LARGE-AS1

Summary

LARGE-AS1 (LARGE antisense RNA 1, HGNC:40336) is a long non-coding RNA gene on chromosome 22q12.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40336
Approved symbol	LARGE-AS1
Name	LARGE antisense RNA 1
Location	22q12.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000224973
Ensembl biotype	lncRNA
Entrez	100506195
RNAcentral	URS000075A914 — lncRNA, 2775 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 17 — 16 lncRNA, 1 retained_intron

ENST00000416275, ENST00000424291, ENST00000438159, ENST00000445892, ENST00000448275, ENST00000450974, ENST00000453336, ENST00000661135, ENST00000663088, ENST00000664675, ENST00000718600, ENST00000718601, ENST00000718602, ENST00000718603, ENST00000718604, ENST00000718605, ENST00000718606

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000416275 — 3 exons

Exon	Start	End
ENSE00001604446	33744129	33744328
ENSE00001685198	33750604	33750683
ENSE00001758280	33747670	33747824

Expression profiles

Bgee: expression breadth ubiquitous, 137 present calls, max score 93.88.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0250 / max 21.6521, expressed in 3 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
191946	0.0144	3
191945	0.0065	3
191944	0.0041	3

Top tissues by expression

226 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sperm	CL:0000019	93.88	gold quality
left testis	UBERON:0004533	88.00	gold quality
right testis	UBERON:0004534	86.65	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	86.22	gold quality
testis	UBERON:0000473	85.34	gold quality
buccal mucosa cell	CL:0002336	77.84	gold quality
colonic epithelium	UBERON:0000397	73.31	gold quality
cortical plate	UBERON:0005343	71.39	gold quality
bone marrow cell	CL:0002092	70.12	gold quality
sural nerve	UBERON:0015488	68.74	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	64.15	gold quality
oviduct epithelium	UBERON:0004804	63.09	gold quality
endothelial cell	CL:0000115	63.06	gold quality
calcaneal tendon	UBERON:0003701	62.50	gold quality
tendon of biceps brachii	UBERON:0008188	62.40	gold quality
biceps brachii	UBERON:0001507	62.30	gold quality
tendon	UBERON:0000043	61.90	gold quality
ganglionic eminence	UBERON:0004023	61.89	gold quality
nasal cavity epithelium	UBERON:0005384	61.41	gold quality
hindlimb stylopod muscle	UBERON:0004252	59.06	gold quality
cartilage tissue	UBERON:0002418	57.77	gold quality
adult organism	UBERON:0007023	57.51	gold quality
corpus callosum	UBERON:0002336	57.29	gold quality
muscle tissue	UBERON:0002385	56.89	silver quality
skeletal muscle tissue	UBERON:0001134	56.73	silver quality
adrenal tissue	UBERON:0018303	56.07	gold quality
deltoid	UBERON:0001476	56.02	gold quality
gall bladder	UBERON:0002110	55.16	gold quality
monocyte	CL:0000576	54.52	gold quality
islet of Langerhans	UBERON:0000006	54.19	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.72

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.