LASP1NB

Summary

LASP1NB (LASP1 neighbor, HGNC:44353) is a protein-coding gene on chromosome 17q12, encoding LASP1 neighbor protein (A0A1B0GWH6). May play a key role in the skin fibroblasts (FBs)-keratinocyte-like cells (KLCs).

Predicted to be located in membrane.

Source: NCBI Gene 100505576 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 1 total
• MANE Select transcript: NM_001414697

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44353
Approved symbol	LASP1NB
Name	LASP1 neighbor
Location	17q12
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000263874
Ensembl biotype	protein_coding
OMIM	617544
Entrez	100505576

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000583195

RefSeq mRNA: 1 — MANE Select: NM_001414697 NM_001414697

Canonical transcript exons

ENST00000583195 — 2 exons

Exon	Start	End
ENSE00002690625	38926417	38929381
ENSE00002700748	38925614	38925891

Expression profiles

Bgee: expression breadth ubiquitous, 192 present calls, max score 88.36.

FANTOM5 (CAGE): breadth broad, TPM avg 1.4268 / max 100.4753, expressed in 332 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
160545	1.1655	297
160544	0.2613	107

Top tissues by expression

252 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
pancreatic ductal cell	CL:0002079	88.36	silver quality
prefrontal cortex	UBERON:0000451	86.04	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	83.41	gold quality
Brodmann (1909) area 9	UBERON:0013540	83.33	gold quality
anterior cingulate cortex	UBERON:0009835	82.84	gold quality
frontal cortex	UBERON:0001870	82.81	gold quality
Brodmann (1909) area 46	UBERON:0006483	82.80	gold quality
neocortex	UBERON:0001950	82.15	gold quality
right frontal lobe	UBERON:0002810	81.35	gold quality
hypothalamus	UBERON:0001898	80.55	gold quality
cerebral cortex	UBERON:0000956	80.42	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	79.19	gold quality
amygdala	UBERON:0001876	78.90	gold quality
superior frontal gyrus	UBERON:0002661	78.77	gold quality
substantia nigra	UBERON:0002038	78.34	gold quality
cerebellar hemisphere	UBERON:0002245	78.34	gold quality
cerebellar cortex	UBERON:0002129	78.28	gold quality
postcentral gyrus	UBERON:0002581	78.12	gold quality
cerebellum	UBERON:0002037	77.62	gold quality
right hemisphere of cerebellum	UBERON:0014890	77.59	gold quality
Ammon’s horn	UBERON:0001954	77.39	gold quality
forebrain	UBERON:0001890	77.06	gold quality
brain	UBERON:0000955	76.91	gold quality
caudate nucleus	UBERON:0001873	76.20	gold quality
putamen	UBERON:0001874	76.19	gold quality
spinal cord	UBERON:0002240	76.16	gold quality
midbrain	UBERON:0001891	76.15	gold quality
nucleus accumbens	UBERON:0001882	76.12	gold quality
temporal lobe	UBERON:0001871	75.93	gold quality
cortical plate	UBERON:0005343	75.44	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-GEOD-36552	no	17.49
E-ANND-3	no	2.90

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• These findings indicate that LINC00672 can influence LASP1 expression as a locus-restricted cofactor for p53-mediated gene suppression, thus impacting endometrial cancer and chemosensitivity to paclitaxel. (PMID:28232485)

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

LASP1 neighbor protein — A0A1B0GWH6 (reviewed: A0A1B0GWH6)

Alternative names: Long intergenic non-protein coding RNA 672

All UniProt accessions (1): A0A1B0GWH6

UniProt curated annotations — full annotation on UniProt →

Function. May play a key role in the skin fibroblasts (FBs)-keratinocyte-like cells (KLCs).

Subcellular location. Membrane.

