LANCL1

Summary

LANCL1 (LanC like glutathione S-transferase 1, HGNC:6508) is a protein-coding gene on chromosome 2q34, encoding Glutathione S-transferase LANCL1 (O43813). Functions as a glutathione transferase.

This gene encodes a loosely associated peripheral membrane protein related to the LanC family of bacterial membrane-associated proteins involved in the biosynthesis of antimicrobial peptides. This protein may play a role as a peptide-modifying enzyme component in eukaryotic cells. Previously considered a member of the G-protein-coupled receptor superfamily, this protein is now in the LanC family. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Source: NCBI Gene 10314 — RefSeq curated summary.

At a glance

• GWAS associations: 8
• Clinical variants (ClinVar): 77 total
• Druggable target: yes
• MANE Select transcript: NM_006055

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:6508
Approved symbol	LANCL1
Name	LanC like glutathione S-transferase 1
Location	2q34
Locus type	gene with protein product
Status	Approved
Aliases	p40
Ensembl gene	ENSG00000115365
Ensembl biotype	protein_coding
OMIM	604155
Entrez	10314

Gene structure

Transcript identifiers

Ensembl transcripts: 18 — 17 protein_coding, 1 nonsense_mediated_decay

ENST00000233714, ENST00000412863, ENST00000431941, ENST00000441020, ENST00000443314, ENST00000448951, ENST00000450366, ENST00000453956, ENST00000853653, ENST00000853654, ENST00000853655, ENST00000853656, ENST00000853657, ENST00000915319, ENST00000961902, ENST00000961903, ENST00000961904, ENST00000961905

RefSeq mRNA: 3 — MANE Select: NM_006055 NM_001136574, NM_001136575, NM_006055

CCDS: CCDS2392

Canonical transcript exons

ENST00000450366 — 10 exons

Exon	Start	End
ENSE00000785346	210441308	210441443
ENSE00000785347	210455107	210455314
ENSE00000785348	210471959	210472076
ENSE00000796767	210476316	210476412
ENSE00001610318	210440598	210440744
ENSE00001688586	210476620	210476759
ENSE00003894327	210431251	210434563
ENSE00003991027	210436216	210436392
ENSE00003991029	210435387	210435459
ENSE00003991030	210437690	210437872

Expression profiles

Bgee: expression breadth ubiquitous, 301 present calls, max score 99.30.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 18.6583 / max 416.2548, expressed in 1771 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
33482	15.5900	1749
33484	1.7712	781
33481	1.1331	518
33483	0.1641	56

Top tissues by expression

303 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
endothelial cell	CL:0000115	99.30	gold quality
corpus callosum	UBERON:0002336	99.17	gold quality
inferior vagus X ganglion	UBERON:0005363	99.11	gold quality
subthalamic nucleus	UBERON:0001906	99.06	gold quality
inferior olivary complex	UBERON:0002127	99.03	gold quality
substantia nigra pars reticulata	UBERON:0001966	98.86	gold quality
Brodmann (1909) area 46	UBERON:0006483	98.86	gold quality
postcentral gyrus	UBERON:0002581	98.75	gold quality
lateral globus pallidus	UBERON:0002476	98.74	gold quality
lateral nuclear group of thalamus	UBERON:0002736	98.71	gold quality
middle temporal gyrus	UBERON:0002771	98.69	gold quality
dorsal plus ventral thalamus	UBERON:0001897	98.67	gold quality
medulla oblongata	UBERON:0001896	98.66	gold quality
Brodmann (1909) area 23	UBERON:0013554	98.64	gold quality
parietal lobe	UBERON:0001872	98.63	gold quality
middle frontal gyrus	UBERON:0002702	98.61	gold quality
substantia nigra pars compacta	UBERON:0001965	98.58	gold quality
pons	UBERON:0000988	98.56	gold quality
superior vestibular nucleus	UBERON:0007227	98.29	gold quality
superior frontal gyrus	UBERON:0002661	98.23	gold quality
spinal cord	UBERON:0002240	98.19	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	98.14	gold quality
occipital lobe	UBERON:0002021	98.04	gold quality
orbitofrontal cortex	UBERON:0004167	97.98	gold quality
primary visual cortex	UBERON:0002436	97.92	gold quality
CA1 field of hippocampus	UBERON:0003881	97.85	gold quality
cranial nerve II	UBERON:0000941	97.71	gold quality
cerebellar vermis	UBERON:0004720	97.68	gold quality
entorhinal cortex	UBERON:0002728	97.63	gold quality
Brodmann (1909) area 10	UBERON:0013541	97.58	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-GEOD-84465	yes	9.62
E-ANND-3	yes	6.80

