LCAL1

Summary

LCAL1 (lung cancer associated lncRNA 1, HGNC:25837) is a long non-coding RNA gene on chromosome 6q14.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25837
Approved symbol	LCAL1
Name	lung cancer associated lncRNA 1
Location	6q14.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	onco-lncRNA-27
Ensembl gene	ENSG00000286042
Ensembl biotype	lncRNA
Entrez	80078
RNAcentral	URS00008121A7 — lncRNA, 3885 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 11 — 11 lncRNA

ENST00000651107, ENST00000651663, ENST00000651762, ENST00000759886, ENST00000759889, ENST00000759890, ENST00000759891, ENST00000759892, ENST00000759893, ENST00000759894, ENST00000759895

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000651107 — 3 exons

Exon	Start	End
ENSE00003843614	79312740	79312828
ENSE00003849434	79312368	79312480
ENSE00003849776	79310900	79311244

Expression profiles

Bgee: expression breadth broad, 92 present calls, max score 78.35.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1451 / max 31.2198, expressed in 45 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
74506	0.0879	34
74507	0.0482	25
74508	0.0090	4

Top tissues by expression

188 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
corpus epididymis	UBERON:0004359	78.35	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	76.47	gold quality
placenta	UBERON:0001987	73.27	gold quality
islet of Langerhans	UBERON:0000006	69.31	gold quality
amniotic fluid	UBERON:0000173	64.62	silver quality
pancreas	UBERON:0001264	62.13	gold quality
sural nerve	UBERON:0015488	62.10	gold quality
body of pancreas	UBERON:0001150	59.07	gold quality
gall bladder	UBERON:0002110	54.65	gold quality
smooth muscle tissue	UBERON:0001135	54.13	gold quality
minor salivary gland	UBERON:0001830	52.81	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	52.73	gold quality
calcaneal tendon	UBERON:0003701	52.33	silver quality
nucleus accumbens	UBERON:0001882	52.24	gold quality
caput epididymis	UBERON:0004358	52.13	silver quality
monocyte	CL:0000576	51.66	gold quality
cauda epididymis	UBERON:0004360	51.51	gold quality
metanephros cortex	UBERON:0010533	51.28	gold quality
body of stomach	UBERON:0001161	50.83	gold quality
saliva-secreting gland	UBERON:0001044	50.67	gold quality
mouth mucosa	UBERON:0003729	50.60	gold quality
caudate nucleus	UBERON:0001873	49.89	gold quality
adrenal tissue	UBERON:0018303	49.68	silver quality
adult mammalian kidney	UBERON:0000082	49.34	gold quality
stomach	UBERON:0000945	49.02	gold quality
putamen	UBERON:0001874	48.35	gold quality
Brodmann (1909) area 9	UBERON:0013540	48.20	gold quality
skin of abdomen	UBERON:0001416	48.17	gold quality
muscle of leg	UBERON:0001383	47.62	silver quality
female reproductive system	UBERON:0000474	47.33	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.93

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• LCAL1 may support lung cancer survival via inhibiting the activity of AMP-activated protein kinase (AMPK). According to our results, LCAL1 may physically interact with the catalytic subunit of tumor suppressor AMPK, prevent AMPK activation by upstream kinase (liver kinase B1), and thus inhibit the downstream AMPK signaling network. (PMID:30741368)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.