RefSeq proteins (1): NP_001401626* (*=MANE)

Domains & families (InterPro)

UniProt features (2 total): chain 1, transmembrane region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A0A1B0GWH6-F1	97.60	1.00

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 16 (showing top): GAUSSMANN_MLL_AF4_FUSION_TARGETS_G_UP, MIKKELSEN_ES_ICP_WITH_H3K4ME3, MIKKELSEN_NPC_ICP_WITH_H3K4ME3, WARTERS_RESPONSE_TO_IR_SKIN, GSE14000_TRANSLATED_RNA_VS_MRNA_4H_LPS_DC_DN, BLANCO_MELO_INFLUENZA_A_INFECTION_A594_CELLS_UP, chr17q12, FAN_EMBRYONIC_CTX_OLIG, HE_LIM_SUN_FETAL_LUNG_C0_ACTC_POS_SMC_CELL, HE_LIM_SUN_FETAL_LUNG_C0_MESENCHYMAL_1_CELL, HE_LIM_SUN_FETAL_LUNG_C0_VASCULAR_SMC_1_CELL, HE_LIM_SUN_FETAL_LUNG_C0_VASCULAR_SMC_2_CELL, GSE25087_FETAL_VS_ADULT_TREG_DN, IZADPANAH_STEM_CELL_ADIPOSE_VS_BONE_DN, GSE21927_EL4_VS_MCA203_TUMOR_MONOCYTES_DN

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (1): membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	1

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A1B0GWH6, A0A7H0DN68, A0A7H0DNB3, A0T0B1, A0T0B4, A0T0P6, A2BVK2, A4ZUB9, A4ZUC7, A5A617, B7K767, C0HJH3, C0HJH4, C7J0R5, O00631, O78448, P0C2G8, P0CAJ2, P0CAJ3, P0CAJ4, P0CK21, P0CK22, P0DN84, P0DPN0, P0DPO4, P0DPO8, P0DTF1, P0DTI0, P11339, P15911, P30396, P37256, P48109, P49487, P49516, P64442, P64443, P64444, P9WEJ6, Q06J23

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

1 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

157 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
17:38925733:G:C	G14R	0.974
17:38925737:T:C	L15P	0.972
17:38925737:T:G	L15R	0.959
17:38925746:T:G	L18R	0.950
17:38925725:C:A	A11D	0.946
17:38925764:T:C	L24P	0.937
17:38925740:T:A	V16D	0.935
17:38925737:T:A	L15Q	0.932
17:38925700:G:C	D3H	0.929
17:38925746:T:C	L18P	0.926
17:38925724:G:C	A11P	0.912
17:38925713:T:G	L7R	0.905
17:38925734:G:A	G14D	0.901
17:38925746:T:A	L18Q	0.899
17:38925713:T:C	L7P	0.894
17:38925767:T:A	L25H	0.894
17:38925731:T:A	I13K	0.884
17:38925767:T:G	L25R	0.878
17:38925716:T:A	M8K	0.874
17:38925731:T:G	I13R	0.871
17:38925716:T:G	M8R	0.869
17:38925701:A:T	D3V	0.868
17:38925713:T:A	L7Q	0.864
17:38925707:T:G	F5C	0.844
17:38925767:T:C	L25P	0.840
17:38925706:T:C	F5L	0.821
17:38925708:C:A	F5L	0.821
17:38925708:C:G	F5L	0.821
17:38925701:A:C	D3A	0.820
17:38925748:T:C	S19P	0.809

dbSNP variants (sampled 300 via entrez): RS1000367858 (17:38923798 A>G), RS1000900916 (17:38928373 C>G), RS1000969853 (17:38925115 T>C,G), RS1001907631 (17:38929763 A>G), RS1002087905 (17:38924094 A>T), RS1002374339 (17:38926631 A>G), RS1002988992 (17:38927721 C>T), RS1003682710 (17:38926593 T>C), RS1003844861 (17:38926513 C>A,T), RS1004370790 (17:38929498 T>C), RS1004514976 (17:38925487 T>A), RS1004837488 (17:38925195 T>A), RS1004848851 (17:38927665 A>G), RS1004968139 (17:38927484 G>A,T), RS1005790617 (17:38926282 C>G,T)

Disease associations

OMIM: gene MIM:617544 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

13 total (human), top 13 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
(+)-JQ1 compound	increases expression	2
Phenylmercuric Acetate	affects cotreatment, decreases expression	2
Particulate Matter	decreases expression, increases expression	2
aristolochic acid I	increases expression	1
sodium arsenite	decreases expression	1
fipronil	affects cotreatment, decreases expression	1
pifithrin	decreases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
DEET	affects cotreatment, decreases expression	1
Tobacco Smoke Pollution	increases expression	1
Paclitaxel	increases response to substance	1
Okadaic Acid	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.