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

159 targeting LANCL1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-4533	100.00	69.48	2758
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-4476	100.00	68.18	2030
HSA-MIR-6876-5P	100.00	67.68	2126
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-513B-5P	99.99	69.96	2150
HSA-MIR-548N	99.98	71.94	4170
HSA-MIR-4482-3P	99.98	72.50	3147
HSA-LET-7F-2-3P	99.98	70.98	2588
HSA-MIR-1185-1-3P	99.98	71.04	2593
HSA-MIR-1185-2-3P	99.98	71.04	2593
HSA-MIR-3688-3P	99.97	72.02	2834
HSA-MIR-548AN	99.97	70.91	2817
HSA-MIR-146A-5P	99.96	68.93	988
HSA-MIR-146B-5P	99.96	69.13	977
HSA-MIR-9-3P	99.96	70.88	2068
HSA-MIR-548AT-5P	99.96	70.83	2666
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-548AB	99.95	71.31	3488
HSA-MIR-559	99.95	72.28	3609
HSA-MIR-7153-5P	99.94	68.89	1006
HSA-MIR-9983-3P	99.94	71.48	3631
HSA-MIR-548A-5P	99.94	71.27	3482
HSA-MIR-548AD-5P	99.94	71.23	3502
HSA-MIR-548AE-5P	99.94	71.23	3502
HSA-MIR-548AK	99.94	71.24	3488
HSA-MIR-548AM-5P	99.94	71.24	3488
HSA-MIR-548AP-5P	99.94	71.14	3489

Literature-anchored findings (GeneRIF, showing 8)

• the crystal structures of human LanCL1, both free of and complexed with glutathione, revealing glutathione binding to a zinc ion at the putative active site formed by conserved GxxG motifs (PMID:19528316)
• Lanthionine synthetase C-like protein 1 interacts with and inhibits cystathionine beta-synthase: a target for neuronal antioxidant defense. (PMID:22891245)
• Results suggest that LanCL1 protects cells from oxidative stress, and promotes cell proliferation. LanCL1 reduces cell death via suppression of JNK signaling pathway. (PMID:29416001)
• Oxygen and glucose deprivation (OGD) exposure induced a temporal increase and persistent decreases in the expression of LanCL1 at both mRNA and protein levels. Overexpression of LanCL1 by lentivirus transfection preserved cell viability, reduced lactate dehydrogenase release and attenuated apoptosis after OGD. LanCL1 stimulated mitochondrial enzyme activities and SOD2 deacetylation in a Sirt3-dependent manner. (PMID:30075199)
• Stable knockout of lanthionine synthase C-like protein-1 (LanCL1) from HeLa cells indicates a role for LanCL1 in redox regulation of deubiquitinating enzymes. (PMID:33049334)
• LANCL1 binds abscisic acid and stimulates glucose transport and mitochondrial respiration in muscle cells via the AMPK/PGC-1alpha/Sirt1 pathway. (PMID:34098144)
• The ABA/LANCL1/2 Hormone/Receptor System Controls Adipocyte Browning and Energy Expenditure. (PMID:36834900)
• LANCL1, a cell surface protein, promotes liver tumor initiation through FAM49B-Rac1 axis to suppress oxidative stress. (PMID:37540188)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	lancl1	ENSDARG00000013741
mus_musculus	Lancl1	ENSMUSG00000026000
rattus_norvegicus	Lancl1	ENSRNOG00000013557
drosophila_melanogaster	CG2061	FBGN0027498

Paralogs (2): LANCL2 (ENSG00000132434), LANCL3 (ENSG00000147036)

Protein

Protein identifiers

Glutathione S-transferase LANCL1 — O43813 (reviewed: O43813)

Alternative names: 40 kDa erythrocyte membrane protein, LanC-like protein 1

All UniProt accessions (5): O43813, E9PHS0, F8WDS9, H7C2E3, Q53TN2

UniProt curated annotations — full annotation on UniProt →

Function. Functions as a glutathione transferase. Catalyzes conjugation of the glutathione (GSH) to artificial substrates 1-chloro-2,4-dinitrobenzene (CDNB) and p-nitrophenyl acetate. Mitigates neuronal oxidative stress during normal postnatal development and in response to oxidative stresses probably through GSH antioxidant defense mechanism. May play a role in EPS8 signaling. Binds glutathione.

