LASTR

Summary

LASTR (lncRNA associated with SART3 regulation of splicing, HGNC:54143) is a long non-coding RNA gene on chromosome 10p15.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:54143
Approved symbol	LASTR
Name	lncRNA associated with SART3 regulation of splicing
Location	10p15.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000242147
Ensembl biotype	lncRNA
OMIM	618938
Entrez	105376382
RNAcentral	URS0000A77231 — lncRNA, 713 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 40 — 40 lncRNA

ENST00000425246, ENST00000427341, ENST00000478294, ENST00000656119, ENST00000660276, ENST00000665493, ENST00000674724, ENST00000674735, ENST00000674838, ENST00000675199, ENST00000675383, ENST00000675480, ENST00000675696, ENST00000675934, ENST00000675960, ENST00000676006, ENST00000676219, ENST00000676326, ENST00000676438, ENST00000830404, ENST00000830405, ENST00000830406, ENST00000830407, ENST00000830408, ENST00000830409, ENST00000830410, ENST00000830411, ENST00000830412, ENST00000830413, ENST00000830414, ENST00000830415, ENST00000830416, ENST00000830417, ENST00000830418, ENST00000830419, ENST00000830420, ENST00000830421, ENST00000830422, ENST00000830423, ENST00000830424

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000425246 — 5 exons

Exon	Start	End
ENSE00001657675	5610108	5610167
ENSE00001704738	5608349	5608731
ENSE00001727977	5609687	5609797
ENSE00001776012	5610732	5610793
ENSE00001777052	5610314	5610436

Expression profiles

Bgee: expression breadth ubiquitous, 125 present calls, max score 84.38.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.6436 / max 59.9156, expressed in 178 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
108099	0.2629	128
108103	0.2486	46
108100	0.1012	44
108102	0.0181	5
108101	0.0099	4
108104	0.0030	1

Top tissues by expression

125 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.38	silver quality
sural nerve	UBERON:0015488	72.67	gold quality
stromal cell of endometrium	CL:0002255	71.22	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	69.51	gold quality
esophagus mucosa	UBERON:0002469	69.43	gold quality
descending thoracic aorta	UBERON:0002345	68.89	gold quality
colonic epithelium	UBERON:0000397	65.95	silver quality
lower esophagus mucosa	UBERON:0035834	65.76	gold quality
cortex of kidney	UBERON:0001225	65.67	gold quality
rectum	UBERON:0001052	65.51	gold quality
mucosa of transverse colon	UBERON:0004991	65.17	gold quality
small intestine	UBERON:0002108	63.99	gold quality
thoracic aorta	UBERON:0001515	63.13	gold quality
duodenum	UBERON:0002114	63.13	gold quality
small intestine Peyer’s patch	UBERON:0003454	63.07	gold quality
right lobe of liver	UBERON:0001114	63.00	gold quality
ascending aorta	UBERON:0001496	62.90	gold quality
skin of abdomen	UBERON:0001416	62.68	gold quality
zone of skin	UBERON:0000014	62.27	gold quality
metanephros cortex	UBERON:0010533	62.14	gold quality
skin of leg	UBERON:0001511	62.13	gold quality
minor salivary gland	UBERON:0001830	62.05	gold quality
liver	UBERON:0002107	62.00	gold quality
vagina	UBERON:0000996	61.91	gold quality
saliva-secreting gland	UBERON:0001044	61.79	gold quality
transverse colon	UBERON:0001157	61.62	gold quality
tonsil	UBERON:0002372	61.52	gold quality
islet of Langerhans	UBERON:0000006	61.40	gold quality
esophagus	UBERON:0001043	61.10	gold quality
popliteal artery	UBERON:0002250	60.93	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.64

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• LASTR promotes splicing efficiency by controlling SART3 association with the U4 and U6 small nuclear ribonucleoproteins (snRNP) during spliceosome recycling. (PMID:31956895)
• Ferroptosisrelated long noncoding RNAs and the roles of LASTR in stomach adenocarcinoma. (PMID:35137922)
• Identification and Validation of Cuproptosis-Related LncRNA Signatures in the Prognosis and Immunotherapy of Clear Cell Renal Cell Carcinoma Using Machine Learning. (PMID:36551318)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.