LBX2-AS1

Summary

LBX2-AS1 (LBX2 antisense RNA 1, HGNC:25136) is a long non-coding RNA gene on chromosome 2p13.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25136
Approved symbol	LBX2-AS1
Name	LBX2 antisense RNA 1
Location	2p13.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000257702
Ensembl biotype	lncRNA
Entrez	151534
RNAcentral	URS0000CCE0BA — lncRNA, 2473 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 14 lncRNA

ENST00000548978, ENST00000603175, ENST00000688827, ENST00000693462, ENST00000734461, ENST00000734462, ENST00000734463, ENST00000734464, ENST00000734465, ENST00000734466, ENST00000734467, ENST00000734468, ENST00000734469, ENST00000734470

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000548978 — 2 exons

Exon	Start	End
ENSE00002372867	74503640	74504678
ENSE00002391627	74502595	74503407

Expression profiles

Bgee: expression breadth ubiquitous, 158 present calls, max score 87.25.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 5.4280 / max 67.2881, expressed in 1290 samples.

FANTOM5 promoters (8 alternative TSS)

Promoter ID	TPM avg	Samples expressed
21041	2.2509	758
21035	1.0041	479
21037	0.7946	486
21040	0.7570	469
21039	0.3041	143
21042	0.1784	86
21036	0.1005	39
21038	0.0385	8

Top tissues by expression

249 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
ileal mucosa	UBERON:0000331	87.25	gold quality
right lobe of liver	UBERON:0001114	86.49	gold quality
pancreatic ductal cell	CL:0002079	84.97	silver quality
liver	UBERON:0002107	80.73	gold quality
mucosa of transverse colon	UBERON:0004991	79.91	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	79.81	gold quality
duodenum	UBERON:0002114	77.36	gold quality
kidney epithelium	UBERON:0004819	75.84	gold quality
cardiac muscle of right atrium	UBERON:0003379	75.33	gold quality
jejunal mucosa	UBERON:0000399	75.09	gold quality
left ventricle myocardium	UBERON:0006566	75.09	gold quality
small intestine Peyer’s patch	UBERON:0003454	74.48	gold quality
small intestine	UBERON:0002108	74.43	gold quality
body of stomach	UBERON:0001161	74.42	gold quality
monocyte	CL:0000576	74.17	gold quality
leukocyte	CL:0000738	74.16	gold quality
granulocyte	CL:0000094	73.77	gold quality
transverse colon	UBERON:0001157	73.39	gold quality
omental fat pad	UBERON:0010414	73.33	gold quality
peritoneum	UBERON:0002358	73.24	gold quality
subcutaneous adipose tissue	UBERON:0002190	72.82	gold quality
adipose tissue of abdominal region	UBERON:0007808	72.66	gold quality
apex of heart	UBERON:0002098	72.64	gold quality
adult mammalian kidney	UBERON:0000082	72.19	gold quality
stomach	UBERON:0000945	71.65	gold quality
rectum	UBERON:0001052	71.35	gold quality
body of pancreas	UBERON:0001150	70.60	gold quality
spleen	UBERON:0002106	70.23	gold quality
tibial nerve	UBERON:0001323	70.13	gold quality
adipose tissue	UBERON:0001013	70.09	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.44

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 12)

• LncRNA LBX2-AS1 promoted cell migration and epithelial-mesenchymal transition process in esophageal squamous cell carcinoma. LBX2-AS1 interacting with HNRNPC to promote ZEB1/2 mRNA stability. (PMID:30824187)
• LBX2-AS1 might be associated with periodontitis (PMID:31512745)
• Novel long non-coding RNA LBX2-AS1 indicates poor prognosis and promotes cell proliferation and metastasis through Notch signaling in non-small cell lung cancer. (PMID:31539129)
• LBX2-AS1/miR-219a-2-3p/FUS/LBX2 positive feedback loop contributes to the proliferation of gastric cancer. (PMID:31673844)
• LncRNA LBX2-AS1 facilitates abdominal aortic aneurysm through miR-4685-5p/LBX2 feedback loop. (PMID:32559617)
• ELK1 activated-long noncoding RNA LBX2-AS1 aggravates the progression of ovarian cancer through targeting miR-4784/KDM5C axis. (PMID:33099720)
• Silencing of lncRNA LBX2-AS1 suppresses glioma cell proliferation and metastasis through the Akt/GSK3beta pathway in vitro. (PMID:33637977)
• Overexpression of Long Noncoding RNA LBX2-AS1 Promotes the Proliferation of Colorectal Cancer. (PMID:33733923)
• Long noncoding RNA LBX2-AS1 promotes colorectal cancer progression via binding with PTBP1 and stabilizing KAT2A expression. (PMID:35253306)
• Long non-coding RNA LBX2-AS1 predicts poor survival of colon cancer patients and promotes its progression via regulating miR-627-5p/RAC1/PI3K/AKT pathway. (PMID:35816228)
• The role of LncRNA LBX2-AS1 in cancers: functions, mechanisms and potential clinical utility. (PMID:36131071)
• LncRNA LBX2-AS1 promotes proliferation and migratory capacity of clear cell renal cell carcinoma through mitophagy. (PMID:38326905)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.