Subunit / interactions. Interacts with the C-terminal of STOM. Interacts with the EPS8 SH3 domain. Interaction with EPS8 is inhibited by glutathione binding. (Microbial infection) Interacts with P.falciparum SBP1.

Subcellular location. Cytoplasm. Cell membrane.

Tissue specificity. Detected in erythrocytes, brain, kidney, testis, ovary, heart, lung, placenta and spleen (at protein level). Ubiquitous. Strongly expressed in brain, spinal cord, pituitary gland, kidney, heart, skeletal muscle, pancreas, ovary and testis.

Miscellaneous. Was originally thought to be a G-protein coupled receptor.

Similarity. Belongs to the LanC-like protein family.

RefSeq proteins (3): NP_001130046, NP_001130047, NP_006046* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR007822	LANC-like	Family
IPR012341	6hp_glycosidase-like_sf	Homologous_superfamily
IPR020464	LanC-like_prot_euk	Family

Pfam: PF05147

Catalyzed reactions (Rhea), 2 shown:

• RX + glutathione = an S-substituted glutathione + a halide anion + H(+) (RHEA:16437)
• 1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+) (RHEA:51220)

UniProt features (45 total): helix 20, turn 10, binding site 5, mutagenesis site 4, strand 2, modified residue 2, initiator methionine 1, chain 1

Structure

Experimental structures (PDB)

6 structures.

PDB	Method	Resolution (Å)
8D19	X-RAY DIFFRACTION	1.52
8CZL	X-RAY DIFFRACTION	1.58
8D0V	X-RAY DIFFRACTION	1.79
8CZK	X-RAY DIFFRACTION	1.91
3E6U	X-RAY DIFFRACTION	2.6
3E73	X-RAY DIFFRACTION	2.8

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O43813-F1	97.52	0.98

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (5): 276; 317; 322; 323; 364–367

Post-translational modifications (2): 2, 142

Mutagenesis-validated functional residues (4):

Position	Phenotype
317	loss of glutathione binding.
322	loss of glutathione binding.
364	loss of glutathione binding.
4	loss of glutathione binding.

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 225 (showing top): GCM_MAP4K4, BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN, GCM_PTPRD, MODULE_522, MODULE_64, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP, GOMF_GLUTATHIONE_TRANSFERASE_ACTIVITY, GOBP_PEPTIDE_METABOLIC_PROCESS, MODULE_289, GOBP_CELLULAR_RESPONSE_TO_TOXIC_SUBSTANCE, MARTINEZ_RB1_TARGETS_DN, PETRETTO_HEART_MASS_QTL_CIS_DN, GOBP_DETOXIFICATION, GOBP_CARBOHYDRATE_METABOLIC_PROCESS

GO Biological Process (4): carbohydrate metabolic process (GO:0005975), G protein-coupled receptor signaling pathway (GO:0007186), peptide modification (GO:0031179), cellular detoxification (GO:1990748)

GO Molecular Function (9): glutathione transferase activity (GO:0004364), G protein-coupled receptor activity (GO:0004930), zinc ion binding (GO:0008270), SH3 domain binding (GO:0017124), glutathione binding (GO:0043295), low-density lipoprotein particle receptor binding (GO:0050750), protein binding (GO:0005515), transferase activity (GO:0016740), metal ion binding (GO:0046872)

GO Cellular Component (3): cytoplasm (GO:0005737), plasma membrane (GO:0005886), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
primary metabolic process	1
G protein-coupled receptor activity	1
signal transduction	1
peptide metabolic process	1
cellular process	1
cellular response to toxic substance	1
detoxification	1
transferase activity, transferring alkyl or aryl (other than methyl) groups	1
transmembrane signaling receptor activity	1
G protein-coupled receptor signaling pathway	1
transition metal ion binding	1
protein domain specific binding	1
anion binding	1
modified amino acid binding	1
oligopeptide binding	1
sulfur compound binding	1
lipoprotein particle receptor binding	1
binding	1
catalytic activity	1
cation binding	1
intracellular anatomical structure	1
membrane	1
cell periphery	1

Protein interactions and networks

STRING

730 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
LANCL1	EPS8	Q12929	848
LANCL1	STOM	P27105	803
LANCL1	ALDH16A1	Q8IZ83	603
LANCL1	ACTR10	Q9NZ32	565
LANCL1	ECD	O95905	506
LANCL1	KANSL1L	A0AUZ9	500
LANCL1	NGF	P01138	486
LANCL1	STXBP1	P61764	461
LANCL1	ROGDI	Q9GZN7	460
LANCL1	PHF24	Q9UPV7	457
LANCL1	ERI3	O43414	446
LANCL1	STYXL1	Q9Y6J8	442
LANCL1	SMYD4	Q8IYR2	427
LANCL1	COPS7A	Q9UBW8	416
LANCL1	RPS9	P46781	409

