LARGE-IT1

Summary

LARGE-IT1 (LARGE intronic transcript 1, HGNC:41357) is a long non-coding RNA gene on chromosome 22q12.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41357
Approved symbol	LARGE-IT1
Name	LARGE intronic transcript 1
Location	22q12.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000232081
Ensembl biotype	lncRNA
Entrez	100874331
RNAcentral	URS0000384946 — lncRNA, 558 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000445391

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000445391 — 2 exons

Exon	Start	End
ENSE00001651607	33723832	33724279
ENSE00001797811	33724803	33724912

Expression profiles

Bgee: expression breadth broad, 96 present calls, max score 90.06.

Top tissues by expression

96 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	90.06	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	70.67	gold quality
colonic epithelium	UBERON:0000397	70.49	gold quality
skeletal muscle tissue	UBERON:0001134	68.35	gold quality
sural nerve	UBERON:0015488	68.27	gold quality
bone marrow cell	CL:0002092	67.76	silver quality
urinary bladder	UBERON:0001255	64.98	silver quality
tonsil	UBERON:0002372	62.71	silver quality
liver	UBERON:0002107	62.58	silver quality
cortex of kidney	UBERON:0001225	59.60	gold quality
monocyte	CL:0000576	57.81	gold quality
lymph node	UBERON:0000029	57.32	gold quality
myometrium	UBERON:0001296	56.48	gold quality
kidney	UBERON:0002113	54.05	gold quality
uterine cervix	UBERON:0000002	52.88	gold quality
prostate gland	UBERON:0002367	52.37	silver quality
prefrontal cortex	UBERON:0000451	52.16	gold quality
small intestine	UBERON:0002108	51.53	silver quality
ovary	UBERON:0000992	50.84	gold quality
pancreas	UBERON:0001264	50.81	gold quality
blood	UBERON:0000178	50.01	gold quality
islet of Langerhans	UBERON:0000006	49.37	gold quality
right lobe of liver	UBERON:0001114	49.24	gold quality
muscle of leg	UBERON:0001383	48.82	gold quality
gastrocnemius	UBERON:0001388	48.44	gold quality
superior frontal gyrus	UBERON:0002661	47.88	silver quality
heart	UBERON:0000948	47.57	gold quality
lung	UBERON:0002048	47.55	silver quality
primary visual cortex	UBERON:0002436	47.48	silver quality
left coronary artery	UBERON:0001626	46.88	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.36

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.