D8 — lncRNA, 533 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 82 — 81 lncRNA, 1 retained_intron

ENST00000444238, ENST00000457535, ENST00000585330, ENST00000585433, ENST00000587691, ENST00000590413, ENST00000590826, ENST00000596890, ENST00000597455, ENST00000598158, ENST00000598350, ENST00000598454, ENST00000599202, ENST00000608067, ENST00000608077, ENST00000608111, ENST00000608152, ENST00000608253, ENST00000608486, ENST00000608499, ENST00000608602, ENST00000608635, ENST00000608719, ENST00000609244, ENST00000609245, ENST00000609512, ENST00000609653, ENST00000609709, ENST00000610148, ENST00000612551, ENST00000616223, ENST00000622324, ENST00000625451, ENST00000625584, ENST00000625992, ENST00000626261, ENST00000626531, ENST00000626572, ENST00000626643, ENST00000627648, ENST00000627735, ENST00000628225, ENST00000629288, ENST00000629484, ENST00000630179, ENST00000630298, ENST00000630455, ENST00000630488, ENST00000630508, ENST00000631010, ENST00000631307, ENST00000659565, ENST00000662452, ENST00000692984, ENST00000702544, ENST00000702827, ENST00000703055, ENST00000715661, ENST00000715662, ENST00000767673, ENST00000767674, ENST00000767675, ENST00000837090, ENST00000837091, ENST00000837092, ENST00000837093, ENST00000837094, ENST00000837095, ENST00000837096, ENST00000837097, ENST00000837098, ENST00000837099, ENST00000837100, ENST00000837101, ENST00000837102, ENST00000837103, ENST00000837104, ENST00000837105, ENST00000837106, ENST00000837107, ENST00000837108, ENST00000837109

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000444238 — 5 exons

Exon	Start	End
ENSE00001541093	110414152	110414231
ENSE00001616218	110416009	110416188
ENSE00001704498	110418247	110418375
ENSE00001730343	110412993	110413094
ENSE00002810591	110421635	110422024

Expression profiles

Bgee: expression breadth ubiquitous, 167 present calls, max score 92.99.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 2.5370 / max 125.3448, expressed in 1158 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
4543	2.4587	1155
201610	0.0783	2

Top tissues by expression

254 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sperm	CL:0000019	92.99	gold quality
right testis	UBERON:0004534	88.98	gold quality
left testis	UBERON:0004533	88.69	gold quality
testis	UBERON:0000473	86.51	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.39	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	85.26	gold quality
calcaneal tendon	UBERON:0003701	82.87	gold quality
sural nerve	UBERON:0015488	81.08	gold quality
right uterine tube	UBERON:0001302	79.45	gold quality
gastrocnemius	UBERON:0001388	77.73	gold quality
muscle of leg	UBERON:0001383	77.67	gold quality
right lobe of liver	UBERON:0001114	76.96	gold quality
adrenal tissue	UBERON:0018303	76.66	gold quality
hindlimb stylopod muscle	UBERON:0004252	75.89	gold quality
ventricular zone	UBERON:0003053	75.04	gold quality
cerebellar hemisphere	UBERON:0002245	74.29	gold quality
right hemisphere of cerebellum	UBERON:0014890	74.29	gold quality
cerebellar cortex	UBERON:0002129	74.25	gold quality
bone marrow cell	CL:0002092	73.54	gold quality
cortical plate	UBERON:0005343	73.43	gold quality
monocyte	CL:0000576	73.18	gold quality
right ovary	UBERON:0002118	73.01	gold quality
leukocyte	CL:0000738	72.78	gold quality
ganglionic eminence	UBERON:0004023	72.78	gold quality
colonic epithelium	UBERON:0000397	72.71	gold quality
tibial nerve	UBERON:0001323	72.57	gold quality
apex of heart	UBERON:0002098	72.55	gold quality
left ovary	UBERON:0002119	72.40	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	72.39	gold quality
cerebellum	UBERON:0002037	71.91	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.66

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• LAMTOR5 expression level is a biomarker for colorectal cancer and lncRNA LAMTOR5-AS1 predicting miRNA sponging effect. (PMID:34374893)
• Long Noncoding RNA LAMTOR5-AS1 Interference Affects MicroRNA-506-3p/E2F6-Mediated Behavior of Non-Small Cell Lung Cancer Cells. (PMID:34588094)
• LncRNA LAMTOR5-AS1 sponges miR-210-3p and regulates cervical cancer progression. (PMID:36173004)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.