IntAct

98 interactions, top by confidence:

A	B	Type	Score
CFTR	ESYT2	psi-mi:“MI:0914”(association)	0.710
LANCL1	HTT	psi-mi:“MI:0915”(physical association)	0.670
AURKB	SEC16A	psi-mi:“MI:0914”(association)	0.570
LANCL1	BAIAP2L1	psi-mi:“MI:0915”(physical association)	0.560
LANCL1	Eps8	psi-mi:“MI:0407”(direct interaction)	0.440
Eps8	LANCL1	psi-mi:“MI:0407”(direct interaction)	0.440
AIFM1	HAX1	psi-mi:“MI:0914”(association)	0.420
RAB11A	LANCL1	psi-mi:“MI:0914”(association)	0.420
RAB11A	LANCL1	psi-mi:“MI:2364”(proximity)	0.420
TNFAIP3	LRRIQ3	psi-mi:“MI:0914”(association)	0.420
LANCL1	YWHAZ	psi-mi:“MI:0915”(physical association)	0.400
JUN	TPM3	psi-mi:“MI:0914”(association)	0.350
HSCB	RBP5	psi-mi:“MI:0914”(association)	0.350
PTPRH	MCRIP1	psi-mi:“MI:0914”(association)	0.350
LMNA	ZNF724	psi-mi:“MI:0914”(association)	0.350
RAB5A	SEC16A	psi-mi:“MI:0914”(association)	0.350
RAB9A	LANCL1	psi-mi:“MI:0914”(association)	0.350
SMARCB1		psi-mi:“MI:0914”(association)	0.350

BioGRID (158): LANCL1 (Affinity Capture-MS), ALDH16A1 (Affinity Capture-MS), DERA (Affinity Capture-MS), TBC1D9 (Affinity Capture-MS), TBC1D9B (Affinity Capture-MS), FIGN (Affinity Capture-MS), MYO7A (Affinity Capture-MS), IPP (Affinity Capture-MS), OCIAD1 (Affinity Capture-MS), UBN2 (Affinity Capture-MS), LANCL1 (Affinity Capture-MS), LANCL1 (Affinity Capture-MS), LANCL1 (Affinity Capture-MS), LANCL1 (Affinity Capture-MS), FIGN (Affinity Capture-MS)

ESM2 similar proteins: A1A5Y5, A2ACP1, B3MZN7, B3NY19, B4PYH5, B4S3A5, F1MVX2, F4IEM5, O01824, O43813, O65583, O74878, O89112, O94710, P56523, Q08DA5, Q25566, Q26609, Q28901, Q28D40, Q290Z2, Q29HZ1, Q2KNB7, Q55D85, Q5JVF3, Q5SRH9, Q5U3P0, Q623S8, Q6CUZ3, Q7K3B9, Q7K3M5, Q80VY9, Q8VYB2, Q8VZQ6, Q90ZL2, Q94263, Q9FJN7, Q9FKS0, Q9H6R0, Q9JJK2

Diamond homologs: F1MVX2, F4IEM5, O43813, O89112, Q29HZ1, Q6ZV70, Q8CD19, Q8VZQ6, Q90ZL2, Q9JJK2, Q9NS86, Q9QX69, Q9Y0Y7, Q9FJN7

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 100 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

GO biological processes:

GO term	Partners	Fold	FDR
cell surface receptor protein tyrosine kinase signaling pathway	6	11.8×	7e-03
cell migration	9	6.3×	7e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

77 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	69
Likely benign	0
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

1525 predictions. Top by Δscore:

