LANCL1-AS1

Summary

LANCL1-AS1 (LANCL1 antisense RNA 1, HGNC:50727) is a long non-coding RNA gene on chromosome 2q34.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50727
Approved symbol	LANCL1-AS1
Name	LANCL1 antisense RNA 1
Location	2q34
Locus type	RNA, long non-coding
Status	Approved
Aliases	LANCLOT
Ensembl gene	ENSG00000234281
Ensembl biotype	lncRNA
Entrez	102724820
RNAcentral	URS0000759A9C — lncRNA, 2186 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 5 lncRNA

ENST00000416344, ENST00000420418, ENST00000433296, ENST00000795994, ENST00000795996

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000416344 — 5 exons

Exon	Start	End
ENSE00001662278	210429365	210429451
ENSE00001728808	210468505	210468584
ENSE00001739454	210460475	210460543
ENSE00004181155	210324662	210324834
ENSE00004181161	210468682	210469246

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 95.64.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.3513 / max 96.9468, expressed in 45 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
25012	0.2004	36
25011	0.1041	29
25010	0.0468	18

Top tissues by expression

136 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
corpus callosum	UBERON:0002336	95.64	gold quality
hindlimb stylopod muscle	UBERON:0004252	89.69	gold quality
skeletal muscle tissue	UBERON:0001134	88.36	gold quality
quadriceps femoris	UBERON:0001377	88.16	silver quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	86.38	gold quality
muscle of leg	UBERON:0001383	83.93	gold quality
gastrocnemius	UBERON:0001388	82.75	gold quality
right lung	UBERON:0002167	77.62	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	76.30	gold quality
spinal cord	UBERON:0002240	76.21	gold quality
lung	UBERON:0002048	73.36	gold quality
upper lobe of left lung	UBERON:0008952	73.34	gold quality
calcaneal tendon	UBERON:0003701	72.24	gold quality
right hemisphere of cerebellum	UBERON:0014890	71.10	gold quality
cerebellar cortex	UBERON:0002129	71.08	gold quality
cerebellar hemisphere	UBERON:0002245	71.02	gold quality
cerebellum	UBERON:0002037	70.99	gold quality
primary visual cortex	UBERON:0002436	70.72	gold quality
colonic epithelium	UBERON:0000397	70.33	silver quality
right frontal lobe	UBERON:0002810	69.97	gold quality
cerebellar vermis	UBERON:0004720	69.89	gold quality
frontal cortex	UBERON:0001870	69.87	gold quality
prefrontal cortex	UBERON:0000451	69.79	gold quality
bone marrow cell	CL:0002092	69.66	silver quality
superior frontal gyrus	UBERON:0002661	69.52	gold quality
pituitary gland	UBERON:0000007	69.05	gold quality
metanephros cortex	UBERON:0010533	68.52	gold quality
right uterine tube	UBERON:0001302	68.50	gold quality
left ovary	UBERON:0002119	68.45	gold quality
brain	UBERON:0000955	68.35	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	14.74

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.