LARGE1-AS2

Summary

LARGE1-AS2 (LARGE1 antisense RNA 2, HGNC:58379) is a long non-coding RNA gene on chromosome 22q12.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:58379
Approved symbol	LARGE1-AS2
Name	LARGE1 antisense RNA 2
Location	22q12.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000232073
Ensembl biotype	lncRNA
Entrez	124905105

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000434741

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000434741 — 2 exons

Exon	Start	End
ENSE00001605648	33164063	33164370
ENSE00001669660	33166181	33166439

Expression profiles

Bgee: expression breadth broad, 82 present calls, max score 65.87.

Top tissues by expression

82 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
ganglionic eminence	UBERON:0004023	65.87	gold quality
skeletal muscle tissue	UBERON:0001134	63.64	gold quality
body of stomach	UBERON:0001161	62.07	gold quality
stomach	UBERON:0000945	61.92	gold quality
left coronary artery	UBERON:0001626	61.24	gold quality
primary visual cortex	UBERON:0002436	59.10	gold quality
placenta	UBERON:0001987	57.93	gold quality
hindlimb stylopod muscle	UBERON:0004252	55.97	gold quality
fundus of stomach	UBERON:0001160	55.72	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	54.87	gold quality
muscle of leg	UBERON:0001383	54.20	gold quality
monocyte	CL:0000576	53.52	gold quality
lymph node	UBERON:0000029	53.43	gold quality
lower esophagus mucosa	UBERON:0035834	53.19	gold quality
gastrocnemius	UBERON:0001388	52.30	gold quality
left ovary	UBERON:0002119	52.09	gold quality
liver	UBERON:0002107	51.86	silver quality
blood	UBERON:0000178	50.84	silver quality
bone marrow	UBERON:0002371	50.80	silver quality
multicellular organism	UBERON:0000468	50.06	gold quality
heart	UBERON:0000948	49.45	gold quality
prefrontal cortex	UBERON:0000451	49.36	gold quality
skin of leg	UBERON:0001511	49.23	gold quality
zone of skin	UBERON:0000014	49.09	gold quality
islet of Langerhans	UBERON:0000006	49.07	gold quality
right adrenal gland cortex	UBERON:0035827	48.86	gold quality
tonsil	UBERON:0002372	48.80	gold quality
subcutaneous adipose tissue	UBERON:0002190	48.08	gold quality
popliteal artery	UBERON:0002250	48.02	gold quality
heart left ventricle	UBERON:0002084	47.96	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.