Variant	Effect	Δscore
2:210435383:ATAC:A	donor_loss	1.0000
2:210435384:TACCT:T	donor_loss	1.0000
2:210435385:AC:A	donor_loss	1.0000
2:210435455:GCAAA:G	acceptor_gain	1.0000
2:210435456:CAAA:C	acceptor_gain	1.0000
2:210435456:CAAAC:C	acceptor_gain	1.0000
2:210435460:C:CC	acceptor_gain	1.0000
2:210436239:T:TA	donor_gain	1.0000
2:210437868:CTGGG:C	acceptor_gain	1.0000
2:210437873:C:CC	acceptor_gain	1.0000
2:210440592:CCTTA:C	donor_loss	1.0000
2:210440593:CTTA:C	donor_loss	1.0000
2:210440595:TA:T	donor_loss	1.0000
2:210440597:C:CT	donor_loss	1.0000
2:210440597:CCTG:C	donor_gain	1.0000
2:210440740:CAAAT:C	acceptor_gain	1.0000
2:210440741:AAAT:A	acceptor_gain	1.0000
2:210440742:AAT:A	acceptor_gain	1.0000
2:210440743:AT:A	acceptor_gain	1.0000
2:210440743:ATCTA:A	acceptor_loss	1.0000
2:210440745:C:CC	acceptor_gain	1.0000
2:210440745:CTAC:C	acceptor_loss	1.0000
2:210440746:T:A	acceptor_loss	1.0000
2:210441307:CCTG:C	donor_gain	1.0000
2:210441439:TTAGC:T	acceptor_gain	1.0000
2:210455312:TAC:T	acceptor_gain	1.0000
2:210455315:CT:C	acceptor_loss	1.0000
2:210455316:T:A	acceptor_loss	1.0000
2:210471961:G:A	donor_gain	1.0000
2:210472074:CAG:C	acceptor_gain	1.0000

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000098809 (2:210465277 A>G), RS1000114454 (2:210437042 T>A,C), RS1000180677 (2:210476736 C>G,T), RS1000208499 (2:210476959 C>G,T), RS1000255390 (2:210475842 A>G), RS1000341409 (2:210443084 T>C), RS1000396203 (2:210436617 C>A), RS1000452765 (2:210435161 A>G), RS1000520651 (2:210448831 A>T), RS1000600017 (2:210460155 T>C), RS1000654889 (2:210449202 A>G), RS1000686277 (2:210461703 T>C), RS1000754035 (2:210454857 C>T), RS1000799596 (2:210445923 G>A), RS1000862418 (2:210447288 T>C)

Disease associations

OMIM: gene MIM:604155 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

8 associations (top):

Study	Trait	p-value
GCST006585_264	Blood protein levels	4.000000e-14
GCST009391_14	Metabolite levels	2.000000e-11
GCST009391_15	Metabolite levels	5.000000e-08
GCST009391_220	Metabolite levels	2.000000e-58
GCST009391_221	Metabolite levels	8.000000e-19
GCST009391_531	Metabolite levels	3.000000e-08
GCST010988_200	Adult body size	3.000000e-09
GCST90026414_12	Severe insulin-resistant type 2 diabetes	8.000000e-06

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0009767	glycine measurement
EFO:0010528	quinolinic acid measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6066415 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

2 potent at pChembl≥5 of 2 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
7.27	Kd	53.19	nM	CHEMBL5653589
7.27	ED50	53.19	nM	CHEMBL5653589

PubChem BioAssay actives

1 with measured affinity, of 2 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(2-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2148637: Binding affinity to human LANCL1 incubated for 45 mins by Kinobead based pull down assay	kd	0.0532	uM

CTD chemical–gene interactions

38 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	affects expression, affects binding, increases reaction, increases expression	3
Cadmium Chloride	decreases expression, increases abundance, increases expression	3
Cisplatin	affects expression, affects response to substance	2
Etoposide	decreases expression, affects response to substance	2
Valproic Acid	affects expression, increases expression	2
Cyclosporine	decreases expression	2
aristolochic acid I	increases expression	1
triphenyl phosphate	affects expression	1
beta-lapachone	decreases expression	1
arsenite	affects binding, decreases reaction	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
sodium arsenite	decreases expression	1
cobaltous chloride	decreases expression	1
butyraldehyde	decreases expression	1
CGP 52608	affects binding, increases reaction	1
K 7174	decreases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	increases expression, affects cotreatment	1
ICG 001	decreases expression	1
bisphenol B	increases expression	1
abrine	decreases expression	1
bisphenol S	increases expression	1
LDN 193189	increases expression, affects cotreatment	1
bisphenol AF	increases expression	1
Sunitinib	increases expression	1
Cadmium	increases abundance, increases expression	1
Enzyme Inhibitors	decreases activity, increases O-linked glycosylation	1
Isoniazid	decreases expression	1
Ivermectin	decreases expression	1
Mercury	decreases expression	1
Silicon Dioxide	decreases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5651679	Binding	Binding affinity to human LANCL1 incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B1VP	Abcam HeLa LANCL1 KO	Cancer cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.